Patents Examined by Glennon H. Hollrah
  • Patent number: 5480585
    Abstract: A photoresist stripping liquid composition comprising an alkanol amine compound, a sulfone compound or sulfoxide compound, and a hydroxy compound. The composition is excellent in its photoresist stripping performance, safety and working efficiency, and does not cause corrosion on a substrate possessing a metal film.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: January 2, 1996
    Assignee: Nagase Electronic Chemicals, Ltd.
    Inventors: Shinichiro Shiotsu, Yoshiaki Horiuchi
  • Patent number: 5478837
    Abstract: Compositions and methods for prevention of adhesion formation, whereby an effective amount of quinacrine as active agent is administered for a period of time sufficient to permit tissue repair. The active agent is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, lipid-based systems, viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the compound at an effective level.
    Type: Grant
    Filed: June 7, 1994
    Date of Patent: December 26, 1995
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. Dizerega
  • Patent number: 5478959
    Abstract: A method for preparing 1,4-(Z,Z)-disubstituted-1,4-disulfurated-1,3-butadienes is disclosed. The butadienes can be further elaborated to provide 3,6-unsymmetrically-substituted-1,2-dithiins. Also disclosed are butadienes prepared by the method of the invention. These butadienes are useful as intermediates in the synthesis of antibiotic 1,2-dithiins.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: December 26, 1995
    Assignee: The Research Foundation of State University of New York
    Inventors: Eric Block, Chuangxing Guo
  • Patent number: 5476969
    Abstract: The invention relates to highly reactive polyoxyalkylene-polyols prepared by oxyalkylation of an initiator molecule containing, in bonded form, at least 2 reactive hydrogen atoms and at least one tertiary amino group bonded via a spacer bridge, which preferably comprises an alkylene radical having at least 3 carbon atoms, by means of at least one alkylene oxide, preferably ethylene oxide and/or 1,2-propylene oxide, to a process for the preparation of these polyoxyalkylene-polyols, and to their use for the production of compact or cellular, preferably flexible polyisocyanate polyaddition products.
    Type: Grant
    Filed: September 28, 1992
    Date of Patent: December 19, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Werner Hinz, Stefan Adams, Ulrich Koehler, Christian Maletzko, Klaus Vorspohl, Ruth Zschiesche
  • Patent number: 5475022
    Abstract: Compounds of Formula 1 ##STR1## wherein m is 1-4; R.sub.1 --R.sub.4 independently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R.sub.5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; R.sub.6 is hydrogen, lower alkyl, Cl, Br, I, OR.sub.11, SR.sub.11, OCOR.sub.11, SCOR.sub.11, NH2, NHR.sub.11, N(R.sub.11).sub.2, NHCOR.sub.11 OR NR.sub.11 --COR.sub.11 ; R.sub.20 is independently hydrogen or lower alkyl; Y is an aromatic group such as phenyl or naphthyl, or a heteroaryl group selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl and oxazolyl; A is (CH.sub.2).sub.n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.
    Type: Grant
    Filed: October 18, 1993
    Date of Patent: December 12, 1995
    Assignee: Allergan, Inc.
    Inventor: Roshantha A. Chandraratna
  • Patent number: 5475140
    Abstract: 4-Amino-3-methyl-N-ethyl-N-(.beta.-hydroxyethyl)-aniline sulfate which is used particularly as a developer for color photography can be easily produced in high yield and high quality by nitrosating N-ethyl-N-(.beta.-hydroxyethyl)-m-toluidine by use of an alkyl nitrite in a homogeneous alcohol solution containing sulfuric acid in an amount of about 0.5 to about 1 mole per mole of N-ethyl-N-(.beta.-hydroxyethyl)-m-toluidine, and then reducing the nitrosation product in an aqueous alcohol solution after or without isolation of the nitrosation product.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: December 12, 1995
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Takehiko Iritani, Ryohiko Kinoshita, Yoshiki Kametani
  • Patent number: 5466470
    Abstract: This invention provides a co-micronized bicarbonate salt composition which is a blend of ingredients having a particle size between about 0.01-1.0 micron. The composition is produced by mill co-micronization of a crystalline bicarbonate ingredient and a crystalline inorganic compound ingredient having a Mohs hardness value between about 3-7. A co-micronized blend such as sodium bicarbonate and zinc oxide is free-flowing and essentially free of agglomerated particles.
