Abstract: A device for administering a medicinal liquid by injection is provided. The device comprises a dose assembly comprising collapsible reservoir. The device further includes at least one actuator element onto which the user may apply a force to actuate the device, the force having a component along an axis perpendicular to a longitudinal axis; and a housing comprising a septum. The at least one actuator element is configured and arranged to act on at least a portion of a dose assembly and the at least one actuator element and dose assembly are configured and arranged such that the needle is displaceable along the longitudinal axis and/or in an axis parallel to the longitudinal axis in response to an actuation force so that a portion of the needle moves from an interior to an exterior of the housing and device to allow for dispensation of the medicinal liquid.

Abstract: A steerable catheter control handle and method are provided for bi-directional control of a steerable catheter, the catheter including at least two control wires, a distal end of each of the control wires being coupled to the catheter at a distal region thereof. The control system comprises a housing. A wire actuation mechanism is disposed within the housing and is operably coupled to at least two control wires for enabling actuation of the at least two control wires. The steerable catheter control handle additionally comprises a proximal control knob that is operably coupled to the wire actuation mechanism to enable actuation of the at least two control wires for causing a distal end deflection of the steerable catheter.

Abstract: The present disclosure relates to a medicament delivery device including a cartridge holder to which an injection needle holder can be fixed, the injection needle holder holding an injection needle having a proximal end and a distal end, the proximal end being protected by an inner injection needle cap detachably connected to the injection needle holder, the cartridge holder being mounted in a housing and configured to receive a cartridge of medicament, a cap assembly detachably connected to the housing, and a gripping mechanism configured to remove the inner injection needle cap from the injection needle holder when the cap assembly is pulled away from the cartridge holder.

Abstract: The present disclosure relates to a basket for a catheter designed to be deployed in complex vasculature to optimally treat vascular and arterial disease conditions such as blood clots, blood emboli, and deep vein thrombosis. The basket may comprise a shaft with a plurality of cuts along a portion of its length to form a plurality of tines that provide support for a plurality of porous tubes to form the limbs of the basket. The limbs of the basket expand radially away from the longitudinal axis of the basket when the longitudinal length of the basket is reduced. The limbs may also be connected to a drug delivery system, and in this manner, baskets of the present disclosure allow for the use of both mechanical and pharmaceutical means of thrombolysis.

Abstract: A medical device configured to be flexible and maintain kink resistance while also reducing strain fractures. The medical device may include an elongate tubular shaft defining a lumen extending from a proximal portion to a distal portion. The elongate tubular shaft may comprise an outer jacket forming an outer surface of the elongate tubular shaft, a support member including at least one filament extending in a helical configuration along at least a portion of the a length of the elongate tubular shaft, and a strain relief layer comprising a material that has a modulus of elasticity less than a modulus of elasticity of the outer jacket, the strain relief layer positioned at least between adjacent windings of the support member. The strain relief layer and the support member may collectively form an inner surface of the elongate tubular shaft.

Abstract: Devices, agents, and associated methods for selective modulation of renal nerves by localized delivery of neural ablative substances are disclosed herein. One aspect of the present technology is directed to a method for delivering a neuromodulatory agent (e.g., capsaicin) via a catheter to a kidney of the patient. The neuromodulatory agent selectively neuromodulates afferent renal nerves in a patient compared efferent renal nerves of the patient. The method can also include removing the catheter from the patient after delivering the neuromodulatory agent to conclude the procedure.

Abstract: A method and a device for needleless injection of liquid into a substrate, in particular of a liquid pharmaceutical or cosmetic preparation into a biological tissue, which makes it possible in a particularly advantageous manner to reliably inject a particularly fine liquid jet into the substrate without a significant increase in the static pressure in the liquid during the injection process. According to the invention, this is achieved by first accelerating the liquid received in a liquid container together with the latter to an initial velocity before the movement of the liquid container is stopped again, while simultaneously ejecting the liquid from the liquid container through an outlet nozzle under at least partial retention of its movement. Preferably, the ejected liquid jet is set in rotation about its jet axis before it impinges on the substrate, so that the jet receives a helical movement and thus practically drills into the substrate without splashing away laterally.

Abstract: A catheter can have a textured outer body surface with protrusions and/or indentations that can reduce friction between the outer body surface and vascular anatomy or an inner lumen of another catheter in contact with the outer body surface. The catheter can include protrusions and/or indentations on an inner lumen surface that can reduce friction between the inner lumen surface and an outer body surface of another catheter within the example catheter. The protrusions can be filled with a lubricant or vasodilating drug, and the protrusions can be configured to break to release the fluid in response to forces on the protrusion during navigation through vascular anatomy and/or an inner lumen of another catheter. The catheter can include a metallic tubular reinforcing layer with openings through which the protrusions and/or indentations extend and/or protrusions and/or indentations shaped into the reinforcing layer.

Abstract: Syringes are described herein. A syringe includes a syringe body, a first plunger, a biasing member, and a retention member. The syringe body defines a syringe cavity and a syringe port, wherein the syringe port is in fluid communication with the syringe cavity. The first plunger comprises a first plunger shaft extending from the first plunger, the first plunger disposed within the syringe cavity and defining a first chamber in the syringe cavity, wherein the first chamber is in fluid communication with the syringe port. The biasing member is coupled to the first plunger shaft, wherein the biasing member urges the first plunger to advance toward the syringe port. The retention mechanism prevents the biasing member from advancing the first plunger in an engaged position and permits the biasing member to advance the first plunger in a released position.

