Patents Examined by Ernst Arnold
  • Chemoablation of tissue using biodegradable, solid salt dosage forms
    Patent number: 8389023
    Abstract: Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: March 5, 2013
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Joseph V. DiTrolio
  • Reinforced absorbable synthetic matrix for hemostatic applications
    Patent number: 8383147
    Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: February 26, 2013
    Assignee: Ethicon, Inc.
    Inventors: Dhanuraj S. Shetty, Olajompo Moloye-Olabisi, Robert W. Van Holten, Degang Zhong
  • Naturally derived glyceryl dimer polyesters having liquid and solid domains
    Patent number: 8377457
    Abstract: The present invention is directed to a series of polymeric glyceryl esters that have two different molecular weight ester chains, one solid and one liquid, which when combined into a single molecule make a polymer that is solid, and crosslinked by dimer acid. These products have very unique skin feel and water proofing properties. These materials find applications as additives to formulations in personal care products where there is a desire to have a structured film (provided by the solid fatty group) and flow properties, (provided by the liquid fatty group). These compounds by virtue of their unique structure provide outstanding skin feel.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: February 19, 2013
    Assignee: SurfaTech Corporation
    Inventors: Kevin A. O'Lenick, Andrew J. O'Lenick, Anthony J. O'Lenick, Jr.
  • Method for producing aqueous suspensions of mineral fillers, the thus obtained aqueous suspensions of mineral fillers and the use thereof
    Patent number: 8372293
    Abstract: The invention concerns a process for the preparation of aqueous suspensions of fluid mineral matter, which are able to be pumped and conveyed by the end user immediately after the filtration stage, possibly followed by a compression, which process comprises filtration in two separate stages. The invention also concerns aqueous suspensions of mineral matter obtained and their uses.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: February 12, 2013
    Assignee: Omya Development AG
    Inventors: Maurice Husson, Christian Jacquemet, Eugène Vorobiev
  • Method for reducing the severity of neurological disorders
    Patent number: 8362078
    Abstract: The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin B12 and precursors thereof, vitamin B6 and derivatives thereof, folic acid, zinc and magnesium, in the manufacture of a preparation for improving the action of receptors. This preparation is advantageously applied in patients suffering from Parkinson's disease, Huntington's chorea, epilepsy, schizophrenia, paranoia, depression, sleep disorders, impaired memory function, psychoses, dementia and ADHD.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: January 29, 2013
    Assignee: N.V. Nutricia
    Inventors: Amanda Johanne Kiliaan, Robert Johan Joseph Hageman
  • Nutrient compositions and methods for enhanced effectiveness of the immune system
    Patent number: 8361512
    Abstract: Provided are methods and compositions for increasing CD4+ cell count in mammals, preferably by at least 25%, while undergoing treatment for various conditions whose treatment can have detrimental effects on immune system function. Such conditions include, but are not limited to, HIV infection, cancer, and hepatitis. The compositions include alpha lipoic acid; acetyl L-carnitine; N-acetyl-cysteine; zinc; selenium; vitamin C; bioflavinoid complex; vitamin E; optionally one or more antioxidants selected from co-enzyme Q10 and glutathione; and one or more vitamins or minerals selected from beta-carotene, vitamin A, vitamin B1, vitamin B2, vitamin B6, niacinamide, calcium pantothenate, folic acid, vitamin B12, copper, manganese, chromium, and molybdenum.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: January 29, 2013
    Assignee: K-PAX Vitamins, Inc.
    Inventor: Jon D. Kaiser
  • Use of benzotriazole derivatives for photostabilisation
    Patent number: 8361446
    Abstract: Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: January 29, 2013
    Assignee: BASF SE
    Inventors: Stefan Müller, Jochen Giesinger, Thomas Ehlis, Bernd Herzog, Peter König, Gilbert Kreyer, Katja Quass
  • Foamable vehicle and pharmaceutical compositions thereof
    Patent number: 8362091
    Abstract: A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: January 29, 2013
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
  • Stable R(+)-lansoprazole amine salt and a process for preparing the same
    Patent number: 8362042
    Abstract: A stable R-(+)-lansoprazole alkylamine salt and a process for preparing the salt.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: January 29, 2013
    Assignee: Watson Pharma Private Limited
    Inventors: Manjunath Narayan Bhanu, Samir Naik, Arjun Bodkhe
  • Benzonatate compositions and methods of use
    Patent number: 8357398
    Abstract: Oral dosage forms of benzonatate useful for anti-tussive and anti-tussive/combination applications.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: January 22, 2013
    Assignee: Alitair Pharmaceuticals Inc.
    Inventors: William Wayne Howard, Russell Francis Somma, Doreen Marie Frank
  • Stable formulations for lyophilizing therapeutic particles
    Patent number: 8357401
    Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: January 22, 2013
    Assignee: BIND Biosciences, Inc.
    Inventors: Greg Troiano, Young-Ho Song, Stephen E. Zale, James Wright, Christina Van Geen Hoven
  • Crystalline solids of a MetAP-2 inhibitor and methods of making and using same
    Patent number: 8349891
    Abstract: The disclosure is in part directed to crystalline forms of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol and variants thereof.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: January 8, 2013
    Assignee: Zafgen, Inc.
    Inventors: Thomas Crawford, Hayley A. Reece
  • Antimicrobial composition, process for preparing the same, and utilization thereof
    Patent number: 8349346
    Abstract: A highly antimicrobial composition having characteristics of a lactic acid polymer such as biodegradability is prepared by combining a lactic acid oligomer with a metal salt thereof.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: January 8, 2013
    Assignee: Koken Ltd.
    Inventors: Hiroshi Imai, Kazushi Kimura
  • Wound healing dressing and methods of manufacturing the same
    Patent number: 8343535
    Abstract: Disclosed are a hydrogel dressing for covering or treating a wound and a method for preparing the same. The hydrogel dressing includes a matrix structure of a cross-linked mixture, and an elastic sheet coated with an elementary metal or ionic metal embodied in the matrix structure. The mixture comprises a hydrophilic polymer, about 0.5 to about 5 wt % of a photocatalyst agent and at least 80 wt % of water based on the total weight of the mixture.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: January 1, 2013
    Assignee: The Chinese University of Hong Kong
    Inventors: Andrew Burd, Michael Wing Wai Tsang
  • Analgesic cream
    Patent number: 8337869
    Abstract: A herbal topical composition is used having complexed trace minerals capable of effectively reducing bone and joint inflammation by inhibiting inflammation pathways and in particular COX-2. The herbal composition having trace elements in a topical carrier reduces inflammation while avoiding the side effects associated with traditional drug therapy.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: December 25, 2012
    Inventors: Robert L. Gross, Nancy L. Leventoff
  • Nasal composition
    Patent number: 8337906
    Abstract: A nasal spray solution for use as a nasal spray and methods of using the solution are disclosed. The nasal spray solution moisturizes nasal passages and alleviates nasal dryness. The solution includes a hypotonic saline solution, wherein the saline solution is hypotonic with respect to cells of the nasal mucosa of the nasal passages, a buffering agent, a lubricating agent, and an anti-microbial agent.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: December 25, 2012
    Inventors: James Zinreich, Eva Zinreich, Helen Zinreich Shafer
  • Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof
    Patent number: 8333997
    Abstract: The invention provides compositions for releasing nitric oxide (NO) comprising a matrix that encapsulates nitric oxide. Nitric oxide is released when the composition is exposed to an aqueous environment. The invention further provides methods of preparing the compositions and uses of the compositions for treating infections and disorders.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: December 18, 2012
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Joel M. Friedman, Adam Friedman, Mahantesh S. Navati
  • Prostaglandin fat emulsion, method for producing the same, method for stabilizing the same, and emulsifying agent
    Patent number: 8334321
    Abstract: A fat emulsion comprises a prostaglandin as an active ingredient, the fat emulsion comprising a phospholipid that comprises phosphatidylcholine (PC) and phosphatidylglycerol (PG) and has a ratio of PC to PG (PC:PG) of 85:15 to 99.7:0.3.
    Type: Grant
    Filed: September 3, 2007
    Date of Patent: December 18, 2012
    Assignee: Q.P. Corporation
    Inventors: Satomi Kamiya, Tomonori Uchida, Hideto Yoshida, Yasutaka Inoue, Noboru Yamada, Kenichi Kajihara
  • Detection of transmembrane potentials using N,N,N?-trialkyl thiobarbituric acid-derived polymethine oxonols
    Patent number: 8329390
    Abstract: The present invention relates generally to the detection and measurement of transmembrane potentials using an N,N,N?-trialkyl thiobarbituric acid-derived polymethine oxonol (shown below). In particular, the present invention is directed to compositions and optical methods for determining transmembrane potentials across the plasma membrane of biological cells using a slightly hydrophobic N,N,N?-trialkyl thiobarbituric acid-derived polymethine oxonols. The method comprises a slightly hydrophobic N,N,N?-trialkyl thiobarbituric acid-derived polymethine oxonol anion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane. In one aspect the method is used to identify compounds which modulate membrane potentials in biological membranes.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: December 11, 2012
    Assignee: AnaSpec Incorporated
    Inventors: Zhenjun Diwu, Jianjun He, Yi Tang
  • Reinforced absorbable multi-layered fabric for hemostatic applications
    Patent number: 8329211
    Abstract: The present invention is directed to a synthetic fabric comprising a multi-layered nonwoven fabric made from staples of a polyglycolide/polylactide copolymer, each layer having a different density. The multi-layer fabric can be used as a reinforced absorbable hemostat medical device.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: December 11, 2012
    Assignee: Ethicon, Inc.
    Inventors: Olajompo Moloye-Olabisi, Dhanuraj S. Shetty, Robert W. Van Holten, Degang Zhong