    Type: Grant
    Filed: May 25, 1994
    Date of Patent: November 14, 1995
    Assignee: Church & Dwight Co., Inc.
    Inventor: M. Stephen Lajoie
  • Patent number: 5464607
    Abstract: R.sub.2, R.sub.2 ', R.sub.3, and R.sub.3 ', which are the same or different, are one of the groups of formula --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH(OH) CH.sub.2 OH --CH(CH.sub.2 OH)CH(OH)CH.sub.2 OH, --CH.sub.2 (CHOH).sub.4 CH.sub.2 OH, or --CH(CH.sub.2 OH).sub.2 ; and X is one of the groups --CH(OH)--, --CH(CH.sub.2 OH)--, --C(OH) (CH.sub.2 OH)--, or --C(CH.sub.2 OH).sub.2 --, are useful as opacifying components for X-ray contrast media.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: November 7, 1995
    Assignee: Dibra S.p.A.
    Inventors: Pierlucio Anelli, Marino Brocchetta, Fulvio Uggeri, Massimo Visigalli
  • Patent number: 5464841
    Abstract: A therapeutic method is provided to elevate a depressed mammalian autologous mixed lymphocyte response and to alleviate the diseases associated therewith by the administration of an effective amount of certain selective delta opioid receptor antagonists to a mammal such as a human patient in need of such treatment.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: November 7, 1995
    Inventors: Philip S. Portoghese, Burt M. Sharp, Kristin M. Linner
  • Patent number: 5462966
    Abstract: Methods for protecting warm-blooded animals against the formation of myocardial infarct through the administration of 2-phenyl-1,3-propanediol dicarbamate are disclosed.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: October 31, 1995
    Assignee: Carter-Wallace Inc.
    Inventor: Robert D. Sofia
  • Patent number: 5463102
    Abstract: Organic carbonates containing at least one aromatic ester group can be obtained in a continuous manner from carbonates containing at least one aliphatic ester group and a phenolic compound in the presence of a transesterification catalyst known per se by carrying out the reaction in at least two stirred containers connected one behind the other in such a way that, in each case, the phenolic compound is metered in liquid form into the first stirred container and the carbonate containing at least one aliphatic ester group is metered in liquid form into one or more of the stirred containers. The carbonate containing at least one aromatic ester group is removed in liquid form from the last stirred container. Volatile reaction products, for example alcohol which has been cleaved out or a dialkyl carbonate are removed in gaseous form from one or more stirred containers.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: October 31, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Norbert Schon, Johann Rechner, Paul Wagner, Hans-Josef Buysch, Hans-Erich Gasche, Ricarda Leiberich
  • Patent number: 5460798
    Abstract: The present invention provides a device and method for determining the quantity and identity of a substance ingested by a user. A detectable material such as barium sulfate is formed into a marker and mixed with a foreign substance such as pills, capsules, caplets, poisons or other hazardous substances. This detectable marker resides in the individual's digestive tract until passed. This material is detectable by use of X-ray equipment or a fluoroscope allowing the attending physician to "see" into the individual's digestive tract to determine the quantity of foreign substance ingested by counting the number of markers. Further, if the detectable markers have a unique geometric shape, the physician can identify the ingested substance associated with that shape of marker.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: October 24, 1995
    Inventor: Patrick A. Barnett
  • Patent number: 5459073
    Abstract: A method and composition for fixing and stabilizing tissues, cells, and cell components such that the antigenic sites are preserved for a useful period of time. The fixative employs a formaldehyde donor that is non-toxic, non-flammable, and that stabilizes the cell with minimal damage to and alteration of the cell morphology. In particular, the cell antigenic sites are left intact so that studies with monoclonal antibodies may be conducted. The invention also discloses a method for developing a positive control for test reagents and for test instrumentation.
    Type: Grant
    Filed: April 26, 1994
    Date of Patent: October 17, 1995
    Assignee: Streck Laboratories, Inc.
