Patents Examined by Ganapathy Krishnan
  • Steroid compounds as RORyt modulators and uses thereof
    Patent number: 9505798
    Abstract: Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R1a, R1b, R2a, R2b, R3a, R3b, R3c, R3d, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: November 29, 2016
    Assignees: New York University, Memorial Sloan-Kettering Cancer Center
    Inventors: Dan R. Littman, Jun R. Huh, Nicolas Gabriel Albert Manel, Daniel A. Ryan, David Y. Gin, Mary S. Gin, Michael R. Krout
  • CDC7 kinase inhibitors and uses thereof
    Patent number: 9492427
    Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: November 15, 2016
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Mark G. Frattini, Hakim Djaballah, Thomas J. Kelly
  • Attractant for bone marrow stem cells and method for attracting bone marrow stem cells
    Patent number: 9486465
    Abstract: Provided are an attractant for bone marrow stem cells containing at least one of cinnamtannin B1 and pentagalloylglucose, and a method for attracting bone marrow stem cells in which bone marrow stem cells are attracted by the attractant.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: November 8, 2016
    Assignees: Pias Corporation, Osaka University
    Inventors: Tadashi Furumoto, Koichi Nakaoji, Kazuhiko Hamada, Noriyasu Ozawa, Yuta Inami, Misaki Toyoshima, Kosuke Fujita, Akito Maeda, Yasufumi Kaneda, Katsuto Tamai
  • Low anticoagulant heparins
    Patent number: 9480701
    Abstract: The present invention relates to a chemically modified heparin, with an antifactor II activity of less than 10 IU/mg, an antifactor Xa activity of less than 10 IU/mg and an average molecular weight (Mw) between about 6.5 and 9.5 kDa. Also disclosed is a method of preparing the heparin and its medical use, including treatment of malaria.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: November 1, 2016
    Assignee: DILAFORETTE AB
    Inventors: Hans-Peter Ekre, Ulf Lindahl, Erik Holmer, Per-Olov Eriksson, Anna Leitgeb, Mats Wahlgren, Stefania Tiddia, Lino Liverani
  • Substrates and methods for collection, stabilization and elution of biomolecules
    Patent number: 9480966
    Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: November 1, 2016
    Assignee: General Electric Company
    Inventors: Ernest William Kovacs, Erik Leeming Kvam, Bing Li, Frank John Mondello
  • Pharmaceutical composition comprising dapagliflozin and cyclodextrin
    Patent number: 9480755
    Abstract: The present invention relates to pharmaceutical compositions comprising dapagliflozin and cyclodextrin, preferably (2-hydroxy)propyl-b-cyclodextrin or ?-cyclodextrin, preferably as inclusion complex. The invention further relates to a process for producing said pharmaceutical compositions. Finally, the invention relates to the use of cyclodextrin for producing dapagliflozin-containing dosage forms and to methods of purification of dapagliflozin.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: November 1, 2016
    Assignee: ratiopharm GmbH
    Inventors: István Puskas, Lajos Szente
  • Method for 2-sulfation of glycosides
    Patent number: 9481701
    Abstract: Method for selective 2-sulfation of glycosides.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: November 1, 2016
    Assignee: University of Washington
    Inventors: Michael H. Gelb, Sophie Blanchard
  • Use of chemically modified heparin derivates in sickle cell disease
    Patent number: 9480702
    Abstract: The present invention relates to chemically modified heparin for use in the treatment of sickle cell disease, with an antifactor II activity of less than 10 IU/mg, an antifactor Xa activity of less than 10 IU/mg and an average molecular weight (Mw) between about 6.5 and 9.5 kDa.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: November 1, 2016
    Assignee: DILAFORETTE AB
    Inventors: Hans-Peter Ekre, Anna Leitgeb, Mats Wahlgren, Dagmar Pikas
  • Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use
    Patent number: 9475888
    Abstract: The present invention relates to a chemically modified glycosaminoglycan with an antifactor II activity of less than 10 IU/mg, an antifactor Xa activity of less than 10 IU/mg and an average molecular weight (Mw, weight average) from about 4.6 to 6.9 kDa. Also disclosed is a method of preparing the modified glycosaminoglycan and its medical uses.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: October 25, 2016
    Assignee: Dilafor AB
    Inventors: Hans-Peter Ekre, Ulf Lindahl, Erik Holmer, Per-Olov Eriksson
  • Kit for adhering biological hard tissues
    Patent number: 9474826
    Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: October 25, 2016
    Assignees: National University Corporation Okayama University, Junsei Educational Institution
    Inventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
  • Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants
    Patent number: 9474703
    Abstract: The antimicrobial composition of the present invention comprises a cationic active ingredient, a quaternized sugar-derived surfactant, and an optional foam boosting surfactant. These formulations have a high cidal activity in a short amount of time and provide stable copious foam. The formulations of the present invention also exhibit enhanced tissue (e.g. skin) compatibility as defined by an in vitro whole toxicology assessment method.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: October 25, 2016
    Assignee: Ecolab USA Inc.
