Patents Examined by Everett White
  • Patent number: 10442870
    Abstract: Provided is a novel cellulose derivative having excellent water resistance. This is a cellulose acylate oxoalkanoate which is a cellulose derivative corresponding to cellulose, except with substituents replacing part or all of hydrogen atoms in the hydroxy groups of the cellulose. The substituents includes a group represented by General Formula (1) and a group represented by General Formula (2). The cellulose acylate oxoalkanoate has a degree x of substitution with the group represented by General Formula (1), a degree y of substitution with the group represented by General Formula (2), and a degree z of unsubstitution, where x, y, and z meet conditions specified by Expressions (A), (B), and (C): 0.1?x?2.99??(A) 0.01?y?2.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: October 15, 2019
    Assignee: DAICEL CORPORATION
    Inventors: Tomohiro Hashizume, Shizuka Ukita, Shu Shimamoto, Toshikazu Nakamura
  • Patent number: 10407830
    Abstract: A surfactant treated bleached softwood kraft pulp fiber, useful as a starting material in the production of cellulose derivatives including cellulose ether, cellulose esters and viscose, is disclosed. Methods for making the kraft pulp fiber and products made from it are also described.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: September 10, 2019
    Assignee: GP Cellulose GmbH
    Inventors: Arthur J. Nonni, Charles E. Courchene, Christopher M. Slone, Philip R. Campbell, Steven C. Dowdle, Joel M. Engle
  • Patent number: 10328095
    Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 25, 2019
    Assignee: Covidien LP
    Inventors: Phillip Blaskovich, Rachit Ohri, Olga Cherniavsky
  • Patent number: 10279042
    Abstract: The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: May 7, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine Schmidt
  • Patent number: 10144786
    Abstract: The method of making nanocrystalline cellulose is a flash lyophilized-acidic hydrolysis method for converting cellulosic fibers into nanocrystalline cellulose. Cellulosic fibers are initially ground in a high-speed, rotary grinder to produce ground cellulose fiber. The ground cellulose fiber is then dried to produce dried, ground cellulose, which is then freeze-dried to yield lyophilized cellulose. Pure concentrated sulfuric acid is then added to the lyophilized cellulose at a liquid/solid ratio of 1:1 (vol/wt) to form a cellulosic paste. The cellulosic paste is diluted in either water or absolute ethanol at a liquid/solid ratio of 1:1 (vol/wt) to form a cellulosic solution, which is then filtered under cooling by liquid nitrogen-vapor. The nanocrystalline cellulose precipitate is then washed until neutralization and dried to yield nanocrystalline cellulose.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: December 4, 2018
    Assignee: King Abdulaziz University
    Inventors: Sherif Shawki Zaki Hindi, Refaat Atalla Abohassan
  • Patent number: 10106625
    Abstract: The presently disclosed and claimed inventive concept(s) relates to a polymer for enhancing drug performance and improving processability. Specifically, the polymer comprises hydroxypropyl methyl cellulose acetate succinate (HPMC-AS). On the HPMC-AS, the percentage of total succinoyl degree of substitution is less than 12% at C6-OH position and greater than 53% at C3-OH, and the percentage of total acetyl degree of substitution is greater than 32% at C6-OH position.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: October 23, 2018
    Assignee: HERCULES LLC
    Inventors: Todd A. Brugel, Tuyen T. Nguyen
  • Patent number: 10076131
    Abstract: The present invention generally relates to the field of nutrition. In particular the present invention relates to infant nutrition in the post natal period and in early life, more particular during the age period of 6-36 months or during a part thereof. One embodiment of the present invention is a kit of diet compositions for children during the age period of 6-36 months or during a part thereof, wherein the macronutrient content of the compositions is gradually changing in the form of a straight line from a composition that comprises about 40-50% energy from fat and about 40-49% energy from carbohydrates for children at the age of 6 months to a composition that comprises about 30-35% energy from fat and about 50-55% energy from carbohydrates for children at the age of 36 months, and its use to prevent obesity later in life.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: September 18, 2018
    Assignee: Nestec S.A.
