Patents Examined by Eric Winakur
  • Patent number: 9861710
    Abstract: A system is provided which includes the composite nanoparticles configured to bind with a target analyte, the composite nanoparticles including a polymer matrix; nanoparticles at least one type; reporter labels at least one type; and targeting entities at least one type, wherein the nanoparticles at least one type, the reporter labels at least one type and the targeting entities at least one type are encapsulated in the polymer matrix; a body-mountable device mounted on an external surface of a living body and configured to detect a target analyte binding response signal transmitted through the external surface, wherein the target analyte binding response signal is related to binding of the composite nanoparticles with one or more target analytes; and a processor configured to non-invasively detect the one or more target analytes based on the target analyte response signal. Composite nanoparticles and methods for use and for making are also provided.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: January 9, 2018
    Assignee: Verily Life Sciences LLC
    Inventors: Timothy Tordella Ruckh, Kimberly Kam, Jerrod Joseph Schwartz, Vasiliki Demas, Andrew Peter Homyk
  • Patent number: 9861303
    Abstract: An exemplary apparatus for measuring the concentration of a test substance in an organism disclosed herein includes: a measurement system which measures first and second concentrations that are concentrations of the test substance at positions A and B, respectively, where the positions A and B are located inside of the organism but outside of the blood vessel of the organism, and the position B is located more distant from the blood vessel than the position A is; and a decision circuit which determines, based on the first and second concentrations, whether or not an equilibrium has been established yet between a concentration of the test substance inside of the blood vessel and a concentration of the test substance measured at a position inside of the organism but outside of the blood vessel of the organism.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: January 9, 2018
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventors: Tatsurou Kawamura, Yasuaki Okumura, Masaru Minamiguchi, Masahiko Shioi
  • Patent number: 9854999
    Abstract: A pulse photometer includes a light emitter, a light detector, a first signal separator that separates a first signal component and a first noise component, a second signal separator that separates a second signal component and a second noise component, a first determining section, a second determining section, and a concentration calculating section that calculates a concentration of a light absorption material in blood of the subject based on a fundamental frequency of the first signal component or a fundamental frequency of the second signal component.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: January 2, 2018
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Yoshinori Ueda, Teiji Ukawa, Kazumasa Ito, Hideki Fujisaki
  • Patent number: 9855009
    Abstract: An apparatus for working in conjunction with a digital sensor, CPU and display of a host device in order to measure blood characteristics that includes a housing configured for association with the host device so as to define between them a chamber into which at least a portion of an appendage of a living being is placed such that a tip of the appendage is deployed adjacent to the digital sensor so as to cover the digital sensor. The chamber substantially encloses the digital sensor. Light from a light source is directed toward the appendage tip, wherein at least some light from the light source is reflected by tissue of the appendage, is received by the sensor and data thereby generated is processed by the CUP to determine the blood characteristics.
    Type: Grant
    Filed: July 15, 2012
    Date of Patent: January 2, 2018
    Assignee: CNOGA MEDICAL LTD.
    Inventor: Yosef Segman
  • Patent number: 9848804
    Abstract: A sensor insertion device for inserting a detection element of a sensor configured to measure biological information of a subject into the body of the subject includes a device body; a data process unit attached to the device body, a movement mechanism detachably attached to the device body, the movement mechanism being configured to move the detection element together with an insertion needle configured to be stuck into the body of the subject to insert the detection element and the insertion needle into the body of the subject; and a displacement preventing member.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: December 26, 2017
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Takahiro Ohkoshi, Atsushi Matsumoto
  • Patent number: 9848785
    Abstract: Disclosed herein is a framework for facilitating patient signal analysis. In accordance with one aspect, first and second patient signal data are received from a patient monitor. The first and second patient signal data may then be segmented into respective first and second regions of interest, from which respective first and second waveform parameters may be extracted. One or more morphology indices may then be generated based on the first and second waveform parameters to compare shapes of the first and second regions of interest.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: December 26, 2017
    Assignee: Siemens Healthcare GmbH
    Inventor: Hongxuan Zhang
  • Patent number: 9848815
    Abstract: Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: December 26, 2017
    Assignee: GEELUX HOLDINGS, LTD.
