Abstract: A device and method for detecting a sign parameter are provided. A luminous source (01) is utilized to irradiate human skin tissue(s) for a preset time. The luminous source (01) can emit light with set wavelength(s) and capable of being absorbed by substance(s) for characterizing human body sign(s) in a human body. A photoelectric sensor (02) is configured to detect absorbance of the human body to the light emitted by the luminous source (01) within the preset time, and send a detection result to a processor (03). The processor (03) is configured to calculate substance concentration(s) of the substance(s) for characterizing the human body sign(s) in the human body according to the detection result sent by the photoelectric sensor (02). Therefore, blood samples of subjects do not need to be collected, and the substances for characterizing the human body signs can be detected through a non-invasive method.

Abstract: Various analyte sensing apparatuses and associated housings are provided. Some apparatuses comprise one or more caps. Some apparatuses comprise a two-part adhesive patch. Some apparatuses comprise one or more sensor bends configured to locate and/or hold a sensor in place during mounting. Some apparatuses utilize one or more dams and/or wells to retain epoxy for securing a sensor. Some apparatuses utilize a pocket and one or more adjacent areas and various transitions for preventing epoxy from wicking to undesired areas of the apparatus. Some apparatuses include heat-sealable thermoplastic elastomers for welding a cap to the apparatus. Related methods of fabricating such apparatuses and/or housings are also provided.

Abstract: A component measurement device for measuring a given component contained in a sample. The component measurement device includes an excitation light source to emit excitation light onto the optical medium portion, a probe light source to emit probe light onto the optical medium portion, an intensity modulation unit to perform intensity modulation on the excitation light emitted by the excitation light source based on stratum corneum information about stratum corneum of the sample to generate intensity-modulated excitation light and emit the generated intensity-modulated excitation light onto the optical medium portion, and a measurement unit to measure the given component based on a difference between the probe light emitted from the optical medium portion in a first state where the excitation light is emitted and the probe light emitted from the optical medium portion in a second state where the intensity-modulated excitation light is emitted.

Abstract: A sensor, system, and method for detecting and correcting for changes to an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an extent to which the analyte indicator has degraded. The analyte sensor may also include a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and degradation measurements to calculate an analyte level.

Abstract: A probe tip of an oximeter device includes first and second printed circuit boards (PCBs) that are coupled to the ends of optical fibers that transmit light between the PCBs and into patient tissue that is to be measured by the oximeter device. The PCBs are oriented at an angle between zero and ninety degrees so that the fibers have a curved shape between the locations at which the fibers are coupled to the first and second PCBs. The angular orientation of the PCBs and curved shape of the fibers allows the fibers to have a longer length than if the fibers were straight and allows for light transmitted through the fibers to have a uniform distribution across a cross-section of the fibers as the light is emitted from the fibers into patient tissue. The uniform distribution of light transmitted into patient tissue allows for reliable oximetry measurements.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: Transdermal optical sensing systems and methods of use and calibration are described. The systems include a master and secondary sensing device, an optical component arranged within the device, with an optical component surface exposed for contact with an epidermis of a subject, an optical emitter, an optical detector, and electronics including a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, to perform a calibration of the sensing device including generating a master calibration curve, to detect a condition state of the sensing device, and to generate a biomarker correlation curve for a biomarker or combination of biomarkers.

Abstract: Provided herein are systems, methods and apparatuses an antenna array or a group of antenna elements for biomarker monitoring, nerve stimulations, and methods of use.

Abstract: A method for calibrating a thermometer unit for measuring a core temperature of a system, includes determining a first heat transfer coefficient of the system, and calculating core temperature data corresponding to the core temperature of the system based on the first heat transfer coefficient. The method also includes identifying a change in the core temperature data that exceeds a predetermined threshold. The thermometer unit is calibrated by determining a second heat transfer in response to the identified change in the core temperature data. The core temperature data is calculated based on the second heat transfer coefficient.

Abstract: An apparatus for estimating bio-information of a user may include a first sensor configured to measure a first signal from the user; a second sensor configured to measure a second signal from the user; and a processor configured to obtain a first characteristic point from the first signal; obtain a second characteristic point from the second signal based on the first characteristic point and a pre-defined probability distribution function; and estimate the bio-information of the user based on the second characteristic point.

Abstract: In an endoscope system, an oxygen-saturation-level calculating unit calculates an oxygen saturation level of the observation target on the basis of a plurality of spectral images acquired by an image acquiring unit. An image creating unit creates an oxygen-saturation-level image that is an image representing the oxygen saturation level. A numerical-value display-position determining unit determines a numerical-value display position for displaying a numerical value of the oxygen saturation level on the oxygen-saturation-level image, on the basis of the spectral images or the oxygen saturation level, or the spectral images and the oxygen saturation level. A display control unit displays the numerical value of the oxygen saturation level on the oxygen-saturation-level image on the basis of the numerical-value display position.

