Patents Examined by Ganapathy Krishnan
  • Patent number: 11498981
    Abstract: The present invention relates to a process for producing a low endotoxin alkali chitosan, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan with an alkali solution to form a mixture and leaving the mixture for at least about 12 hours. The low endotoxin alkali chitosan may be used the manufacture of other useful chitosan based products.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: November 15, 2022
    Assignee: MEDTRADE PRODUCTS LIMITED
    Inventors: June Gladman, Craig Hardy, Andrew Hoggarth
  • Patent number: 11491232
    Abstract: The present disclosure relates to the field of pharmaceutical chemistry, and particularly to a compound represented by Formula (I), a preparation method and medical use thereof. In the compound represented by Formula (I), a lactulosyl group is connected to a heteroatom of genin (G) via a glycosidic bond, wherein the genin (G) is a group formed by removing one hydrogen atom from a heteroatom of an active pharmaceutical molecule, and “” indicates that the lactulosyl group is connected to the heteroatom of the genin (G) via an ?-glycosidic bond or a ?-glycosidic bond. Pharmacokinetic experiments prove that the lactuloside compound according to the present disclosure can pass through the gastrointestinal tract of a mammal without being absorbed significantly by the gastrointestinal tract and hydrolyzed significantly by endogenous enzymes of a mammal host. Therefore, the lactuloside compound can arrive at the colon site of the mammal, and release an active drug in the colon under the action of colon flora.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: November 8, 2022
    Assignee: Fruithy Holdings Limited
    Inventors: Shanchun Zhang, Jiashi Peng, Bin Yang, Yihua Wang, Min Xu, Xiao Wang, Kaisheng Cheng
  • Patent number: 11485799
    Abstract: The present disclosure discloses an ultrasonic-assisted method of extracting a pectin rich in RG-I. The method includes: (1) dispersing citrus peel powders in an alkaline solution containing sodium borohydride; (2) placing a solution obtained in step (1) in a water bath of 25 to 40° C., and performing an ultrasonic treatment on the solution obtained in step (1); (3) centrifuging the solution subjected to step (2) at a speed of 6000-8000 rpm to remove residues, retaining a supernatant, and precipitating a pectic polysaccharide with absolute ethanol; and (4) adding water to the pectic polysaccharide precipitant subjected to step (3) to obtain a redissolved solution, transferring the solution to a dialysis bag with a molecular weight cut-off of 3000 to 3500 Da, dialyzing for 48 hours, and freeze-drying in a vacuum freezer to obtain the pectin rich in RG-I.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: November 1, 2022
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Xingqian Ye, Weiwei Hu, Shiguo Chen, Huan Cheng, Donghong Liu
  • Patent number: 11485798
    Abstract: The present invention relates to a process for producing a low endotoxin alkali chitosan, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan with an alkali solution to form a mixture and leaving the mixture for at least about 12 hours. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products.
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: November 1, 2022
    Assignee: MEDTRADE PRODUCTS LIMITED
    Inventors: June Gladman, Craig Hardy, Andrew Hoggarth
  • Patent number: 11479765
    Abstract: The present disclosure relates to a method/system for preparing encapsulated exosomes from a biological sample containing exosomes, said method comprising: a) dispersing inorganic oxide particles into a buffer solution comprising a polymer and a biological sample comprising exosomes, b) allowing the polymer to react with the inorganic oxide particles to form capsules, wherein the exosomes are inside the capsules. The present disclosure also relates to a method/system for isolating and purifying encapsulated exosomes, said method comprising: a) preparing an aqueous micellar system comprising at least one surfactant, and at least one salt; b) mixing a biological sample containing encapsulated exosomes with the aqueous micellar system from step a); c) allowing the aqueous micellar system to phase separate, wherein the surfactant partitions substantially into one phase, and the other phase has a lower concentration of surfactant; and d) obtaining the encapsulated exosomes from the capsule-rich phase.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: October 25, 2022
    Assignee: Phase Scientific International, Ltd.
    Inventor: Yin To Chiu
  • Patent number: 11470845
    Abstract: The present application is directed to antimicrobial compositions comprising chitosan polymers of at least two different average molecular weights (Mws), wherein the Mw of each different chitosan polymer is selected to target a different microorganism as well as method of making and using the compositions and product comprising the compositions.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: October 18, 2022
    Assignee: CHINOVA BIOWORKS INC.