    Inventor: Marcio Marc Abreu
  • Patent number: 9848808
    Abstract: An apparatus and method for non-invasively determining a blood oxygen parameter value of a subject's tissue is provided. An embodiment of the method includes the steps of: a) providing a spectrophotometric sensor that includes a processing portion and a transducer, b) detecting at least a portion of transmitted light after passage through the subject's tissue and producing initial signal data from the detected light; and c) using the processing portion to: (i) determine a value representative of an attenuation of at least one wavelength of light detected; (ii) determine whether the representative attenuation value is outside a predefined range of attenuation values; and (iii) determine the blood oxygen parameter value using a first interrogation or an alternate interrogation setting.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: December 26, 2017
    Assignee: CAS Medical Systems, Inc.
    Inventor: Paul Benni
  • Patent number: 9848807
    Abstract: A tissue profile wellness monitor measures a physiological parameter, generates a tissue profile, defines limits and indicates when the tissue profile exceeds the defined limits. The physiological parameter is responsive to multiple wavelengths of optical radiation after attenuation by constituents of pulsatile blood flowing within a tissue site. The tissue profile is responsive to the physiological parameter. The limits are defined for at least a portion of the tissue profile.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: December 26, 2017
    Assignee: MASIMO CORPORATION
    Inventor: Marcelo M. Lamego
  • Patent number: 9848812
    Abstract: fNIRS may be used in real time or near-real time to detect the mental state of individuals. Phase measurement can be applied to drive an adaptive filter for the removal of motion artifacts in real time or near-real time. In this manner, the application of fNIRS may be extended to practical non-laboratory environments. For example, the mental state of an operator of a vehicle may be monitored, and alerts may be issued and/or an autopilot may be engaged when the mental state of the operator indicates that the operator is inattentive.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: December 26, 2017
    Assignee: The United States of America as Represented by the Administrator of National Aeronautics and Space Administration
    Inventors: Angela Harrivel, Tristan Hearn
  • Patent number: 9848806
    Abstract: A pulse oximeter may reduce power consumption in the absence of overriding conditions. Various sampling mechanisms may be used individually or in combination. Various parameters may be monitored to trigger or override a reduced power consumption state. In this manner, a pulse oximeter can lower power consumption without sacrificing performance during, for example, high noise conditions or oxygen desaturations.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: December 26, 2017
    Assignee: MASIMO CORPORATION
    Inventor: Ammar Al-Ali
  • Patent number: 9844342
    Abstract: A sensor attached to a living body includes a sensor body that outputs a signal corresponding to biological information, and a cable that is connected to a sensor body and transmits the signal. The cable has a first portion having a first flexibility and a second portion having a second flexibility lower than the first flexibility. The second flexibility enables the second portion to be bent, and is able to retain a shape of the second portion in a bent state.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: December 19, 2017
    Assignee: NIHON KOHDEN CORPORATION
    Inventor: Nobuyoshi Watanabe
  • Patent number: 9844348
    Abstract: Embodiments of the present invention include systems and methods that relate to pulse oximetry. Specifically, one embodiment includes an oximeter sensor comprising a light emitting element configured to emit light, a light detector configured to detect the light, and a memory chip having a built-in trimmed resistor, the trimmed resistor having a resistance value that is detectable by a monitor.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: December 19, 2017
    Assignee: Coviden LP
    Inventors: Paul D. Mannheimer, Michael E. Fein
  • Patent number: 9844345
    Abstract: In a combination invasive and non-invasive bioparameter monitoring device an invasive component measures the bioparameter and transmits the reading to the non-invasive component. The non-invasive component generates a bioparametric reading upon insertion by the patient of a body part. A digital processor processes a series over time of digital color images of the body part and represents the digital images as a signal over time that is converted to a learning vector using mathematical functions. A learning matrix is created. A coefficient of learning vector is deduced. From a new vector from non-invasive measurements, a new matrix of same size and structure is created. Using the coefficient of learning vector, a recognition matrix may be tested to measure the bioparameter non-invasively. The learning matrix may be expanded and kept regular. After a device is calibrated to the individual patient, universal calibration can be generated from sending data over the Internet.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: December 19, 2017
    Assignee: CNOGA MEDICAL LTD.
