Patents Examined by G. Breitenstein
  • Patent number: 4007220
    Abstract: High yields of phthalaldehydic acid from .alpha.,.alpha.,.alpha.,.alpha.',.alpha.'-pentachloro-o-xylene can be obtained in an excellent degree of purity if a mixture of said pentachloroxylene and phthalaldehydic acid in water is heated to a temperature between about 80.degree. and about 180.degree. C., and preferably at the boiling temperature of the reaction mixture. The mutual ratio of the reactants is not critical, and may vary within wide ranges, although it is usually preferred to have such a ratio between the said pentachloroxylene and phthalaldehydic acid that for each part by weight of the former at least 0.1 part by weight of the latter is present. Practically, there is no upper limit to the amount of phthalaldehydic acid which may be present, even to a large molecular excess.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: February 8, 1977
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Giorgio Montorsi, Renato Pellizzato, Anacleto Gianantonio
  • Patent number: 4002671
    Abstract: Organic amine-organic acid addition salts are employed in compositions for topical application to a human being having a scalp or skin characterized by an excessive secretion of sebum to improve the condition of the scalp or skin by reducing said excessive secretion.
    Type: Grant
    Filed: December 20, 1974
    Date of Patent: January 11, 1977
    Assignee: Societe Anonyme dite: L'Oreal
    Inventor: Gregoire Kalopissis
  • Patent number: 4000201
    Abstract: Organic liquids subject to oxidative decomposition, such as ethers, are stabilized against such decomposition by the addition of particulate, insoluble solid polymer resin to which is covalently bonded a plurality of oxidation active groups.
    Type: Grant
    Filed: October 4, 1974
    Date of Patent: December 28, 1976
    Assignee: Dynapol Corporation
    Inventor: Ned M. Weinshenker
  • Patent number: 3994977
    Abstract: Manufacture of formaldehyde by oxidative dehydrogenation of methanol in the presence of a silver catalyst, wherein methanol and water are evaporated in the presence of air in a plate column containing a number of double plates each consisting of a sieve plate and a lower plate having the form of a shallow bowl and inclined at a specific angle to the horizontal, the resulting vaporous mixture then being reacted. The formaldehyde which may be produced by the process of the invention is a disinfectant, tanning agent, reducing agent and a valuable starting material for the manufacture of synthetic resins, adhesives and plastics.
    Type: Grant
    Filed: May 10, 1974
    Date of Patent: November 30, 1976
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Aicher, Hans Haas, Oskar Hussey, deceased, Hans Diem, Guenther Matthias, Gunter Lehmann
  • Patent number: 3994961
    Abstract: 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methylene-2 or 3 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methylene-5H-dibenzo[a,d]cyclohe ptane, prepared by various methods including acid dehydration of the corresponding dibenzo[a,d]cycloheptene-5-ols. The compounds are useful as anti-depressants.
    Type: Grant
    Filed: February 13, 1974
    Date of Patent: November 30, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Patent number: 3991103
    Abstract: 11-Halo derivatives of amitriptyline and its analogues, i.e. 5-(1'-halo-3'-aminoprop-1'-yl-idene)-5H-dibenzo[a,d]-10,11-dihydrocyclohep tenes and corresponding 11-oxa analogues as well as the acid addition salts thereof, have notable anti-depressant and tranquillising activity. They are prepared by reacting a 5-(3'-aminoprop-1'-ylidene)-5H-dibenz[a,d]-10,11-dihydrocycloheptene or an 11-oxa analogue thereof, or an acid addition salt thereof, with an electrophilic halogenating agent.
    Type: Grant
    Filed: October 21, 1974
    Date of Patent: November 9, 1976
    Assignee: Research Institute for Medicine and Chemistry Inc.
    Inventors: Derek Harold Richard Barton, Robert Henry Hesse
  • Patent number: 3988370
    Abstract: Antibacterial and antifungal mono- and disubstituted amidinoureas and amidinothioureas are obtained by interaction of guanidines and isocyanates or isothiocyanates.
    Type: Grant
    Filed: August 24, 1973
    Date of Patent: October 26, 1976
    Assignee: Sterling Drug Inc.
    Inventors: Royal A. Cutler, Samuel Schalit
  • Patent number: 3988380
    Abstract: A new process for preparing 1,2-disubstituted-trans-olefins selectively by reacting specific 2-alkenyl phosphonic acid derivatives with metal hydrides, and a new process for producing the specific 2-alkenylphosphonic acid derivatives. The 1,2-disubstituted-trans-olefins are useful as precursors for synthesis of insect pheromones.
