Patents Examined by Eric F. Winakur
  • Patent number: 10292631
    Abstract: Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting one or more properties of a probe located in subsurface vasculature of the body. A wearable body-mountable device can be worn for a protracted period of time to detect a probe in the vasculature at low concentrations and/or at low rates. A body-mountable device can detect properties of the probe that are indicative of whether the probe has interacted with a tumor of the body and determine the presence or status of a tumor in the body based on such detected properties. Additionally or alternatively, the probe could be introduced into the body as a probe aggregate and released from if the probe aggregate is absorbed by a tumor. The presence of released probes could be detected to determine a presence or status of a tumor in the body.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: May 21, 2019
    Assignee: Verily Life Sciences LLC
    Inventors: Andrew Homyk, Jerrod Joseph Schwartz, Alberto Clemente Vitari, Joshua Simon Klein, Mark Audeh
  • Patent number: 10292628
    Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 21, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Jeroen Poeze, Marcelo Lamego, Sean Merritt, Cristiano Dalvi, Hung Vo, Johannes Bruinsma, Ferdyan Lesmana, Massi Joe E. Kiani, Greg Olsen
  • Patent number: 10292663
    Abstract: A method for monitoring autoregulation includes receiving a blood pressure signal and an oxygen saturation signal, determining a phase difference between the blood pressure signal and the oxygen saturation signal, and determining a patient's autoregulation status based at least in part on a phase difference between the blood pressure signal and the oxygen saturation signal.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: May 21, 2019
    Assignee: Covidien LP
    Inventors: Paul S. Addison, James N. Watson
  • Patent number: 10292657
    Abstract: An ear sensor provides a sensor body having a base, legs extending from the base and an optical housing disposed at ends of the legs opposite the base. An optical assembly is disposed in the housing. The sensor body is flexed so as to position the housing over a concha site. The sensor body is unflexed so as to attach the housing to the concha site and position the optical assembly to illuminate the concha site. The optical assembly is configured to transmit optical radiation into concha site tissue and receive the optical radiation after attenuation by pulsatile blood flow within the tissue.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 21, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Yassir Abdul-Hafiz, Ammar Al-Ali, Kevin Forrest, Eugene Mason, John Schmidt, Virginia Thanh Ta
  • Patent number: 10292654
    Abstract: A device for determining a physiological property of a body includes an insulating support having a compliant contact surface with a conductive element to contact the body. A mounting fixture disposed over a mounting surface of the support removably holds a rigid sensor spaced apart from the body and coupled to the conductive element to determine the physiological property via that element. A method for enabling a physiological parameter to be measured without direct contact between an active device and the body includes arranging a conductive element over an inner surface of an insulating circumferential band. A sensor with the active device is attached to the exterior of the band and thus coupled to the element. A system includes the sensor having a mounting connector, and sensor carriers with respective supports, mounting fixtures, and conductive elements. The sensor mounted on a carrier determines the property via the respective conductive element.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: May 21, 2019
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Curtis Lee, Ryan Walsh, Alan Trojanowski
  • Patent number: 10285624
    Abstract: Systems, methods, and devices are provided for estimating bilirubin levels. In one aspect, a method for estimating the level of bilirubin in a patient includes receiving image data for at least one image including a region of the patient's skin and a color calibration target. Color-balanced image data for the skin region is generated based on a subset of the image data corresponding to the color calibration target and the skin region. The bilirubin level in the patient is estimated based on the color-balanced image data for the skin region.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: May 14, 2019
    Assignee: University of Washington
    Inventors: James A. Taylor, Shwetak N. Patel, James W. Stout, Lilian De Greef, Mayank Goel, Eric C. Larson
  • Patent number: 10285630
    Abstract: A biological information measurement system includes a light emitting portion, a light receiving portion, a light detection portion, a wireless transmission portion, a reception portion that receives information to specify a change corresponding to an increase or a decrease in the concentration or the amount of hemoglobin, wirelessly transmitted from the wireless transmission portion, and a determination portion that monitors information regarding a change in a blood flow based on the information for specifying a change corresponding to an increase or a decrease in the concentration or the amount of hemoglobin, received by the reception portion, over time, and determines whether or not a rate of the change in a blood flow exceeds a predetermined reference value in a case where there is a change in the information regarding a change in a blood flow according to a timing of chest compressions of the subject.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 14, 2019
    Assignee: Trilobite Co. Ltd.
