Abstract: Tissue-integrating electronic apparatuses, systems comprising such apparatuses and methods of using these apparatuses and systems for the detection of one or more signals are provided.

Abstract: A regional oximetry system has a display and at least one processor causing a plurality of views to be displayed on the display, each configured to occupy at least a portion of the display. The views are adapted to present data responsive to at least one physiological signal. A first sensor port is configured to receive at least a first physiological signal representative of a regional tissue oxygenation level, and a second sensor port is configured to receive at least a second physiological signal representative of an arterial oxygen saturation level. One view presents a first trend graph of the first physiological signal and a second trend graph of the second physiological signal. An area between the first trend graph and the second trend graph can include a differential analysis of regional-to-central oxygen saturation.

Abstract: The invention provides an intelligent dental ornament and a method of using the same, the intelligent dental ornament comprising: a dental ornament body with a cavity, a tester located within the cavity and for detecting a physiological parameter, a battery used by the tester, and a trigger switch for triggering the tester to start test; the dental ornament body is further provided with a through-hole for at least one pipette of the tester stretching out of the dental ornament body, and a sealing cover for sealing the through-hole. When the trigger switch activates the tester, the sealing cover is opened, and the pipette of the tester stretches out of the dental ornament body through the through-hole to obtain the saliva of the subject, and the physiology parameter in the saliva is detected, and the detection result is sent to an external device in communication with the tester.

Abstract: A first embodiment of the implantable real-time oximeter of the present invention is attached around a blood vessel near the site of a likely stroke to monitor large and medium size cerebral arteries. Another embodiment of the implantable real-time oximeter can be passed within cerebral blood vessels to monitor the oxygenation status of the surrounding cerebral tissues. When used within cerebral blood vessels, the emitter and detector are coplanar and contained in a small area, for example, 50-120 ?m.

Abstract: A variety of wearable magnetic assemblies are provided that are configured to produce magnetic fields having high field magnitudes and/or high field gradients. Such magnetic assemblies include a plurality of magnetic segments arranged in a linear array. Individual magnetic segments of the magnetic array can each include multiple magnetic elements. An individual magnetic segment can include elements that have similar shape, size, composition, and relative location to elements of neighboring magnetic segments while having magnetic moments that are antiparallel to the magnetic moments of corresponding elements of the neighboring magnetic segments. These wearable magnetic assemblies are configured to exert forces on magnetic particles disposed in a portion of subsurface vasculature to attract, slow, speed, separate, or otherwise influence the magnetic particles in various applications. The magnetic particles can be configured to bind to an analyte of interest.

Abstract: The invention provides an endoscope system for the early detection of suture failure. Parts of the large intestine separated by the resection of a tumor are sutured by using a suturing member 167. A sutured portion is imaged. An oxygen saturation image 180 is generated by imaging the oxygen saturation of the sutured portion based on image information obtained by the imaging. The generated oxygen saturation image 180 is displayed on a display device 14. In the case of suture failure, a low oxygen region 180a is displayed in the oxygen saturation image.

Abstract: A method of making a sensor includes depositing a layer of hydrogel over a substrate, the hydrogel configured to change thickness or volume in response to a selected condition and including a plurality of magnetic particles disposed in the hydrogel so that a magnetic property of the hydrogel changes with changes of thickness or volume of the hydrogel. The hydrogel is sacrificed in selected region(s) of the layer so that the hydrogel outside the selected region(s) forms a plurality of spaced-apart islands of the hydrogel. The islands of the hydrogel are enclosed in an enclosure at least partly permeable to a selected fluid. A sensor for detecting a condition includes the substrate, islands, and a device coil arranged with respect to the hydrogel so that changes in the magnetic property modulate an electrical property of the sensor. A system includes the substrate, islands, and a magnetic-field detector.

Abstract: A method of protecting an in-vivo sensor includes forming a sensing surface on a surface of the in-vivo sensor, the sensing surface including a functionalized monolayer that will bind to an analyte of interest; and coating the sensing surface of the sensor with a bioabsorbable polymeric coating including a bioabsorbable polymer; wherein the bioabsorbable polymeric coating is configured to protect the in-vivo sensor until needed for implantation.

Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.

Abstract: Methods and systems are presented for displaying physiological information with a physiological monitor. A physiological parameter, for example oxygen saturation, is computed from a received physiological signal, for example a PPG signal. At least one metric associated with the received physiological signal is determined, for example a statistical measure of uncertainty associated with the determined physiological parameter. Display parameters are determined, for example a width parameter, based on the metrics and a trace of the computed physiological parameter for a subject is displayed. In some embodiments, the width of the displayed trace may be varied based on the width parameter. In some embodiments, additional or alternative characteristics of the displayed trace may be varied based on respective display parameters.