    Type: Grant
    Filed: December 3, 1974
    Date of Patent: October 26, 1976
    Assignee: Sagami Chemical Research Center
    Inventors: Kiyosi Kondo, Akira Negishi, Daiei Tunemoto
  • Patent number: 3987108
    Abstract: Compounds of the formula ##SPC1##WhereinN represents the number 0 or 1,Y represents --CH.sub.2 --, --N=N--, --CH.sub.2 O--, --NH--, ##EQU1## or the direct bond, Z represents oxygen or sulphur,R.sub.1 represents hydrogen, C.sub.1 -C.sub.5 -alkyl; ethynyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.3 -C.sub.5 -alkenyloxy, C.sub.3 -C.sub.5 -haloalkenyloxy, C.sub.3 -C.sub.5 -alkynyloxy, halogen, nitro, C.sub.2 -C.sub.5 -alkoxy-carbonyl, C.sub.3 -C.sub.5 -alkenyloxycarbonyl, C.sub.3 -C.sub.5 -alkynyl-oxycarbonyl, C.sub.1 -C.sub.2 -alkanoyl, di(-C.sub.1 -C.sub.4 -alkyl)carbamoyl, C.sub.1 -C.sub.4 -alkylthio,R.sub.2 represents hydrogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkoxy or halogen, orR.sub.1 and R.sub.2 together represent a 3,4-methylenedioxy group,R.sub.3 represents hydrogen or C.sub.1 -C.sub.3 -alkyl,R.sub.4 represents hydrogen, C.sub.1 -C.sub.3 -alkyl or halogen,R.sub.5 represents cyclohexyl or the group ##SPC2##andR.sub.
    Type: Grant
    Filed: April 12, 1974
    Date of Patent: October 19, 1976
    Assignee: Ciba-Geigy Corporation
    Inventor: Friedrich Karrer
  • Patent number: 3987186
    Abstract: Compounds of the formula ##SPC1##Wherein theR.sub.1 ' s are hydrogen, alkyl of 1 to 3 carbon atoms or together a double-bonded oxygen,R.sub.2 is hydrogen, fluorine, chlorine, methyl, hydroxyl, methoxy, hydroxy-ethoxy, nitro or --SO.sub.3 H,R.sub.3 is hydrogen, fluorine, chlorine or methoxy,R.sub.4 is hydrogen, methyl or methoxy,R.sub.5 is hydrogen, fluorine, chlorine or methyl, andR.sub.6 is hydrogen or alkyl of 1 to 8 carbon atoms, and, when R.sub.6 is hydrogen, salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antiallergics.
    Type: Grant
    Filed: February 7, 1975
    Date of Patent: October 19, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: John P. Devlin, Patrick Brian Stewart, Kurt Freter
  • Patent number: 3983168
    Abstract: Metal salts and amine salts of 2-nitro-5-(halophaenoxy) benzoic acids comprise a class of compounds that are highly effective pre- and post-emergence herbicides.
    Type: Grant
    Filed: September 4, 1975
    Date of Patent: September 28, 1976
    Assignee: Mobil Oil Corporation
    Inventor: Robert J. Theissen
  • Patent number: 3982018
    Abstract: 4-Phenylethers of 3-amino-5-sulfamoylbenzoic acids e.g. those of the formula ##SPC1##R = an araliphatic radicalX = o or SR' = h, alkyl or aminophenylAlkyl esters or salts thereof are diuretic agents.
    Type: Grant
    Filed: October 4, 1974
    Date of Patent: September 21, 1976
    Assignee: Ciba-Geigy Corporation
    Inventor: Lincoln Harvey Werner
  • Patent number: 3978134
    Abstract: The present invention concerns novel compounds of the formula: ##EQU1## wherein R.sub.1 to R.sub.9 have various significances including e.g. alkyl, X and Y include O and S and s, v, w and z are O or whole numbers and Ar.sub.1 is a formyl phenyl radical.The compounds possess insecticidal properties.
    Type: Grant
    Filed: May 21, 1974
    Date of Patent: August 31, 1976
    Assignee: Sandoz Ltd.