    Inventors: David Brown, Tanzina Huq, Natasha Dhayagude
  • Patent number: 11453693
    Abstract: A purified composition of steviol glycoside molecules is described. The composition imparts desirable taste, flavor and flavor modifying properties to food, beverages, and other consumable products.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: September 27, 2022
    Assignees: PURECIRCLE USA INC., The Coca-Cola Cola Company
    Inventors: Siddhartha Purkayastha, Avetik Markosyan, Siew Yin Chow, Indra Prakash, John Clos, Ivory Xingyu Peng, Michael Z. Kagan, Steven F. Sukits, Kasi V. Somayajula, Khairul Nizam Bin Nawi
  • Patent number: 11446319
    Abstract: A composition containing one or more materials selected from the group consisting of fatty acids, proteins, peptides, amino acids, vitamins, minerals, alcohols, sweeteners, acidulants, antioxidants, thickening stabilizer, and surfactants, and a flavonoid-cyclodextrin inclusion compound, wherein the inclusion compound contains an inclusion compound obtained by treating a flavonoid having a rhamnoside structure with an enzyme having rhamnosidase activity in the presence of a cyclodextrin. According to the present invention, the bitterness and the changes in color tones originated from flavonoids can be inhibited, and foodstuff or the like having an unpleasant taste can be improved, so that the present invention can be suitably utilized in fields such as medicaments, foodstuff, health foods, foods for specified health use, and cosmetics.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: September 20, 2022
    Assignee: TAIYO KAGAKU CO., LTD.
    Inventors: Masamitsu Moriwaki, Kentaro Kumoi, Ryo Nakagawa, Miki Sagisaka, Makoto Ozeki
  • Patent number: 11440975
    Abstract: The invention relates a process for preparing a cross-linked starch-based polymer comprising the following steps: 1) dissolving a starchy material in a suitable solvent to form a starchy material solution; and 2) adding a episulfide of formula (I), wherein R1, R2, R3 and R4 are independently selected from hydrogen and (C1-C3)alkyl in the starchy material solution in order to obtain the disulfide crosslinked starch-based polymer. In another aspect the invention concerns a disulfide-cross-linked starch-based polymer obtainable by the process of the invention, that is characterized by only disulfide bridges.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: September 13, 2022
    Assignee: ROQUETTE FRERES
    Inventors: Francesco Trotta, Fabrizio Caldera
  • Patent number: 11440932
    Abstract: The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing an aqueous solution of biological membrane-associated membrane proteins into contact with at least one compound of the invention. The present invention also relates to a method for stabilizing membrane proteins in solution in an aqueous solution, comprising a step (i) consisting in bringing an aqueous solution of a membrane protein in solution into contact with at least one compound of the invention.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: September 13, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE GRENOBLE ALPES
    Inventors: Pierre Falson, Julien Dauvergne, Ahcène Boumendjel, Marine Peuchmaur, Kim Anh Nguyen, Sandrine Magnard
  • Patent number: 11440931
    Abstract: Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: September 13, 2022
    Assignee: Jinan University
    Inventors: Xinsheng Yao, Yang Yu, Dan Zhang, Yang Ni, Xiuqi Bao, Lin Li, Caixía Zang, Hao Gao, Yuanpeng Zheng
  • Patent number: 11434307
    Abstract: There is described a process for obtaining a target chemical species, in particular alginate and/or cellulose, from seaweed. The process comprises the steps of: (i) providing a seaweed portion; (ii) bleaching the seaweed portion; and (iii) extracting the target chemical species from the seaweed portion; wherein the bleaching comprises a neutral or alkaline bleaching step, the neutral or alkaline bleaching step comprising using a bleaching composition under neutral or alkaline conditions. The neutral or alkaline bleaching step may precede the extraction step. Also described is alginate, an alginate salt, alginic acid, an alginic acid salt, an alginate derivative, an alginate derivative salt, cellulose, and/or a cellulose derivative obtained by the process.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: September 6, 2022
    Assignee: MARINE BIOPOLYMERS LTD
    Inventors: David Mackie, Marianne O'Byrne, Audrey Jaszewski
  • Patent number: 11432578
    Abstract: A synthetic mixture of human milk oligosaccharides (HMOs) consisting essentially of lacto-N-neotetraose (LNnT), lacto-N-tetraose (LNT), 2?-fucosyllactose (2?FL), 3?-O-sialyllactose (3?-SL), 6?-O-sialyllactose (6?-SL) either difucosyllactose (DFL) or 3-fucosyllactose (3-FL), preferably DFL, and optionally lactose. Said synthetic composition is useful for: treating or preventing viral and/or bacterial infection in a non-infant human; modulating the microbiota of a non-infant human; and/or improving the cognitive function of a non-infant human and as a pharmaceutical or nutritional composition.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: September 6, 2022
    Assignee: GLYCOM A/S
    Inventors: Bruce McConnell, Louise Kristine Vignæs
  • Patent number: 11433092
    Abstract: Described herein are a solution, composition, and kit of poly (acetyl, arginyl) glucosamine (PAAG), methods of making the solution, and method of treating wounds with the solution, the method comprising administering to a subject an effective amount of a solution comprising PAAG, wherein the PAAG when administered topically contacts the wound, thereby treating the wound.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 6, 2022
    Assignee: SYNEDGEN, INC.
