Patents Examined by Eric F. Winakur
  • Patent number: 11369295
    Abstract: A material, article, system and method include a probe composition that includes a hydrophobic portion, a hydrophilic portion, an analyte-binding portion and a fluorophore portion. The analyte-binding portion is configured to bind to an analyte in an aqueous solution. The fluorophore portion is configured to change an optical property of fluorescent light emitted in response to incident excitation light when the probe composition changes between a first state in which the analyte is not bound to the analyte-binding portion and a second state in which the analyte binds to the analyte-binding portion. A material includes the probe composition and a silicone hydrogel substrate having a hydrogel network that allows flow of aqueous solution through the solution and a silicone network that occupies interstices of the hydrogel network. A contact lens having the material enables remote detection of glucose concentration in tear fluid of a subject.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: June 28, 2022
    Inventors: Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
  • Patent number: 11369349
    Abstract: A device (100) for sensing a first analyte in sweat on skin includes an analyte-specific sensor (120) for sensing the first analyte and an active sweat coupling component (130) for transporting at least one sweat sample inside the device (100) and into fluid communication with the analyte-specific sensor (120). A method of sensing a first analyte in sweat on skin includes actively transporting at least one sweat sample into fluid communication with an analyte-specific sensor (120) for sensing the first analyte using an active sweat coupling component (130) and sensing the first analyte using the analyte-specific sensor (120).
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 28, 2022
    Assignee: University of Cincinnati
    Inventor: Jason C. Heikenfeld
  • Patent number: 11369412
    Abstract: A sensor insertion device comprises a main body, needle slider, disposal slider, spring, puncture knob, and opening mechanism (window member and handle). The needle slider grips a needle and a sensor on a first end side, and is slidable inside the main body. The disposal slider is slidable inside the main body. The puncture knob has an insertion hole into which the rear end portion of the needle slider can be inserted. The opening mechanism puts the insertion hole into a closed state when the needle slider is being slid in the sensor insertion direction, and, puts the insertion hole in an open state in which the second end side of the needle slider has been inserted into the insertion hole by opening up the contact portion between the puncture knob and the second end side of the needle slider when the puncture operation is complete.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: June 28, 2022
    Inventors: Yoshiteru Ii, Kenichi Hamanaka, Ryuji Shimizu, Akira Nishio, Takashi Endoh, Kazuaki Edagawa, Tetsuya Norikane, Junko Ikeda
  • Patent number: 11367525
    Abstract: A system for continuous non-invasive blood pressure monitoring may include processing circuitry configured to determine calibration data for a continuous non-invasive blood pressure model at a calibration point, receive, from an oxygen saturation sensing device, a PPG signal at a particular time subsequent to the calibration point, derive values of the set of metrics for the patient from the PPG signal, and determine, using the continuous non-invasive blood pressure model and based at least in part on inputting the calibration data determined at the calibration point, the values of the set of metrics, and an elapsed time at the particular time since the calibration point into the continuous non-invasive blood pressure model, a blood pressure of the patient at the particular time.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: June 21, 2022
    Assignee: COVIDIEN LP
    Inventors: Paul S. Addison, Dean Montgomery, Andre Antunes
  • Patent number: 11363974
    Abstract: A method for monitoring a blood glucose level of an individual comprises the steps of receiving (S1) a first glucose value, which has been measured in a body fluid of the individual other than the individual's blood, the first glucose value representing the blood glucose level of the individual with a first delay; receiving (S6) speech of the individual; analyzing (S7) the individual's speech; and determining (S8) a supplementary glucose value, which represents the blood glucose level of the individual with a shorter delay than the first delay; wherein the determination of the supplementary glucose value is based on the analyzing of the individual's speech.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: June 21, 2022
    Assignee: Sony Group Corporation
    Inventors: Jim Rasmusson, Peter C Karlsson, Magnus Svensson, Claes Nilsson, Jimmy Eklund
  • Patent number: 11363976
    Abstract: A method and apparatus for non-invasively determining a blood oxygen saturation level within tissue of an internal organ is provided. The method includes: applying a near infrared spectrophotometric sensor on an external surface of an organ; operating the sensor to emit light from a light source directly into the tissue of the organ at a first tissue location, and to sense the emitted light at a second tissue location, which emitted light has traveled through the tissue between the first and second tissue locations, and to produce signals representative of the intensity of the sensed emitted light; using a processor to execute instructions, which instructions cause the processor to: determine an attenuation value of the emitted light for each wavelength, and determine a blood oxygen saturation level of the organ tissue using the determined attenuation values for each of the plurality of wavelengths.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: June 21, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventor: Paul B. Benni
  • Patent number: 11363973
    Abstract: A personal hand-held monitor (PHHM) comprising a signal acquisition device for acquiring signals which can be used to derive a measurement of a parameter related to the health of the user, wherein the signal acquisition device comprises a blood photosensor having one or more photo-emitters for transmitting light to a body part of a user, one or more photo-detectors for detecting light transmitted through or scattered by the body part and two or more optical cells, at least one of which contains an analyte to be detected or which mimics the absorption spectrum of the analyte to be detected, through which the light that has been or will be transmitted through or scattered by the body part passes before it reaches the or each photo-detector, wherein the processor of the PHHM is adapted to process the signals received from the or each photo-detector to calculate the difference in intensity of light which has passed through the or each analyte cell and light which has passed through the or each non-analyte cell an
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: June 21, 2022
    Inventors: Christopher Elliott, Mark-Eric Jones
  • Patent number: 11350861
    Abstract: A method and system for measuring oxygen levels and various blood constituents utilizing a sensor having one or more light sources, and one or more light detectors is disclosed. The system is capable of using data collected by the one or more detectors from a non-monochromatic light source to provide accurate information during motion events occurring with an extremity the sensor. The system is also capable of detecting and providing an alert if the sensor is not properly placed on a patient or becomes disengaged therefrom.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: June 7, 2022
    Assignee: Medtor, Inc.
