Patents Examined by Eric S. Olson
  • Method of administering hyaluronan formulation for the amelioration of osteophytes
    Patent number: 8163716
    Abstract: Disclosed is a method for the amelioration of osteophyte formation including administering to a subject a therapeutically effective amount of an exogenous hyaluronan formulation.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: April 24, 2012
    Inventor: James D. Smith
  • Cellulose esters and their production in halogenated ionic liquids
    Patent number: 8158777
    Abstract: Ionic liquids and cellulose ester compositions and processes for producing ionic liquids and cellulose esters. Cellulose esters can be produced by esterifying cellulose in a reaction medium comprising one or more halide ionic liquids and at least one binary component. Cellulose esters prepared via the methods of the present invention can have a degree of substitution (“DS”) of at least 1.5 and can comprise a plurality of ester substituents, where at least 50 percent of the ester substituents comprise alkyl esters having a carbon chain length of at least 6 carbons.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: April 17, 2012
    Assignee: Eastman Chemical Company
    Inventors: Charles Michael Buchanan, Norma Lindsey Buchanan
  • Morphine derivatives
    Patent number: 8158764
    Abstract: The present invention relates to new morphine-6-glucuronide derivatives, to pharmaceutical compositions thereof and uses thereof.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: April 17, 2012
    Assignee: Neorphys
    Inventors: Karine Larbouret, Roger Lahana, Cedric Castex
  • Non-sedating barbiturate compounds as neuroprotective agents
    Patent number: 8158639
    Abstract: Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. Preferred compounds are in the family of diphenylbarbituric acid and analogs. Preferred doses for a neuroprotective effect exceed the dosage of a corresponding sedative barbiturate without sedative side-effects such as anesthesia and death.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: April 17, 2012
    Assignee: Taro Pharmaceutical Industries Ltd.
    Inventors: Daniel A. Moros, Barrie Levitt, Avraham Yacobi
  • De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
    Patent number: 8148335
    Abstract: The present invention generally provides compositions methods and composition relating to the diagnosis and/or treatment of cancers having a cell surface de-N-acetylated sialic acid antigen, e.g., an at least partially de-N-acetylated ganglioside and/or a de-N-acetylated sialic acid-modified cell surface protein.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: April 3, 2012
    Assignee: Children's Hospital & Research Center Oakland
    Inventors: Gregory R. Moe, Charles Paul Plested
  • Use of dietary fibres against muscle wasting
    Patent number: 8143235
    Abstract: A composition nutritional containing dietary fibres is useful for the treatment of muscle wasting, if the dietary fibre comprise at least 30 wt. % of galacto-oligosaccharides or other oligosaccharides having mainly anhydropyranose units, and having a chain length of 3-10 units. The composition may further contain other oligo- or polysaccharides, especially polysaccharides having a majority of anhydrofuranose units.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: March 27, 2012
    Assignee: N.V. Nutricia
    Inventors: Marchel Gorselink, Adrianus Lambertus Bertholdus van Helvoort, Robert Johan Joseph Hageman
  • Process for the synthesis of oligonucleotides
    Patent number: 8138330
    Abstract: The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5?-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5?-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: March 20, 2012
    Assignee: Sigma-Aldrich Co. LLC
    Inventors: Michael Leuck, Andreas Wolter, Alfred Stumpe
  • Palmarumycin based inhibitors of thioredoxin and methods of using same
    Patent number: 8124651
    Abstract: Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: February 28, 2012
    Assignees: The University of Pittsburgh Office of Technology Transfer, Arizona Board of Regents
    Inventors: Garth Powis, Peter Wipf
  • Composition for relieving discomfort
    Patent number: 8124585
    Abstract: The invention relates to a method of controlling feelings of pain in infants or diseased or elderly persons using a complete nutrition or a nutritional supplement. The method comprises administering increased levels of folic acid, vitamin B6 and vitamin B12 or their functional equivalents.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: February 28, 2012
    Assignee: N.V. Nutricia
    Inventors: Robert Johan Joseph Hageman, Jacob Geert Bindels
  • Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity
    Patent number: 8119599
    Abstract: A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in the tissue.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: February 21, 2012
    Assignee: Orthopeutics, L.P.
