Patents Examined by Eric S. DeJong
  • Patent number: 11035006
    Abstract: Disclosed are gene signatures that may be used to predict the recurrence of colorectal cancer in a human patient. These signatures can be used to determine when to treat a patient with post-operative adjuvant chemotherapy, i.e., when a high risk of colorectal cancer recurrence is predicted.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: June 15, 2021
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Gibbs Cancer Center & Research Institute
    Inventors: Michael Schell, Timothy Yeatman
  • Patent number: 11031102
    Abstract: This invention provides, inter alia, a complement-inhibitor-based treatment plan coupled with a risk evaluation and management strategy (“REMS”) and a safety support program (“SSP”) for reinforcing the REMS. The REMS and SPP are implemented using one or more computer devices with software tools programmed to enforce conditions of the REMS and/or prompt follow-ups by registered nurses enrolled in the SSP. The software tool(s) determines whether a prescriber requesting the complement inhibitor has agreed to abide by the REMS, and can prompt a provider of the complement inhibitor to provide updated educational materials to the prescriber at predetermined times or intervals, to monitor the prescriber for compliance with the REMS, and/or to monitor patients for signs of adverse events. Using exemplary embodiments described herein, a risk of adverse events (especially, but not limited to, meningococcal infections) can be managed and an incidence of the adverse events can be reduced.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: June 8, 2021
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Leonard Bell, Camille Bedrosian
  • Patent number: 11022609
    Abstract: The invention relates to a method for determining interaction kinetics for an analyte. The method comprises first contacting a solution containing the analyte with immobilized ligand, or analogue thereof, immobilized on an optical sensor surface; monitoring the binding of the analyte to the immobilized ligand or analogue, wherein the binding is measured as a resulting change in a property of the surface; and automatically determining the interaction kinetics, which determining step includes first defining parts of the dissociation phase that contains kinetic information for fitting. The invention further relates to an analytical system for studying molecular interactions, which system is capable of performing the novel method, as well as a computer program product for performing the steps of the method.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 1, 2021
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Olof Karlsson
  • Patent number: 11024492
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: June 1, 2021
    Assignee: Institute for Systems Biology
    Inventors: Robert L. Moritz, Samuel Bader, Ulrike Kusebauch
  • Patent number: 11021759
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: June 1, 2021
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey, Michael Thomas Nguyen
  • Patent number: 10978281
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: April 13, 2021
    Assignee: Institute for Systems Biology
    Inventors: Robert L. Moritz, Samuel Bader, Ulrike Kusebauch
  • Patent number: 10920283
    Abstract: The present invention provides a method to define normal maturation of the gut microbiota using a limited number of bacterial taxa found in the gut microbiota. Regressing the relative abundance of age-discriminatory taxa in their gut microbiota against the chronological age of each healthy subject at the time a sample of the gut microbiota was collected produces a regression model that may be used to characterize the maturity of another subject's gut microbiota to provide a measure of gastrointestinal health without having to query the whole microbiota. The present invention also provides composition and methods for preventing and/or treating a disease in a subject in need thereof.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: February 16, 2021
    Inventors: Jeffrey I. Gordon, Sathish Subramanian, Ansel Hsiao
  • Patent number: 10910086
    Abstract: A computer-implemented method for determining minor variants. The method includes receiving electropherogram sequence data from a test sample, identifying any non-primary peaks in the electropherogram, and characterizing identified non-primary peaks using at least one signal feature. The method may further include analyzing the at least one signal feature across identified non-primary peaks to identify variant candidates, evaluating at least one peak characteristic of each of the identified variant candidates, and classifying variant candidates as bona fide variants based on the evaluation of peak characteristics.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: February 2, 2021
    Assignee: Life Technologies Corporation
    Inventors: Harrison Leong, Edgar Schreiber
  • Patent number: 10902938
    Abstract: A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: January 26, 2021
    Assignee: PSOMAGEN, INC.