    Inventors: Daniel E. Pedersen, Angela R. Eder, Charles Allen Hodge
  • Cellulose mixed esters
    Patent number: 9458248
    Abstract: The present invention relates to cellulose mixed esters, processes for preparing these and uses of the cellulose mixed esters, for example in coating compositions. The cellulose mixed esters have glass transition temperatures that fall within an appropriate range to allow for film formation to occur at ambient temperatures and have a total degree of substitution per anhydroglucose unit of about 2.5 to about 3.5; a residual hydroxyl functionality per anhydroglucose unit of 0 to about 0.5; a degree of substitution per anhydroglucose unit by C2-C6 ester groups of about 0.5 to about 2.8; and a degree of substitution per anhydroglucose unit by Ievulinyl ester groups of about 0.2 to about 2.6.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: October 4, 2016
    Assignee: Resene Paints Limited
    Inventors: Mark Glenny, Colin Gooch, Simon Hinkley, Jennifer Mason, Cameron Tristram, Dennis Williams
  • Pharmaceutical/cosmetic compositions comprising hyaluronic acid and treatment of dermatological conditions therewith
    Patent number: 9452126
    Abstract: Pharmaceutical/cosmetic compositions containing a dermatologically effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation, formulated into a physiologically acceptable medium therefor, are useful for the treatment of wrinkles, fine lines, fibroblast depletions and scars.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: September 27, 2016
    Assignee: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Marc Moutet, Jean-Claude Yadan
  • Process for treating microfibrillated cellulose and microfibrillated cellulose treated according to the process
    Patent number: 9447540
    Abstract: The present invention relates to a process for dewatering a slurry comprising microfibrillated cellulose wherein the process comprises the following steps of, providing a slurry comprising microfibrillated cellulose and liquid, subjecting the slurry to an electric field inducing the liquid of the slurry to flow and separating the liquid from the microfibrillated cellulose. The invention also relates to microfibrillated cellulose dewatered according to the process.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: September 20, 2016
    Assignee: Stora Enso OYJ
    Inventors: Isto Heiskanen, Kaj Backfolk, Ari Kotilainen, Valentas Gaidelis, Jonas Sidaravicius
  • Semisynthetic derivatives of Nystatin A
    Patent number: 9447136
    Abstract: The invention provides semisynthetic derivatives of Nystatin A1, water soluble salts and complexes, pharmaceutical compositions and plant protection products comprising the derivatives and their use, as antifungal antibiotics (Formula 1a).
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: September 20, 2016
    Assignee: BLIRT S.A.
