Abstract: The invention provides a body-worn system that continuously measures pulse oximetry and blood pressure, along with motion, posture, and activity level, from an ambulatory patient. The system features an oximetry probe that comfortably clips to the base of the patient's thumb, thereby freeing up their fingers for conventional activities in a hospital, such as reading and eating. The probe secures to the thumb and measures time-dependent signals corresponding to LEDs operating near 660 and 905 nm. Analog versions of these signals pass through a low-profile cable to a wrist-worn transceiver that encloses a processing unit. Also within the wrist-worn transceiver is an accelerometer, a wireless system that sends information through a network to a remote receiver, e.g. a computer located in a central nursing station.

Abstract: Blood oxygenation sensors including high-aspect-ratio photodetector elements are discussed herein. Such high-aspect-ratio photodetector elements may provide improved signal-strength-to-power-consumption performance for blood oxygenation sensors incorporating such photodetector elements as compared with blood oxygenation sensors incorporating, for example, square photodetector elements.

Abstract: Embodiments of the present disclosure provide a hypersaturation index for measuring a patient's absorption of oxygen in the blood stream after a patient has reached 100% oxygen saturation. This hypersaturation index provides an indication of the partial pressure of oxygen of a patient. In an embodiment of the present invention, a hypersaturation index is calculated based on the absorption ratio of two different wavelengths of energy at a measuring site. In an embodiment of the invention, a maximum hypersaturation index threshold is determined such that an alarm is triggered when the hypersaturation index reaches or exceeds the threshold. In another embodiment, an alarm is triggered when the hypersaturation index reaches or falls below its starting point when it was first calculated.

Abstract: A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.

Abstract: A sensing system and method for sensing a component in a liquid is disclosed. The system comprises a microfluidic channel, the microfluidic channel comprising a first end and a second end, wherein the microfluidic channel is open at the first end and closed at the second end. The system also comprises at least one measurement sensor positioned adjacent the first end, the measurement sensor being arranged for detecting a measurement signal and a reference sensor positioned in the microfluidic channel adjacent the second end, the reference sensor being arranged for detecting a reference signal of the liquid. The system further is configured for combining the measurement signal and the reference signal so as to filter out background influences.

Abstract: The present invention relates to a device and a method for extracting physiological information from detected electromagnetic radiation emitted or reflected by a subject. A data stream derived from detected electromagnetic radiation is received. The data stream comprises a continuous or discrete characteristic signal including physiological information indicative of at least one vital parameter, the characteristic signal comprising at least one indicative signal component representative of a detected spectral portion indicative of the at least one vital parameter. The data stream at least sectionally comprises at least one auxiliary signal component detected along with the at least one indicative signal component, the at least one auxiliary signal component being representative of a distinct spectral portion.

Abstract: A variety of wearable magnetic assemblies are provided that are configured to produce magnetic fields having high field magnitudes and/or high field gradients. These wearable magnetic assemblies are configured to exert forces on magnetic particles disposed in a portion of subsurface vasculature (e.g., a portion of the ulnar artery near the wrist) proximate to the magnetic assemblies. These magnetic assemblies include a plurality of dipolar permanent magnets. The forces can act to attract, slow, speed, separate, or otherwise influence the magnetic particles in various applications. In some embodiments, the magnetic particles are configured to bind to an analyte of interest. The collection, separation, and/or concentration of the magnetic particles can enable detection of one or more properties of the analyte, modification of the analyte, and/or extraction of the analyte bound to the magnetic particles.

Abstract: A method including placing a portion of a foot of a newborn in a device, the device including a light emitter and a corresponding receiver coupled on opposite sides of the device, the device further including a processor for processing data from the light emitter and receiver; and determining a presence of congenital heart disease. An apparatus including a body including a chamber of a size to accommodate a portion of a newborn's foot; at least one light emitter and a corresponding detector coupled on opposite sides of the body, the emitter configured to emit light of a prescribed wavelength into the chamber; and a processor coupled to the body and configured to receive a signal from the at least one detector.

Abstract: An analyzer apparatus and method of use thereof is described to dynamically irradiate a sample with incident light where the incident light is varied in time in terms of any of: position, radial position relative to a point of the skin of a subject, solid angle, incident angle, depth of focus, energy, and/or intensity. For example, the incident light is varied in radial position as a function of time relative to one or more of a sample site, a point on skin of the subject, a detection optic, and/or a sample volume observed by a detection system. The radially varied incident light is used to enhance and/or vary light probing the epidermis, the dermis, and/or the subcutaneous fat of the subject or of a group of subjects.

Abstract: Methods and devices are provided for optically interrogating subsurface tissues of a body. Optical interrogation includes illumination of a target tissue through an external body surface and detection of light emitted in response to the illumination. Parameters of such optical interrogation are controlled according to operational modes that are selected to maximize detector sensitivity to a target property of the target subsurface tissues. Operational modes are selected based on detected properties of the target tissue and of intervening tissues (e.g., thickness of intervening tissues between the target tissue and an external body surface) between the target tissue and an interrogating optical device. Operational modes can be determined based on simulated optical interrogation of subsurface tissue across a range of optical detector configurations and tissue conditions. Operational modes can include calibration curves specifying optical interrogation parameters based on intervening tissue properties.

