Abstract: Controlled-release therapeutic compositions including melatonin combined with sedative and/or analgesic ingredients are described. The compositions have a solid core including melatonin in an acidified polymeric matrix. A sedative ingredient such as GABA receptor agonist may also be in the acidified polymeric matrix. The composition may include an expedited release portion providing a burst release of active ingredients and a sustained release portion providing a sustained release of active ingredients.
Type:
Grant
Filed:
May 6, 2016
Date of Patent:
January 3, 2017
Assignee:
Physician's Seal, LLC
Inventors:
Syed M. Shah, Daniel Hassan, Christopher Diorio, Fred Hassan
Abstract: Methods of treatment of NTM lung infections using formulations of liposomal ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
Type:
Grant
Filed:
March 31, 2015
Date of Patent:
January 3, 2017
Assignees:
ARADIGM CORPORATION, OREGON STATE UNIVERSITY
Inventors:
Igor Gonda, James Blanchard, David C. Cipolla, Luiz Eduardo Moreira Bermudez
Abstract: A composition having a pH in the range of from 3 to 8.5, comprising: (a) in the range of from 0.1% to <10% w/w (based on the total weight of the composition) of a stock solution comprising a mixture of bioflavonoids and fruit acids or salts thereof; (b) sodium hyaluronate; and (c) water; and, optionally, (d) a pharmaceutically acceptable carrier therefor; wherein the sodium hyaluronate has an average molecular weight of between 800,000 and 4,000,000.
Abstract: Provided are a method for searching for a malodor inhibitor by using the response of an olfactory receptor as an indicator; a method for inhibiting malodor based on the antagonism of olfactory receptors; and a malodor inhibitor. Disclosed are a method for searching for a malodor inhibitor, the method including: adding a test substance and a malodor-causing substance to any one olfactory receptor selected from the group consisting of OR51E1, OR2W1, OR10A6, OR51I2, and OR51L1, measuring the response of the olfactory receptor to the malodor-causing substance, identifying the test substance that suppresses the response of the olfactory receptor on the basis of the measured response, and selecting the identified test substance as a malodor inhibitor; an antagonist to any one olfactory receptor selected from the group consisting of OR51E1, OR2W1, OR10A6, OR51I2, and OR51L1; a method for inhibiting malodor using the antagonist.
Abstract: Disclosed herein are compositions comprising a fluoride ion source, a poly(propylene oxide)/poly(ethylene oxide) copolymer, and optionally a sparingly soluble acid; and methods of using and of making the same.
Type:
Grant
Filed:
December 20, 2011
Date of Patent:
December 20, 2016
Assignee:
Colgate-Palmolive Company
Inventors:
Andre Morgan, Marilou Joziak, Michael Prencipe
Abstract: The present invention relates to an antimicrobial and immunostimulatory system, applications thereof and a process for the production of the antimicrobial and immunostimulatory system. The present invention provides a storage-stable antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme, a substrate for the oxidoreductase enzyme and hydrogen peroxide in an aqueous solution wherein the substrate for the oxidoreductase enzyme is present up to 90% by weight and water is present up to 20% by weight based on the weight of the total composition; the system has a pH from approximately 4 to 8; and the system provides a two-stage hydrogen peroxide release.
Type:
Grant
Filed:
December 20, 2012
Date of Patent:
December 20, 2016
Assignee:
INSTITUTE OF TECHNOLOGY SLIGO
Inventors:
John Reginald Barrett, James Joseph Brennan, Thomas Patrick Patton
Abstract: The present invention relates to a formulation and method for the treatment of fungal nail infections, such as those caused by Trichophyton rubrum and/or Aspergillus niger. The formulation of the invention comprises glucose oxidase, D-glucose and hydrogen peroxide in an aqueous solution. Advantageously, the formulation of the invention provides a two-stage hydrogen peroxide release for the treatment of the fungal nail infections.
Type:
Grant
Filed:
January 2, 2013
Date of Patent:
December 20, 2016
Assignee:
Institute of Technology Sligo
Inventors:
John Reginald Barrett, James Joseph Brennan, Thomas Patrick Patton
Abstract: A dispersible moist wipe used to clean urine and fecal matter from the skin. The wetting solution is an oil-in-water emulsion containing silicone oil. Phase separation is prevented with one or more gums, propylene glycol alginate, and a Gemini surfactant or phosphate ester.