    Inventors: Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Maria Milewska, Malgorzata Wysocka, Slawomir Milewski, Andrzej Skladanowski, Adam Treder, Ewa Sadowska, Izabela Chabowska
  • Process for treating cellulose and cellulose treated according to the process
    Patent number: 9447541
    Abstract: The present invention relates to a process for purifying a slurry comprising cellulose, such as microfibrillated cellulose, wherein the process comprises the following steps: —providing a slurry comprising cellulose and liquid, —subjecting the slurry to an electric field inducing the liquid of the slurry to flow, —separating the liquid from the cellulose thus obtaining a liquid depleted slurry, —adding a washing liquid, such as an organic solvent, to the liquid depleted slurry—subjecting the liquid depleted slurry to an electric field inducing the washing liquid of the slurry to flow and—separating the washing liquid from the cellulose, thus obtaining a purified cellulose. The invention also relates to cellulose such as microfibrillated cellulose obtainable from said process.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: September 20, 2016
    Assignee: Stora Enso OYJ
    Inventors: Isto Heiskanen, Kaj Backfolk, Ari Kotilainen, Valentas Gaidelis, Jonas Sidaravicius
  • Compositions and methods for disinfecting materials
    Patent number: 9439998
    Abstract: The present invention relates to methods for disinfecting or decontaminating a material or for preventing an infection or contamination of a material. The invention further relates to compositions which are suitable for disinfecting a material or for preventing an infection or contamination of a material and to uses of such compositions. The invention further relates to a medical use of chitosan and to a pharmaceutical composition comprising the chitosan. The invention further relates to a method of treating a microbial infection and to an aqueous solution comprising chitosan. The invention moreover relates to a chitosan or a pharmaceutical composition comprising a chitosan for an epithelial cell growth stimulating treatment of a patient's tissue and to a method of stimulating the growth of epithelial cells. The invention also relates to a tissue dressing material.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: September 13, 2016
    Assignee: Medoderm GmbH
    Inventors: Karsten Henco, Thomas Freier, Rivelino Montenegro
  • Cosmetic solution, method for producing cosmetic solution, and cosmetic method
    Patent number: 9439839
    Abstract: Provided are a cosmetic solution and a method for producing the cosmetic solution, the cosmetic solution being easy to store and also easy to handle during use, and moreover having a high moisturizing function, without the use of a preservative. Hyaluronic acid/or a hyaluronic acid compound is dispersed in a polyvalent alcohol, also, an organic acid and/or organic acid salt different from the hyaluronic acid and/or hyaluronic acid compound is dispersed in a polyvalent alcohol such that it contains no water. The solution contains 0.01 to 2.0 wt % hyaluronic acid and/or hyaluronic acid compound 97 wt % or more polyvalent alcohol, is weakly acidic; i.e. 5?pH<7 due to the organic acid and/or organic acid salt.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: September 13, 2016
    Inventor: Yukako Sugawara
  • Phytoestrogenic compositions for preventing or treating symptoms associated with menopause
    Patent number: 9433595
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating a menopausal symptom, comprising cinnamic acid, shanzhiside methylester or a mixture thereof as an active ingredient. The composition of the present invention exhibits an excellent estrogenic activity, and is effectively utilized for treating or preventing diverse menopausal symptoms generated by estrogen deficiency during perimenopause, menopause and postmenopause.
    Type: Grant
    Filed: December 26, 2008
    Date of Patent: September 6, 2016
    Assignee: Natural Endotech Co., Ltd.
    Inventors: Jae-Soo Kim, Bo-Yeon Kwak, Kwontaek Yi, Jaekyoung Lee
  • Isoflavone compositions for reducing accumulation of body fat in male mammals, and methods for their use
    Patent number: 9427002
    Abstract: Edible compositions useful for weight management in male animals are disclosed. The compositions comprise one or more isoflavones or isoflavone metabolites and are particularly useful for reducing or preventing the accumulation of body fat. Also disclosed are methods useful for weight management in an animal utilizing compositions comprising one or more isoflavones. The compositions and methods are particularly useful for the reduction or prevention of body fat accumulation during periods of excess caloric intake, and preferably have a sparing effect on lean body mass.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: August 30, 2016
    Assignee: Nestec S.A.
    Inventor: Yuanlong Pan