Abstract: A pramipexole transdermal patch for treatment of neurological disorders including Parkinson's disease that may be administered on a daily basis. The pramipexole transdermal patch of the present invention preferably comprises a drug-containing layer that comprises pramipexole or a pharmaceutically acceptable salt thereof at 2% to about 15% by weight of the drug-containing layer and at least two acrylic polymers wherein each polymer may further comprise carboxyl and/or hydroxyl functional groups. The pramipexole transdermal patch of the present invention may further comprise two or more permeation enhancers with combined pramipexole solubility of great than 50 mg/mL.
Abstract: Improved, micronutrient-supplemented polymeric seed coatings are provided which include at least one polyanionic polymer in combination with respective amounts of Zn, Mn, and Cu micronutrients. Preferably, the coatings comprise polyanionic polymers having a backbone comprising dicarboxylic repeat units with Zn, Mn, and Cu bound to the backbone. The most preferred polymers contain maleic and itaconic repeat units, optionally with sulfonate repeat units. The invention also provides a method of treating seeds using the coatings, and coated seed products.
Abstract: The present invention relates to pharmaceutical compositions comprising collagen and hyaluronic acid, and optionally containing silver. Said compositions may be in the form of a hydrogel, pad or dry spray. The invention also relates to the preparation process of said compositions in pad form. Finally, the invention relates to the use of the compositions for the treatment of skin lesions.
Type:
Grant
Filed:
May 29, 2014
Date of Patent:
February 8, 2022
Assignee:
FIDIA FARMACEUTICI S.p.A.
Inventors:
Giovanni Gennari, Susi Panfilo, Juan Francisco Scalesciani
Abstract: The present invention relates to the use of monosubstiuted urea derivatives of the formula I as self-tanning substance, for increasing melanin synthesis, for improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these urea derivatives.
Type:
Grant
Filed:
October 2, 2017
Date of Patent:
February 1, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Julian Osthoff, Hansjuergen Driller, Christophe Carola, Robin Back, Michael Krohn
Abstract: A vascular access device includes an antimicrobial coating that provides kink resistance to a catheter. The antimicrobial coating can extend along a length of the catheter to provide antimicrobial protection when the catheter is inserted into the patient's vasculature. The antimicrobial coating can also increase the effective diameter of the catheter to minimize the likelihood that the catheter will become kinked.
Type:
Grant
Filed:
February 6, 2019
Date of Patent:
January 11, 2022
Assignee:
Becton, Dickinson and Company
Inventors:
Jonathan Karl Burkholz, Siddarth K. Shevgoor, Tony Farnsworth Adams
Abstract: The present invention belongs to the technical field of pesticides, particularly relates to sulfonyl-structure-containing triazinone derivatives, their preparation methods, and their uses in insect killing and/or bacterium killing. The sulfonyl-structure-containing triazinone derivatives are compounds represented by formula (Ia) or (Ib). The sulfonyl-structure-containing triazinone derivatives provided in the present invention exhibit outstanding insecticidal activity as well as bactericidal activity.
Type:
Grant
Filed:
September 21, 2017
Date of Patent:
December 21, 2021
Assignee:
NANKAI UNIVERSITY
Inventors:
Qingmin Wang, Hongjian Song, Yan Yang, Yuxiu Liu, Ziwen Wang
Abstract: The invention relates to a method for the production of carrier pellets for pharmaceutical active substances. Likewise, the invention relates to such carrier pellets and also to pharmaceutical formulations containing these. The carrier pellets according to the invention are used for transporting and releasing pharmaceutical active substances, in particular in the human body.
Abstract: A compound represented by Formula (I), or a salt or N-oxide compound thereof is provided. In Formula (I), A1 to A4 each independently represents a carbon atom or nitrogen atom, X1 represents a C1-6 alkyl group or the like, n represents the number of X1 groups, R1 represents a C1-6 alkylthio group or the like, and D is a group represented by Formula (D-1) or (D-2), and in Formula (D-1) and (D-2), * represents a binding position, Q represents a C1-6 alkyl group or the like, B1 and B2 each independently represents a nitrogen atom or the like, R2 represents a C1-6 alkyl group or the like that is bound to one of the nitrogen atoms in Formula (D-1), B3 and B4 each independently represents a nitrogen atom or carbon atom, R4 represents a C1-6 alkyl group or the like, and m represents the number of R4 groups.
Abstract: A micro structure and antifouling active substance synergistic antifouling material and a preparation method thereof are provided. The micro structure and antifouling active substance synergistic antifouling material includes a matrix arrangement formed by a plurality of micro structure basic units in a cylindrical structure, an inner lower layer of each micro structure basic unit is filled with an antifouling active substance, and an inner upper layer of the each micro structure basic unit is filled with a sealing agent. A process for preparing a micro structure and antifouling active substance synergistic antifouling material includes three steps of preparing a micro structure, preparing a liquid antifouling active substance and preparing a synergistic antifouling material.
