Abstract: A leadless biostimulator, such as a leadless cardiac pacemaker, having a header assembly is described. The header assembly includes a helix mount mounted on a flange. An inner surface of the helix mount conforms to an outer surface of the flange, and the outer surface has a non-circular profile such that the conforming surfaces interfere with rotation of the helix mount relative to the flange. The non-circular profile includes a linear segment, such as a radial segment, that resists rotational movement of the helix mount. The helix mount has a protrusion that extends into a recess of the flange to interfere with longitudinal movement between the helix mount and the flange. The protrusion is formed before or after mounting the helix mount on the flange. The interfering surfaces threadlessly interconnect the header assembly components. Other embodiments are also described and claimed.

Abstract: Systems, devices and methods are disclosed that allow recharging a power source located in an implanted medical device implanted in a patient, the recharging device comprising first and second pairs of electrical coils configured to generate first and second uniform magnetic fields in overlapping first and second cylindrical regions located between the respective pairs of electrical coils.

Abstract: A system may include a leadless cardiac pacing device including a body, a proximal hub, and a helical fixation member opposite the proximal hub; and a first elongate shaft having a lumen extending from a distal end of the elongate shaft proximally into the elongate shaft and a transverse member extending transversely across the lumen. The proximal hub may include a transverse channel extending into the proximal hub, the transverse channel being configured to engage the transverse member.

Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Abstract: The present invention changes the magnet-mode of an active implantable medical device (AIMD) such that repeated application of a clinical magnet in a predetermined and deliberate time sequence will induce the AIMD to enter into its designed magnet-mode. In one embodiment, a clinical magnet is applied close to and over the AIMD and removed a specified number of times within a specified timing sequence. In another embodiment, the clinical magnet is applied close to and over the AIMD and flipped a specified number of times within a specified timing sequence. This makes it highly unlikely that the magnet in a portable electronic device, children's toy, and the like can inadvertently and dangerously induce AIMD magnet-mode.

Abstract: An example of a system for delivering neurostimulation energy may include a programming control circuit and a user interface. The programming control circuit may be configured to generate stimulation parameters according to a neurostimulation program including a pattern of interferential stimulation configured to effect asynchronous and/or non-regular activation of nerve fibers by simultaneously delivering a first stimulation current having a first waveform with a first frequency using a first electrode configuration and a second stimulation current having a second waveform with a second frequency using a second electrode configuration.

Abstract: Techniques are disclosed for implementing the use of electrically evoked compound action potentials (ECAPs) to adaptively adjust parameters of high frequency electrical stimulation. In one example, a medical device delivers electrical stimulation therapy comprising a train of electrical stimulation pulses to a patient, wherein the train of electrical stimulation pulses comprises a pulse frequency greater than or equal to 500 Hertz. After delivering the train of electrical stimulation pulses, the medical device ceases delivery of the high frequency electrical stimulation therapy for a predetermined period of time. During the predetermined period of time, the medical device senses an ECAP from the patient and determines, based on the sensed ECAP, a value of a parameter at least partially defining the train of electrical stimulation pulses.

Abstract: An example device includes an elongated housing, a first and second electrode, and signal generation circuitry. The housing can be implanted within a single first chamber of the heart. The first electrode extends distally from the distal end of the elongated housing. A distal end of the first electrode can penetrate into wall tissue of a second chamber of the heart. The second electrode, extending from the distal end of the elongated housing, is configured to flexibly maintain contact with the wall tissue of the first chamber without penetration of the wall tissue of the first chamber by the second electrode. Signal generation circuitry can be within the elongated housing and coupled to the first and second electrode. The signal generation circuitry can deliver cardiac pacing to the second chamber via the first electrode and the first chamber via the second electrode.

Abstract: A neuromodulation system and method of providing sub-threshold modulation therapy. Electrical modulation energy is delivered to a target tissue site of the patient at a programmed intensity value, thereby providing therapy to a patient without perception of stimulation. In response to an event, electrical modulation energy is delivered at incrementally increasing intensity values. At least one evoked compound action potential (eCAP) is sensed in a population of neurons at the target tissue site of the patient in response to the delivery of the electrical modulation energy at the incrementally increasing intensity values. One of the incrementally increased intensity values is selected based on the sensed eCAP(s). A decreased intensity value is automatically computed as a function of the selected intensity value. Electrical modulation energy is delivered to the target tissue site of the patient at the computed intensity value, thereby providing sub-threshold therapy to the patient.

Abstract: An example of a neurostimulation system may include a storage device for storing data representing physiological signals and a user interface including a user input, a display screen, and a presentation control circuit. The user input may be configured to receive a selection of signal(s) from the physiological signals and a selection of viewing mode from viewing modes including a metric mode and/or a presence mode. The metric mode allows for visualization of a signal property indicated by a parameter measured from the selected signal(s). The presence mode allows for viewing presence of a feature in the selected signal(s). The presentation control circuit may be configured to allow for the selection of the signal(s) and the viewing mode, to determine a segment of each of the selected signal(s) for presentation according to the selected viewing mode, and to present the determined segment on the display screen.