    Inventor: Thomas Dietiker
  • Patent number: 11350875
    Abstract: A wearable device may be provided for detecting cumulative alcohol consumption. Such a wearable device may include an adhesive layer that adheres to skin and that allows sweat from the skin to pass through and a customizable ink layer that reacts irreversibly to change color along a gradient as ethanol is detected in the sweat. The customizable ink continues to increase color intensity along the gradient as ethanol continues to be detected in the sweat over time.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: June 7, 2022
    Inventors: Tal Danino, Ian Fritz, Carlos Olguin, Skylar Tibbits, Marcelo Coelho
  • Patent number: 11344255
    Abstract: An apparatus for measuring a body fluid includes: an optical sensor configured to emit light onto an object, receive the light returning from the object, and measure a first intensity of a first wavelength and a second intensity of a second wavelength from the received light; and a processor configured to estimate a body fluid volume of the object based on the first intensity and the second intensity.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: May 31, 2022
    Inventors: So Young Lee, Sang Kyu Kim, Hyun Seok Moon, Eui Seok Shin
  • Patent number: 11342070
    Abstract: A device and method for monitoring a user's health state by continuously measuring data on triglycerides of the user and a device for managing the user's health state are disclosed. According to an embodiment, a user health state monitoring device includes a measurement unit configured to continuously measure a triglyceride concentration level of the user for a predetermined period; an analysis unit configured to analyze a graph showing the triglyceride concentration level to acquire analytical information; and a monitoring unit configured to monitor the user's health state based on the acquired analytical information.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: May 24, 2022
    Inventors: Jung Yong Nam, Sang Kyu Kim, Jung Mok Bae, So Young Lee, Joon Hyung Lee, Ki Young Chang
  • Patent number: 11337629
    Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: May 24, 2022
    Inventors: Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin
  • Patent number: 11331016
    Abstract: Robust estimation of a characteristic of a user's physiological signals can be achieved by filtering or classifying samples. Rather than estimating the characteristic of the user's physiological signals based on each sample at a first wavelength and a second wavelength, a robust system and method can, in some examples, estimate the characteristic using samples at the first wavelength and the second wavelength that meet one or more criteria and filter out samples that fail to meet the one or more criteria. In some examples, the system and method can weight samples based on the one or more criteria, and estimate the characteristic using the weighted samples. Samples failing to meet the one or more criteria can be given less weight or no weight in the estimation. The one or more criteria can include a criterion based on at least the physiological signal at a third wavelength.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: May 17, 2022
    Assignee: Apple Inc.
    Inventors: Saeed Mohammadi, Albert E. Cerussi, Paul D. Mannheimer
  • Patent number: 11324412
    Abstract: A system is provided that furnishes expert procedural guidance based upon patient-specific data gained from surgical instruments incorporating sensors on the instrument's working surface, one or more reference sensors placed about the patient, sensors implanted before, during or after the procedure, the patient's personal medical history, and patient status monitoring equipment. Embodiments include a system having a surgical instrument with a sensor for generating a signal indicative of a property of a subject tissue of the patient, which signal is converted into a current dataset and stored. A processor compares the current dataset with other previously stored datasets, and uses the comparison to assess a physical condition of the subject tissue and/or to guide a procedure being performed on the tissue.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: May 10, 2022
    Inventors: Jason Matthew Zand, Gregory Scott Fischer
  • Patent number: 11317816
    Abstract: In one embodiment, a method for creating a blood oxygen saturation (SpO2) value, the method comprises receiving one or more photoplethysmography (PPG) signals for SpO2 detection from one or more PPG sensors; receiving one or more PPG signals for characterizing a heart rate from the one or more PPG sensors; using the one or more PPG signals for SpO2 detection, forming one or more SpO2 datasets wherein the SpO2 datasets respectively comprise one or more noise components; removing the one or more noise components from the one or more SpO2 datasets that are inconsistent with a feature of the one or more PPG signals characterizing the heart rate to produce one or more filtered SpO2 datasets; and using the one or more filtered SpO2 datasets, creating and storing the SpO2.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: May 3, 2022
    Assignee: Fitbit, Inc.
