Patents Examined by G. Breitenstein
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Patent number: 4007220Abstract: High yields of phthalaldehydic acid from .alpha.,.alpha.,.alpha.,.alpha.',.alpha.'-pentachloro-o-xylene can be obtained in an excellent degree of purity if a mixture of said pentachloroxylene and phthalaldehydic acid in water is heated to a temperature between about 80.degree. and about 180.degree. C., and preferably at the boiling temperature of the reaction mixture. The mutual ratio of the reactants is not critical, and may vary within wide ranges, although it is usually preferred to have such a ratio between the said pentachloroxylene and phthalaldehydic acid that for each part by weight of the former at least 0.1 part by weight of the latter is present. Practically, there is no upper limit to the amount of phthalaldehydic acid which may be present, even to a large molecular excess.Type: GrantFiled: August 13, 1975Date of Patent: February 8, 1977Assignee: Gruppo Lepetit S.p.A.Inventors: Giorgio Montorsi, Renato Pellizzato, Anacleto Gianantonio
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Patent number: 4002671Abstract: Organic amine-organic acid addition salts are employed in compositions for topical application to a human being having a scalp or skin characterized by an excessive secretion of sebum to improve the condition of the scalp or skin by reducing said excessive secretion.Type: GrantFiled: December 20, 1974Date of Patent: January 11, 1977Assignee: Societe Anonyme dite: L'OrealInventor: Gregoire Kalopissis
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Patent number: 4000201Abstract: Organic liquids subject to oxidative decomposition, such as ethers, are stabilized against such decomposition by the addition of particulate, insoluble solid polymer resin to which is covalently bonded a plurality of oxidation active groups.Type: GrantFiled: October 4, 1974Date of Patent: December 28, 1976Assignee: Dynapol CorporationInventor: Ned M. Weinshenker
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Patent number: 3994977Abstract: Manufacture of formaldehyde by oxidative dehydrogenation of methanol in the presence of a silver catalyst, wherein methanol and water are evaporated in the presence of air in a plate column containing a number of double plates each consisting of a sieve plate and a lower plate having the form of a shallow bowl and inclined at a specific angle to the horizontal, the resulting vaporous mixture then being reacted. The formaldehyde which may be produced by the process of the invention is a disinfectant, tanning agent, reducing agent and a valuable starting material for the manufacture of synthetic resins, adhesives and plastics.Type: GrantFiled: May 10, 1974Date of Patent: November 30, 1976Assignee: BASF AktiengesellschaftInventors: Albrecht Aicher, Hans Haas, Oskar Hussey, deceased, Hans Diem, Guenther Matthias, Gunter Lehmann
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Patent number: 3994961Abstract: 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methylene-2 or 3 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methylene-5H-dibenzo[a,d]cyclohe ptane, prepared by various methods including acid dehydration of the corresponding dibenzo[a,d]cycloheptene-5-ols. The compounds are useful as anti-depressants.Type: GrantFiled: February 13, 1974Date of Patent: November 30, 1976Assignee: Sandoz, Inc.Inventors: William J. Houlihan, Jeffrey Nadelson
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Patent number: 3991103Abstract: 11-Halo derivatives of amitriptyline and its analogues, i.e. 5-(1'-halo-3'-aminoprop-1'-yl-idene)-5H-dibenzo[a,d]-10,11-dihydrocyclohep tenes and corresponding 11-oxa analogues as well as the acid addition salts thereof, have notable anti-depressant and tranquillising activity. They are prepared by reacting a 5-(3'-aminoprop-1'-ylidene)-5H-dibenz[a,d]-10,11-dihydrocycloheptene or an 11-oxa analogue thereof, or an acid addition salt thereof, with an electrophilic halogenating agent.Type: GrantFiled: October 21, 1974Date of Patent: November 9, 1976Assignee: Research Institute for Medicine and Chemistry Inc.Inventors: Derek Harold Richard Barton, Robert Henry Hesse