    Inventor: Yosef Segman
  • Patent number: 9839360
    Abstract: An end stage renal disease (ESRD) monitoring system may include an implantable sensor and a reader device with an optical sensor. The implantable sensor may be configured to detect a group of analytes relevant to ESRD, such as glucose, creatinine, urea, and potassium. The implantable sensor may be implanted into the dermis of an animal, and may exhibit color changes in response to the presence of the target analytes or reaction product(s) thereof. The reader device may be configured to capture an image of the implanted sensor and to determine the concentration of the target analytes based at least in part on the image. The reader device may be a personal electronic device such as a cell phone, PDA, or personal computer.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: December 12, 2017
    Assignee: Optica, Inc.
    Inventors: Mihailo V. Rebec, Slavko N. Rebec, Richard G. Sass, Mihailo R. Rebec
  • Patent number: 9839381
    Abstract: Disclosed herein is a physiological measurement system that can automatically adjust the number of wavelengths used based on the quality of a sensor signal that is reflective of an optical radiation detected at a sensor after tissue attenuation. The signal quality is examined to determine if it is sufficient to support the use of a full set of wavelengths. If it is determined to be insufficient to support the full set, a reduced number of wavelengths is used.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: December 12, 2017
    Assignee: Cercacor Laboratories, Inc.
    Inventors: Walter M. Weber, Ammar Al-Ali
  • Patent number: 9839362
    Abstract: An apparatus and method for measuring at least two patient parameters is provided. A first cuff includes a first inflatable bladder, a first light emitting device and a first sensor that senses light data for use in calculating at least two patient parameters. A second cuff includes a second inflatable bladder, a second light emitting device and a second sensor that senses light data for use in calculating the at least two patient parameters. A controller is coupled the first and second sensors and when the controller causes the bladder of one of the first and second cuffs to inflate, the sensor of the one of the first and second cuffs sensing first light data used in determining a first of the at least two patient parameters and the sensor of the other of the one of first and second cuffs simultaneously senses second light data used in determining of a second of the at least two patient parameters.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: December 12, 2017
    Assignee: Draeger Medical Systems, Inc.
    Inventor: Donald Fournier
  • Patent number: 9839379
    Abstract: A regional oximetry pod drives optical emitters on regional oximetry sensors and receives the corresponding detector signals in response. The sensor pod has a dual sensor connector configured to physically attach and electrically connect one or two regional oximetry sensors. The pod housing has a first housing end and a second housing end. The dual sensor connector is disposed proximate the first housing end. The housing at least partially encloses the dual sensor connector. A monitor connector is disposed proximate a second housing end. An analog board is disposed within the pod housing and is in communications with the dual sensor connector. A digital board is disposed within the pod housing in communications with the monitor connector.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: December 12, 2017
    Assignee: Masimo Corporation
    Inventors: Ammar Al-Ali, Kevin Forrest, David Dalke, Walter M. Weber
  • Patent number: 9839378
    Abstract: Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: December 12, 2017
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: David R. Markle, Ritchie A. Wessling, Donald J. Kolehmainen
  • Patent number: 9839365
    Abstract: Systems are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with a coherent light source and detecting time-varying patterns of constructive and destructive interference in light received from portions of the biological tissue by an imager. The movement of blood cells and other light-scattering elements in the biological tissue causes transient, short-duration changes in light emitted from portions of the biological tissue proximate to the moving blood cells or other scatterers. High-frequency sampling or other high-bandwidth processing of light intensities detected by an imager could be used to determine the flow of blood or other fluids at a plurality of points in the biological tissue, to detect and/or localize a tumor in the biological tissue, to determine the location, pattern, width, or other properties of vasculature in the biological tissue, or to provide information for some other application(s).
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: December 12, 2017
    Assignee: Verily Life Sciences LLC
    Inventors: Andrew Homyk, Jason Donald Thompson