Abstract: A method for determining lung function in a patient is disclosed, in which a multi-lumen catheter with an expandable occluding element at its end is used to isolate a targeted lung compartment, and respiratory characteristics at the targeted lung compartment are measured over multiple respiratory cycles. The relation between various characteristics of the respiratory cycle is used to determine compliance of lung tissue within the targeted lung compartment.

Abstract: Various techniques for measuring cardiac cycle length and pressure metrics based on pulmonary artery pressures are described. One example method described includes identifying a point within a derivative signal of a cardiovascular pressure signal without reference to electrical activity of a heart, initiating a time window from the identified point in the derivative signal, identifying a point within the cardiovascular signal within the time window, and determining at least one of a systolic pressure or diastolic pressure based on the identified point.

Abstract: A method for using electrical stimulation for cerebral network analysis. A first source localization procedure is performed, including a first source measurement procedure which produces first source measurement data, using the first source measurement data to find a solution to a first ill-posed problem which provides a first estimated location of the source. The body is electrically stimulated by targeting the first estimated location, and a second, fast source measurement procedure producing second source measurement data is performed thereafter while measurable effects of the step of stimulating, on the source, still remain. The second source measurement data are compared with the first source measurement data for assessing an extent to which the first estimated location is correct.

Abstract: A sweat sensing device includes a plurality of sweat collection pads communicating with a sensor. Each of the pads is activated by a timing circuit which allows one or more of the pads to be activated at a selected time and subsequent deactivated after a defined period of time. This allows for selective collection of sweat from a plurality of pads over a prolonged period of time. An impedance measuring circuit can be employed to determine if one or more of the pads becomes disconnected, in order to avoid irritation. Further, the devices can use a common microfluidic device which both transports sweat activating substance, such as pilocarpine, to the surface of the skin and directs sweat away from the skin to a sensing device.

Abstract: Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.

Abstract: The invention relates to a methods and systems for determining an insulin dosing recommendation. The invention employs Linear Quadratic methodology to determine the insulin dosing recommendation based on a patient's present physiological state, which is estimated by an adaptive filter methodology employing a dynamic model, which utilizes real-time measurements of blood glucose concentration.

Abstract: The present document describes a pressure guidewire. It comprises a shaft tube having a proximal section and a sensor housing having a distal end, the proximal section and the sensor housing being the continuity of the same shaft tube. A fiber optic pressure sensor is embedded in the sensor housing and comprises an optical fiber extending within the sensor housing, the sensor adapted to measure a pressure of a fluid which is substantially applied in an axis collinear with the longitudinal axis of the guidewire. A marker band, to help in localizing the pressure guidewire in a patient's vessels, is embedded inside the sensor housing and fixed to the optical fiber for holding the pressure sensor inside the sensor housing.

Abstract: Methods, devices and systems for obtaining heart rate by obtaining apical and non-apical heart rate datum using first and second heart rate monitoring devices. The apical and non-apical heart rate data are input into a heart rate verification module (HRVM) that includes a number of programming instructions for effecting the invention. An apical heart rate measure and non-apical heart rate measure are calculated in the HRVM, and an acceptable heart rate range is generated using the apical heart rate measure. Whether the non-apical heart rate measure is a reliable measure of a true heart rate is identified by determining whether the non-apical heart rate measure falls within or outside the acceptable heart rate range. A split display screen of the HRVM displays the apical heart rate measure, non-apical heart rate measure, and information identifying whether the non-apical heart rate measure falls within or outside the acceptable heart rate range.

Abstract: Devices that sense sweat and are capable of providing chronological assurance are described. The device uses at least one sensor to measure sweat or its components and to determine a sweat sampling rate. The chronological assurance is determined, at least in part, using the sweat sampling rate. The sweat sampling rate may be determined, at least in part, using a sweat volume and/or a sweat generation rate, both of which may be measured or predetermined.

Abstract: Embodiments of the present disclosure include detecting a concurrent occurrence of a decrease in monitored analyte level and a corresponding decrease in monitored on-skin temperature, confirming a presence of an impending hypoglycemic condition, and asserting a notification corresponding to the confirmed impending hypoglycemic condition. Devices, methods, systems and kits incorporating the same are also provided.

Abstract: An alertness device includes: a respiration sensor that obtains respiratory data of a person; a calculation unit; a waveform generation unit that generates a respiratory interval (RI) waveform which is a transition in a predetermined time period of an RI which is an interval for one respiration; and a determination unit. The calculation unit calculates an average value of the RI and RrMSSDn in a predetermined time period. In a case where an average value of the subsequent RI is greater than an average value of the RI directly previous to the subsequent RI and in a case where the RrMSSDn of the subsequent RI is greater than a value which is obtained by multiplying the RrMSSDn of the previous RI by a constant ?, the determination unit determines on the basis of values calculated by the calculation unit that the person is in a state of low alertness.

