Abstract: Syringe pumps are described herein. A syringe pump is disclosed comprising a syringe pump body, a flange clamp and a sensing switch. The syringe pump body defining a syringe body recess and a syringe plunger recess, wherein the syringe body recess and the syringe plunger recess are configured to cooperatively receive a syringe. The flange clamp is coupled to a mating surface of the syringe pump body disposed between the syringe body recess and the syringe plunger recess, wherein the flange clamp is configured to be spaced apart from the mating surface to receive a syringe flange of the syringe. The sensing switch extends through the mating surface, wherein the sensing switch is configured to be in a closed state when the flange clamp is in contact with the sensing switch and in an open state when the flange clamp is spaced apart from the sensing switch.

Abstract: A safety needle assembly includes a housing and a cannula hub connected within a side wall of the housing, a needle connected to the cannula and extending from the cannula hub outward from a proximal end of the housing, and a spring connected with the housing. The assembly includes a barrel connected with the spring and at least partially contained within the housing to least partially cover the cannula hub. The barrel is configured for moving, sliding, traveling, activating, relocating, or transitioning from a first mode in which the barrel is securely retracted and locked at least partially within the housing and the needle extends through an aperture of the barrel and the proximal end of the housing, to a second mode in which the barrel extends from the proximal end and beyond the needle.

Abstract: The invention relates to systems and methods for intracranial vessel access. In particular, a system including a co-axial combination of a steerable variable thickness microwire operatively supporting a tapered larger bore support and larger bore distal access catheter is described. Methods of advancing the intracranial access system through the vasculature are also described.

Abstract: There are provided an intradermal needle, a packaged article, and an injection device. The intradermal needle includes: a tubular needle that has a needle tip capable of puncturing a living body; a needle hub that holds the tubular needle; a flange part that extends in a flange shape from the needle hub; and a ring projection that extends toward a leading end of the flange part and is formed in a cylindrical shape to surround the tubular needle. The flange part has a cut portion formed by partially cutting to achieve downsizing of the flange part.

Abstract: A drug delivery device for delivering a medicament includes a housing arranged to contain a container, a receiver coil, and an energy storage unit. The receiver coil is arranged to receive energy from a transmitter coil by electromagnetic induction. The energy storage unit is arranged to be charged by at least a portion of the energy received by the receiver coil. At least a portion of the energy received by the receiver coil is converted to heat energy. The receiver coil is arranged in the drug delivery device to transfer the heat energy to the container to heat medicament contained in the container. A system comprising the drug delivery device is also disclosed.

Abstract: A drug delivery device includes a casing and a storage container with a dose delivery member, at least a portion of which extends through an opening in the casing. A guard is movable relative to the casing between extended and retracted positions. The guard surrounds the extended portion of the dose delivery member in the extended position, and exposes the extended portion in the retracted position. An interference arrangement is included for providing selected threshold of resistance to movement of the guard from the extended position to the retracted position during insertion of the dose delivery member into body tissue. The arrangement has first and second members engaging one another to retain the guard in the extended position. The first or second member can move if the selected threshold of resistance is exceeded to allow the members to slide and allow the guard to move into the retracted position.

Abstract: A device is provided for supplying electrical current to an intervertebral disc. The device comprises a cannula having a proximal end and a distal end and a longitudinal axis therebetween. The distal end comprises a beveled tip for contacting a region of the intervertebral disc, and an electrode disposed within or on a surface of the cannula adjacent to the distal end. The electrode is configured to discharge electrical current to the region of the intervertebral disc. Methods of diagnosing and/or treating discogenic back pain are also provided.

Abstract: An adaptor includes a tubular body having a proximal region and a distal region, the proximal region configured to engage a distal tip of a drug delivery device and the distal region being configured to be connected to a connector. The distal region has a distal end delimiting a distal opening so as to permit introduction of the connector inside the distal region. The distal end is configured to be clamped to the connector when the connector is introduced inside the tubular body. The distal end includes a deformable element having a free end, which is configured to deform towards the proximal region when the connector is introduced inside the tubular body.

Abstract: A grip accessory for a manual injection device comprises a housing comprising a generally hollow body configured to support a manual injection device therein. The housing comprises a distal portion comprising a first opening into which a manual injection device can be inserted, a proximal portion having a second opening through which the needle of the manual injection device extends. The proximal portion comprises a skin contacting surface at a proximal end of the device that can be placed against an injection site. An intermediate portion extends between the proximal and distal portions.

Abstract: A conformable guide for directing penile injections has an elastomeric or conformable tube having an open end distally for passing over a glans and a shaft of a penis toward a root of the penis on placement. The conformable guide can have an annulus shaped spirally wrapped portion of the elastomeric tube at the distal end configured to unwrap on placement toward the root. The elastomeric tube has one or more observable injection site locations marked or otherwise indicated on the elastomeric tube when positioned onto the shaft of the penis. The conformable guide is made of a stretchable synthetic polymer.