Abstract: A wearable device includes a main body, and a strap connected to the main body, the strap being configured to be flexible. The wearable device further includes a light source disposed in the strap, the light source being configured to emit light onto a surface of a user. The wearable device further includes a spectrum portion disposed in the main body, and an optical waveguide disposed in the strap, the optical waveguide being configured to receive the emitted light traveling into and out from the surface, and transmit the received light to the spectrum portion. The wearable device further includes a detector disposed in the main body, the detector being configured to detect the transmitted light dispersing through the spectrum portion.

Abstract: A system for determining a vital sign of a subject releases the likelihood of generating and outputting false alarms. The system includes a vital sign processor that processes the vital sign information signal measured by a sensor attached to a subject to obtain a vital sign of said subject. An image analysis unit detects motion of a marker attached to the sensor from image data obtained by an imaging unit from at least an imaging region containing the sensor. An alarm unit generates and outputs an alarm signal based (1) on the measured vital sign information signal and/or the obtained vital sign and (2) the detected motion of said marker.

Abstract: A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.

Abstract: A biosensor includes a PPG circuit that emits light directed at skin tissue at a plurality of wavelengths. A first and second spectral response of light reflected from the tissue is obtained around a first wavelength and a second wavelength. Using absorption coefficients for substances at the plurality of wavelengths, concentration levels of a plurality of substances may then be determined from the spectral responses. The biosensor may thus be used to determine concentrations of a plurality of substances in arterial blood flow using the spectral response.

Abstract: A health care band operably attaches a biosensor to a patient. The biosensor includes one or more sensors for collecting vitals of a patient and a wireless transmitter that is configured to communicate with an EMR network that stores and maintains an EMR of the patient. The biosensor stores a unique identification associated with the patient's EMR such that vitals measured by the biosensor may be transmitted with the patient's unique identification for storage in the patient's EMR. The sensors in the biosensor may include a temperature sensor and motion detector/accelerometer. In an embodiment, one of the sensors includes a photoplethysmography (PPG) based sensor configured to continuously or periodically measure a patient's vitals, such as heart rate, pulse, blood oxygen levels, NO concentration levels, or other blood analytics.

Abstract: A device and system for measuring and/or monitoring an analyte present on the skin is provided. The system includes a skin-mountable device that may be attached to an external skin surface and a reader device. The skin-mountable device includes a substrate, a plurality of micro-needles, and nanosensors. The micro-needles are attached to the substrate such that attachment of the substrate to an external skin surface causes to the micro-needles to penetrate into the epidermis, intradermis, or dermis. The nanosensors include a detectable label and are configured to interact with a target analyte present in the interstitial fluid in the epidermis, intradermis, or dermis. The reader device is configured to detect the analyte in interstitial fluid via interaction with the skin-mountable device.

Abstract: A medical system (10) and method measures hemoglobin level of a subject (38). A hemoglobin color scale (HbCS) (22) is projected into afield of view (FOV) (42) of an imaging system (12). The HbCS (22) includes a plurality of blood color regions (26a-f), each blood color region (26a-f) corresponding to a hemoglobin level and colored to represent the color of blood at the corresponding hemoglobin level. An image of blood of the subject (38), and the projected HbCS, is acquired using the imaging system (12).

Abstract: A biosensor includes an optical sensor circuit that emits light directed at skin tissue of a patient at a plurality of wavelengths. A first and second spectral response of light reflected from the tissue is obtained around a first wavelength in a UV range and a second wavelength in an IR range. A measurement of nitric oxide (NO) is then determined from the spectral responses. A risk of septic condition is obtained using the measurement of NO.

Abstract: Light reflected from a pregnant woman's abdomen and fetus contained therein that has been received by a detector and converted into a reflected electronic signal may be received by a processor. A portion of the reflected electronic signal that is reflected from the fetus may be isolated and the isolated portion of the reflected electronic signal may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. The isolation may be achieved by synchronizing the reflected electronic signal with a fetal heartbeat signal and multiplying the synchronized reflected electronic signal by the synchronized fetal heartbeat signal.

Abstract: A multispectral medical imaging device includes illumination devices arranged to illuminate target tissue. The illumination devices emit light of different near-infrared wavelength bands. The device further includes an objective lens, a near-infrared image sensor positioned to capture image frames reflected from the target tissue, and a visible-light image sensor positioned to capture image frames reflected from the target tissue. A processor is configured to modulate near-infrared light output of the plurality of illumination devices to illuminate the target tissue. The processor is further configured to determine reflectance intensities from the image frames captured by the near-infrared image sensor and to generate a dynamic tissue oxygen saturation map of the target tissue using the reflectance intensities. The device further includes an output device connected to the processor for displaying the dynamic tissue oxygen saturation map.