Patents Examined by Eric S. DeJong
  • Patent number: 10777320
    Abstract: A method for at least one of characterizing, diagnosing, and treating a mental health associated condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the mental health associated condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the mental health associated condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: September 15, 2020
    Assignee: PSOMAGEN, INC.
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman, Siavosh Rezvan Behbahani
  • Patent number: 10761028
    Abstract: Methods and systems for determining extracellular concentration data of an analyte are disclosed. A method for determining extracellular concentration data of an analyte includes receiving sensor data from one or more arrays of functionalized plasmonic nanostructures on a localized surface plasmon resonance imaging chip in contact with a fluid containing at least one living cell for a plurality of times, determining intensity data for the one or more arrays, determining fractional occupancy based on the intensity data, and determining extracellular concentration data based on the fractional occupancy data. A system for determining extracellular concentration data of an analyte includes a LSPRi chip, a sensor component, an intensity component, a fractional occupancy component, a concentration component, and a processor to implement the components.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 1, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • Patent number: 10755800
    Abstract: A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: August 25, 2020
    Assignee: PSOMAGEN, INC.
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman, Siavosh Rezvan Behbahani
  • Patent number: 10746651
    Abstract: The present invention provides an optical method for predicting treatment response, survival and recurrence of esophageal cancer patients, comprising analyzing the spectral signatures of patient's tumor tissue spectra. By the features of the present invention, the prediction result achieves the sensitivity of 75% and specificity of 73.3% in concurrent chemoradiotherapy (CCRT) response; the survival prediction rate achieves the sensitivity of 100%; the recurrence prediction rate achieves the sensitivity of 85.7%.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: August 18, 2020
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Jang-Ming Lee, I-Jen Hsu, Max Ti-Kuang Hou, Pei-Wen Yang
  • Patent number: 10739248
    Abstract: Methods and systems are disclosed for controlling a particle analyzer based at least in part on a generated entrainment factor for a sample. The features include flowing a sample with a series of particles through the particle analyzer, detecting events and calculating an expected frequency of those events based on a distribution, such as a Poisson distribution, and measuring an observed frequency of particle events. An entrainment factor may be generated from a ratio of observed event frequency to expected event frequency. Further adjustment to the particle analyzer maybe performed based on the indicated entrainment factor such as adjusted sorting bias.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: August 11, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Joseph Trotter, Sujata Iyer
  • Patent number: 10731222
    Abstract: A method for the prediction and/or prognosis of survival time of a patient suffering from cancer, comprising the steps of: a) measuring a RDA score in a tumor tissue sample comprising cellular RNA from said patient after said patient has received one or more doses of a cancer treatment; b) comparing said RDA score to one or more predetermined RNA disruption reference values; and c) providing a favorable prediction and/or prognosis of survival time for said patient when said RDA score is higher than said predetermined RNA disruption reference value; or providing an unfavorable prediction and/or prognosis of survival time for said patient when said RDA score is lower than said predetermined RNA disruption reference value, wherein the RDA score is proportional to the degree of RNA disruption.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: August 4, 2020
    Assignee: RNA Diagnostics Inc.
    Inventors: Kenneth Pritzker, Laura Pritzker, Amadeo Mark Parissenti, Xiaohui Wang
  • Patent number: 10725028
    Abstract: The automatic analysis device is provided with (1) a measurement mechanism having a light measuring unit having a reaction container in which the sample is dispensed, a light source which emits light to the reaction container, and a detection unit that detects scattered light from the sample in the reaction container, (2) an amplifier circuit unit having an adder-subtractor that adds or subtracts a correction signal to or from a first measurement signal from the detection unit, and an amplifier circuit which amplifies the output signal by the adder-subtractor at a fixed amplification rate to output a second measurement signal, and (3) an arithmetic operation unit which calculates the correction signal on the basis of a difference between the signal level of the second measurement signal and a target value, and which executes an analysis action based on the second measurement signal after correction by means of the correction signal.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: July 28, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Toshiyuki Inabe, Akihisa Makino, Sakuichiro Adachi, Chie Yabutani
  • Patent number: 10679728
    Abstract: Among other aspects provided herein is a method describing the use of Single Nucleotide Polymorphism (SNP) genotyping microarrays to resolve whether genetic material (such as genomic DNA) derived from a particular individual is present in a genetic material mixture (such as a complex genomic DNA mixture) is disclosed. Furthermore, it is demonstrated that the identification of the presence of genetic material (such as genomic DNA) of specific individuals within a series of complex genomic mixtures is possible.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: June 9, 2020
    Assignees: The Translational Genomics Research Institute, The Regents of the University of California
    Inventors: David Craig, Nils Homer
  • Patent number: 10672503
    Abstract: Methods and apparatuses for conducting analyses are provided.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: June 2, 2020
    Assignees: OPKO Diagnostics, LLC, Oy Arctic Partners Ab
    Inventors: Andrew J. Vickers, Peter T. Scardino, Hans Lilja, Vincent Linder, David Steinmiller
  • Patent number: 10669567
    Abstract: The present disclosure provides methods for detecting early Lyme disease. The present disclosure provides a biosignature indicative of the presence or absence of Borrelia burgdorferi infection.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: June 2, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Colorado State University Research Foundation, New York Medical College
    Inventors: John T. Belisle, Claudia R. Molins, Gary P. Wormser
  • Patent number: 10663461