Abstract: Disclosed herein are microneedle devices, kits comprising the microneedle devices, and methods of using the microneedle devices. Specifically, disclosed is a device for transport of a material across a biological barrier of a subject comprising: a plurality of microneedles each having a base end and a tip, with at least one pathway disposed at or between the base end and the tip; a substrate to which the base ends of the microneedles are attached or integrated; and at least one reservoir which is in connection with the base ends of the microneedles array, wherein the reservoir comprises an agent delivery system, wherein the agent delivery system comprises an agent to be transported across the biological barrier, or a means for producing an agent to be transported across the biological barrier, and a means for detecting a physiological signal from the recipient.

Abstract: A pump including a disposable component including a disposable component inlet port coupled to a first disposable conduit in fluid communication with a fluid medium source, wherein the first disposable conduit includes a disposable piston pump assembly and a disposable bubble eliminator, and the first disposable conduit is in fluid communication with a disposable component outlet port, wherein the disposable bubble eliminator is in fluid communication with a lumen of the first disposable conduit and is operable to reduce a gas content of a fluid medium; wherein the disposable piston pump assembly is operable to pump the fluid medium from the disposable component inlet port, through the first disposable conduit and the disposable bubble eliminator, to the disposable component outlet port; and a reusable component including a reusable movable stage operable to compress the disposable piston pump assembly; and a reusable mechanical actuator operable to drive the movable stage.

Abstract: A surgical device includes a housing and an elongate body extending distally from the housing. The housing defines a filter chamber and a pump chamber therein, the filter chamber in fluid communication with the pump chamber. A filter assembly is disposed within the filter chamber, and a pump is disposed within the pump chamber. The elongate body defines first and second lumens therethrough, and includes at least one first opening in fluid communication with the first lumen and at least one second opening in fluid communication with the second lumen. The first lumen is in fluid communication with the filter chamber of the housing and the second lumen is in fluid communication with the pump chamber of the housing thereby forming a closed filtration loop through the surgical device.

Abstract: A gas mixture apparatus includes a measurement control system, an activation system, a pressurized chamber with one or more gases, and a mixing chamber. A filter can be preattached to an outlet of the mixture apparatus, allowing excess gas to be discharged therethrough and then atmospheric air to be drawn into the mixture apparatus through the filter for creating a therapeutic gas mixture.

Abstract: A medical device for infusing medical substances has activation buttons accessible on an exterior of a device housing. The activation buttons and corresponding electrical switches within the housing are configured to prevent inadvertent activation of the buttons and therefore inadvertent operation of the switches to initiate a process such as medical substance delivery to a user. The device employs overlap of respective time traces initiated by activation of the activation buttons to determine whether the activation is intended and valid. The respective time traces do not have to be initiated simultaneously or in any particular sequence. The activation buttons can be elastomeric overmolded buttons set within cutouts in the housing, and, when depressed, make physical contact with respective switches.

Abstract: Systems and methods are provided for signaling a condition of an infusion assembly. A system may comprise an elastomeric pump that includes a chamber for receipt of a volume of fluid, an outer layer configured to expand and contract as the chamber receives and dispenses fluid, and a passive indicator provided on the outer layer for signaling a change in the volume of fluid in the chamber. The system further may comprise an image capture device configured to capture an image of the pump, and a processing system configured to process the image to signal the condition of the infusion assembly to a user of the system. A method may comprise capturing an image of a pump; processing the image; and displaying information to a user of the pump to communicate the condition of the pump to the user. Elastomeric pumps for infusion assemblies also are provided.

Abstract: Provided is an apparatus, system, and method for a nested syringe assembly. The nested syringe assembly includes a first syringe having a cylindrical body defining an inner diameter and a second syringe having a cylindrical body defining an outer diameter. The outer diameter of the second syringe is less than the inner diameter of the first syringe. At least a portion of the cylindrical body of the second syringe is disposed within the cylindrical body of the first syringe.

Abstract: A syringe receptacle device for collecting a liquid from an extraction device, a cylindrical barrel, and a plunger. The barrel has an inner circumferential surface that extends between opposite first and second ends. The first end of the barrel is adapted to be removably coupled to the extraction device. The plunger is slidably coupled to the barrel and includes a plunger head and an actuating rod. The plunger head is frictionally engaged with the inner circumferential surface of the barrel. The actuating rod is fixedly attached to the plunger head and extends out through the second end of the barrel.

Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.

Abstract: A syringe including a syringe body extending from a proximal end to a distal end, and a stabilizing element provided on the distal end of the syringe body, a portion of the stabilizing element extending substantially perpendicular to a longitudinal axis of the syringe body. A multi-use disposable set (MUDS) includes a plurality of syringes, each syringe having a syringe body, a proximal end, a distal end spaced apart from the proximal end along a longitudinal axis of the syringe body, a stabilizing element provided on the distal end, a portion of the stabilizing element extending substantially perpendicular to the longitudinal axis of the syringe body, and a manifold in fluid communication with the distal end of each of the plurality of syringes.