Abstract: Embodiments of a method and/or system for characterizing a headache-related condition for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more headache-related conditions for the set of users; and performing a characterization process for the one or more headache-related conditions, based on the supplementary dataset and microbiome features extracted from the microbiome dataset.
Type:
Grant
Filed:
November 21, 2017
Date of Patent:
August 20, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Jessica Richman, Daniel Almonacid, Rodrigo Ortiz, Catalina Valdivia, Inti Pedroso, Paz Tapia
Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome-derived functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
November 16, 2017
Date of Patent:
August 20, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
August 13, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
May 26, 2017
Date of Patent:
August 13, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Jessica Richman, Daniel Almonacid
Abstract: Embodiments of a method and/or system for characterizing an allergy-related condition for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more allergy-related conditions for the set of users; and performing an allergy-related characterization process for the one or more allergy-related conditions, based on the supplementary dataset and/or microbiome features extracted from the microbiome dataset.
Type:
Grant
Filed:
December 15, 2017
Date of Patent:
August 13, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Jessica Richman, Daniel Almonacid, Catalina Valdivia, Rodrigo Ortiz, Inti Pedroso, Victoria Dumas, Paz Tapia, Eduardo Morales
Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
June 13, 2017
Date of Patent:
July 30, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: Raman spectra of cells, such as normal human T- and B-cells from peripheral blood or human tonsil and the corresponding transformed cells are obtained by optically trapping the cells and obtaining their Raman spectra. The trapped cells can be subjected to one, two, or more different excitation wavelengths, and each wavelength of the corresponding Raman spectra can be stored in a separate channel. In preferred embodiments, two spectra are subtracted from each other to give a difference spectrum and each channel is analyzed independently to characterize the trapped cell. Alternatively, the Raman spectrum can be subjected to Principal Component Analysis (PCA) in order to characterize the trapped cell. The trapped cell thus classified can be sorted, or further manipulated.
Type:
Grant
Filed:
May 31, 2006
Date of Patent:
July 30, 2019
Assignee:
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
Inventors:
James W. Chan, Thomas R. Huser, Stephen M. Lane, John C. Rutledge, Douglas S. Taylor, Theodore Zwerdling, Ronald Li
Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
November 17, 2017
Date of Patent:
July 30, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: Embodiments of a method and/or system for characterizing a microorganism-related condition (e.g., human behavior condition, disease-related condition, etc.) for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more microorganism-related conditions for the set of users; and performing a microorganism-related characterization (e.g., human behavior characterization, disease-related characterization, etc.) process for the one or more microorganism-related conditions, based on the supplementary dataset and/or microbiome features extracted from the microbiome dataset.
Type:
Grant
Filed:
December 18, 2017
Date of Patent:
July 30, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Jessica Richman, Daniel Almonacid, Catalina Valdivia, Rodrigo Ortiz, Inti Pedroso, Victoria Dumas, Paz Tapia, Eduardo Morales
Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
June 28, 2017
Date of Patent:
July 23, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
June 13, 2017
Date of Patent:
July 23, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
May 26, 2017
Date of Patent:
July 23, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Jessica Richman, Daniel Almonacid
Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
June 13, 2017
Date of Patent:
July 23, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome-derived functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
April 13, 2016
Date of Patent:
July 23, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman, Siavosh Rezvan Behbahani
Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
July 16, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
July 16, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman
Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
July 6, 2016
Date of Patent:
July 9, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman, Siavosh Rezvan Behbahani
Abstract: A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
May 26, 2017
Date of Patent:
July 9, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Jessica Richman, Daniel Almonacid
Abstract: A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
May 26, 2017
Date of Patent:
July 9, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Jessica Richman, Daniel Almonacid
Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
July 9, 2019
Assignee:
uBiome, Inc.
Inventors:
Zachary Apte, Daniel Almonacid, Jessica Richman