    Inventors: Shenda M. Baker, William P. Wiesmann, Stacy M. Townsend
  • Patent number: 11426424
    Abstract: A method for treatment of vaginal disorders may include: administering topically to a subject in need thereof a therapeutically effective amount of molecular oxygen and hyaluronic acid. The molecular oxygen may be in gaseous form. The vaginal disorders may be selected between vaginal dryness and vulvovaginal atrophy.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: August 30, 2022
    Assignee: CARESS FLOW S.r.l.
    Inventor: Leone Condemi
  • Patent number: 11414551
    Abstract: A complex of beta-cyclodextrin and graphene (CD-G) and a method of use of the complex in corrosion protection of the metal surfaces exposed to high saline concentrations. Composite laminates comprise CD-G, zinc (optionally magnesium) powder embedded in a resin matrix and adjacent to the metal, followed by polyurethane comprising a polymeric zinc chelator, followed by a hermetic sealant layer and finally by a hydrophobic self-cleaning fouling release layer as a topcoat. Optional managed stress of the laminated layers by temperature swings and mechanical vibration ensures resolution of local strain at the formative stage and not during functioning, producing defects that are healed during deposition of the next layer. More than 99% of the zinc and other toxic ions extracted from the metal and coating are intercepted by the selective chelator layer insulated under the sealer and fouling-release layers.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: August 16, 2022
    Assignee: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: Rami Khalid Suleiman, Tawfik Abdo Saleh
  • Patent number: 11382884
    Abstract: A method of treating or preventing a bacterial infection in the lung of a subject by administering an inhaled antibiotic, and at least 37.5 mg/day of an inhaled chelating agent, each in one or more doses, wherein the or each dose of the chelating agent and/or antibiotic is administered over a period of no more than 8h.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: July 12, 2022
    Assignee: Respirion Pharmaceuticals PTY LTD
    Inventor: Barry Clements
  • Patent number: 11377470
    Abstract: Disclosed herein are methods for purifying RNA comprising poly A. Also disclosed herein are compositions such as surfaces and oligonucleotides for purifying RNA comprising polyA. Other embodiments are also disclosed. Commercially-available resins having polythymidine oligonucleotide ligands typically contain less than 30 thymidine (2?deoxy) residues and some commercial resin suppliers utilize a distribution of dT chain lengths, not of a discreet length.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 5, 2022
    Assignee: ModernaTX, Inc.
    Inventors: William Joseph Issa, John Grant Aunins, Stephane Bancel
  • Patent number: 11370848
    Abstract: A glycosaminoglycan derivative endowed with heparanase inhibitory activity and antitumor activity, bearing carboxylate groups in positions 2 and 3 of at least part of the glycosaminoglycan residues, and to the process for preparing the same. The glycosaminoglycan derivatives of the present invention are generated starting from natural or synthetic glycosaminoglycans, preferably heparin or low molecular weight heparin, optionally 2-O- and 2-N-desulfated by two steps of oxidation. By the first oxidation, adjacent dials and optionally adjacent OH/NH2 of the glycosaminoglycan residues are converted to aldehydes and by the second oxidation said dialdehydes are converted to carboxylate groups. The first oxidation preferably leads to the cleavage of C2-C3 linkage of the ring of oxidable residues. The invention relates to a process for the preparation of said glycosaminoglycan derivatives and to their use as active ingredients of medicaments.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: June 28, 2022
    Assignee: Novahealth Biosystems, LLC
    Inventors: Giangiacomo Torri, Annamaria Naggi
  • Patent number: 11369680
    Abstract: Compositions and methods of using these compositions that can include a targeting moiety and a therapeutic agent are described herein. These compositions can be used for treating inflammatory diseases, such as parasitic diseases that result in cutaneous lesions. For example, and without limitation, such an parasitic disease can be leishmaniasis.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 28, 2022
    Assignee: Navidea Biopharmaceuticals, Inc.
    Inventor: Frederick O. Cope