Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.

Abstract: The present invention, herein is a method and apparatus that significantly limits the effect of high frequency (“HF”) interferences on acquired electro-physiological signals, such as the EEG and EMG. Preferably, this method comprises of two separate electronic circuitries and steps or electronics for processing the signals. One circuit is used to block the transmission of HF interferences to the instrumentation amplifiers. It is comprised of a front-end active filter, a low frequency electromagnetic interference (“EMI”) shield, and an isolation barrier interface which isolates the patient from earth ground. The second circuit is used to measure the difference in potential between the two isolated sides of the isolation barrier. This so-called “cross-barrier” voltage is directly representative of the interference level that the instrumentation amplifier is subjected to. This circuit is used to confirm that the acquired signals are not corrupted by the interference.

Abstract: A system for detecting dehydration, hemorrhaging, and increases in blood volume comprising monitors the time difference between the arrival of the primary left ventricular ejection pulse (pulse T1) and the arrival of the iliac reflection (pulse T3) to determine an arterial pulse parameter which is the time difference between T1 T3. Changes in T3 minus T1 are indicative of something happening to blood volume. If the T1-3 value goes up and the patient is on an infusion system, it can be an indication of having too much fluid pumped and if T1-3 is lower than it should be for an individual, they are either dehydrated (which can result in decreases in blood volume), they are hemorrhaging, or they have hemorrhaged. A downtrend in T13 can tell whether someone is continuing to hemorrhage.

Abstract: A patient monitor has multiple sensors adapted to attach to tissue sites of a living subject. The sensors generate sensor signals that are responsive to at least two wavelengths of optical radiation after attenuation by pulsatile blood within the tissue sites.

Abstract: Provided is a device for detecting stress of a user based on a bio-signal of the user, and when the stress is detected, outputting information of a peripheral device.

Abstract: A SoC includes an AFE to receive a plurality of differential input channels and generate digitized data corresponding to the channels, and a classification processor configured to receive the digitized data from the AFE. The AFE includes a Dual-Channel Chopper to perform channel multiplexing of two channels while simultaneously chopping the channels, a Dual Channel Charge Recycled-AFE having an Chopper-Stabilized Capacitive-Coupled IA including bias sampling capacitors that store bias values associated with the first and second channels to enable swapping between the channel, and a DC servo loop (DSL) having a reduced setting time based on a reduction in a resistance of the pseudo-PMOS in response to engaging a system reset. The classification processor includes a Frequency-Time Division Multiplexing (FTDM) Feature Extraction (FE) engine and a Dual-Detector Architecture (D2A) classification processor.

Abstract: Methods, systems and arrangements are provided for obtaining electroencephalograph (“EEG”) EEG signals from a patient e.g., during a concurrent EEG/MRI examination of the patient. The methods, systems and arrangements include a cap made of conductive inks with sensor positions for attaching a plurality of sensors to the patient's head. The sensors can include electrodes as well as motion sensors for improving EEG signal quality and MRI image quality in the presence of motion noise and other artifacts within the MRI environment. The electrodes may be composed of conductive inks, and can be used in high magnetic fields due to a weak interaction with the RF fields generated by the MRI scanner. The exemplary methods, systems and arrangements can achieve lower SAR and lower temperature increase, as compared to conventional electrodes.

Abstract: The method of classifying raw EEG signals uses a classification method based on nuclear features extracted as dominant singular values from an EEG signal segment using singular value decomposition (SVD) and a class means-based minimum distance classifier (CMMDC) to classify a patient's EEG signals. From a mean EEG signal, a set of zero-centered EEG signals are calculated, and from the zero-centered EEG signals and a standard deviation of the EEG signals, a unit variance is calculated for each component. Using the standardized component signals a nuclear matrix is calculated, to which singular value decomposition is applied to generate a set of singular values. The CMMDC is applied to class means associated with first and second classes and a nuclear feature vector to classify the patient's EEG signals as belonging in either the first or second class.

Abstract: A method and system for detecting bioelectrical signals and audio signals from a user, including establishing bioelectrical contact between a user and one or more sensors of a biomonitoring neuroheadset; collecting, at the one or more sensors, one or more bioelectrical signal datasets; collecting one or more reference signal datasets; collecting, at a microphone of the biomonitoring neuroheadset, an audio signal dataset; and generating a combined audio and bioelectrical signal processed dataset, including producing a noise-reduced bioelectrical signal dataset, and producing a conditioned audio signal dataset.

Abstract: The present invention describes an apparatus and method for determining the energy expenditure of a subject by indirect calorimetry where respiratory gases O2 and CO2 are captured in a tent mask coupled through a pneumotach flow meter to a vacuum inlet of a blower fan whose speed is controlled by a computer running a program that ensures that the bias flow being drawn through the mask always exceeds the subject's peak expiratory flow. VO2 and VCO2 and flow values are measured on a breath-by-breath basis and used in arriving at a bias flow adjustment voltage to be applied to the blower fan for adjusting its speed.

Abstract: An external data retrieval apparatus receives a low resolution version of a physiological signal from an active implantable medical device and determines if the physiological signal represents a clinically significant event. The apparatus provides an indication of such determination to the implantable medical device. If the physiological signal does represent a clinically significant event, the apparatus receives a full download of the physiological signal from the implantable device.

Abstract: Systems, devices, and methods are provided for the assembly and subsequent delivery of an in vivo analyte sensor. An applicator with sensor electronics is inserted into a tray containing an assembly that includes a sharp and an analyte sensor. The insertion causes the assembly to couple with the sensor electronics and form a deliverable sensor control device retained within the applicator, which can then be placed in position on a body of a user to monitor that user's analyte levels.

Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.

Abstract: Disclosed is an apparatus and method for measuring glucose concentration by using Optical Coherence Tomography (OCT), and more particularly, an apparatus and method for increasing the blood volume around a measurement part by using a blood concentrating device and noninvasively measuring glucose concentration of the measuring portion by using OCT. A glucose concentration measuring apparatus and method using OCT according to the invention can noninvasively measure glucose concentration by using OCT and help a user to easily measure glucose concentration.

Abstract: Forehead oximetry sensor devices and methods for determining physiological parameters using forehead oximetry sensors. One method includes placing an oximetry sensor on the forehead of a patient, such that the sensor is placed on the lower forehead region, above the eyebrow with the sensor optics placed lateral of the iris and proximal the temple; and operating the pulse oximeter to obtain the physiological parameter. In one aspect, the method also includes providing and placing a headband over the oximetry sensor, or alternately, the sensor is a headband-integrated sensor. The headband has an elastic segment sized to fit around the patient's head. The headband also includes a non-elastic segment that is smaller than and attached with the elastic segment. The non-elastic segment is sized to span a portion of the elastic segment when the elastic segment is stretched. In addition, the non-elastic segment is larger than the portion of the elastic segment it spans when the elastic segment is not stretched.

Abstract: The present invention relates to a method for estimating blood glucose levels using a noninvasive optical coherence tomography- (OCT-) based blood glucose monitor. An algorithm correlates OCT-based estimated blood glucose data with actual blood glucose data determined by invasive methods. OCT-based data is fit to the obtained blood glucose measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood glucose levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based blood glucose monitor is calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.

Abstract: A method for use and an improved oximeter sensor substrate that is conforming to the shape of the patient's forehead. In one embodiment, the present invention is an oximeter sensor, having a substrate with a shape similar to a shape of at least a portion of a patient's forehead and including a section adapted to substantially fit over a portion of a forehead of a patient; an emitter disposed on the substrate at a position located on the section; and a detector disposed on the substrate at a distance from the emitter. In one embodiment, the substrate includes a hat that holds the emitter and the detector in a spaced-part manner against the patient's forehead.

Abstract: Embodiments of the present invention include systems and methods that relate to a sensor with memory. Specifically, one embodiment includes a sensor comprising a light emitting element configured to emit light, a light detecting element configured to detect the light, and a memory storing at least one patient-specific parameter, the memory providing access to an oximeter monitor to read the at least one patient-specific parameter.

Abstract: A method for use and an improved oximeter sensor substrate that is conforming to the shape of the patient's forehead. In one embodiment, the present invention is an oximeter sensor, having a substrate with a shape similar to a shape of at least a portion of a patient's forehead and including a section adapted to substantially fit over a portion of a forehead of a patient; an emitter disposed on the substrate at a position located on the section; and a detector disposed on the substrate at a distance from the emitter. In one embodiment, the substrate includes a hat that holds the emitter and the detector in a spaced-part manner against the patient's forehead.

Abstract: Embodiments of the invention are related to electro-optical implantable sensors, amongst other things. In an embodiment, the invention includes an implantable medical device including a housing defining an interior volume, the housing comprising a housing wall and defining an aperture. The implantable medical device can include an optical sensor assembly coupled to the housing wall. The optical sensor assembly can occlude the aperture in the housing wall. The optical sensor assembly can include an electro-optical module including an optical excitation assembly and an optical detection assembly. The optical sensor assembly can also include a chemical sensing element configured to detect a physiological analyte by exhibiting a change in optical properties. An optical window can be disposed between the electro-optical module and the chemical sensing element. The optical window can be configured to allow the transmission of light between the electro-optical module and the chemical sensing element.