    Inventors: Anjian Wu, Chris H. Sarantos, Peter W. Richards, Shelten Gee Jao Yuen
  • Patent number: 11319570
    Abstract: The present invention provides a measuring method for prolonging a usage lifetime of a micro biosensor implanted subcutaneously to measure a physiological signal associated with an analyte. The micro biosensor includes a working electrode and a counter electrode, wherein the counter electrode includes silver and a silver halide having an initial amount. The method includes cyclic steps of: applying a measurement voltage to drive the working electrode to measure the physiological signal, where the silver halide is consumed by a specific amount; stopping applying the measurement voltage; and whenever the physiological parameter is obtained, applying a replenishment voltage to drive the counter electrode, thereby the silver halide of a replenishment amount being replenished to the counter electrode, wherein a guarding value of a sum of the replenishment amount and the initial amount subtracting the consumption amount is controlled within a range of the initial amount plus or minus a specific value.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: May 3, 2022
    Inventors: Chun-Mu Huang, Chieh-Hsing Chen
  • Patent number: 11317866
    Abstract: An optical sensor, an optical sensor array, and an apparatus and method for measuring a bio-signal are provided. The optical sensor includes a photodetector, and a light source disposed on the photodetector. The optical sensor is configured to operate the light source in a light source mode, and operate the photodetector in a photodetector mode, based on a control signal.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: May 3, 2022
    Inventor: Dong Ho Kim
  • Patent number: 11311250
    Abstract: The present disclosure relates to devices, systems, methods and computer program products for continuously monitoring, diagnosing and providing treatment assistance to patients using sensor devices, location-sensitive and power-sensitive communication systems, analytical engines, and remote systems. The method of non-invasively measuring multiple physiological parameters in a patient includes collecting photoplethysmograph (PPG) signal data from a wearable sensor device, applying one or more filters to correct the signal data and extracting a plurality of features from the corrected data to determine values for blood glucose, blood pressure, SpO2, respiration rate, and pulse rate of the patient. An alert may be automatically sent to one or more computing devices when the value falls outside a custom computed threshold range for the patient.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 26, 2022
    Inventors: Unni Krishna K. A. Menon, Sruthi Krishna, Kripesh V. Edayillam, Gayathri Bindu, Harikrishnan Krishnannair, Maneesha Vinodhini Ramesh
  • Patent number: 11304636
    Abstract: Embodiments of the disclosure provide an oximeter, including a blood oxygen collecting unit that has a first light emitting unit, a second light emitting unit, and a light receiving sensor, the first light emitting unit emitting a red light, the second light emitting unit emitting an infrared light, and the light receiving sensor receiving the red light emitted by the first light emitting unit and the infrared light emitted by the second light emitting unit and not absorbed by the human body, and converting them into an electrical signal, a storage unit that stores a first threshold value, a microprocessor that calculates a blood oxygen saturation of the human body based on the electrical signal detected by the light receiving sensor, and includes a judging unit that judges whether the blood oxygen saturation is lower than the first threshold value, and a display unit.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: April 19, 2022
    Inventors: Kun Hu, Yunlong Xu, Jinling Zhang, Yatao Zhao, Zhichao Song, Di Wu, Bohua Yan
  • Patent number: 11304649
    Abstract: Disclosed is a system for objective self-assessment of physical capabilities and condition changes of individuals with conditions like multiple sclerosis, the system has a mobile device with an appropriate software for carrying out a set of tests for assessment of motor capabilities such as body balance, muscle strength, and muscle spasticity, and receiving assessment feedback. The system has inertial motion sensors for performing motion sensing, wherein said inertial motion sensors are integrated with said mobile device, e.g., a smartphone, a smart watch, or a personal computer, or in a separate wearable sensor device, connected with said mobile device over wired or wireless data connection. Also disclosed is a method for such self-assessment with such system.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: April 19, 2022
    Assignees: Tallinn University of Technology, Motionmon OÜ
    Inventors: Alar Kuusik, Katrin Gross-Paju, Muhammad Mahtab Alam