    Inventors: Yasaman Shahkhalili, Kevin Acheson, Katherine Mace, Julie Moulin, Irene Zbinden, Olivier Aprikian, Theresa Voss
  • Patent number: 10066028
    Abstract: The method of fabricating biocompatible cellulose nanofibrils produces cellulose nanofibrils from used agro-waste Borassus flabellifer leaf stalks. The method uses a three-step process, including alkali treatment, bleaching, and acid hydrolysis to produce cellulose nanofibrils, which may be converted to pellets for storage. The pellets may be converted to a transparent film for cell attachment by dispersion in water and heating in a hot air oven. Testing shows that cellulose nanofibrils made by the method easily attract human mesenchymal stem cells and will be applicable for skin tissue engineering applications.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 4, 2018
    Assignee: KING SAUD UNIVERSITY
    Inventors: Jegan Athinarayanan, Ali A. Alshatwi, Vaiyapuri Subbarayan Periasamy
  • Patent number: 10064889
    Abstract: The present invention discloses a mercapto-modified biocompatible macromolecule derivative with a low degree of modification. The mercapto-modified biocompatible macromolecule derivative not only maintains the initial structure, physiological function and biocompatibility as much as possible, but also allows the preparation of the biocompatible macromolecule cross-linked material with a low degree of cross-linking through the effectively chemical cross-linking with the introduced mercapto group. The present invention further discloses a disulfide-bond cross-linked biocompatible macromolecule material with a very low degree of cross-linking.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: September 4, 2018
    Assignee: Bioregen Biomedical (Changzhou) Co., Ltd.
    Inventors: Xiaozheng Shu, Weiping Zhong, Yunyun Wang, Meixia Yu
  • Patent number: 10047172
    Abstract: A process for manufacturing a cross-linked hyaluronic acid (HA) containing a functionalizing group including the step of reacting HA with a mixture of: (i) a first cross-linking agent selected from the group of bifunctional epoxides and polyfunctional epoxides, and (ii) a functionalized agent of a functionalizing group coupled via a 1,2,3-triazole linkage to a second cross-linking agent selected from the group of bifunctional epoxides and polyfunctional epoxides, to obtain a cross-linked HA containing the functionalizing group. The process provides a cross-linked hyaluronic acid (HA) containing a functionalizing group. The process utilizes a functionalized agent of a functionalizing group coupled via a 1,2,3-triazole linkage to a cross-linking agent.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: August 14, 2018
    Assignee: GALDERMA S.A.
    Inventor: Jean-Guy Boiteau
  • Patent number: 10005849
    Abstract: A process for producing a cellulose derivative, comprising: a first step including reacting a cellulose and a first reactant comprising a long-chain reactant for reacting with a hydroxy group of the cellulose to introduce a long-chain organic group having 5 or more carbon atoms, in a solid-liquid heterogeneous system, to form a cellulose derivative in a swollen state, the cellulose derivative having the long-chain organic group having 5 or more carbon atoms introduced therein and having a part of hydroxy groups of the cellulose remained, and performing solid-liquid separation to obtain the cellulose derivative as an intermediate; and a second step including reacting the intermediate cellulose derivative and a second reactant comprising a short-chain reactant for reacting with a remaining hydroxy group of the intermediate cellulose derivative to introduce a short-chain organic group having 4 or less carbon atoms to form a final cellulose derivative having the short-chain organic group having 4 or less carbon a
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: June 26, 2018
    Assignee: NEC Corporation
    Inventors: Kiyohiko Toyama, Masatoshi Iji, Shukichi Tanaka
  • Patent number: 9949946
    Abstract: Inclusion complexes of pinocembrin with cyclodextrin or its derivatives and their preparation are provided. The inclusion complexes can be used to make drugs.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: April 24, 2018
    Assignee: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.
    Inventors: Song Wu, Guanhua Du, Yan Qi, Mei Gao, Qingyun Yang, Hongmei Guang, Wei Li, Yuehua Wang, Yuanfeng Tong
  • Patent number: 9937134
    Abstract: The present invention provides compositions suitable for topical administration to a mammalian subject including sodium hyaluronate and a pharmaceutically acceptable excipient. The present invention also provides methods for making and using the same.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: April 10, 2018
    Assignee: Cypress Pharmaceuticals, Inc.
