Patents Examined by Glennon H. Hollrah
  • Acetamide derivatives
    Patent number: 5270342
    Abstract: The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: December 14, 1993
    Assignee: Imperial Chemical Industries PLC
    Inventors: David R. Brittain, Steven P. Brown, Anthony L. Cooper, Jethro L. Longridge, Jeffrey J. Morris, John Preston, Linda Salter
  • Method for defoliating and desiccating cotton
    Patent number: 5270287
    Abstract: N-Aryl tetrahydrophthalimides are useful as cotton defoliants nd desiccants.
    Type: Grant
    Filed: October 19, 1992
    Date of Patent: December 14, 1993
    Assignee: Valent U.S.A. Corporation
    Inventor: Billy R. Corbin, Jr.
  • Increasing blood-brain barrier permeability with permeabilizer peptides
    Patent number: 5268164
    Abstract: Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more permeable. The permeabilizer A-7 or conformational analogues can be intravenously co-administered to a host together with molecules whose desired destination is the cerebrospinal fluid compartment of the brain. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive at this destination.
    Type: Grant
    Filed: April 23, 1991
    Date of Patent: December 7, 1993
    Assignee: Alkermes, Inc.
    Inventors: John W. Kozarich, Gary F. Musso, Bernard Malfroy-Camine
  • Methods and compositions for treating plants exposed to ozone
    Patent number: 5268017
    Abstract: Methods and compositions for the protection of plant tissue from damage upon exposure to air pollutants, and to assist plant tissue in recovering from air pollution injury, include the application of an effective amount of stress-protectant compositions selected from the group consisting of tetrahydrofurfuryl alcohol, tetrahydrofurfuryl amine and mixtures thereof. The compositions are applied as aqueous solutions containing between about 0.005 and about 25 wt % of the stress-protectant components. Surfactants may be included to improve application of the compositions to the plants.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: December 7, 1993
    Assignee: Great Lakes Chemical Corporation
    Inventors: Charles C. Shin, Nicolai A. Favstritsky
  • Cyclophosphamide--amino acid lyophilizates
    Patent number: 5268368
    Abstract: A stable rapidly dissolving lyophilized composition of cyclophosphamide and an amino acid selected from the group consisting of glycine, valine and serine is provided which contains an amount of water which is equimolar to the amount of amino acid and the amount of cyclophosphamide in said composition; the composition is preferably prepared from a solution containing at least 2% (W/V) of the amino acid and having a pH in the range of 5.0 to 7.0.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: December 7, 1993
    Assignee: Erbamont, Inc.
    Inventor: Nageswara R. Palepu
  • Herbicidal emulsifiable suspension concentrate compositions
    Patent number: 5268352
    Abstract: There are provided compositions comprising concentrated amount of an herbicidally active agent, or combination of agents, in a solid state suspended in a water immiscible solvent containing an anionic surfactant and a nonionic surfactant and optionally containing an antifoam agent and a suspending or thickening agent. Upon dilution with hard or soft water, said compositions readily form sprayable herbicidal emulsions.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: December 7, 1993
    Assignee: American Cyanamid Company
    Inventor: Robin W. Dexter
  • Preparation of amide derivatives of hydroxy acids
    Patent number: 5268507
    Abstract: Depolymerizing high molecular weight polyhydroxy acid by reacting with an amine to produce an amide derivative.
    Type: Grant
    Filed: November 22, 1991
    Date of Patent: December 7, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Loren D. Brake
  • Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
    Patent number: 5268165
    Abstract: Compositions comprising a covalently bounded adduct of deferoxamine, ferric iron and polymer for image enhancement in magnetic resonance (MR) imaging are provided. A pharmaceutical composition comprising the adduct and method of using the composition in magnetic resonance imaging are also disclosed.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: December 7, 1993
    Assignee: Biomedical Frontiers, Inc.
    Inventors: Bo E. Hedlund, Philip E. Hallaway
  • Electrocatalytic hydrogenations of nitriles to amines
    Patent number: 5266731
    Abstract: Described are processes for producing amines from nitriles. The processes include electrocatalytic hydrogenations of nitriles in the presence of transition metal-oxide and/or transition metal-hydroxide cathodes to thereby form amines. Preferred modes of the invention provide highly advantageous processes for producing hexamethylenediamine from adiponitrile.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: November 30, 1993
    Assignee: Reilly Industries
    Inventors: William M. Ayers, Mary H. Dean
  • Enzymatic production of maltohexaose-rich compositions
    Patent number: 5266467
    Abstract: Malto-oligosaccharide compositions which contain up to about 40% maltohexaose by weight are produced from starchy substrates and maltodextrins by a simple, one-step hydrolysis with certain thermostable .alpha.-amylase from Bacillus stearothermophilus. This process is particularly useful in the production of novel compositions with properties that will lead to new applications in both food and nonfood industries.
    Type: Grant
    Filed: February 1, 1991
    Date of Patent: November 30, 1993
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventor: George E. Inglett
  • Method for rapid in vivo assessment of intravenous irritation of pharmaceutical compositions
    Patent number: 5266301
    Abstract: The present invention is a method for rapid in vivo assessment of intravenous irritation of pharmaceutical compositions. The assessment of the vascular irritability of new pharmaceutical agents, vehicles and their pharmaceutical compositions has traditionally been limited to histological characterization of postinfusion damage. These studies utilized about 15 conscious animals and required about two weeks to complete. The method of the present invention in contrast utilizes fewer animals and can be completed in as short as only about 2-4 hr. In addition the direct observation is contemporaneous with the infusion and utilized a central vein.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: November 30, 1993
    Assignee: The Upjohn Company
    Inventors: Ricardo Ochoa, Bruce C. Graves
  • Method of manufacturing a dry water-soluble herbicidal salt composition
    Patent number: 5266553
    Abstract: A method of manufacturing a solid, water-soluble herbicidal composition comprising a water-soluble salt of a herbicidal compound is disclosed. The herbicidal compound is a water-insoluble compound that includes a carboxylic acid functionality, such as a phenoxy-substituted carboxylic acid compound or a substituted benzoic acid compound, and is sufficiently pure to form a dry, solid herbicidal salt composition after interaction with a suitable neutralizing base, such as ammonia, an alkylamine, a dialkylamine, a trialkylamine, a hydroxyalkylamine, a dihydroxyalkylamine, an alkaline salt of an alkali metal or a combination thereof. The dry herbicidal salt composition includes at least about 90% by weight of the water-soluble herbicidal salt, and dissolves rapidly and essentially completely in water to form an aqueous herbicidal solution including up to about 75% by weight of the water-soluble herbicidal salt.