    Inventor: Wayne L. Ryan
  • Patent number: 5457133
    Abstract: R(+)-N-propargyl-1-aminoindan, its preparation and use and pharmaceutical compositions containing it. The novel compound was found to be useful for the treatment of human patients for Parkinson's disease, memory disorders, dementia of the Alzheimer type (DAT), depression and the hyperactive syndrome.
    Type: Grant
    Filed: February 17, 1994
    Date of Patent: October 10, 1995
    Assignees: Teva Pharmaceutical Industries Ltd., Technion Research and Development Foundation Ltd.
    Inventors: Moussa B. H. Youdim, John P. M. Finberg, Ruth Levy, Jeffrey Sterling, David Lerner, Tirtsah Berger-Paskin, Haim Yellin
  • Patent number: 5457233
    Abstract: A process for the preparation of amines of formula ##STR1## wherein the variables are defined as in the claims, which comprises reacting 1 molar equivalent of an amine of formula ##STR2## with 0.8 to 1.5 molar equivalents of an aldehyde of formulaR--CHO (3)and 0.8 to 2 molar equivalents of formic acid, in aqueous medium, and adjusting the pH by addition of a mineral acid such that, at the conclusion of the reaction, the pH is in the range from 3 to 7. The compounds obtainable by the process are useful intermediates for the synthesis of dyeing assistants.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: October 10, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Philippe Ouziel
  • Patent number: 5455264
    Abstract: RS-thioctic acid with a novel morphology which is obtained by a recrystallization process.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: October 3, 1995
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Thomas Beisswenger, Horst Bethge, Joachim Goede, Frank Hubner, Klaus Huthmacher, Herbert Klenk, Roland Moller
  • Patent number: 5451566
    Abstract: Herbicidal 1-aryl pyrrolopyridine compounds of the formula: ##STR1## wherein at least one of Y, Z or J is N or N--O and the remainder of Y, Z or J is C--R.
    Type: Grant
    Filed: November 17, 1993
    Date of Patent: September 19, 1995
    Assignee: Zeneca Limited
    Inventor: Christopher J. Mathews
  • Patent number: 5449693
    Abstract: The present invention relates to compounds of the formula ##STR1## in which: R.sub.1 is hydrogen or a halogen atom;R.sub.2 is a cyclohexyl or a phenyl;R.sub.3 is a (C.sub.3 -C.sub.6) cycloalkyl;R.sub.4 is hydrogen, (C.sub.1 -C.sub.6) alkyl or a (C.sub.3 -C.sub.6) cycloalkyl;A is --CO--CH.sub.2 --, --CH(Cl)--CH.sub.2 --, --CH(OH)--CH.sub.2 --, CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- and --C.tbd.C--, or their addition salts with mineral or organic acids. These compounds are active on the immune system. The present invention further relates to a method of preparing said compounds and to the pharmaceutical compounds in which they are present.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: September 12, 1995
    Assignee: Sanofi
    Inventors: Jean-Claude Breliere, Pierre Casellas, Serge Lavastre, Raymond Paul
  • Patent number: 5449831
    Abstract: 2-methyl-3-aminobenzo-trifluoride is prepared with high yields and high productivity by first halogenating o-trifluoromethylbenzalhalide, then secondly hydrogenating 2-trifluoromethyl-4-halogeno-benzalhalide formed by the first reaction, then thirdly nitrating 2-methyl-monohalogenobenzotrifluoride formed by the second reaction, and then fourthly hydrogenating 2-methyl-3-nitro-5-halogenobenzotrifluoride formed by the third reaction.
    Type: Grant
    Filed: January 5, 1994
    Date of Patent: September 12, 1995
    Assignee: Central Glass Company, Limited
    Inventors: Takayuki Nishimiya, Masatomi Kanai, Toshikazu Kawai
  • Patent number: 5449826
    Abstract: To provide an excellent compound having anti-inflammatory, antipyretic, analgesic and antirheumatic actions.A 5-amino-2-phenoxysulfonanilide compound represented by the formula: ##STR1## and the salts thereof have potent anti-inflammatory, antipyretic, analgesic and antirheumatic actions, and therefore they are useful as anti-inflammatory, antipyretic, analgesic and antirheumatic agents.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: September 12, 1995
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Kensei Yoshikawa, Shuji Saito, Yohichi Shimazaki, Mariko Kashiwa, Katsuo Hatayama