    Inventor: Robert Lewis
  • Patent number: 9926384
    Abstract: This invention relates a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate and processes to produce the cellulose solution. Another aspect of this invention relates to shaped articles prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising derivatives of cellulose prepared from a cellulose solution comprising at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising regioselectively substituted cellulose esters prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. In another embodiment of the invention, the cellulose esters of the present invention are used as protective and compensation films for liquid crystalline displays.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: March 27, 2018
    Assignee: EASTMAN CHEMICAL COMPANY
    Inventors: Charles Buchanan, Norma Buchanan, Elizabeth Guzman-Morales
  • Patent number: 9914786
    Abstract: The invention relates to a dry or slurry process to prepare phosphate-crosslinked cellulose ethers from a cellulose starting material comprising the steps of adding an alkalizing agent to the cellulose starting material to achieve mercerization, adding an ethehfying agent to the reaction mixture to achieve etherification of the cellulose, and adding a crosslinking agent to the reaction mixture to achieve crosslinking of the cellulose, wherein at least part of the alkalizing agent is added to the cellulose starting material before the etherification and/or crosslinking reactions take place to obtain alkalized cellulose; the crosslinking agent and the etherifying agent are added one after the other in random order or simultaneously; the crosslinking agent is an alkali metal thmetaphosphate; and the crosslinking and etherification steps are performed at an elevated temperature.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: March 13, 2018
    Assignee: Akzo Nobel Chemicals International B.V.
    Inventor: Paulus Pieter De Wit
  • Patent number: 9856328
    Abstract: Described herein are methods for chemical modification of nitrocellulose to generate lyophobic properties which are useful in propellant compositions. Such methods include the steps of: a) dissolving neat nitrocellulose in an organic solvent; b) adding a silyl based isocyanate and a catalyst to the solution; (d) stirring the solution in a moisture free environment; e) hydrolyzing the solution by exposing said solution to moisture; and (e) adding fluorinated oxysilane. The modified nitrocellulose retains its energetic properties while exhibiting high water and organic solvent phobicity, effectively functioning as a barrier to migration or diffusion of liquid components in propellant compositions.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: January 2, 2018
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Henry Grau, Alexander Fadeev
  • Patent number: 9826768
    Abstract: A process for preparing an aqueous solution of a methylcellulose having anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups, comprises the step of mixing the methylcellulose with an aqueous liquid at a temperature of not higher than 10° C. at a shear rate of at least 1000 s?1.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 28, 2017
    Assignee: Dow Global Technologies LLC
    Inventors: Puspendu Deo, Kathryn Brown, David E. Wallick, Robert L. Sammler, Yongfu Li
  • Patent number: 9820498
    Abstract: An aqueous solution comprising (a) one or more mono-, di- and/or oligosaccharides and (b) a methylcellulose, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, is produced by i) mixing the methylcellulose with an aqueous liquid comprising one or more mono-, di- and/or oligosaccharides at a shear rate of at least 1000 s?1 or ii) mixing one or more mono-, di- and/or oligosaccharides with the methylcellulose and/or an aqueous liquid before, simultaneously with or after mixing the methylcellulose with the aqueous liquid at a shear rate of at least 1000 s?1.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 21, 2017
    Assignee: Dow Global Technologies LLC
    Inventors: Puspendu Deo, Roland Adden, Matthias Knarr, Robert L. Sammler, Kathryn Brown
  • Patent number: 9796793
    Abstract: The present invention is a multilayered composite comprising porous metal oxide particles that are covalently bonded by way of inorganic ether groups to one or more sites of a first polyhydroxyl-functionalized polymer. This first polymer is in turn covalently bonded by way of inorganic ether groups to one or more sites of a second polyhydroxyl-functionalized polymer. The multilayered composites can be prepared by contacting porous inorganic-oxide particles with a sufficient amount of OH-reactive crosslinking agent to form metal oxide particles imbibed with the crosslinking agent, and then contacting the inorganic-oxide particles with a solution of polyhydroxyl-functionalized polymer under reactive conditions.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: October 24, 2017
    Assignees: The Regents of the University of California, Dow Global Technologies LLC, Rohm and Haas Company
    Inventors: Joseph Jankolovits, Alexander S. Katz, Oz M. Gazit, James C. Bohling, John A. Roper, III
  • Patent number: 9782430
    Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting an oxidized cellulose embolization solution into a lumen of a blood vessel to form an embolism within the lumen. The oxidized cellulose is present in an amount from about 10 % by weight to 20 % by weight of the oxidized cellulose embolization solution. The method also includes adjusting recanalization time of the embolism, which may be adjusted by tailoring a degradation rate of the oxidized cellulose.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: October 10, 2017
    Assignee: Covidien LP
    Inventors: Rachit Ohri, Phillip D. Blaskovich