Patents Examined by Frederick Krass
  • Wound covering and method of preparation
    Patent number: 9585983
    Abstract: A wound covering fabricated from amniotic, chorionic, or intact amniotic and chorionic membranes obtained from human birth tissue is provided. Methods of processing a membrane to form a wound covering are provided. Methods of treating a wound or surgical incision are also provided.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: March 7, 2017
    Assignee: BioDlogics, LLC
    Inventor: Timothy R. Brahm
  • Pharmaceutical composition containing 13 triglycerides, and preparations and use thereof
    Patent number: 9585858
    Abstract: The present invention relates to a pharmaceutical composition containing 13 compounds: 1,3-diolein, 1-linolein-3-olein, 1,2-diolein, 1-olein-2-linolein, 1,2-dilinolein, trilinolein, 1-olein-2,3-dilinolein, 1-palmitin-2,3-dilinolein, 1,3-diolein-2-linolein, 1-palmitin-2-linolein-3-olein, 1,3-dipalmitin-2-linolein, triolein and 1-palmitin-2,3-diolein. The invention also relates to pharmaceutical preparations of this composition and the use thereof in the treatment of tumors and in the immuno-enhancement.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: March 7, 2017
    Assignee: ZHEJIANG KANGLAITE GROUP CO., LTD.
    Inventor: Dapeng Li
  • Anticancer formulation
    Patent number: 9585864
    Abstract: This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this formulation to treat tumor.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: March 7, 2017
    Assignee: National Dong Hwa University
    Inventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin
  • Kits comprising a beverage composition and information for use
    Patent number: 9585827
    Abstract: The present invention is directed to a method of treating dental erosion comprising orally administering to a mammal (preferably, a human) a beverage composition having a pH of less than about 5; wherein the beverage composition comprises a compound having the structure: wherein n is an integer averaging from about 7 to about 100 and M, M?, and M? are each, independently, selected from the group consisting of sodium and potassium. The present invention is further directed to kits comprising the foregoing beverage composition and information that use of the beverage composition provides treatment against dental erosion.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: March 7, 2017
    Assignee: The Procter & Gamble Company
    Inventor: Gary Stephenson
  • Method of producing lipid nanoparticles for drug delivery
    Patent number: 9579338
    Abstract: What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a water miscible organic solvent, such as ethanol, at a concentration of 2.3 mg/ml, and adding this solution to the polymer dissolved in water to a final concentration of 35% ethanol in water. The final charge ratio of drug:lipid is 1:2.5. The resulting nanoparticles have a mean size of 50 to 150 nm.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: February 28, 2017
    Assignee: Nitto Denko Corporation
    Inventors: Victor Knopov, Richard P. Witte, Priya Karmali, Robin Lee, David Webb, Violetta Akopian
  • Elution-stabilized preparation
    Patent number: 9572806
    Abstract: The invention provides a solid preparation which does not undergo the delay of elution of the active ingredient even after long-term storage. The solid preparation independently contains a teneligliptin-containing part containing teneligliptin or a salt thereof, or a solvate of teneligliptin or the salt thereof, in an amount 1.5- to 10-fold larger than that desired for the solid preparation.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 21, 2017
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Yasuaki Obayashi, Shinichiro Yasui, Hidaka Abe
  • Polyherbal composition for skin care
    Patent number: 9572766
    Abstract: Described herein is a polyherbal composition effective in skin care, including singularly or in certain combinations 0.01% to 15% of Ziziphus extract, 0.01% to 10% of Prunus extract, suitable delivery system, and a suitable carrier.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: February 21, 2017
    Assignee: Shiromani Gurudwara Prabandhak Committee's Guru Nanak Khalsa College
    Inventors: Sukhjeet Kaur Gujral, Ramesh Trimbak Sane
  • Vectors including an anionic macromolecule and a cationic lipid for delivering small nucleic acids
    Patent number: 9572776
    Abstract: The invention relates to a composition including (1) an anionic macromolecule except nucleic acids, (2) a cationic lip, and (3) a nucleic acid having a size lower than or equal to 200 nucleotides, such as an interference RNA, and to the use thereof in gene therapy.
