Patents Examined by Everett White
  • Patent number: 9771317
    Abstract: There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: September 26, 2017
    Assignees: Cambrex Karlskoga AB, Cambrex Profarmaco Milano
    Inventors: Stefano Radaelli, Giuseppe Zurlo, Lars Eklund, Margus Eek, Ants Maasalu, Malle Schmidt
  • Patent number: 9751955
    Abstract: A method for regeneration of a cellulose containing material, comprises the steps: a) exposing the cellulose containing material to oxygen with an alkali aqueous solution at a pH of at least 9, and a temperature of at least 20° C., b) dispersing the cellulose containing material in the alkali aqueous solution, wherein the temperature of the alkali aqueous solution is lowered below 15° C., and wherein the pH of the alkali aqueous solution is above 9, c) adding an organic solvent to the dispersion to precipitate cellulose, and d) separating the precipitated cellulose by at least one method selected from filtering and centrifugation. The method makes it possible to maintain a high alkali pH value in the process, which saves costs since the pH value does not have to be lowered by additions of various additives. The method makes it possible to remove non-cellulose parts of the cloth.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: September 5, 2017
    Assignee: RE:NEWCELL AB
    Inventors: Mikael Lindström, Gunnar Henriksson
  • Patent number: 9737495
    Abstract: The present invention relates to a process of extraction and purification of a stilbenoid, pterostilbene, from botanical sources. The process involves obtaining pterostilbene having high degree of purity and the present invention also relates to pure form of pterostilbene obtained. The invention also relates to complexing the pterostilbene with carriers such as cyclodextrin for improving its water solubility and bioavailability. The present invention also describes a process for inhibition of Histone Deacetylases using pterostilbene optionally along with a carrier, and a method of managing Poly Glutamine repeat disorders by the administration of pterostilbene optionally along with a carrier.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: August 22, 2017
    Assignee: Indus Biotech Private Limited
    Inventors: Sunil Bhaskaran, Mohan Vishwaraman
  • Patent number: 9732108
    Abstract: The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: August 15, 2017
    Inventor: Bahram Memarzadeh
  • Patent number: 9718947
    Abstract: A process for the preparation of a chondroitin sulphate salt with an average molecular weight (Mw) of 10-30 kDa via chemical sulphation of an unsulphated chondroitin backbone is provided. The unsulphated chondroitin can be obtained by acid hydrolysis of a capsular polysaccharide K4 made directly from E. coli strain O5:K4:H4 or directly produced from a genetically modified strain of E. coli. Sulphation of the N-acetyl-D-galactosamine residue at position 4 or 6 takes place simultaneously in the same polysaccharide chain, simulating the sulphation pattern observed in natural chondroitin sulphate.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: August 1, 2017
    Assignee: Gnosis S.p.A.
    Inventors: Davide Bianchi, Marco Valetti, Paola Bazza, Nicolò Miraglia, Ermanno Valoti
  • Patent number: 9649329
    Abstract: Administration of low molecular weight (10,000-20,000 Daltons, or lower) pectins, particularly modified citrus pectins (MCP), like PectaSol-C reduces galectins-3 levels in vivo. Reduction of galectin-3 levels by MCP inhibits inflammation, inhibits fibrosis formation in organs and tissues, and inhibits cancer formation, progression, transformation and metastases. The reduction in circulating, serum and cellular galectin-3, inherently resulting from the administration of MCP, provides benefit over a spectrum of biological conditions, as evidenced by in vivo trials.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: May 16, 2017
    Assignee: ecoNugenics, Inc.