Abstract: A capnography device including a suitable sensor to measure carbon dioxide concentration for a target patient/user is provided. Such a device utilizes at least one microprocessor (MCU) to govern overall activation and communication between the capnograph and ultimately a data center. Such a component is provided with at least one RFID tag in order to charge device and transfer data via inductive coupling and to use as device ID for data routing purposes. The MCU may thus provide pre-programmed information to determine alert levels for a target patient/user, with the utilization, additionally of a data recordation device to capture all sensor results for such a target patient/user as well. If an alert occurs, the MCU transfers of all subsequent information from the sensors to the data center. Thus, the inventive device and system provides a real-time, reliable, wireless surveillance and notification platform that has been lacking in the industry.

Abstract: A breath analyzing and training assembly for detecting CO2 concentration in the breathing gas of a user, includes a selective colorimetric CO2 detector having a detector surface which rapidly and reversibly changes color with CO2 concentration, when exposed thereto, and an adapter including: a docking part for receiving a mobile unit including an image capturing element, a display, and a processing element, the docking part configured to position the image capturing element in a fixed relation to the colorimetric detector, such that the image capturing element captures images of the detector surface; a detector holding part for receiving the colorimetric detector; a conduit for leading breathing gas to and from the user such that part thereof passes the detector surface; wherein the processing element measures CO2 concentration changes in the breathing gas by identifying color changes of images of the detector surface captured by the image capturing element.

Abstract: Analyte sensor faults are detected. Datasets of glucose values sensor electronics are coupled to a glucose sensor in fluid contact with interstitial fluid under a skin surface. Baseline median glucose value and glucose variability values are computed, based on the first dataset. A baseline data point is stored. Evaluation median glucose value and variability are computed, based on the second dataset of glucose values. An evaluation data point is stored. A magnitude of a vector that extends between the baseline data point and the evaluation data point is computed. A component of the magnitude of the vector that is parallel to a hypoglycemia risk contour line is computed and compared to a predefined threshold value. An indication that a sensor fault has been detected if the component is greater than a threshold is displayed.

Abstract: A device for in vivo detecting and quantifying a concentration of an analyte in a peritoneal fluid of a subject. The device includes (a) a catheter having an open proximal end configured to be disposed external to the subject, an open distal end configured to be disposed within the peritoneal cavity comprising the peritoneal fluid, an anchor portion, an outer wall, and an inner wall, (b) a sensor disposed adjacent to the open distal end and configured to detect and quantify the concentration of the analyte in the peritoneal fluid, and (c) a main control unit disposed external to the subject, connected to the sensor via a wire, and configured to control the sensor, receive and store detection and quantification data from the sensor, and transmit the data to a second device. A portion of the wire is disposed between the inner wall and the outer wall of the catheter.

Abstract: A wearable respiration monitoring system and associated method that is configured to (i) determine three dimensional displacement of the spine of a subject with respect to the axial displacement of the subject's chest wall, (ii) process the three dimensional anatomical data, (iii) determine at least one respiration parameter associated with the monitored subject as a function of the three dimensional anatomical data, and (iv) generate at least one respiration parameter signal representing the respiration parameter.

Abstract: A system analyzes neuro-response measurements including regional electroencephalography (EEG) measurements from subjects exposed to stimulus materials to determine locations in stimulus materials eliciting controlled attention and automatic attention. Additional stimulus materials are inserted into locations having salient attention attributes. In some examples, a challenging task is used to direct controlled attention onto a location and additional stimulus material is subtly presented in the location to benefit from automatic attention and salient attention measurements.

Abstract: The invention relates to medicine, in particular, to vascular and endovascular surgery, and can be used for assessment of the condition of an isolated space of an aneurysmal sac after implantation of a stent-graft by measuring pressure inside the sac, and for administration of drugs to an aneurysm in a blood vessel as far as necessary. The device for measurement pressure in an isolated space of an aneurysmal sac and for administration of drugs to an aneurysm in a blood vessel is made in the form of a hollow tube. The tube has side apertures and is adapted to change a shape when introduced into an aneurysm, and to fill the entire interior space of the aneurysm at its circumference. The tube is also adapted to be connected to a pressure-measuring sensor through a detachable hollow tube to measure pressure between the vessel wall and the wall of a stent-graft implanted to the blood vessel, and to administer drugs through said detachable hollow rube.

Abstract: Systems and methods for analyte monitoring, particularly systems and methods for monitoring and managing life of a battery in an analyte sensor system worn by a user, are provided.

Abstract: Molded electronic structures configured for use in body-mountable devices and methods for embedding molded electronic structures in a body-mountable device are described. An example method may include molding an electronic structure to have first curvature corresponding to a first radius of curvature. The electronic structure may include an antenna, a sensor, and an electronic device. The example method may also include adhering the molded electronic structure to a first polymer layer. The example method may additionally include forming a second polymer layer over the molded electronic structure adhered to the first polymer layer.