    Inventors: Thomas P. Hedman, Paul Slusarewicz
  • Synthetic heparin monosaccharides
    Patent number: 8114970
    Abstract: Preparation of synthetic monosaccharides, for use in the preparation of synthetic heparinoids.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: February 14, 2012
    Assignee: Alchemia Limited
    Inventors: Joachim Seifert, Latika Singh, Tracie E. Ramsdale, Michael L. West, Nicholas B. Drinnan
  • 2? and 3?-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation
    Patent number: 8114994
    Abstract: Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: February 14, 2012
    Assignee: Emory University
    Inventors: Dennis C. Liotta, Shuli Mao, Michael Hager, Raymond F Schinazi
  • Methods of evaluating mixtures of polysaccharides
    Patent number: 8101733
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of polysaccharides includes polysaccharides having a desired structural moiety. In some instances, one or more polysaccharides in the mixture are chemically modified prior to analysis.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: January 24, 2012
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Cuihua Liu, Nur Sibel Gunay, Ishan Capila, Ganesh Venkataraman
  • Use of D-ribose to treat cardiac arrhythmias
    Patent number: 8101581
    Abstract: D-ribose, given in doses of five to 15 grams daily, reduces or prevents the occurrence of atrial fibrillation in persons experiencing atrial fibrillation.
    Type: Grant
    Filed: January 23, 2008
    Date of Patent: January 24, 2012
    Assignee: Bioenergy, Inc.
    Inventor: James D. Herrick
  • Thioether substituted aryl carbonate protecting groups
    Patent number: 8097711
    Abstract: Embodiments of the invention include nucleotide and nucleoside monomers protected at the 5?- or 3?-hydroxyls with thioether substituted aryl carbonate protecting groups. In certain cases, the carbonate protecting groups include an aryl moiety, e.g., a phenyl group, attached to the carbonate, where the aryl moiety further includes a thioether group, e.g., an alkyl or aryl thioether group, bound directly to the aryl ring. Aspects of the invention further include methods of synthesizing nucleic acids, e.g., oligonucleotides, using such protected nucleoside monomer monomers, as well as nucleic acids produced using methods of the invention and compositions thereof.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: January 17, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Zoltan Timar, Zoltan Kupihar, Douglas J. Dellinger, Marvin H. Caruthers
  • Activators for oligonucleotide synthesis
    Patent number: 8093397
    Abstract: A process for the synthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1?6-benzo[d]isothiazol-3-one, preferably in the presence of an organic base.
    Type: Grant
    Filed: October 6, 2008
    Date of Patent: January 10, 2012
    Assignee: Avecia Biotechnology, Inc.
    Inventors: Nanda Sinha, William Edward Zedalis, Gregory Keith Miranda
  • Methods for assaying alpha-L-iduronidase enzymatic activity
    Patent number: 8088745
    Abstract: Methods for assaying ?-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: January 3, 2012
    Assignee: University of Washington
    Inventors: Michael H. Gelb, Sophie Blanchard
  • Process for starch modification
    Patent number: 8076473
    Abstract: A starch thinning and etherification process is provided comprising the steps of (a) mixing a starch substrate with a thinning agent, an alkalizing agent and an etherification agent; (b) drying the mixture of step (a); and (c) allowing the dried mixture to react with the etherification agent, wherein: the thinning agent consists of one or more hypochlorites; step (a) is carried out at an alkaline pH and does not involve any artificial heating; and step (b) is carried out before the mixture of step (a) reaches the starch substrate's gelatinisation temperature.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: December 13, 2011
    Assignee: Cargill, Incorporated
    Inventors: Marc Charles Florent Berckmans, Dogan Sahin Sivasligil
  • Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
    Patent number: 8076346
    Abstract: The present invention relates to a composition and a method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administering an oral dosage form of a sodium salt of 5,5-diphenyl barbituric acid to enhance the bioavailability of 5,5-diphenyl barbituric acid and brain delivery of same.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: December 13, 2011
    Assignee: Taro Pharamaceutical Industries Ltd.
    Inventors: Daniella Gutman, Barrie Levitt, Daniel A. Moros, Avraham Yacobi, Howard Rutman
  • Saccharidic fluorescent substrates, their process of preparation and their use
    Patent number: 8076466
    Abstract: The present invention relates to fluorescent enzymatic substrates of saccharidic nature having a self-cleavable spacer arm functionalized by a fluorophore F and by at least one inhibitor of the fluorescence of F, to the use thereof for preparation of a diagnostic reagent for functional imaging in vivo, and to the diagnostic reagent for functional imaging containing at least one such enzymatic substrate.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: December 13, 2011
    Assignee: Commissariat a l'Energie Atomique
    Inventors: François Durrat, Isabelle Texier-Nogues, Véronique Robert