Abstract: A low profile gripping device having a locking assembly attached to a base, wherein the locking assembly comprises a locking strap with pairs of fins disposed for insertion into an aperture of a buckle. The locking assembly comprises an offset anchor block having opposing sides, the locking strap attached to one side, and the buckle attached to the opposing side. The interface between the locking strap and the anchor block forms a groove for seating a flexible polymer tube or polymer coated cable. The groove is located above the base such that the seated tube or cable is substantially centered above the base. The locking strap is inserted through the aperture to secure the tube or cable in the groove, and the fins retain the locking strap in fixed relation to the buckle.

Abstract: A cannula capture mechanism is described herein. The capture mechanism may include an inner housing, outer housing, and a cannula. The outer housing may be configured to move between a compressed and a decompressed state. An outer surface of the inner housing may include one or more interlock components. When the cannula is exposed from a distal end of the inner housing, the one or more interlock components may interact with one or more interlock surfaces formed in another surface of the catheter device. When the cannula is retracted proximally within the inner housing, the inner housing may contract radially inward causing the one or more interlock components to be separated from the one or more interlock surfaces and the outer housing to move to the decompressed state and extend distally over a distal portion of the inner housing.

Abstract: An auto injector for delivery of a medicament to a patient is provided. The auto injector is adapted for receiving a cartridge assembly supporting a syringe. The auto injector includes a housing, a plunger, a plunger spring, and a clutch assembly. The plunger is movably positioned inside the housing. The plunger spring is adapted to move the plunger for delivery of the medicament. The clutch assembly is positioned inside the housing and includes a bi-stable clutch plate.

Abstract: An access closure device for closing an opening in tissue is provided. The access closure device may comprise a balloon delivery system and a sealant delivery system. The balloon delivery system may comprise a suture, a delivery shaft, an inflatable balloon, and a balloon segment releasably attached to the delivery shaft. The sealant delivery system may comprise a sealant delivery shaft, an ejection tube, and a snare wire configured to snare a suture of the delivery system.

Abstract: The present disclosure relates to drug delivery devices, and in particular, to drug delivery devices configured to reconstitute a lyophilized drug powder into liquid form prior to delivery into a patients body. In some embodiments, such devices include a flexible drug reservoir having a proximal reservoir component storing a liquid diluent and a distal reservoir component storing a lyophilized drug powder, wherein the two compartments are separated by a frangible seal. A compression member may be positioned above the reservoir and held up by a releasable mechanism. When released, the compression member may be driven downwards to compress the proximal compartment so as to break the frangible seal and allow the diluent to mix with the drug powder and form a liquid drug mixture, and then to eject the liquid drug mixture from the reservoir.

Abstract: A universal add-on for an injection pen is provided. A static portion (110) has opposing gripping members to grip a body (112) of the injection pen. A moving portion (106) has opposing gripping members to grip an actuator (114) of the injection pen. Displacement measurement devices (102) measure relative linear and rotational movement of the actuator relative to the injection pen body (112). Doses are determined and recorded based on relative movement of the static portion (110) and moving portion (106), and the dose data is transmitted wirelessly to a mobile device. The device is easily installed on injection pens by pressing opposing buttons to relieve gripping pressure imparted by the gripping members.

Abstract: Disinfection cap includes housing comprising closed top, essentially cylindrical sidewall, and open bottom formed by the sidewall with opening to inner cavity within the housing for receiving tip including mating feature of needleless connector. Disinfection sponge can be configured within inner cavity, removable cover sealing opening to inner cavity to seal sponge within inner cavity prior to cap use. Inner cavity includes at least one thread on inner surface of its sidewall that does not correspond to the mating feature of needleless connector, but is sufficient to interlock with mating feature of needleless connector. Plurality of disinfection caps are disposed on strip of IV pole hanging device such that each cap can be peeled off the strip unsealed for immediate use, or separated from the strip sealed for later use.

Abstract: A drug delivery device and a method of operating the drug delivery device are provided. The drug delivery device includes a light emitter disposed in a body to emit light based on a control signal, a drug reservoir configured to react to the light emitted from the light emitter and to release a drug, a photosensor configured to sense light passing through the drug reservoir, and a controller configured to monitor a degree to which the drug reservoir reacts to the light, based on an amount of light sensed by the photosensor.

Abstract: To provide a medical needle capable of preventing malfunction of a movement mechanism at the time of use, and improving safety even further. A medical needle 1A includes: a needle portion 10; a case 20 which is capable of exposing a needle tip of the needle portion 10 from a distal end, and is capable of accommodating the needle portion 10; a movement mechanism M which moves the needle portion 10 inside the case 20; an operation portion 62 for operating the movement mechanism; and an operation regulation portion 80A that regulates operation of the operation portion 62.

Abstract: An insertion device includes a housing, a sheath, a guidewire, and a wheel assembly. The housing has a distal opening at a distal end and a proximal opening at a proximal end. The sheath is coupled to the proximal end of the housing and has an interior in communication with a proximal opening of the housing. The guidewire extends through the proximal opening and into the sheath. The guidewire includes a feature to limit distal advancement of the guidewire. The wheel assembly is rotatably coupled to the housing and connected to the guidewire such that rotation of the wheel assembly distally advances the guidewire through the distal opening of the housing.