    Abstract: A method of screening a plurality of fluid samples for the presence of species capable of specifically binding to a binding partner immobilized on a sensing surface of a sensor is disclosed. The method comprises contacting each sample with the sensing surface and a reference surface, and subjecting the sensing surface responses obtained for all samples to a computational process which comprises fitting al responses to a model equation for the relationship between a response at the sensing surface and the corresponding response at the reference surface. In an iterative process residuals above a pre-determined threshold value are removed, the model equation is adjusted, and all remaining samples are refitted to the adjusted model equation until the model equation at least substantially converges. Residuals above the predetermined threshold value are considered as species specifically binding to the binding partner.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: May 26, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Markku Hamalainen, Hakan Roos
  • Patent number: 10662481
    Abstract: The present invention relates to a method of testing whether a patient suffering from multiple myeloma will respond or not to a combination treatment consisting of at least one histone deacetylase inhibitor (HDACi) with at least one DNA methyltransferase inhibitors (DNMTi) comprising: i) determining the expression level (ELi) of several genes G1-Gn selected from table A in a biological sample obtained from said patient ii) comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii) calculating the HADMS score trough the following formula (I) wherein ?i represent the regression ? coefficient reference value for the gene Gi and Ci=1 if the expression of the gene Gi (ELi) is higher than the predetermined reference level (ELRi) or Ci=?1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) iv) comparing the score HADMS determined at step iii) with a predetermined reference value HADMSR v) and concluding that the patie
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: May 26, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE MONTPELLIER, CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
    Inventors: Jérôme Moreaux, Bernard Klein
  • Patent number: 10641707
    Abstract: Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: May 5, 2020
    Assignee: Gen-Probe Incorporated
    Inventors: Robert E. Heinz, Dennis Newell, David Opalsky, Jason Rhubottom
  • Patent number: 10624926
    Abstract: The present invention relates to blood-derived luterial and a method for isolating and culturing the same. The luterial according to the present invention is a cell or cell-like structure having the following characteristics: (1) it is present in body fluids, including blood, sperm, intestinal juices, saliva, and cellular fluids; (2) it shows a positive staining with Janus green B, Acridine Orange and Rhodamine 123 in an immunofluorescence test; (3) in an optimal environment (pH 7.2-7.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: April 21, 2020
    Assignee: LUTERION CO., LTD.
    Inventors: Won Cheol Choi, Young Ah Kwon, Suk Hoon Choi, Chang Hoon Choi
  • Patent number: 10610332
    Abstract: The present disclosure provides computing device implemented methods, computing device readable media, and systems for adjustment of tooth position in a virtual dental model. Virtual dental modeling can include detecting space and/or collision between posterior teeth of an upper jaw and posterior teeth of a lower jaw in a virtual dental model that has been set in a preliminary target position. An energy function can be defined including the space and/or collision, tooth root movement, and align points. Weights can be assigned for each variable in the energy function. A position of the posterior teeth of the upper jaw and the posterior teeth of the lower jaw can be adjusted in six degrees of freedom to minimize the energy function. The detection, definition, assignment, and adjustment can be repeated until the energy function converges. The weights can be adjusted to reduce the space and/or collision.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: April 7, 2020
    Assignee: Align Technology, Inc.
    Inventors: Fuming Wu, Vadim Matov, Artem Borovinskih, Rene M. Sterental, Pavel Agapov, Anton Spiridonov, Anatoliy Boltunov
  • Patent number: 10612083
    Abstract: The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: April 7, 2020
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jens Gundlach, Ian M. Derrington, Andrew Laszlo, Elizabeth Manrao
  • Patent number: 10590494
    Abstract: A method and system for increasing process performance in a biological process comprising at least one process step, the method comprising: (a) an identification phase, in which at least seven factors are identified, wherein a factor is defined as a feature of or within a process that when modified will affect the performance of the process, and wherein the factors are selected from at least one process factor and at least one genetic factor; (b) a factor screening phase, in which individual and combined contributions to process performance of each of the at least seven factors are determined, such that at least one multi-factorial interaction is identified; and (c) a refinement phase, in which higher order interactions that result in an increase in process performance between the at least seven factors are identified and tested. The method may be incorporated within automated laboratory and design of experiment systems.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: March 17, 2020
    Assignee: Synthace Limited
    Inventors: Markus Christian Gershater, Sean Michael Ward, Michael Ian Sadowski, Christopher Richard Grant
  • Patent number: 10590384
    Abstract: The present disclosure relates to luterial, which is a mitochondrial-like unidentified nano-sized particle derived from a body fluid, and to a method for isolating the same.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: March 17, 2020
    Assignee: LUTERION CO., LTD.
    Inventors: Won Cheol Choi, Young Ah Kwon, Suk Hoon Choi, Chang Hoon Choi
  • Patent number: 10553412
    Abstract: Systems, computer-readable media, and methods using mass spectrometry to analyze a sample are provided. For example, a method includes: acquiring a precursor ion spectrum; analyzing the precursor ion spectrum to identify precursor ions that preliminarily match one or more peptides that each belong to at least one protein of interest for the analysis; selecting each of the identified precursor ions in an order according to a ranking protocol for maximizing the number of proteins that are identified in the sample; for each selected precursor ion: acquiring a corresponding product ion spectrum, determining whether the acquired product ion spectrum matches one of the peptides that belong to the set of proteins of interest, and identifying a matched peptide as being present in the sample; and identifying proteins of interest that are present in the sample based on the peptides that are identified as being present in the sample.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: February 4, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Javier E. Satulovsky
  • Patent number: 10537253
    Abstract: In one embodiment, a method includes accessing first time-series data based on electromagnetic radiation in a first spectrum and second time-series data based on electromagnetic radiation in a second spectrum. The method also includes comparing the first time-series data with the second time-series data and determining, based on the comparison, (1) whether a stopping condition associated with a device has occurred or (2) whether a discarding condition associated with the first time-series data or the second time-series data has occurred.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: January 21, 2020
    Assignee: Samsung Electronics Company, Ltd.
    Inventors: Jawahar Jain, Cody Wortham, James Young, Sajid Sadi, Pranav Mistry