    Inventor: Isaac Eliaz
  • Patent number: 9642929
    Abstract: The present invention relates to a highly liquid absorbent and hardly water-soluble carboxymethyl cellulose (CMC) foam, which absorbs body fluid or water, expands in volume when absorbing liquid, does not gelate, and maintains shape. The hardly water-soluble CMC foam prepared according to the preparation method of the present invention has remarkably superior liquid absorption property, shows large volume expansibility when absorbing liquid, does not gelate, and maintains shape. Therefore, a remarkably improved ability is shown when used as a hemostatic agent and a wound dressing. In addition, when the CMC foam is treated with a CMC powder dispersing liquid, the surface characteristics change, thereby preventing adhesion with the skin and improving liquid retention capability. Thus, it is possible to control the liquid absorption property thereof to meet the desired purpose.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: May 9, 2017
    Assignee: Korea Institute of Industrial Technology
    Inventors: Jung Nam Im, Song Jun Doh, Tae Hee Kim, Min Ji Yoon, Chae Hwa Kim
  • Patent number: 9637560
    Abstract: A reactive extrusion process for the production of substituted polysaccharides, in particular, cellulose acetate, starch acetate, carboxymethyl cellulose, and carboxymethyl starch.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: May 2, 2017
    Assignee: NUtech Ventures
    Inventors: Milford Hanna, Pratik Bhandari
  • Patent number: 9617686
    Abstract: A surfactant treated bleached softwood kraft pulp fiber, useful as a starting material In the production of cellulose derivatives including cellulose ether, cellulose esters and viscose, is disclosed. Methods for making the kraft pulp fiber and products made from it are also described.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: April 11, 2017
    Assignee: GP Cellulose GmbH
    Inventors: Arthur James Nonni, Charles Edward Courchene, Christopher Michael Slone, Philip Reed Campbell, Steven Chad Dowdle, Joel Mark Engle
  • Patent number: 9617350
    Abstract: The invention is a method for efficiently preparing alkali cellulose having a uniform alkali distribution therein. More specifically, the invention is a method for preparing alkali cellulose comprising steps of bringing pulp into continuous contact with an alkali metal hydroxide solution in a bucket conveyor type contactor to generate a contact mixture, and draining the contact mixture; a method for preparing a cellulose ether comprising use of the alkali cellulose thus prepared; and an apparatus for preparing alkali cellulose comprising a bucket conveyor contactor comprising at least one inlet port for introducing pulp and an alkali metal hydroxide solution at one end and at least one outlet port for discharging a contact mixture wherein the pulp and the alkali metal hydroxide solution can be moved from one end to the other end while bringing them into contact with each other to generate the contact mixture; and a drainer for separating a cake from the contact mixture discharged from the outlet port.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: April 11, 2017
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Mitsuo Narita, Masaki Tabata, Atsushi Yoshida, Hiroshi Umezawa
  • Patent number: 9611586
    Abstract: The invention relates to a method for manufacturing cellulose material, the method comprising introducing cellulose fibers as raw material pulp (1) to a system, adding an alkalizing agent into the system in order to absorb the alkalizing agent into the cellulose fibers (1), adding an anionic agent into the system in order to absorb said agent into the cellulose fibers (1), feeding the cellulose fibers (1) to a sieve plate press (6), performing a reaction between the cellulose fibers and the anionic agent at least partly in the sieve plate press (6) in order to produce anionized cellulose fibers having a degree of substitution between 0.05 and 0.35, wherein the reaction is performed at least partly at a consistency of at least 50%. In addition, the invention relates to a system for manufacturing cellulose material and to fibril cellulose produced from anionized cellulose fibers.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: April 4, 2017
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Eino Sivonen, Kyösti Valta, Markus Nuopponen
  • Patent number: 9611333
    Abstract: The invention is a method for efficiently preparing alkali cellulose having a uniform alkali distribution therein. More specifically, pulp and an excess alkali metal hydroxide solution are introduced continuously in a screw conveyor type contactor and brought into contact with each other in the screw conveyor type reactor. By changing at least one factor selected from the group consisting of a rotation speed of the screw conveyor, a screw pitch and a length of immersion zone, a ratio of an alkali to cellulose in the alkali cellulose obtained by draining is controlled. The alkali cellulose thus obtained is etherified into the corresponding cellulose ether.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: April 4, 2017
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Mitsuo Narita, Masaki Tabata, Atsushi Yoshida, Hiroshi Umezawa
  • Patent number: 9587037
    Abstract: A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid to precipitate the esterified cellulose ether from the reaction product mixture, (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i), and (iii) suspending the isolated esterified cellulose ether in an aqueous liquid to provide a suspension having a temperature of at least 28° C., and (iv) recovering the esterified cellulose ether from the suspension of step (iii).