Abstract: Disclosed is an artificial retinal stimulator and an artificial retinal device which are for providing image jittering. The artificial retinal stimulator for providing the image jittering includes: a photodiode configured to sense light stimulation and generate a current based on an intensity of the stimulation; a pulse generator configured to generate a pulse to be provided to a corresponding stimulation electrode on the basis of the current coming from the photodiode; a switch configured to connect an output terminal of the pulse generator and ground; and a jittering switch configured to determine whether to transfer the generated pulse to the corresponding stimulation electrode or to transfer to a stimulation electrode corresponding to another artificial retinal stimulator. According to the present disclosure, an image jittering function capable of emulating an eye blinking effect is provided, so that it is possible to enable a low vision patient to see images better.

Abstract: A cardiac simulation method includes storing, in a memory, a measured electrophysiological (EP) map of at least part of wall tissue of a heart of a patient. Based on the stored EP map, simulated electrical activity in response to computer-simulated pacing, which simulates actual electrical activity that would occur across the wall tissue of the heart of the patient in response to actual pacing, is calculated in a processor. Based on the simulated electrical activity calculated in the processor, one or more candidate locations on the wall tissue of the heart at which arrhythmia is suspected of originating are identified and indicated to a user.

Abstract: The invention concerns an assembly (100) for delivering electrical currents to and/or sensing electrical signals from a skin portion of an individual. The assembly comprises an electrode (1) having an electrical conductive portion (2) with a surface for entering in contact with a skin portion (200) of the individual and an electrical insulating stratum (3) covering the electrical conductive portion (2). The assembly comprises a conductor assembly (40) having a connector assembly (4) with protuberances (8) for removably retaining the electrode and electrically connecting said electrical conductive portion (2) of the electrode to said monitoring and/or stimulating device. The protuberances have sharpened elements (8) for piercing the insulating stratum (3) and engaging themselves inside the electrical conductive portion (2).

Abstract: A blood pump can include a pump housing, an impeller, and a hub. The pump housing can be configured to move blood from an inlet to an outlet thereof. The impeller can be housed in the pump housing, have a plurality of blades joined by a central ring, and be radially supported at the central ring by a bearing. The hub can transmit torque to the impeller using a radial magnetic coupling.

Abstract: A system and method for synchronizing patient medical parameters and dialysis parameters. The system and related method allow for the determination of the effect of dialysis on patient health. The invention also allows for the determination of whether observed patient health effects are due to specific dialysis parameters and for making necessary changes to the dialysis parameters in order to improve patient health.

Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.

Abstract: A system and method for synchronizing patient medical parameters and dialysis parameters. The system and related method allow for the determination of the effect of dialysis on patient health. The invention also allows for the determination of whether observed patient health effects are due to specific dialysis parameters and for making necessary changes to the dialysis parameters in order to improve patient health.

Abstract: An implantable medical device includes a device housing, a fixation device, a first prong projecting from a proximal end of the device housing and a second prong projecting from the proximal end of the device housing. The second prong is spaced apart from the first prong. The first prong includes a first flange projecting away from a longitudinal axis of the device housing. The second prong includes a second flange projecting away from the longitudinal axis. The first prong and the second prong are configured to extend to a first flange diameter in a relaxed configuration and to extend to a second flange diameter in an expanded configuration.

Abstract: Measuring a neural response to a stimulus comprises applying an electrical stimulus, then imposing a delay during which the stimulus electrodes are open circuited. During the delay, a neural response signal present at sense electrodes is measured with a measurement amplifier, while ensuring that an impedance between the sense electrodes is sufficiently large that a voltage arising on the sense electrode tissue interface in response to the stimulus is constrained to a level which permits assessment of the neural response voltage seen at the sense electrode. For example the input impedance to the measurement amplifier (ZIN) can be Z IN > Z C ? ( V S ? ? 1 - V S ? ? 2 ) V E , where ZC is the sense electrode(s) constant phase element impedance, Vs1?Vs2 is the differential voltage arising on the sense electrode tissue interface, and VE is the neural response voltage seen at the sense electrode.

Abstract: A conductive transfer for application to an article comprises first and second non-conductive layers and a conductive layer positioned between the two non-conductive layers. The conductive transfer further comprises an adhesive layer for adhering the conductive transfer to an article, such as a wearable item. The conductive layer comprises a plurality of tessellated cells defined by a printed conductive ink. The conductive layer comprises a main element and an input track with the plurality of tessellated cells being comprised over the input track of said conductive layer.