Type:
Grant
Filed:
March 15, 2018
Date of Patent:
October 26, 2021
Assignee:
LUOYANG SHIP MATERIAL RESEARCH INSTITUTE
Inventors:
Jiyong Zheng, Cunguo Lin, Li Wang, Zhiyong Sun
Abstract: An isoxazolin-5-one derivative represented by the following (1): wherein R1 represents a C1-C6 haloalkyl group, and R2 to R4 and X each represents a certain substituent or the like; and n represents an integer of 1 to 4, wherein X's may be different from each other when n represents an integer of 2 to 4, and an herbicide containing the isoxazolin-5-one derivative as an active ingredient are provided.
Abstract: The present invention relates to an edible composition having a lipid continuous phase and self-assembled structures, the composition comprising oil, phospholipids, caffeine and water. Further aspects of the invention are the use of a composition to provide controlled release of caffeine, a composition for use in the treatment or prevention of drowsiness, the non-therapeutic use of a composition to increase mental alertness, and an edible capsule.
Abstract: A composition for weed control and fertilizer comprising iron hydroxyl ethylenediaminetriacetic acid, fertilizer mineral supplement, feed grade urea, a natural-based wetting agent, molasses desugarized solubles, and water, and may further comprise glycerin and/or preservatives, are provided. Methods for weed control and fertilization of plants comprising the steps of providing a composition comprising an effective amount of iron hydroxyl ethylenediaminetriacetic acid, fertilizer mineral supplement, feed grade urea, natural-based wetting agent, and molasses desugarized solubles, and applying an effective amount of the composition to soil or a plant or a weed, are also provided.
Abstract: Disclosed are a high stress resistant plant growth regulator and a preparation and use thereof. In particular, the compound provided by the present invention is an ABA substitute for significantly improving the stress resistance of plants, and therefore has a very wide application prospect.
Type:
Grant
Filed:
November 18, 2016
Date of Patent:
August 3, 2021
Assignee:
CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES
Abstract: The present disclosure relates to a composition for the destruction of microalgae or mosses. The composition for the destruction of microalgae or mosses may suppress the growth and proliferation of microalgae when treated in moss cultivation facilities, marine microalgae cultivation facilities, areas in which green or red tide is occurring, or areas in which green or red tide is expected to occur, thereby preventing damage caused by the green or red tide.
Type:
Grant
Filed:
August 18, 2016
Date of Patent:
June 29, 2021
Assignee:
CUREARTH, INC.
Inventors:
Hoon Cho, Sun Jong Yu, Seung Ho Baek, Hyung Joon Cha
Abstract: The present invention relates to a novel dendrimer. The present invention also relates to formulations comprising the dendrimer with improved characteristics. For instance, the present invention relates to formulations comprising pesticides such as 2-(2,4-dichlorophenoxy)acetic acid with improved characteristics such as reduced crystallisation, compatibility with hard water and an extended shelf life at low temperatures.
Type:
Grant
Filed:
December 16, 2016
Date of Patent:
April 20, 2021
Assignees:
Priostar Pty Ltd, Dendritic Nanotechnologies, Inc.
Inventors:
Harsh Vardhan, Sarigama Rajesh, Peter Karellas
Abstract: Compositions and methods for enhancing plant growth and crop yield in legumes and non-legumes are described. The compositions include lipo-chitooligosaccharides in combination with chitins/chitosans or in combination with compounds or in combination with a herbicide. The method includes applying the compositions to seeds and/or plants either concomitantly or sequentially.
Type:
Grant
Filed:
January 25, 2016
Date of Patent:
April 13, 2021
Assignee:
NOVOZYMES BIOAG A/S
Inventors:
Raymond Stewart Smith, Robert Martin Osburn
Abstract: Disclosed are vanadyl complexes of Formula 1, Formula 2, and Formula 3, wherein R1, R2, and R are defined as in the description. The pharmaceutical compositions containing these complexes and uses of the complexes for treatment of Diabetes Mellitus, such as Diabetes Mellitus Type 2, are also disclosed.
Abstract: The present invention provides pyrazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Type:
Grant
Filed:
January 3, 2019
Date of Patent:
March 9, 2021
Assignee:
Gilead Apollo, LLC
Inventors:
Shomir Ghosh, Jeremy Robert Greenwood, Geraldine C. Harriman, Silvana Marcel Leit de Moradei
Abstract: Provided herein are compounds that exhibit activity as fungicides and are useful, for example, in methods for the control of fungal pathogens in plants and can be applied to said plants in a variety of ways.
Type:
Grant
Filed:
July 9, 2018
Date of Patent:
March 9, 2021
Assignee:
Gilead Apollo, LLC
Inventors:
Jennifer Lynn Bennett, Karen C. Fitzsimmons, Shomir Ghosh, Jeremy Robert Greenwood, William P. Haakenson, Jr., Geraldine C. Harriman, Silvana Marcel Leit De Moradei, Barry J. Shortt, Urszula J. Slomczynska, Jeffrey Michael Stein