Type:
Grant
Filed:
June 21, 2013
Date of Patent:
December 6, 2016
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Stacy Averic Mundschau, Philip Eugene Kieffer, Corey Thomas Cunningham, Robert E Kasper
Abstract: The present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component thereof) and one or more fruit acid. The compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be added to other antimicrobial agents to enhance their activity. The invention provides effective alternatives to harsher products which may be particularly useful in personal care and household products and where children and/or pet exposure may be a concern.
Type:
Grant
Filed:
June 6, 2008
Date of Patent:
December 6, 2016
Assignee:
The Trustees of Columbia University in the City of New York
Inventors:
Shanta M. Modak, Nayana Baiju, Lauserpina A. Caraos
Abstract: Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) and other CNS stimulant responsive conditions include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 5 to 8 hours or longer, followed by an extended release.
Type:
Grant
Filed:
March 21, 2016
Date of Patent:
December 6, 2016
Assignee:
Ironshore Pharmaceuticals & Development, Inc.
Abstract: Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.
Type:
Grant
Filed:
June 17, 2015
Date of Patent:
November 29, 2016
Assignee:
LifeCell Corporation
Inventors:
Hui Xu, Wenquan Sun, Hua Wan, Rick T. Owens
Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.
Abstract: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth.
Abstract: Therapeutic compositions deliver a therapeutic amount of methylphenidate in a delayed and extended release formulation. The dosage form exhibits a lag time prior to release of from 6 to 8 hours or longer, followed by a sustained release period.
Type:
Grant
Filed:
March 14, 2016
Date of Patent:
November 22, 2016
Assignee:
Ironshore Pharmaceuticals & Development, Inc.
Abstract: Provided are compositions, e.g., oral and personal care products, comprising (i) a tetrabasic zinc-amino acid or trialkyl glycine-halide complex, and (ii) cysteine in free or in orally or cosmetically acceptable salt form, together with methods of making and using the same.
Type:
Grant
Filed:
November 7, 2013
Date of Patent:
November 22, 2016
Assignee:
COLGATE-PALMOLIVE COMPANY
Inventors:
Zhiqiang Liu, Long Pan, Joseph Convery, Shaotang Yuan, Harsh M. Trivedi
Abstract: The present invention relates to abradable films useful, e.g., in dentifrice formulations, wherein the film is stable in formulation, but abrades to release pigment or oral care active components upon brushing. The invention provides, e.g., an orally acceptable, water insoluble film which does not dissolve under formulation conditions but disintegrates upon brushing, comprising a polymer matrix, plasticizer (e.g., propylene glycol), releasable material (e.g., color or pigment) incorporated therein; and (optionally) nonionic surfactant (e.g. polysorbate), wherein the polymer matrix comprises at least 50%, e.g., at least 75%, of poly(vinyl alcohol), and 50% or less, e.g. 25% or less, of a water-soluble cellulose ether, for example hydroxypropyl methyl cellulose; together with dentifrice comprising such films, and methods of making and using the same.
Abstract: A system and method which enables application of a composition of matter to teeth (and gums), which composition of matter remains in contact with, and adheres to, said teeth and gums for a period long enough to neutralize acids in dental plaque biofilm, inhibit plaque from adhering to teeth and gums, encourage removal of dental plaque, and form a barrier between the teeth and gums and the oral environment.
Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
Type:
Grant
Filed:
November 9, 2012
Date of Patent:
November 15, 2016
Assignee:
Trustees of Tufts College
Inventors:
Gary G. Leisk, Tim Jia-Ching Lo, Lei Li, Evangelia Bellas, David L. Kaplan
Abstract: Methods and compositions are provided for treating an intervertebral disc herniation by local administration of one or more biodegradable drug depots comprising a therapeutically effective amount of a glucocorticoid at or near the intervertebral disc herniation to reduce the size of the intervertebral disc herniation.
Type:
Grant
Filed:
March 2, 2009
Date of Patent:
November 15, 2016
Assignee:
Warsaw Orthopedic, Inc.
Inventors:
Vanja M. King, John M. Zanella, Jared Wilsey
Abstract: A low calorie sweetener composition with sweetness synergy, providing a reduction in off-taste and a desirable temporal profile. The sweetener composition is suitable for use as a substitute for high calorie sugars. The sweetener composition may be used in food and beverage products, pharmaceutical products, nutritional product and cosmetic products.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
November 15, 2016
Assignee:
Tate & Lyle Ingredients Americas LLC
Inventors:
Ryan D. Woodyer, Jason C. Cohen, John R. Bridges