Abstract: The present invention provides for a formulation comprising: at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid.

Abstract: The present invention generally relates to the transdermal delivery of various compositions. In some aspects, the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt, a nitric oxide donor, and optionally, a hostile biophysical environment. In some cases, the composition may be stabilized using a stabilization polymer such as xanthan gum, KELTROL® BT and/or KELTROL® RD; propylene glycol; and a polysorbate surfactant such as Polysorbate 20, which unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

Abstract: The pharmaceutical composition includes a drug layer comprising an active ingredient, a surfactant, an acidic component and an effervescent ingredient. The active ingredient comprises a nucleic acid, a peptide or a protein. The acidic component and effervescent ingredient of the drug layer are dissolved in the water to react for generating carbon dioxide and bubbles thereof. The surfactants surround the carbon dioxide gas core and form a double-layer structure having an inner layer and outer layer. The active ingredient is embedded in a gap formed between the inner layer and the outer layer of the double-layer structure.

Abstract: The invention relates to a cosmetic composition in particular in the form of an emulsion for topical application to keratin materials, in particular the skin, comprising, in a physiologically acceptable medium: (i) at least one dispersion (pre-dispersion) of bismuth oxychloride (CI 77163) in an oily dispersant chosen from a) monoesters of formula R1COOR2 in which R1 represents a linear or branched hydrocarbon-based chain comprising from 4 to 40 carbon atoms, preferably from 4 to 30 carbon atoms, and preferentially from 7 to 20 carbon atoms, and R2 represents a branched hydrocarbon-based chain containing from 3 to 40 carbon atoms, preferably from 10 to 30 carbon atoms, and preferentially from 16 to 26 carbon atoms; b) oils whose solubility parameter at 25° C., ?a, is greater than 6 (J/cm3)1/2, and mixtures thereof, and (ii) at least one oil chosen from hydrocarbon-based oils having a refractive index greater than 1.42 and a solubility parameter at 25° C.

Abstract: The invention provides for a low pH disinfectant composition that includes a relatively low amount of alcohol. Also provided is an article of manufacture that includes a textile and the composition, as well as methods of using the composition and article of manufacture (e.g., for reducing the number of microbes located upon a substrate, for killing or inhibiting a broad spectrum of microorganisms, for killing or inhibiting spore forming bacteria, and/or for disinfecting a substrate). The composition can optionally include a stable residual antimicrobial compound, thereby providing a combination of high-level disinfection and long-lasting residual effect.

Abstract: The present invention provides compositions methods and kits for improved infant formula, particularly to insulin-supplements and formulae comprising same that mimic the diurnal rhythm and/or the postpartum variation of insulin in human milk.

Abstract: Improved pharmacokinetic profiles for the iontophoretic delivery of sumatriptan are described.

Abstract: Methods of mitigating the effects of radiation exposure or providing a radioprotective effect in a subject are provided herein. The methods include administering a therapeutically effective amount of cerium oxide nanoparticles to the subject to mitigate the effects of radiation exposure or to offer a radioprotective effect to the subject. The cerium oxide nanoparticles are suitably less than 20 nm in diameter and have over 50% of the cerium in the 3+ oxidation state.

Abstract: The invention relates to a product for oral delivery of nicotine containing a core comprising a powder of at least one free nicotine salt, at least one pH adjusting agent and at least one filler, and a water insoluble pouch, wherein said pouch is permeable for saliva and therein dissolved parts of the powder, wherein said product upon contact with purified water gives a pH of at least 6. The invention also relates to a method to manufacture such a product.

Abstract: A nanocomposite includes carbon-encapsulated transition metal oxide nanoparticles. The carbon-encapsulated transition metal oxide nanoparticles comprise a transition metal oxide core having a diameter of from 5 nm to 50 nm covered by a graphitic coating having a thickness of from 1 nm to 5 nm.

Abstract: The present invention is directed to an anti-aging product, a single use multi-chamber packaging and a method of using the anti-aging product for reducing and/or preventing age-related skin symptoms. More particularly, the present invention is directed to a single use multi-chamber packet that has at least two chambers or compartments each containing at least one portion of an anti-aging composition, wherein said portions can be combined prior to application to the skin for reducing and/or preventing age-related skin symptoms. In another embodiment, the present invention is directed to an anti-aging kit comprising at least two or more single use multi-chamber packets, each having at a different composition for reducing and/or preventing age-related skin symptoms.

Abstract: Provided are systems for controlled release of proteins from decomposable thin films constructed by layer-by-layer deposition. Such films generally comprise alternating layers of polymers and proteins, and may further comprise additional layers of polyions. In some embodiments, decomposable thin films and methods of using such films allow proteins to be released over an extended period of time and/or retention of as much as 100% of function of released protein.

Abstract: The present disclosure is directed to a method for delivering a pharmaceutical composition to a patient in need thereof, comprising: administering to said patient a pharmaceutical composition in unit dose form comprising naproxen, or pharmaceutically acceptable salt thereof, and esomeprazole, or pharmaceutically acceptable salt thereof.

Abstract: Exopolysaccharide of a bacterial strain for its use in treatment and/or care of the skin, mucous membranes, hair and/or nails, as well as its cosmetic and/or dermopharmaceutical compositions. In particular, for the aging of skin and in particular for the treatment and/or prevention of wrinkles.

Abstract: A method of stimulating elastin and/or collagen production in the tissues of the vagina, comprising the steps of providing a composition including at least one of a water soluble zinc salt such as zinc sulfate and a peroxisome proliferator-activated receptor beta/delta (PPAR ?/?) agonist, and administering the composition to the tissue of the vagina. Compositions for stimulating 5 elastin and/or collagen production in the tissues of the vagina are also disclosed.

Abstract: The invention provides methods and compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a prebiotic composition, optionally in combination with effective amount of a probiotic microbe or microbes.

Abstract: A consumable aqueous gel is provided for use in pest control. The gel sates the thirst of pests and increases the consumption of bait by pests. The gel is substantially free of biocides. The gel may be provided as a combination for use in a pest control device. The combination comprises an aqueous gel which is substantially free of biocides and a bait. A pest control device comprises a container having a first compartment containing an aqueous gel which is substantially free of biocides. A method of controlling pests comprises the step of deploying any of the aforementioned aqueous gel, combination according or pest control device. An aqueous gel which is substantially free of biocides may be used with or in a pest control device.

Abstract: Disclosed are water-based cosmetic compositions comprising a synthetic non-associative thickening polymer, a synthetic associative thickening polymer, an emulsifier, and a liquid fatty substance, wherein the composition has a viscosity of from about 2,000 Pa·s to about 90,000 Pa·s at low shear rate as measured on a TA instrument G2 Rheometer.

Abstract: An antimicrobial metal complex surface and a method of fabricating the same, and the method includes providing an article, and the article has a first metal complex surface treated by anodization. The first metal complex surface is formed with a first pore. Secondly a silver suspension is provided. The silver suspension also has pore sealing agent. The article is soaked in the suspension to form a pore sealing layer having silver particles on the first metal complex surface such that the silver particles are distributed in the pore sealing layer. The antimicrobial metal complex surface fabricated by the method inhibits microorganism growth on the anodized metal surface.

Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per litre ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.