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: March 7, 2017
    Inventors: Oliver Petermann, Matthias Sprehe, Robert Appell, Robert Nilsson
  • Patent number: 9580517
    Abstract: Prepare lithium carboxymethyl cellulose by treating sodium carboxymethyl cellulose with a weak acid to form an acid from of carboxymethyl cellulose and then treating the acid form of the carboxymethyl cellulose with lithium chloride.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: February 28, 2017
    Assignee: Dow Global Technologies LLC
    Inventors: Alexandra Hild, Hans-Juergen Juhl, Roland Adden
  • Patent number: 9580518
    Abstract: A method for fractionating dextrin, belonging to the technical field of food processing. In principle, the method for fractionating dextrin of the present invention is based on the fact that the dextrin is incompatible with polyethylene glycol in aqueous solution and a larger molecular weight of the dextrin results in more significant incompatibility with polyethylene glycol. Accordingly, the stepwise precipitation of dextrin components having a molecular weight from large to small may be realized by gradually increasing the concentration of polyethylene glycol by gradually adding polyethylene glycol to dextrin in aqueous solution.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: February 28, 2017
    Assignee: Jiangnan University
    Inventors: Zhengyu Jin, Yaoqi Tian, Xiuting Hu, Binghua Sun, Bao Zhang, Benxi Wei, Chunsen Wu, Na Yang, Xueming Xu
  • Patent number: 9580516
    Abstract: When a combination of pulps having different alkali metal hydroxide solution absorption rates is as a raw material, contact conditions such as a contact temperature and a contact time have to be changed frequently, depending on the absorption rate of pulps currently processed, thereby causing a problem of reduced productivity. For solving the problem, provided is a method for producing alkali cellulose, comprising at least the steps of: bringing two or more types of pulps having different alkali metal hydroxide solution absorption rates into contact with an alkali metal hydroxide solution to obtain a contact product; and draining the contact product, wherein the highest absorption rate is not more than 4.0 times as fast as the lowest absorption rate.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: February 28, 2017
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventor: Mitsuo Narita
  • Patent number: 9567707
    Abstract: A method of recovering purified partly-hydrolyzed cellulose (36) from a composition (14) comprising partly-hydrolyzed cellulose and an acid, such as sulfuric acid. A base (28) having a cation that forms a precipitate with the anion of the acid is added to the composition. For example, a base such as barium hydroxide is added to form a sulfate precipitate. The precipitate (38) is then separated from the partly-hydrolyzed cellulose (36), thus reducing its acid content. The method may include additional steps of centrifugation (18) of the composition, breaking-up agglomerations (44) in the composition after precipitation, and dialysis (42).
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: February 14, 2017
    Assignee: NORAM Engineering and Constructors Ltd.
    Inventor: James M. Lockhart
  • Patent number: 9546222
    Abstract: Provided is a method for producing low-substituted hydroxypropylcellulose in which depolymerization capable of achieving a target viscosity in a short time is carried out safely after an etherification reaction step. More specifically, provided is a method for producing low-substituted hydroxypropylcellulose having a degree of hydroxypropoxy substitution of from 9.5 to 16.0% by weight, comprising at least a step of reacting alkali cellulose with an etherifying agent and a step of carrying out depolymerization after the reaction.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: January 17, 2017
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Akira Kitamura, Takahiro Suzuki, Mitsuo Narita
  • Patent number: 9534320
    Abstract: Method for fabricating fiber and film products and composites includes: introducing an aqueous gel of nanofibrillar cellulose into a volume of organic extraction agent miscible with water so that the aqueous gel is kept as a separate phase and forms one or several discrete physical entities containing the nanofibrillar cellulose within the phase; changing water with the organic extraction agent in said one or several discrete physical entities of nanofibrillar cellulose; and drying the nanofibrillar cellulose by removing the organic extraction agent from the one or several discrete physical entities of nanofibrillar cellulose. In the method the aqueous gel of nanofibrillar cellulose is introduced into the volume of organic extraction agent in the form of one or several elongated elements which form a fiber-like or ribbon-like or film-like product after drying.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: January 3, 2017
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Antti Laukkanen, Jan-Erik Teirfolk, Markus Samuli Nuopponen, Andreas Walther, Olli Ikkala
  • Patent number: 9534061
    Abstract: The invention is an efficient method for preparing alkali cellulose having the low water content and a uniform alkali distribution therein. More specifically, the invention is a method for continuously preparing alkali cellulose comprising steps of bringing pulp into continuous contact with an alkali metal hydroxide solution to generate a contact mixture and then draining the contact mixture by a centrifugal separator. The invention also includes a method for preparing cellulose ether comprising a step of etherifying the alkali cellulose.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: January 3, 2017
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Mitsuo Narita, Masaki Tabata, Atsushi Yoshida, Hiroshi Umezawa