    Inventors: Hans-Peter Schelling, Fritz Schaub
  • Patent number: 3976685
    Abstract: Compounds having the formula ##EQU1## wherein X is OH or NH.sub.2 and n is a whole, positive integer of from 1-4, inclusive.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: August 24, 1976
    Assignee: American Cyanamid Company
    Inventor: Joseph Adrian Hoffman
  • Patent number: 3976682
    Abstract: Novel secondary alkylammonium 3-secondary alkylaminoalkanoates are provided along with a method for preparing same by reacting a secondary alkyl primary amine and an alkenoic acid in the presence of an alcohol. The compounds have utility as freeze-thaw additives for paints, corrosion inhibitors, pigment grinding aids and paraffin inhibitors.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: August 24, 1976
    Assignee: Texaco Inc.
    Inventors: Jack H. Kolaian, John A. Patterson, Frank K. Ward
  • Patent number: 3975431
    Abstract: Process for preparing carboxylic acids by converting a glycidonitrile to the enol acylate via hydrohalogenation, acylation and dehydrohalogenation procedures, and conversion of the enol acylate to the carboxylate salt with a base and of the salt to the carboxylic acid with acid. Cyanide content in the mixture is destroyed by adding persulfate or hypochlorite salts. This process, can be used, e.g., to prepare 2-(4'-isobutylphenyl)propionic acid, now known generically as ibuprofen, a highly active anti-inflammatory drug, as well as a host of other useful carboxylic acids.
    Type: Grant
    Filed: December 10, 1974
    Date of Patent: August 17, 1976
    Assignee: The Upjohn Company
    Inventor: David R. White
  • Patent number: 3969102
    Abstract: 2,4-Dichloro-3'-(.beta.-chloroethoxy)-4'-nitrodiphenyl ether is prepared by condensing 2,3',4-trichloro-4'-nitrodiphenyl ether with ethyleneglycol in the presence of an acid-binding agent and then chlorinating the hydroxyethoxy group of the resulting condensate. This compound posesses an excellent herbicidal activity to a wide variety of undesirable weeds with an extremely low phyto-toxicity to useful crops.
    Type: Grant
    Filed: August 21, 1974
    Date of Patent: July 13, 1976
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Takeo Yoshimoto, Keiichi Igarashi, Takeo Harayama, Masaaki Ura, Naoki Sato, Teruhiko Toyama, Osamu Morikawa, Yoshio Takasawa, Taisuke Kurechi
  • Patent number: 3968168
    Abstract: 1,1-Diphenylalkanes having a p-tert-butyl and a p'-alkoxy group substituted thereon are a novel class of compounds having a broad range of insecticidal activity.
    Type: Grant
    Filed: August 23, 1974
    Date of Patent: July 6, 1976
    Assignee: Mobil Oil Corporation
    Inventor: Jerry G. Strong
  • Patent number: 3968163
    Abstract: Indane is reacted with an .alpha.,.alpha.-dichloromethyl lower alkyl ether, the reaction mixture is treated with water to produce a mixture of 4-formylindane and 5-formylindane, the aldehyde isomers are separated and the aldehydes are catalytically hydrogenated to produce 4-methylindane and 5-methylindane.
    Type: Grant
    Filed: August 19, 1974
    Date of Patent: July 6, 1976
    Assignee: Marion Laboratories, Inc.
    Inventors: William Ebenezer Solomons, Ian William Mathison
  • Patent number: 3966805
    Abstract: The present invention concerns novel N,N'-diphenyl-N-(N"-alkylcarbamoyl)formamidine derivatives of the formula: ##EQU1## wherein R.sub.1 is hydrogen or alkyl, R.sub.2 is alkyl and Ar.sub.1 and Ar.sub.2 are each phenyl or a substituted phenyl, which compounds are useful as herbicides.The present invention relates to N,N'-diphenyl-N-(N"-alkylcarbamoyl)formamidine derivatives.The present invention provides compounds of formula I, ##EQU2## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.2 is alkyl of 1 to 4 carbon atoms, and eitherAr.sub.1 and Ar.sub.2 are the same, and are each phenyl or a substituted phenyl group selected from ##SPC1##WhereinR.sub.3 is chlorine, bromine, methyl, methoxy, or dimethyl or diethylsulphonamide andR.sub.4 is chlorine, bromine, methyl, methoxy or trifluoromethyl, orAr.sub.2 is phenyl andAr.sub.1 is a substituted phenyl group selected from ##SPC2##WhereinR.sub.3 ' is chlorine or methyl andR.sub.4 ' is chlorine, methyl or trifluoromethyl,With the proviso that Ar.sub.
    Type: Grant
    Filed: February 23, 1973
    Date of Patent: June 29, 1976
    Assignee: Sandoz Ltd.
    Inventors: Karl Seckinger, Fritz Reisser