    Type: Grant
    Filed: October 21, 1991
    Date of Patent: November 30, 1993
    Assignee: Riverdale Chemical Company
    Inventors: James K. Champion, Conrad T. Harwell
  • Sterically hindered oxime color improvers for polyolefin processing
    Patent number: 5266726
    Abstract: Sterically hindered oximes provide polyolefin compositions, including those also containing a phenolic antioxidant, with improved resistance to discoloration during processing at elevated temperatures.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: November 30, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Stephen D. Pastor, Paul A. Odorisio
  • New intermediates, process for their preparation, and their use for the synthesis of vitamins A and E
    Patent number: 5266708
    Abstract: New intermediates and processes for the preparation of vitamins A and E, which are the acetals of 5,6-dihalo-3-methyl-3-hydroxyhexanal or of 6-halo-3-hydroxy-3-methyl-5-hexenal or 3-methyl-3-hydroxy-5-hexenal, as well as processes for making the intermediates. After dehydrohalogenation and dehydration these intermediates are condensed directly with .beta.-ionone or with 2-methyl-2-heptene-6-one to synthesize vitamins A and E respectively.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: November 30, 1993
    Assignee: Rhone-Poulenc Nutrition Animale
    Inventors: Pierre F. Charbardes, Lucette Duhamel, Pierre Duhamel, Jerome Guillemont, Jean-Marie Poirier
  • Herbicidal method comprising the use of diflufenican
    Patent number: 5264411
    Abstract: The present invention relates to a method of controlling the growth of weeds at a cereal crop locus which comprises applying to the locus (a) bromoxynil, which is 3,5-dibromo-4-hydroxybenzonitrile, or ioxynil, which is 4-hydroxy-3,5-diiodobenzonitrile, an agriculturally acceptable salt or ester thereof or a mixture thereof and (b) diflufenican which is N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)nicotinamide.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: November 23, 1993
    Assignee: May & Baker Limited
    Inventors: Richard H. Hewett, Ponnan Veerasekaran
  • Hydrophilic free radicals for magnetic resonance imaging
    Patent number: 5264204
    Abstract: Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance contrast media within the scope of the present invention include stable hydrophilic free radicals having a hydrophilic moiety, such as polyhydroxyalkyl groups and heterocyclic amino-alcohols such as dihydroxypyrrolidine, dihydroxypiperidine, and trihydroxypiperidine, and a stable free radical moiety, such as a nitroxide, phenoxy, or phenoxazinyl free radical moiety.
    Type: Grant
    Filed: April 30, 1992
    Date of Patent: November 23, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: William P. Cacheris, T. Jeffrey Dunn, Lynn deLearie, Youlin Lin, Jeffrey A. Levine
  • Process for the preparation of aromatic amines
    Patent number: 5262539
    Abstract: Electrophilic aromatic compounds can be reacted with sulphenamides in the presence of bases to form the corresponding aromatic amines.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: November 16, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Mieczyslaw Makosza, Maciej Bialecki
  • Synthesis of polysaccharide covered superparamagnetic oxide colloids
    Patent number: 5262176
    Abstract: In a method for the synthesis of a colloid including a superparamagnetic metal oxide coated with a polymer, an acidic solution of a metal salt and a polymer may be cooled, and then neutralized by the controlled addition of a cool solution of a base, and may then be converted, by the application of heat, to a homogenous superparamagnetic metal oxide colloid. According to a preferred embodiment, the polymer may be a polysaccharide. In a further embodiment of the invention, the polysaccharide may be dextran and the metal salt may be ferrous and ferric salts, which produces, according to the methods of the invention, a superparamagnetic iron oxide colloid with an extended plasma half-life.
    Type: Grant
    Filed: May 2, 1991
    Date of Patent: November 16, 1993
    Assignee: Advanced Magnetics, Inc.
    Inventors: Stephen Palmacci, Lee Josephson
  • Salts of N-nitrosophenylhydroxylamine
    Patent number: 5262569
    Abstract: Disclosed are salts of N-nitrosophenylhydroxylamine and their use as polymerization inhbitors.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: November 16, 1993
    Assignee: Rohm and Haas Company
    Inventors: Rita K. Upmacis, William Bauer, Jr., Samuel F. Reed, Jr.
  • Herbicidal compositions with increased crop safety
    Patent number: 5262380
    Abstract: Disclosed are herbicidal concentrate formulation compositions having reduced crop plant phytotoxicity comprising N-(2,6-difluorophenyl)-5-methyl-1,2,4-triazolo(1,5-a) pyrimidine-2-sulfonamide or an amine salt thereof in admixture with one or more amine salts of 2,4-D; also disclosed is the preparation of said compositions and the pre- and post-emergent agricultural uses thereof in water diluted form.
    Type: Grant
    Filed: March 24, 1992
    Date of Patent: November 16, 1993
    Assignee: DowElanco
    Inventor: Robert L. Noveroske