Abstract: A drug delivery device for delivering a medicament includes a housing arranged to contain a container, a receiver coil, and an energy storage unit. The receiver coil is arranged to receive energy from a transmitter coil by electromagnetic induction. The energy storage unit is arranged to be charged by at least a portion of the energy received by the receiver coil. At least a portion of the energy received by the receiver coil is converted to heat energy. The receiver coil is arranged in the drug delivery device to transfer the heat energy to the container to heat medicament contained in the container. A system comprising the drug delivery device is also disclosed.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: A catheter assembly is disclosed, which includes a catheter; a catheter hub fixed to a base end portion of the catheter; an inner needle having a needlepoint, inserted into the catheter; a needle hub coupled to the inner needle; a needle support portion configured to support the inner needle through the catheter on a leading end side beyond the catheter hub, the needle support portion having a pair of support arms openable and closeable in a different direction to an axis of the inner needle; a restraining portion capable of restraining the pair of support arms in a closed state and releasing a restraint of the pair of support arms; and wherein the restraining portion is movable with respect to the pair of support arms by a movement of the catheter hub relative to the inner needle, which releases the restraint with respect to the pair of support arms.

Abstract: A steerable catheter control handle and method are provided for bi-directional control of a steerable catheter, the catheter including at least two control wires, a distal end of each of the control wires being coupled to the catheter at a distal region thereof. The control system comprises a housing. A wire actuation mechanism is disposed within the housing and is operably coupled to at least two control wires for enabling actuation of the at least two control wires. The steerable catheter control handle additionally comprises a proximal control knob that is operably coupled to the wire actuation mechanism to enable actuation of the at least two control wires for causing a distal end deflection of the steerable catheter.

Abstract: A device for administering a medicinal liquid by injection is provided. The device comprises a dose assembly comprising collapsible reservoir. The device further includes at least one actuator element onto which the user may apply a force to actuate the device, the force having a component along an axis perpendicular to a longitudinal axis; and a housing comprising a septum. The at least one actuator element is configured and arranged to act on at least a portion of a dose assembly and the at least one actuator element and dose assembly are configured and arranged such that the needle is displaceable along the longitudinal axis and/or in an axis parallel to the longitudinal axis in response to an actuation force so that a portion of the needle moves from an interior to an exterior of the housing and device to allow for dispensation of the medicinal liquid.

Abstract: The present disclosure relates to a medicament delivery device including a cartridge holder to which an injection needle holder can be fixed, the injection needle holder holding an injection needle having a proximal end and a distal end, the proximal end being protected by an inner injection needle cap detachably connected to the injection needle holder, the cartridge holder being mounted in a housing and configured to receive a cartridge of medicament, a cap assembly detachably connected to the housing, and a gripping mechanism configured to remove the inner injection needle cap from the injection needle holder when the cap assembly is pulled away from the cartridge holder.

Abstract: The present disclosure relates to a basket for a catheter designed to be deployed in complex vasculature to optimally treat vascular and arterial disease conditions such as blood clots, blood emboli, and deep vein thrombosis. The basket may comprise a shaft with a plurality of cuts along a portion of its length to form a plurality of tines that provide support for a plurality of porous tubes to form the limbs of the basket. The limbs of the basket expand radially away from the longitudinal axis of the basket when the longitudinal length of the basket is reduced. The limbs may also be connected to a drug delivery system, and in this manner, baskets of the present disclosure allow for the use of both mechanical and pharmaceutical means of thrombolysis.

Abstract: A medical device configured to be flexible and maintain kink resistance while also reducing strain fractures. The medical device may include an elongate tubular shaft defining a lumen extending from a proximal portion to a distal portion. The elongate tubular shaft may comprise an outer jacket forming an outer surface of the elongate tubular shaft, a support member including at least one filament extending in a helical configuration along at least a portion of the a length of the elongate tubular shaft, and a strain relief layer comprising a material that has a modulus of elasticity less than a modulus of elasticity of the outer jacket, the strain relief layer positioned at least between adjacent windings of the support member. The strain relief layer and the support member may collectively form an inner surface of the elongate tubular shaft.

Abstract: A method and a device for needleless injection of liquid into a substrate, in particular of a liquid pharmaceutical or cosmetic preparation into a biological tissue, which makes it possible in a particularly advantageous manner to reliably inject a particularly fine liquid jet into the substrate without a significant increase in the static pressure in the liquid during the injection process. According to the invention, this is achieved by first accelerating the liquid received in a liquid container together with the latter to an initial velocity before the movement of the liquid container is stopped again, while simultaneously ejecting the liquid from the liquid container through an outlet nozzle under at least partial retention of its movement. Preferably, the ejected liquid jet is set in rotation about its jet axis before it impinges on the substrate, so that the jet receives a helical movement and thus practically drills into the substrate without splashing away laterally.

Abstract: A catheter can have a textured outer body surface with protrusions and/or indentations that can reduce friction between the outer body surface and vascular anatomy or an inner lumen of another catheter in contact with the outer body surface. The catheter can include protrusions and/or indentations on an inner lumen surface that can reduce friction between the inner lumen surface and an outer body surface of another catheter within the example catheter. The protrusions can be filled with a lubricant or vasodilating drug, and the protrusions can be configured to break to release the fluid in response to forces on the protrusion during navigation through vascular anatomy and/or an inner lumen of another catheter. The catheter can include a metallic tubular reinforcing layer with openings through which the protrusions and/or indentations extend and/or protrusions and/or indentations shaped into the reinforcing layer.