Abstract: In a patient management system, a remote monitoring device interrogates an implantable device on an intermittent basis over a wireless telemetry link, with interrogations being performed either according to a programmed schedule or upon receiving a command to do so via the user interface or the network interface. Described is a system and method for optimizing, limiting, and/or monitoring an implantable device's telemetry usage in order to avoid premature battery depletion and/or raise an alert if excessive battery depletion is beginning to occur.

Abstract: The various aspects of the invention pertain to devices and related methods for treating heart conditions, including, for example, dilatation, valve incompetencies, including mitral valve leakage, and other similar heart failure conditions. The devices and related methods of the present invention operate to assist in the apposition of heart valve leaflets to improve valve function. According to one aspect of the invention, a method improves the function of a valve of a heart by placing an elongate member transverse a heart chamber so that each end of the elongate member extends through a wall of the heart, and placing first and second anchoring members external the chamber. The first and second anchoring members are attached to first and second ends of the elongate member to fix the elongate member in a position across the chamber so as to reposition papillary muscles within the chamber.

Abstract: An implantable spool is used for spooling the excess wiring associated with a lead that extends between at least one electrode and a pulse generator of an electrical stimulation implant system. The present invention also has application to providing a spool for coiling tubing of an implantable drug delivery system. Embodiments of the invention include a method of implanting an implantable system in a body, wherein the implantable system includes a source unit and an elongated member. A method of assembling an implantable system is also described.

Abstract: An implantable, multi-chamber cardiac stimulation device and method automatically adjust inter-chamber stimulation delays whenever stimulation rate is changed according to a patient's metabolic need. Inter-chamber stimulation delays include inter-atrial delays, inter-ventricular delays, and atrio-ventricular delays. Inter-chamber stimulation delays are defined according to whether the event which triggers the start of the delay is an intrinsic sensed event or the delivery of a stimulation pulse. Adjustment to inter-chamber stimulation delays is made as a function of the stimulation rate changes. By providing automatically adjustable inter-chamber stimulation delays optimal synchronization of heart chamber contractions may be maintained at all stimulation rates.

Abstract: A medical electrode includes a moderately conductive flexible member having a top side and a bottom side with a connector and contact with a flexible member top side for establishing electrical contact with an external apparatus. A non-conductive flexible sheet covers the conductive flexible member top and the connector and a highly conductive ink pattern is disposed on a conductive flexible member bottom side. A moderately high conductive hydrogel adhesive disposed on the conductive flexible member bottom side and cover the conductive ink pattern is provided for adhering electrode to a patients' skin.

Abstract: The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.

Abstract: Systems, devices and methods provide for evaluation of heart failure symptoms. Sensor data associated with one or more symptoms of heart failure are acquired and trended. Statistical features, such as slope, are extracted from the data trend in a moving window and are used to develop a cumulative sum. The cumulative sum is compared to a threshold value or V-mask to detect a shift in cumulative sum indicating changes in heart failure symptoms. A shift beyond the threshold value may trigger an alert or implementation of therapy.

Abstract: In one example, the present invention is directed to a wound-healing patch including a flexible substrate, at least one wound electrode, at least one guard electrode and at least one return electrode. The guard electrode is positioned between the wound and return electrodes in the electrical path of current traveling between the return and wound electrodes on the surface of the skin, sinking the surface current and force the wound current to travel deeper into the tissue. In the invention, the wound electrode(s) is positioned on a portion of the flexible substrate designed to be placed over wounded tissue and the return electrode is positioned on a portion of the substrate substantially surrounding the wound and guard electrodes and is designed to be placed over healthy tissue.

Abstract: Various systems and methods are provided for intervening where aberrant heart and/or respiratory functionality is detected. For example, some embodiments of the present invention provide a monitor capable of detecting the occurrence of various aberrant events, and in some cases for intervening in the event. In some cases, a pacemaker or some other medical device detects an abnormality, and an information signal indicating the detected abnormality is transmitted from the pacemaker to a bedside monitor or some other monitor associated with the patient. Based on the received information signal, the bedside monitor can deliver an appropriate therapy. Such a therapy can be, but are not limited to, the sounding of an audible alarm to awake the patient, and/or the programming of a medical device implanted in the patient. Further, in some cases, the detected aberrant behavior and/or events surrounding the aberrant behavior can be transmitted from the bedside monitor to a remote monitor.