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Patent number: 10878939
    Abstract: The invention provides methods, kits and systems related to personalized pain management.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: December 29, 2020
    Assignee: Children's Hospital Medical Center
    Inventor: Senthilkumar Sadhasivam
  • Patent number: 10878936
    Abstract: BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: December 29, 2020
    Inventor: Dennis Sunga Fernandez
  • Patent number: 10835169
    Abstract: Provided is a technique for computing a brain function index for diagnosing a mental disorder at the individual level, which can be applied to even a child around school age. A brain function index computing device includes a brain activity value calculation processing unit configured to calculate from brain activity signals of a subject a first brain activity value of a region including the meddle frontal gyrus (MFG) and a second brain activity value of a region including the inferior frontal gyrus (IFG); and a brain function index calculation processing unit configured to calculate a brain function index associated with a mental disorder using the first brain activity value and the second brain activity value.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: November 17, 2020
    Assignees: Hitachi, Ltd., Jichi Medical University
    Inventors: Hiroki Sato, Atsushi Maki, Yukifumi Monden, Ippeita Dan, Masako Nagashima, Eiju Watanabe, Takanori Yamagata
  • Patent number: 10832794
    Abstract: The invention provides a computer implemented method of quantifying the quality of packing for a residue comprising one or more residue atoms in a first protein in a first conformation, the method comprising: (a) calculating one or more close contact potentials based on a distance between the one or more residue atoms and one or more environment atoms, (b) calculating a contact area of the one or more residue atoms that is exposed to the one or more environment atoms and (c) calculating a close contact surface density (CCSD) by dividing the sum of the one or more close contact potentials by the contact area.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: November 10, 2020
    Assignee: ZYMEWORKS INC.
    Inventor: Anders Ohrn
  • Patent number: 10822644
    Abstract: Embodiments disclosed herein relate to methods and systems for performing an automated assay, and particularly to performing an assay on a plurality of samples on an automated instrument.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: November 3, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Adam Steel, Thomas Wojeck, Michael Young, Mark Larsen
  • Patent number: 10820844
    Abstract: Wireless electrochemical measurements methods using minimally invasive micro-sensors that monitor response of cells to specific analytes are described. Micro-actuators integrated on a same chip as the micro-sensors are used to provide closed loop in-vivo local therapy on demand. An in-vivo bio-electronic system that can monitor the health of cell colonies and accordingly dispense corresponding therapeutic drugs is also described.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: November 3, 2020
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Axel Scherer, Arti Gaur
  • Patent number: 10818380
    Abstract: Disclosed herein are methods, devices and systems of treating dysfunctional biochemical pathway(s) using an individualized treatment plan (ITP) of metabolic support intervention(s) for a patient. The ITP has metabolic support intervention(s) that restore proper functioning of biochemical pathway(s) correcting dysfunction(s) therein. Methods can include determining if the biochemical pathway(s) are dysfunctional by subjecting, via a bio-communication device, the patient to a noninvasive test that includes simulating one or more stimuli that are indicative of the biochemical pathway(s)' s functioning.
    Type: Grant
    Filed: April 26, 2014
    Date of Patent: October 27, 2020
    Inventor: Amy Kathleen Davis Moore
  • Patent number: 10815516
    Abstract: A method is provided for establishing resistance characteristics of a biological indicator in a sterilization process using a sterilant vapor. The method includes the step of creating a biological indicator inactivation profile by obtaining differential sterilant vapor pressure values in a sterilization chamber during sterilant vapor injection and determining D-values as a function of the differential sterilant vapor pressure values obtained. The biological indicator inactivation profile, when represented as a function of differential sterilant vapor pressure, may be linear over the full range of inactivation. The biological indicator inactivation profile may be created by injecting the sterilant vapor into the sterilization chamber and measuring biological indicator survival at different differential sterilant vapor pressure values.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: October 27, 2020
    Assignee: TSO3 Inc.
    Inventor: Sylvie Dufresne
  • Patent number: 10809246
    Abstract: A hemolysis detection method and system includes measuring a conductance of a blood sample in a sample test module at a plurality of multiple-frequency AC inputs provided by a sine-wave generator module, calculating an immittance value for each of the plurality of multiple-frequency AC inputs received from a multichannel A/D converter module using a computer processing module, and subjecting each immittance value calculated to a function that maps immittance values to either lysed blood levels or hematocrit levels residing in the processing module and applying further processing residing in a memory module to produce respective percent-lysed value or hematocrit value of the blood sample.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: October 20, 2020
    Inventor: Michael Cafferty
  • Patent number: 10803147
    Abstract: A method for at least one of characterizing, diagnosing, and treating a locomotor system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the locomotor system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the locomotor system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: October 13, 2020
    Assignee: PSOMAGEN, INC.
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Patent number: 10803991
    Abstract: A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: October 13, 2020
    Assignee: PSOMAGEN, INC.
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid