Abstract: 1,3-dichloroacetone oxime is prepared from 1,3-dichloropropanone by reaction with a hydroxylamine salt in a strongly acidic medium in the presence of a base selected from the group consisting of tertiary amines, lower alkyl amides, alkali metal bicarbonates, alkali metal carbonates and alkaline earth metal carbonates. 1,3-dichloroacetone oxime acetate is advantageously prepared by reaction of the oxime with acetic anhydride. The acetate is obtained in high purity.

Abstract: Carbamate derivatives of ketoximes are useful in combatting pests such as insects, mites, and nematodes.

Abstract: 19-Hydroxy carbinol analogues of PGE.sub.1 having the structure ##STR1## are disclosed as bronchodilators. Methods of preparing the analogues are also disclosed.

Abstract: A process for preparing penicillins, in which 6APA is treated with a polar solvent, then with an organic base to give a mixture which is cooled at a temperature lower than -25.degree. C. A cyclic derivative of boron is added to the mixture and the temperature is increased to about 0.degree. C.An intermediate compound is formed which by treatment first with an acylating agent and then with a mixture of water and alcohol provides a solution containing the penicillin.

Abstract: N,N'-[1,2-Ethanediylbis(thio)]bis[N-methylcarbamic fluoride] useful as an intermediate in preparation of insecticides.

Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

Abstract: Ketonimine dyes of the formula selected from: ##STR1## wherein X.crclbar. is a chloride, bromide, thiocyanate, sulfamate, formate, acetate, lactate, hydrogen sulfate or dihydrogen phosphate ion; and ##STR2## wherein Y is a sulfate or hydrogen phosphate ion are hydrosulfite bleachable dyes for paper.

Abstract: The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).

Abstract: A process for the production of a monohaloacetylhalide characterized in that a ketene is reacted with a halogen in the presence of a diester of phosphonic acid of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different alkyl or aryl, or R.sub.1 and R.sub.2 are the same or different alkyl or aryl and R.sub.3 is --COOR or --CH.sub.2 COOR, wherein R is alkyl or aryl. The diester is a solvent which impedes or prevents the formation of polyhaloacylhalides and which keeps the formation of acylhalides to a minimum.

Abstract: An alkyl ester of a chloro- or bromo-fluoroacetic acid is reacted with chlorosulfonic acid to produce the corresponding acid chloride. Exemplary is the reaction of ethylchlorofluoroacetate with chlorosulfonic acid at 120.degree.-200.degree. C to produce chlorofluoroacetyl chloride.

Abstract: An improved process is described for the reduction of ammonium ions, while avoiding any increase in nitrate ion concentration, in a liquid stream recycled between a zone of synthesis of hydroxyl ammonium salt and a zone for synthesis of oxime, wherein the liquid stream is contacted with a gas stream consisting essentially of nitrogen monoxide and containing nitrogen dioxide at a pressure above 1 atmosphere, at a temperature of at least 80.degree. C., such that after the contact the molar NO.sub.2 /NO ratio of the gas stream is within the range of between about 10.sup.-1 to 10.sup.-4 :1.

Abstract: There are prepared acyl cyanides of the formula ##STR1## where R is a straight or branched chain alkyl group having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, and which also can be substituted by one or more phenyl groups or halogen atoms, preferably chlorine, or R is preferably a cycloalkyl group having 3 to 8 carbon atoms, preferably cyclopropyl, which can have one or more 1 to 3 carbon atoms alkyl or halogen, preferably chlorine, substituents wherein in all of the above set forth substitutions the halogen atoms and the phenyl groups are not on the carbon atom adjacent to the carbonyl group or R is a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a five membered heterocyclic group, e.g., furyl, thienyl or alkyl substituted thienyl wherein the substituents on the phenyl or naphthyl are halogen atoms, nitro groups or alkyl or alkoxy groups having 1 to 5 carbon atoms.

Abstract: This disclosure teaches that certain halo aniline derivatives, when applied post-emergence to plants, effect a modification of the growth pattern of said plant.

Abstract: Perfluoro-alkoxy propionic acid fluorides may be obtained by reacting hexafluoro-propene epoxide with a perfluoro-carboxylic fluoride in an aprotic polar solvent in the presence of a N,N,N', N'-tetrasubstituted diaminodifluoromethane as catalyst.The compounds obtained may be used as starting products for valuable perfluoro ethers which are highly inert towards heat or aggressive chemicals, such as fluorine.

Abstract: Benzoyl cyanide is made by reacting benzoic anhydride with an alkali cyanide in an inert organic solvent.

Abstract: The novel process of the invention comprises selectively chlorinating benzoyl chloride in the absence of a solvent to about 7-8% unconverted benzoyl chloride, and recovering the resultant 3-chlorobenzoyl chloride in high yield from the reaction product mixture. A feature of the process is that the ratio of 3-chlorobenzoyl chloride to 2,5-dichlorobenzoyl chloride by-product is maximized.

Abstract: Bis-chloromethyl ether (CME) and 1,1,1,2-tetrachloroethane (TCE) impurities are efficiently eradicated from chloroacetyl chloride (CAC) by a process comprising contacting the CAC, containing about 100 to about 250 ppm CME and about 1 weight percent, based on the weight of the CAC, of TCE, with a catalytic amount of ferric and/or aluminum cations at a temperature at least about 50.degree. C. This process does not require hydrochloric acid and yields CAC containing less than detectable (<0.5 ppm CME, <0.05 wt. % TCE) amounts of the impurities.

Abstract: Phloroglucinol may be produced by converting s-triacetyl benzene to benzene-1,3,5-tris-acetoxime which is a novel compound. Said acetoxime is subjected to a Beckmann rearrangement and the resulting mixture subsequently hydrolyzed to produce phloroglucinol.

Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.

Abstract: Certain novel 6-acylamino-2,2-dimethyl-3-(5-tetrazolyl)penam derivatives, and salts thereof; their use as broad-spectrum antibacterial agents; and methods for their preparation. Their preparation comprises acylation of the novel intermediate, 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam or simple derivatives thereof, followed, in some cases, by further transformations of the 6-acylamino group or by removal of a protecting group from the 5-tetrazolyl moiety. Process for the preparation of 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam, simple derivatives thereof and intermediates therefor.