    Inventor: Ruita Takagi
  • Patent number: 10285631
    Abstract: A band limiter comprises an optical filter, which has first and second filter sections, and a filter moving mechanism for moving the optical filter to place the first or second filter section in a light path of blue light. A passband where transmittance of the first filter section is greater than or equal to half a peak value thereof is defined as a first transmission band. The first transmission band includes a peak wavelength, at which an absorption coefficient of hemoglobin is at its peak. A passband where transmittance of the second filter section is greater than or equal to half a peak value thereof is defined as a second transmission band. The second transmission band does not include an isosbestic wavelength (in the order of 450 nm), at which an absorption coefficient of oxyhemoglobin equals or crosses an absorption coefficient of deoxyhemoglobin.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 14, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Yoshinori Morimoto, Satoshi Ozawa
  • Patent number: 10278591
    Abstract: Blood glucose measurement methods and apparatuses are provided using multiple body signals. The methods and apparatuses are employed to estimate blood glucose in a noninvasive manner by using a change in the absorbance of glucose according to a blood glucose level and to correct the estimated blood glucose using different types of blood glucose measurement methods. The blood glucose measurement apparatus includes a main body worn on a human body, a first light source provided on an inner surface of the main body, a second light source provided on the inner surface of the main body, a light receiver configured to receive light from the first light source and the second light source, and a calculator configured to calculate a glucose level in blood based on an amount of light received by the light receiver and configured to measure blood glucose.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: May 7, 2019
    Assignee: HUINNO CO., LTD.
    Inventor: Yeong Joon Gil
  • Patent number: 10278626
    Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: May 7, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett
  • Patent number: 10278628
    Abstract: A band limiter comprises an optical filter, which has first and second filter sections, and a filter moving mechanism for moving the optical filter. The first filter section reduces intensity of blue light, which is emitted from a B-LED, in a wavelength range of greater than or equal to a peak wavelength of the blue light to generate first blue light. The second filter section reduces intensity of the blue light in a wavelength range of less than or equal to the peak wavelength of the blue light to generate second blue light. A light source controller places the first filter section in a light path of the blue light in a normal mode to generate the first blue light, and places the second filter section in the light path of the blue light in an oxygen saturation mode to generate the second blue light.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 7, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Yoshinori Morimoto, Satoshi Ozawa
  • Patent number: 10278648
    Abstract: Automated critical congenital heart defect (“CCHD”) screening systems and processes are described. A caregiver may be guided to use a single or dual sensor pulse oximeter to obtain pre- and post-ductal blood oxygenation measurements. A delta of the measurements indicates the possible existence or nonexistence of a CCHD. Errors in the measurements are reduced by a configurable measurement confidence threshold based on, for example, a perfusion index. Measurement data may be stored and retrieved from a remote data processing center for repeated screenings.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: May 7, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Ammar Al-Ali, Bilal Muhsin
  • Patent number: 10278625
    Abstract: Provided is a blood measuring apparatus including: a spectroscope; an optical system configured to irradiate a living body with excitation light from a light source, and to guide, to the spectroscope, Raman scattered light from the living body; a control unit configured to adjust an irradiation position at which the living body is irradiated with the excitation light by the optical system; and a detector configured to detect a spectrum of the Raman scattered light using light of each wavelength dispersed by the spectroscope. A plurality of the spectra detected by the detector are integrated, and numerical value information regarding a substance included in blood of the living body is measured based on an integration result, and the control unit adjusts the irradiation position such that the plurality of spectra are detected at changed positions.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: May 7, 2019
    Assignee: ARKRAY, Inc.