    Type: Grant
    Filed: January 20, 2010
    Date of Patent: February 21, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS DESCARTES, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Virginie Escriou, Pascal Bigey, Daniel Scherman
  • Volatile anesthetic compositions and methods of use
    Patent number: 9566251
    Abstract: The present invention provides methods for reducing pain in a subject in need thereof by delivering a volatile anesthetic in a solution or an emulsion that can additionally include an extractive solvent in an amount effective to reduce pain without substantially interfering with motor function. Chronic or acute pain may be treated, or the volatile anesthetic may be delivered as a regional anesthetic to a subject to anesthetize a portion of the subject prior to surgery. Dosing regimes including a one-time administration, continuous and/or periodic administration are contemplated.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: February 14, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Allen Burton, Phillip C. Phan, Hatice Ozsoy, Christopher C. Capelli
  • Formulation of PEGylated-liposome encapsulated glycopeptide antibiotics
    Patent number: 9566238
    Abstract: This invention is directed to a novel method of treating an individual suffering from a bacterial infection, such as bacterial infections of various tissues or organs of an individual. In general, the method of treatment involves administering to an individual a pharmaceutical formulation that comprises a liposome-encapsulated antimicrobial agent, wherein polyethylene glycol (PEG) molecules are covalently attached to the surface of the liposomes.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: February 14, 2017
    Assignee: WESTERN UNIVERSITY OF HEALTH SCIENCES
    Inventors: Andrew Pumerantz, Guru Betageri, Jeffrey Jinghua Wang
  • High-purity steviol glycosides
    Patent number: 9562064
    Abstract: Methods of preparing highly purified steviol glycosides, particularly Rebaudioside D, are described. The methods include purification from the extraction stage of the Stevia rebaudiana Bertoni plant, purification of steviol glycoside mixtures, Rebaudioside D and Rebaudioside A from a commercial Stevia extract, and purification of Rebaudioside D from remaining solutions obtained after isolation and purification of Rebaudioside A and a high purity mixture of steviol glycosides. The methods are useful for producing high purity Rebaudioside D, Rebaudioside A, and steviol glycoside mixtures. The high purity steviol glycosides are useful as non-caloric sweeteners in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 7, 2017
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Oral care composition and processes for preparing same
    Patent number: 9561160
    Abstract: Described herein are processes for preparing an alcohol-free aqueous liquid toothpaste composition which is usable as a mouthwash, the liquid toothpaste being an oil-in-water emulsion with a clear appearance.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 7, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Aarti Rege, David F. Suriano, Richard Sullivan, Ricardo Couso
  • Labeled alginate conjugates for molecular imaging applications
    Patent number: 9562113
    Abstract: Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: February 7, 2017
    Assignee: Bellerophon BCM LLC
    Inventors: Fuqiang Ruan, Thomas L. Deckwerth, Martin D. Meglasson
  • Alkyl sulfate free and orthophosphate free dentifrice composition comprising fluoride source and a silica dental abrasive
    Patent number: 9554975
    Abstract: A dentifrice composition is described for combating dental erosion and/or tooth wear comprising a fluoride ion source and a silica dental abrasive, the dentifrice having a Relative Dentine Abrasivity (RDA) value from 20 to 60 and a pH in the range of 6.5 to 7.5 and being free of an orthophosphate buffer or a water soluble salt of a C10-18 alkyl sulfate.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: January 31, 2017
    Assignee: Glaxo Group Limited
    Inventors: Craig Sinclair Newby, Mark Andrew Nisbet, Katherine Sarah Price
  • Pharmaceutical composition and uses thereof
    Patent number: 9555001
    Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and/or a SGLT-2 inhibitor drug, and metformin XR, processes for the preparation thereof, and their use to treat certain diseases.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: January 31, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Masanori Ito, Kenji Egusa, Kyle Kleinbeck, Roman Messerschmid, Peter Schneider, Venkata Voleti
  • Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
    Patent number: 9550780
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: January 24, 2017
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • Controlled-release melatonin compositions and related methods
    Patent number: 9549900
    Abstract: A method of treating a human subject in need of melatonin therapy includes administering to a human subject a compressed tablet comprising melatonin, citric acid, and a cellulosic polymer. The melatonin, citric acid, and cellulosic polymer combine after ingestion to form an acidic hydrogel that dissolves the melatonin and is effective to provide a first release dose of melatonin for assisting in inducement of sleep and a subsequent sustained release dose of melatonin for assisting in sustaining sleep while in the human subject's gastrointestinal tract.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: January 24, 2017
    Assignee: Physician's Seal, LLC
    Inventors: Syed M. Shah, Daniel Hassan
  • Compositions and methods for controlling a honey bee parasitic mite infestation
    Patent number: 9545110
    Abstract: As described below, the present invention features methods and compositions for controlling a honey bee parasitic mite or for the treatment or prevention of a parasitic mite infestation in a honey bee hive. In particular embodiments, the invention provides a miticidal delivery device, wherein the device is a corrugated strip comprising a liquid composition comprising at least about 15% potassium salts of hop beta acids, solvent and an emulsifier.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: January 17, 2017
    Assignee: JOHN I. HAAS, INC.
    Inventors: Gene Probasco, Lloyd Schantz, Mark M. Bossert
  • Biomineral and metal binding liposomes, their synthesis, and methods of use thereof
    Patent number: 9545452
    Abstract: Drug carriers, methods of synthesizing, and methods of use thereof are provided. The drug carriers are liposomes comprising at least one functionalized cholesterol of the formula: Chol-X-T, wherein X is a linker domain, T is at least one targeting moiety which binds hard tissue and/or medical implants, and Chol is cholesterol or a derivative or analog thereof. The liposomes may encapsulate at least one therapeutic agent for the treatment of an oral disease or disorder.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: January 17, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Dong Wang, Xin-Ming Liu
  • Targeted delivery of anti-fungal agents
    Patent number: 9539273
    Abstract: The present application discloses a targeting composition that actively targets chitin-like substances, such as those found in fungi, protists, arthropods, Alzheimer's plaques, etc. Methods are disclosed for preparation of chitin-targeted drug delivery vehicles composed of the targeting composition and one or more bioactive compounds.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: January 10, 2017
    Assignee: EDH Biotech Corp
    Inventors: Thomas Meehan, Quyen Ong