Abstract: A method for determining a membership function, the membership functions allowing a stress level of a user to be determined on the basis of a physiological parameter measured on the user, the membership function varying, depending on the physiological parameter, between: a first value, representative of a rest state; and a second value, representative of a stressed state; the membership function taking into account a distribution function, which is defined beforehand, the distribution function being a continuous and monotonic function, the distribution function being applied to a normalized parameter established on the basis of a measured physiological parameter, the method comprising determining a normalization function, and optionally a standardization function, the normalization function and the optional standardization function being determined on the basis of physiological parameters measured on a plurality of test individuals, in various calibration periods.

Abstract: Methods and systems for obtaining and analyzing electromyography responses of electrodes of an implanted neurostimulation lead for use neurostimulation programming are provided herein. System setups for neural localization and/or programming include a clinician programmer coupleable with a temporary or permanent lead implantable in a patient and at least one pair of EMG sensing electrodes minimally invasively positioned on a skin surface or within the patient. The clinician programmer is configured to determine a plurality of recommended electrode configurations based on thresholds and EMG responses of the plurality of electrodes and rank the electrode configuration according to pre-determined criteria.

Abstract: A biostimulator, such as a leadless cardiac pacemaker, having a header assembly that includes an antenna, is described. The antenna can be integrated into an insulator that separates an electrode of the header assembly from a flange of the header assembly. The antenna includes an antenna loop embedded in a ceramic material of the insulator. The antenna loop is located distal to the flange to reduce the likelihood of signal interference and increase communication range of the antenna. The header assembly is mounted on a housing have an electronics compartment, and an antenna lead extends from the antenna loop to electronic circuitry contained within the electronics compartment. Other embodiments are also described and claimed.

Abstract: A wireless charger device is configured to charge an implantable medical device (IMD). A patient controller obtains one or more power parameters from the charger device during charging of the IMD. The patient controller estimates a temperature range of the IMD using the one or more power parameters from the charger device and compares to a heating threshold. The patient controller then determines whether one or more spacers are recommended in response to the comparison. The one or more spacers are removably attached to the wireless charger device and are configured to lay in a position between the wireless charger device and a patient's skin to increase a charging path.

Abstract: A blood pump comprises a pump casing having a blood flow inlet and a blood flow outlet, and an impeller arranged in said pump casing so as to be rotatable about an axis of rotation. The impeller has blades sized and shaped for conveying blood from the blood flow inlet to the blood flow outlet. The blood pump also has an outflow cannula having an upstream end portion, a downstream end portion and an intermediate portion extending between the upstream end portion and the downstream end portion. The upstream end portion of the outflow cannula is connected to the pump casing such that blood is conveyed from the blood flow outlet of the pump casing into and through the intermediate portion of the outflow cannula towards the downstream end portion of the outflow cannula, wherein the downstream end portion has a blood flow outlet through which blood can exit the outflow cannula.

Abstract: Disorders of the eye can be treated by photobiomodulation therapy according to a device designed to direct light into a patient's eye, no matter the configuration of the eye. The device, including a printed circuit board that includes an array of light delivery devices and a heat sink lens, can be placed proximal to the patient's eye. The light delivery devices can be powered to generate light. The light can be directed into the patient's eye regardless of a position of the patient's eye.

Abstract: Provided are systems and methods for correcting a corneal surface irregularity surface in a subject. The system generally comprises a infrared laser, for example, and infrared laser and a laser control unit, a corneal contacting unit, a gel solidifying unit and an electronic device tangibly storing algorithms to operate the units. In the methods, a polymerizable or thermo-reversible gel or polymerized resin is applied to the anterior corneal surface and solidified as a layer over the cornea. A first correcting cut is lasered into the stroma of an applanated cornea, the gel layer is then removed and a second correcting cut is lasered in the stroma of the applanated cornea. The lenticule formed intrastromaly by the first and second correcting cuts is removed such that the cornea has a corrected corneal curvature.

Abstract: Techniques are disclosed for defining a homeostatic window for controlling delivery of electrical stimulation therapy to a patient. In one example, a method includes generating and delivering electrical stimulation therapy to tissue of a patient via electrodes. Further, the method includes adjusting a level of a parameter of the electrical stimulation therapy such that a signal of the patient is not less than a lower bound and not greater than an upper bound. The lower bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce one or more symptoms of a disease while the patient was receiving medication for reduction of the one or more symptoms. Further, the upper bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce the one or more symptoms when the patient was not receiving the medication.

Abstract: A medical device, such as an extra-cardiovascular implantable cardioverter defibrillator (ICD), senses R-waves from a first cardiac electrical signal by a first sensing channel and stores a time segment of a second cardiac electrical signal acquired by a second sensing channel in response to each sensed R-wave. The ICD determines morphology match scores from the stored time segments of the second cardiac electrical signal and, based on the morphology match scores, withholds detection of a tachyarrhythmia episode. In some examples, the ICD detects T-wave oversensing based on the morphology match scores and withholds detection of a tachyarrhythmia episode in response to detecting the T-wave oversensing.

Abstract: An ophthalmic surgical laser system and method for forming a lenticule in a subject's eye using “fast-scan-slow-sweep” scanning scheme. A high frequency scanner forms a fast scan line, which is placed by the XY and Z scanners at a location tangential to a parallel of latitude of the surface of the lenticule. The XY and Z scanners then move the scan line in a slow sweep trajectory along a meridian of longitude of the surface of the lenticule in one sweep. Multiple sweeps are performed along different meridians to form the entire lenticule surface, and a prism is used to change the orientation of the scan line of the high frequency scanner between successive sweeps. In each sweep, the sweeping speed along the meridian is variable, being the slowest at the edge of the lenticule and the fastest near the apex.

Abstract: This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient while automatically rescheduling stimulation programs based on detected patient activity.

Abstract: A system includes a laser catheter and a rotating optical member to receive a laser beam along an optical path and rotate to a selected position to redirect the laser beam from the optical path onto one or more selected optical fibers of a laser catheter, wherein a distal end of the laser catheter irradiates an endovascular structure.

Abstract: In general, innovative aspects of the subject matter described in this specification can be embodied in an electrode headset and methods of using an electrode headset. An exemplary electrode headset includes a head covering, an electrode assembly, and a plurality of electrodes. The head covering has a plurality of holes and the electrode assembly includes a plurality of first connectors arranged to align with the plurality of holes of the head covering. Each electrode has a second connector configured to releasably mate with one of the first connectors of the electrode assembly through one of the plurality of holes of the head covering.

Abstract: An implantable lead includes a lead body, electrical conductors, and a lead anchor. The lead body includes an electrode segment configured to be positioned along a pericardial membrane of a heart and including a plurality of electrodes configured to at least one of sense electrical signals from the heart or deliver therapy to the heart. The electrical conductors extend through the lead body between distal and proximal ends of the lead body, and are configured to electrically couple the electrodes to a pulse generator. The lead anchor is configured to be secured to a chest wall. The electrical conductors extend through the lead anchor, and the electrode segment extends from the lead anchor to the pericardial membrane. The electrode segment includes a transition portion that is configured to extend a depth into a mediastinum and a contoured portion to extend alongside and curve about the pericardial membrane.

Abstract: Disorders of the eye can be treated by photobiomodulation therapy (PBMT) delivered by a PBMT device. The PBMT device can be configured for placement directly over a patient's eye socket to deliver light into the patient's eye regardless of a position of the patient's eye, while preventing blue light from entering the patient's eye (e.g., due to a filter within the PBMT device and/or an opacity of the housing of the PBMT device). The PBMT device can be powered by a controller.

Abstract: In accordance with one embodiment, a method for determining changes in health of a user is disclosed. The method includes sensing multi-dimensional motion of a body part of a user to generate a first multi-dimensional motion signal at a first time and date; in response to the first multi-dimensional motion signal, generating a first neuro-mechanical fingerprint; generating a first health measure in response to the first NFP and user calibration parameters; sensing multi-dimensional motion of the body part of the user to generate another multi-dimensional motion signal at another time and date; in response to the another multi-dimensional motion signal, generating another neuro-mechanical fingerprint; generating another health measure in response to the another NFP and the user calibration parameters; and comparing the first health measure with the another health measure to determine a difference representing the health degradation of the user.

Abstract: An implantable medical device having a package, including: a device body, and a package configured for packaging the device body. The package includes at least one organic film layer and at least one inorganic film layer that are stacked on one another. An innermost layer of the package is an organic film layer or an inorganic film layer, and an outermost layer of the package is an organic film layer or an inorganic film layer. Each organic film layer is a parylene film or polyimide resin film with biocompatibility, and each inorganic film layer is an inorganic film with biocompatibility. A method for packaging an implantable medical device is also provided.

Abstract: A method for remote programming a therapy device for neurostimulation comprises: generating a stimulation program for the therapy device by means of a clinician programmer; transferring the stimulation program to a patient programmer; loading the stimulation program on the therapy device from the patient programmer; and increasing a stimulation amplitude of the stimulation program by means of the patient programmer. An initial stimulation amplitude setting of the stimulation program is limited to a minimal dose amplitude.

Abstract: Devices and methods for monitoring the temperature of tissue at various locations in a treatment volume during fluid enhanced ablation therapy are provided. In one embodiment, an ablation device is provided having an elongate body, at least one ablation element, and at least one temperature sensor. The elongate body includes a proximal and distal end, an inner lumen, and at least one outlet port to allow fluid to be delivered to tissue surrounding the elongate body. The at least one ablation element is configured to heat tissue surrounding the at least one ablation element. The at least one temperature sensor can be positioned a distance away from the at least one ablation element and can be effective to output a measured temperature of tissue spaced a distance apart from the at least one ablation element such that the measured temperature indicates whether tissue is being heating to a therapeutic level.

Abstract: The present disclosure provides a stimulation lead for providing stimulation signals to nerve tissue and improved methods for constructing and manufacturing such a stimulation lead. The stimulation lead and/or methods includes a lead with a cable disposed within. At each end of the lead body a portion of the cable is exposed, and a metal ferrule is securely attached to the exposed cable portion. An electrode/contact is then securely attached to the metal ferrule such that the electrode covers the metal ferrule, a portion of the lead body, and a transition point where the exposed cable exits the lead body. A tine component may be swaged around a portion of the term end, configured to provide a retaining force against an force acting upon the stimulation lead, while allowing insertion of the stim end of the stimulation lead during implantation, and extraction of the stim end during explantation.