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Patent number: 3988370Abstract: Antibacterial and antifungal mono- and disubstituted amidinoureas and amidinothioureas are obtained by interaction of guanidines and isocyanates or isothiocyanates.Type: GrantFiled: August 24, 1973Date of Patent: October 26, 1976Assignee: Sterling Drug Inc.Inventors: Royal A. Cutler, Samuel Schalit
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Patent number: 3988380Abstract: A new process for preparing 1,2-disubstituted-trans-olefins selectively by reacting specific 2-alkenyl phosphonic acid derivatives with metal hydrides, and a new process for producing the specific 2-alkenylphosphonic acid derivatives. The 1,2-disubstituted-trans-olefins are useful as precursors for synthesis of insect pheromones.Type: GrantFiled: December 3, 1974Date of Patent: October 26, 1976Assignee: Sagami Chemical Research CenterInventors: Kiyosi Kondo, Akira Negishi, Daiei Tunemoto
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Patent number: 3987186Abstract: Compounds of the formula ##SPC1##Wherein theR.sub.1 ' s are hydrogen, alkyl of 1 to 3 carbon atoms or together a double-bonded oxygen,R.sub.2 is hydrogen, fluorine, chlorine, methyl, hydroxyl, methoxy, hydroxy-ethoxy, nitro or --SO.sub.3 H,R.sub.3 is hydrogen, fluorine, chlorine or methoxy,R.sub.4 is hydrogen, methyl or methoxy,R.sub.5 is hydrogen, fluorine, chlorine or methyl, andR.sub.6 is hydrogen or alkyl of 1 to 8 carbon atoms, and, when R.sub.6 is hydrogen, salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antiallergics.Type: GrantFiled: February 7, 1975Date of Patent: October 19, 1976Assignee: Boehringer Ingelheim GmbHInventors: John P. Devlin, Patrick Brian Stewart, Kurt Freter
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Patent number: 3987108Abstract: Compounds of the formula ##SPC1##WhereinN represents the number 0 or 1,Y represents --CH.sub.2 --, --N=N--, --CH.sub.2 O--, --NH--, ##EQU1## or the direct bond, Z represents oxygen or sulphur,R.sub.1 represents hydrogen, C.sub.1 -C.sub.5 -alkyl; ethynyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.3 -C.sub.5 -alkenyloxy, C.sub.3 -C.sub.5 -haloalkenyloxy, C.sub.3 -C.sub.5 -alkynyloxy, halogen, nitro, C.sub.2 -C.sub.5 -alkoxy-carbonyl, C.sub.3 -C.sub.5 -alkenyloxycarbonyl, C.sub.3 -C.sub.5 -alkynyl-oxycarbonyl, C.sub.1 -C.sub.2 -alkanoyl, di(-C.sub.1 -C.sub.4 -alkyl)carbamoyl, C.sub.1 -C.sub.4 -alkylthio,R.sub.2 represents hydrogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkoxy or halogen, orR.sub.1 and R.sub.2 together represent a 3,4-methylenedioxy group,R.sub.3 represents hydrogen or C.sub.1 -C.sub.3 -alkyl,R.sub.4 represents hydrogen, C.sub.1 -C.sub.3 -alkyl or halogen,R.sub.5 represents cyclohexyl or the group ##SPC2##andR.sub.Type: GrantFiled: April 12, 1974Date of Patent: October 19, 1976Assignee: Ciba-Geigy CorporationInventor: Friedrich Karrer
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Patent number: 3983168Abstract: Metal salts and amine salts of 2-nitro-5-(halophaenoxy) benzoic acids comprise a class of compounds that are highly effective pre- and post-emergence herbicides.Type: GrantFiled: September 4, 1975Date of Patent: September 28, 1976Assignee: Mobil Oil CorporationInventor: Robert J. Theissen
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Patent number: 3982018Abstract: 4-Phenylethers of 3-amino-5-sulfamoylbenzoic acids e.g. those of the formula ##SPC1##R = an araliphatic radicalX = o or SR' = h, alkyl or aminophenylAlkyl esters or salts thereof are diuretic agents.Type: GrantFiled: October 4, 1974Date of Patent: September 21, 1976Assignee: Ciba-Geigy CorporationInventor: Lincoln Harvey Werner
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Patent number: 3978134Abstract: The present invention concerns novel compounds of the formula: ##EQU1## wherein R.sub.1 to R.sub.9 have various significances including e.g. alkyl, X and Y include O and S and s, v, w and z are O or whole numbers and Ar.sub.1 is a formyl phenyl radical.The compounds possess insecticidal properties.Type: GrantFiled: May 21, 1974Date of Patent: August 31, 1976Assignee: Sandoz Ltd.Inventors: Hans-Peter Schelling, Fritz Schaub