Abstract: Disclosed are embodiments that relate to the deployment of a glucose sensor comprising an optical fiber into a physiological fluid, wherein the optical fiber has disposed along a distal region thereof a chemical indicator system comprising a fluorophore and a glucose binding moiety immobilized within a hydrogel, wherein the components of the chemical indicator system are in a dry state before deployment. Also disclosed is a one-point in vivo calibration of the chemical indicator system based on an independently measured glucose concentration.

Abstract: Light beams emitted from one or more light sources may be directed into an abdomen of a pregnant mammal toward a fetus contained therein. Some of the light may be reflected by the pregnant woman and fetus and received at a detector over a first time. A photo detector into an electronic reflected signal, which may be communicated to a computer, may then convert the received light. The electronic reflected signal may then be processed and/or analyzed to isolate a portion of the electronic reflected signal reflected from the fetus. The isolated portion of the electronic reflected signal reflected from the fetus may then be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. An indication of the fetal hemoglobin oxygen saturation level may then be provided to an operator by way of, for example, a computer display.

Abstract: A physiological sensor has light emitting sources, each activated by addressing at least one row and at least one column of an electrical grid. The light emitting sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.

Abstract: The invention relates to a device (200) for taking a sample of a body fluid, such as blood, to be incorporated into a fluid circuit of a perfusion (100) of a patient who has a perfusion catheter (104), said device having a tubular structure (202) for connecting to the fluid circuit of the perfusion, provided with a zone for intubation, during use, of a sampling channel (300) comprising a distal end (301); and a means (203) for holding, during use, in the tubular structure, the part of the sampling channel (300) comprising a distal end (301) in such a way that the distal end (301) is oriented towards the perfusion catheter (104), in the direction of flow (F1) of the perfusion product (102), from a perfusion product reservoir (101) towards the perfusion catheter (104).

Abstract: Access is provided to certain pulse oximetry systems utilizing a keyed sensor and a corresponding locked sensor port of a restricted access monitor. In such systems, the keyed sensor has a key comprising a memory element, and the monitor has a memory reader associated with the sensor port. The monitor is configured to function only when the key is in communications with the locked sensor port, and the memory reader is able to retrieve predetermined data from the memory element. The monitor is accessed by providing the key separate from the keyed sensor, integrating the key into an adapter cable, and connecting the adapter cable between the sensor port and an unkeyed sensor so that the monitor functions with the unkeyed sensor.

Abstract: Some embodiments relate to a device, method, and/or computer-readable medium storing processor-executable process steps to remove a component of a signal corresponding to ambient light in a photoplethysmographic sensor device, including capturing a first detected light signal representing an ambient light at a first time, causing a light emitter to generate a source light signal driven at a first level, capturing a second detected light signal representing the source light signal after interacting with a user's tissue plus the first detected light signal, generating a first output signal based on the second detected light signal adjusted by the first detected light signal, causing the light emitter to generate a source light signal driven at a second level, capturing a third detected light signal representing the source light signal driven at the second level after interacting with the user's skin plus the first detected light signal, and generating a second output signal based on the third detected light sig

Abstract: Systems and methods for transcutaneously implanting medical devices, such as in vivo analyte sensors, are provided. The systems and methods involve the use of introducers or inserters made of shape memory alloy (SMA) materials which are transitionable from one operative state or configuration to another operative state or configuration, wherein the transition from state to state enables the transcutaneous implantation and/or transcutaneous explantation of the medical device.

Abstract: An optical isolation element is provided on an optical sensor comprising a light source, at least one photodetector, and indicator material that emits light that is detected by the photodetector when optically excited by the light source. The optical isolation element limits the optical paths by which light may be transmitted by the light source, thereby limiting exposure of the excitation light source to regions of interest. The optical isolation element also limits the optical paths by which light may be transmitted to the photodetector, thereby limiting exposure of the photodetector to light from extraneous sources.

Abstract: Systems, methods, and devices of the various embodiments provide a device capable of determining a blood property based at least in part on the measurement of the amount of light received by a receiver circuit with a limited current capacity by charging a capacitor with a low voltage power supply and intermittently discharging the capacitor through a light emitting diode. In some embodiments the device may be a pulse oximeter capable of taking blood oxygen readings. In some embodiments the device may be a heart rate monitor to determine a heart rate based on an amount of light passed through tissue. The various embodiments may enable pulse oximeters and/or heart rate monitors to be incorporated into small unobtrusive body patches, while enabling the pulse oximeters to operate from a power output equivalent to that of a small coin cell battery or printed cell battery.

Abstract: The present invention provides a pulse oximeter of the portable type, which is possible to carry around and to use widely regardless of the adult, the infant, the newborn baby, and which can keep the finger still for performing the precise measurement. The pulse oximeter 100 comprises a measurement cavity 110 for accepting the examined portion (for example finger) of the subject, a measurement device 120 including a light emitting part 121 and a photo detecting part 122 facing between the measurement cavity 110, a filling element 140 formed from a material that the light used for the measurement can penetrate. The height and the curvature of the inner surface of the filling element 140 is larger than that of the outer surface of the filling element 140. The filling element 140 converts the height and the curvature of the inner space.