    Inventors: Takeshi Shimizu, Yasuhide Kusaka
  • Patent number: 10278595
    Abstract: Disclosed herein is a framework for facilitating patient signal analysis. In accordance with one aspect, first and second patient signal data are received from a patient monitor. The first and second patient signal data may then be segmented into respective first and second regions of interest, from which respective first and second waveform parameters may be extracted. One or more morphology indices may then be generated based on the first and second waveform parameters to compare shapes of the first and second regions of interest.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: May 7, 2019
    Assignee: Siemens Healthcare GmbH
    Inventor: Hongxuan Zhang
  • Patent number: 10278622
    Abstract: The object of the invention is a device that allows measuring blood sugar levels in mammals—primarily humans—by measuring the refraction of electromagnetic radiation from the skin or body tissue, without the need for invasive sampling, such as penetrating or pricking the skin. The device uses the blue light portion of the visible spectrum and near-infrared (IR) radiation as a source of electromagnetic radiation. The device falls within the field of medical diagnostics and is essentially designed to be portable, so that the users can wear it on their wrists, for example. The signals of reflected light/radiation measured by the sensor unit are filtered by the frequency filtering set and mathematically processed in order to Calculate the current blood sugar level. The accuracy of the measurement result of the device is comparable to the results obtained with the standard method of measuring by blood sampling. A method for measuring of blood sugar level using said device is also disclosed.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: May 7, 2019
    Assignee: DIA-VIT LTD.
    Inventors: Zoran Arko, Tadej Tofant
  • Patent number: 10271749
    Abstract: A patient monitor capable of measuring microcirculation at a tissue site includes a light source, a beam splitter, a photodetector and a patient monitor. Light emitted from the light source is split into a reference arm and a sample arm. The light in the sample arm is directed at a tissue site, such as an eyelid. The reflected light from the tissue site is interfered with the light from the reference arm. The photodetector measures the interference of the light from both the sample arm and the reference arm. The patient monitor uses the measurements from the photodetector to calculate the oxygen saturation at the tissue site and monitor the microcirculation at the tissue site.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: April 30, 2019
    Assignee: Masimo Corporation
    Inventor: Massi Joe E. Kiani
  • Patent number: 10271745
    Abstract: Examples of monolithic integrated emitter-detector array in a flexible substrate for biometric sensing and associated devices and methods are disclosed. One disclosed example device includes a flexible substrate; a first array of emitters embedded in the flexible substrate, the first array of emitters configured to emit first electromagnetic (EM) signals; a first array of detectors embedded in the flexible substrate, the first array of detectors configured to detect reflections of the first EM signals; a first scanning circuit coupled to the first array of emitters, the first scanning circuit configured to selectively activate individual emitters of the first array of emitters; and a first sensing circuit coupled to individual detectors of the first array of detectors, the first sensing circuit configured to receive a detection signal from at least one of the detectors of the first array of detectors.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: April 30, 2019
    Assignee: QUALCOMM Incorporated
    Inventors: Shiqun Gu, Matthew Michael Nowak, Kenneth Kaskoun, Eugene Dantsker, Russel Allyn Martin
  • Patent number: 10271779
    Abstract: A method for monitoring autoregulation includes using a processor for receiving blood pressure data and oxygen saturation data from a patient, fitting a dynamic model to the blood pressure data and the oxygen saturation data to determine one or more parameters of the dynamic model indicative of autoregulation, and determining the patient's autoregulation status based on the one or more parameters.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: April 30, 2019
    Assignee: Covidien LP
    Inventors: Paul S. Addison, James N. Watson
  • Patent number: 10271748
    Abstract: As placement of a physiological monitoring sensor is typically at a sensor site located at an extremity of the body, the state of microcirculation, such as whether vessels are blocked or open, can have a significant effect on the readings at the sensor site. It is therefore desirable to provide a patient monitor and/or physiological monitoring sensor capable of distinguishing the microcirculation state of blood vessels. In some embodiments, the patient monitor and/or sensor provide a warning and/or compensates a measurement based on the microcirculation state. In some embodiments, a microcirculation determination process implementable by the patient monitor and/or sensor is used to determine the state of microcirculation of the patient.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: April 30, 2019
    Assignee: MASIMO CORPORATION
    Inventor: Ammar Al-Ali
  • Patent number: 10271780
    Abstract: The present invention provides systems and methods employing a surface enhanced Raman biosensor and sensing devices for collecting spatially offset Raman spectra from the biosensor. In certain embodiments, the present invention provides systems and methods for quantifying the concentration of an analyte in a subject, and/or identifying the presence or absence of an analyte in a subject, from a plurality of spatially offset Raman spectra generated from a surface enhanced Raman biosensor implanted in a subject.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 30, 2019
    Assignee: Northwestern University
    Inventors: Richard P. Van Duyne, Matthew R. Glucksberg, Joseph T. Walsh, Jr., Jonathan M. Yuen, Nilam C. Shah