Abstract: Described is an indication system for a drug delivery device, including a component moveable with respect to a housing during operation of the drug delivery device, an electric circuit having an electrical property, and an electronic-ink label configured to be disposed on the exterior of the housing and in contact with the electric circuit. The electric circuit is operatively coupled to the moveable component to modify the electrical property based on a position of the moveable component such that the electrical property is an indication of the position of the moveable component. The electronic ink label includes printed electronics arranged to be in communication with the electric circuit and configured to display a visual indication related to the position of the moveable component in response to the electrical property. In some instances, the position of the moveable component indicates a dose set or dispensed from the drug delivery device.

Abstract: An insertion mechanism for a drug pump includes an insertion mechanism housing; a sleeve; a rotational biasing member initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the sleeve. The needle is inserted into a target tissue by the rotational biasing member and interaction between the hub and housing. Retraction of the needle is caused by decompressing or de-energizing of the retraction biasing member. A drug delivery pump includes an activation mechanism, a drive mechanism, a sterile access connection, and the insertion mechanism. Assembly and operation methods are provided.

Abstract: An injection device uses telescoping and/or nested components and other features to make the overall device compact in size. The device is configured to have a storage position and an extended position, such that its needle is positioned within the housing of the device in a storage position, with the needle extending beyond the device housing when needed for an injection. The telescoping plunger mechanism has a storage position and an extended position for use. The device includes a needle depth cover, which extends from the device housing for use, and guides the user as to the correct depth for the needle to penetrate the user's skin. A switch allows different depth settings, for example allowing a deeper penetration for injection into a leg, and shallower penetration for injection into an arm.

Abstract: This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

Abstract: The subject guide catheter extension system with a micro-catheter delivery catheter includes an outer sheath, an inner member extending within the sheath, and a mechanism for engagement/disengagement of the inner member to/from the sheath. Several mechanisms of engagement/disengagement between the inner and outer members are provided including a friction mechanism, threaded mechanism, pull away sheath, and engagement/disengagement mechanism for pusher's handles. The sheath and the inner member are modified for different engagement/disengagement mechanisms operation. A micro-catheter delivery system provides for an improved atraumatic crossability to the treatment site in an expedited and simplified fashion. During a procedure, a guidewire along with a guide catheter are advanced to the vicinity of the treatment site within a blood vessel.

Abstract: An introducer needle may include a proximal end, a distal tip, and a needle lumen extending therebetween. The introducer needle may include a wall defining the needle lumen, a first notch formed through the wall, and a second notch formed through the wall. A catheter system may include a catheter adapter, a catheter extending distally from the distal end of the catheter adapter, a flash chamber coupled to the introducer needle, and the introducer needle, which may extend through the catheter. The first and second notches and the flash chamber may facilitate pressure-driven blood flow into the catheter for improved flashback and detection of transfixation when the catheter is primed prior to insertion into vasculature of a patient or otherwise.

Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.

Abstract: The subject guide catheter extension/pre-dilatation system includes an outer delivery sheath, an inner member extending within the sheath, and a mechanism for engagement/disengagement of the inner member to/from the sheath. The inner member is configured with a tapered distal tip having a delivery micro-catheter and a pre-dilatation balloon member attached to the tapered distal tip in proximity to the micro-catheter. The outer delivery sheath and the inner member are modified for different engagement/disengagement mechanisms operation. The delivery micro-catheter provides for an improved crossability for the balloon member to the treatment site in an atraumatic, expedited and convenient fashion. During the cardiac procedure, a guidewire and a guide catheter are advanced to the vicinity of the treatment site within a blood vessel.

Abstract: A problem with injecting cells such as fat cells into organic tissue to act as a filler material is that the cells must be distributed evenly and reasonably thinly to ensure that all of the injected cells are situated near to a blood supply and do not die. Injecting devices have been produced that use electronic controls and electro-mechanical mechanisms to improve distribution. The present approach however solves the problem of even distribution by coupling a skin surface sensing means to a plunger in a reservoir of the filler cells. In this way, the flow of cells out of a cannula relates directly to the rate at which the tip of the cannula penetrates the organic tissue into which the cells are being injected.

Abstract: Syringe assemblies are described herein. A syringe assembly includes an assembly housing, a first syringe, a second syringe, and a connecting gear. The first syringe is disposed within the assembly housing. Each plunger is movable within the respective syringe cavity and defines a respective chamber in the respective syringe cavity, wherein the respective chamber is in fluid communication with the respective syringe port, the respective plunger comprising a respective gear rack extending longitudinally along the respective plunger. The connecting gear is rotatably coupled to the assembly housing. The connecting gear is configured to be in meshed engagement with at least one of the first gear rack and the second gear rack of the syringes.

Abstract: A medical device may include an introducer sheath, having a distal and a proximal end and a lumen extending from the distal end to the proximal end. The introducer sheath may also include a tab formed at the distal end and extending distal to the lumen, and a frangible portion extending between the distal end and the proximal end.