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Patent number: 3976682Abstract: Novel secondary alkylammonium 3-secondary alkylaminoalkanoates are provided along with a method for preparing same by reacting a secondary alkyl primary amine and an alkenoic acid in the presence of an alcohol. The compounds have utility as freeze-thaw additives for paints, corrosion inhibitors, pigment grinding aids and paraffin inhibitors.Type: GrantFiled: August 5, 1974Date of Patent: August 24, 1976Assignee: Texaco Inc.Inventors: Jack H. Kolaian, John A. Patterson, Frank K. Ward
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Patent number: 3976685Abstract: Compounds having the formula ##EQU1## wherein X is OH or NH.sub.2 and n is a whole, positive integer of from 1-4, inclusive.Type: GrantFiled: August 11, 1975Date of Patent: August 24, 1976Assignee: American Cyanamid CompanyInventor: Joseph Adrian Hoffman
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Patent number: 3975431Abstract: Process for preparing carboxylic acids by converting a glycidonitrile to the enol acylate via hydrohalogenation, acylation and dehydrohalogenation procedures, and conversion of the enol acylate to the carboxylate salt with a base and of the salt to the carboxylic acid with acid. Cyanide content in the mixture is destroyed by adding persulfate or hypochlorite salts. This process, can be used, e.g., to prepare 2-(4'-isobutylphenyl)propionic acid, now known generically as ibuprofen, a highly active anti-inflammatory drug, as well as a host of other useful carboxylic acids.Type: GrantFiled: December 10, 1974Date of Patent: August 17, 1976Assignee: The Upjohn CompanyInventor: David R. White
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Patent number: 3969102Abstract: 2,4-Dichloro-3'-(.beta.-chloroethoxy)-4'-nitrodiphenyl ether is prepared by condensing 2,3',4-trichloro-4'-nitrodiphenyl ether with ethyleneglycol in the presence of an acid-binding agent and then chlorinating the hydroxyethoxy group of the resulting condensate. This compound posesses an excellent herbicidal activity to a wide variety of undesirable weeds with an extremely low phyto-toxicity to useful crops.Type: GrantFiled: August 21, 1974Date of Patent: July 13, 1976Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Takeo Yoshimoto, Keiichi Igarashi, Takeo Harayama, Masaaki Ura, Naoki Sato, Teruhiko Toyama, Osamu Morikawa, Yoshio Takasawa, Taisuke Kurechi
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Patent number: 3968163Abstract: Indane is reacted with an .alpha.,.alpha.-dichloromethyl lower alkyl ether, the reaction mixture is treated with water to produce a mixture of 4-formylindane and 5-formylindane, the aldehyde isomers are separated and the aldehydes are catalytically hydrogenated to produce 4-methylindane and 5-methylindane.Type: GrantFiled: August 19, 1974Date of Patent: July 6, 1976Assignee: Marion Laboratories, Inc.Inventors: William Ebenezer Solomons, Ian William Mathison
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Patent number: 3968168Abstract: 1,1-Diphenylalkanes having a p-tert-butyl and a p'-alkoxy group substituted thereon are a novel class of compounds having a broad range of insecticidal activity.Type: GrantFiled: August 23, 1974Date of Patent: July 6, 1976Assignee: Mobil Oil CorporationInventor: Jerry G. Strong
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Patent number: 3966805Abstract: The present invention concerns novel N,N'-diphenyl-N-(N"-alkylcarbamoyl)formamidine derivatives of the formula: ##EQU1## wherein R.sub.1 is hydrogen or alkyl, R.sub.2 is alkyl and Ar.sub.1 and Ar.sub.2 are each phenyl or a substituted phenyl, which compounds are useful as herbicides.The present invention relates to N,N'-diphenyl-N-(N"-alkylcarbamoyl)formamidine derivatives.The present invention provides compounds of formula I, ##EQU2## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.2 is alkyl of 1 to 4 carbon atoms, and eitherAr.sub.1 and Ar.sub.2 are the same, and are each phenyl or a substituted phenyl group selected from ##SPC1##WhereinR.sub.3 is chlorine, bromine, methyl, methoxy, or dimethyl or diethylsulphonamide andR.sub.4 is chlorine, bromine, methyl, methoxy or trifluoromethyl, orAr.sub.2 is phenyl andAr.sub.1 is a substituted phenyl group selected from ##SPC2##WhereinR.sub.3 ' is chlorine or methyl andR.sub.4 ' is chlorine, methyl or trifluoromethyl,With the proviso that Ar.sub.Type: GrantFiled: February 23, 1973Date of Patent: June 29, 1976Assignee: Sandoz Ltd.Inventors: Karl Seckinger, Fritz Reisser