Abstract: A system and method for automatically detecting abnormal heart contractions originating in the ventricles, in a way that is independent of signal morphology is provided. As an uninterrupted series of ventricular detections indicates a possible ventricular arrhythmia, all ventricular beats are detected including isolated premature ventricular contractions (PVCs) and the associated R-R intervals are corrected. Premature ventricular contractions (ectopic beats) in non-standard lead configuration in a noisy signal from an ambulatory subject from a low-cost sensor that may be a small form factor sensor with 1 inch lead separation and may be rotated through multiple placements to correct an R-R interval time series used to detect atrial fibrillation.

Abstract: A pacing protocol is provided that reduces or minimizes ventricular pacing in favor of intrinsic conduction. When operating in a mode that provides ventricular pacing, a series of conduction checks are performed to determine if intrinsic conduction has returned. These conduction checks occur according to a predetermined pattern that generally includes longer intervals between subsequent attempts. The AV interval provided for dual chamber based pacing is modulated and generally moves from a larger value to a nominal value as the interval between unsuccessful conduction checks increases.

Abstract: A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.

Abstract: Methods and systems involve determining the cardiac response to pacing pulses. The variability cardiac signal features detected during initialization is used to establish a variability threshold. A cardiac signal associated with a pacing pulse is sensed and one or more features of the cardiac signal are detected. The variability of the one or more features is compared to the variability threshold. The cardiac response to the pacing pulse is determined based on the feature variability.

Abstract: An implantable medical device and methods of manufacture are provided for implantation in a body. The device includes a device housing having an interior cavity and electronic circuitry located in the interior cavity of the device housing. The electronic circuitry detects a physiologic condition of the body and delivers a therapy to the body. The device further includes a feed-through assembly having a feed-through housing that is joined to the device housing. The feed-through assembly includes conductors held in the feed-through housing and electronically connected to the electronic circuitry. A back-fill member is joined to the feed-through housing. The back-fill member has an opening there through communicating with the interior cavity of the device housing. A sealing element is hermetically secured in the opening through the back-fill member. The sealing element and back-fill member are formed of different first and second materials, respectively.

Abstract: Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks.

Abstract: A method for stimulating a particular area of a brain using a stimulation device includes detecting a spatial structure of a head and determining electrical and/or magnetic properties of at least one part of anatomical structures of the head. An energy amount to be provided by the stimulation device for stimulating the particular area of the brain is calculated automatically based on the spatial structure of the head and the determined electrical and/or magnetic properties of at least one part of the anatomical structures of the head.

Abstract: The disclosure provides a description of a tissue modulation device, for treating at least one of obesity, metabolic syndrome, and Type 2 diabetes in a patient. In some embodiments, the device includes a storage module having computer-readable instructions for delivering an electrical stimulation pattern to a splanchnic nerve of the patient. The stimulation pattern includes at least one on-time. The on-time includes at least one of a suprathreshold period and a subthreshold period. The splanchnic nerve is selected from the group consisting of the greater splanchnic nerve, the lesser splanchnic nerve, and the least splanchnic nerve. The pattern is effective to ameliorate at least one attendant condition of obesity, metabolic syndrome, and Type 2 diabetes in the patient. The attendant condition includes dyslipidemia, hypertension, hyperinsulinemia, hyperglycemia, and/or insulin resistance.

Abstract: A medical electrode includes a conductive flexible member having a top side and a bottom side with a connector in contact with a flexible member for establishing electrical contact with an external apparatus. An oversize non-conductive flexible sheet covers the conductive flexible member top. A conductive hydrogel adhesive disposed on the conductive flexible member bottom side for adhering the electrode to a patient's skin.

Abstract: A medical electrode includes a conductive flexible member having a top side and a bottom side with a connector in contact with a flexible member for establishing electrical contact with an external apparatus. An oversize non-conductive flexible sheet covering the conductive flexible member top utilizes concentric adhesives. A conductive hydrogel adhesive disposed on the conductive flexible member bottom side for adhering the electrode to a patient's skin.

Abstract: A device, potentially implantable in a living organism, intended to utilize at least a part of the hydraulic energy generated by the heart (10)—the primary unit—at the natural phases of work when the cavities of the heart (11, 12 and 16, 17) are filed with blood. The device includes at least one secondary unit (24), which is connectable to the cardiovascular system of the organism and arranged to utilize said hydraulic energy. The secondary unit is represented by at least one hydraulic motor (24a) arranged to transfer the hydraulic energy to a transferal organ (28). The transferal organ (28) is arranged to influence at least one tertiary unit, for example an executive device (29), which is constructed in order to convert the transferred energy to an alternative form of energy, with the purpose to influence certain defined functions within the organism. Preferably is arranged a regulating device (30) in order to control running parameters of the unit.