Abstract: A system for monitoring autoregulation includes an oxygen saturation sensor configured to obtain an oxygen saturation signal indicative of an oxygen saturation of a patient. The system also includes a controller having a processor configured to receive a blood pressure signal indicative of a blood pressure of the patient and the oxygen saturation signal, determine a change in the oxygen saturation signal and a change in the blood pressure signal over a period of time, and provide an indication that the patient's autoregulation is intact if the oxygen saturation changes by more than an oxygen saturation threshold and if the blood pressure changes by less than a blood pressure threshold during the period of time.

Abstract: A wearable health monitoring device can include a physiological parameter measurement sensor or module configured to be in contact with a wearer's skin when the device is worn by the wearer on the wrist. The physiological parameter measurement sensor can noninvasively and optionally continuously measure one or more physiological parameters, for example, the oxygen saturation, of the wearer. The sensor can include a convex curvature to improve pressure, and therefore optical coupling, between the wearer's skin and the physiological parameter measurement sensor while balancing the pressure and the wearer's comfort. The sensor can include a light barrier between emitters and detectors and other light barriers to improve signal strength and reduce noise.

Abstract: A method of operation of a compute system includes: generating a skin segmentation including a non-skin region and a skin prediction based on a patient image; generating a body part segmentation based on the patient image; generating a cropped image based on the skin segmentation and the body part segmentation with the cropped image includes the non-skin region based on the skin prediction; generating a eczema segmentation based on the cropped image and the skin prediction; generating intermediate scores for erythema, papulation, lichenification, and excoriation for the cropped image; and generating a full body EASI score based on the eczema segmentation and the intermediate scores for displaying on a device to assist in diagnosis.

Abstract: A method of operation of a compute system includes: generating a skin segmentation including a non-skin region and a skin prediction based on a patient image; generating a body part segmentation based on the patient image; generating a cropped image based on the skin segmentation and the body part segmentation with the cropped image includes the non-skin region based on the skin prediction; generating a lesion segmentation based on the cropped image and the skin prediction; generating intermediate scores for erythema, induration, desquamation for the cropped image; and generating a full body severity score based on the lesion segmentation and the intermediate scores for displaying on a device to assist in diagnosis.

Abstract: Because reprocessing or refurbishing of physiological sensors reuses large portions of an existing sensor, the material costs for refurbishing sensors is significantly lower than the material costs for making an entirely new sensor. Typically, existing reprocessors replace only the adhesive portion of an adhesive physiological sensor and reuse the sensing components. However, re-using the sensing components can reduce the reliability of the refurbished sensor and/or reduce the number of sensors eligible for refurbishing due to out-of-specification sensor components. It is therefore desirable to provide a process for refurbishing physiological sensors that replaces the sensing components of the sensor. While sensing components are replaced, generally, sensor cable and/or patient monitor attachments are retained, resulting in cost savings over producing new sensors.

Abstract: The present disclosure provides systems and methods to monitor analytes present in a biological sample of a subject using a piercing element coupled to a support configured to pierce a body surface of the subject, an analyte binding probe on or within the piercing to provide a change in an optical signal when contacting an analyte in the biological sample of the subject, and a detector configured to detect the optical signal.

Abstract: A system for noninvasively measuring blood alcohol concentration using light includes one or more emitters each configured to emit light in the near infrared or infrared light spectrum at one or more wavelengths that respond to varied chromophore concentrations of ethanol and water in blood of a human subject. One or more detectors is configured to detect light emitted at the one or more wavelengths and output a representation of a photoplethysmography (PPG) waveform for one or more of the one or more wavelengths. A processing subsystem is coupled to the one or more emitters and the one or more detectors.

Abstract: A system, devices, and methods are described for imaging and measuring the mechanical properties of both surface and subcutaneous tissues found in living organisms, animals, and in natural and synthetic materials, and may include a first device configured to determine a modulus of a portion of bulk material or subcutaneous tissue (via measurement of vibrations), and/or determine resonant frequency of the vibrations, and a second device operably connected to the first device and configured to generate vibrations. The first device may be an optical coherence tomography device. The system may include a processor and data storage device with instructions which when executed by the processor, cause the processor to process of the frequency data and the displacement data to determine a resonant frequency of the material under investigation and calculate the mechanical modulus of elasticity of the material from a resonance frequency spectrum of the analyzed spectral image.

Abstract: Disclosed is a device for non-invasively sampling interstitial fluid including one or more analytes from dermis to the skin surface by employing the magneto-hydrodynamic effect and/or reverse iontophoresis. According to a preferable embodiment the device includes a first frame including a first electrode and a second frame including a second electrode, power source and preferably also a first magnet. The first frame is connected to the second frame by a formable connector adapted to provide mechanical connection between the first frame and the second frame and electrical connection between the power source and the first electrode. The direction of the magnetic field and the direction of the electric current produced by the magnet and the power source is such that the Lorenz force drives the fluid from the dermis towards the skin surface.