Patents Examined by Golam M M Shameem
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Patent number: 9879000Abstract: The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.Type: GrantFiled: April 14, 2015Date of Patent: January 30, 2018Assignee: GRÜNENTHAL GMBHInventors: Stefan Schunk, Melanie Reich, Florian Jakob, Nils Damann, Michael Haurand, Achim Kless, Marc Rogers, Kathy MacKenzie
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Patent number: 9878981Abstract: Provided is a production method of a synthetic intermediate for a heterocyclic compound having a renin inhibitory activity and useful as a prophylactic or therapeutic drug for diabetic nephropathy, hypertension and the like. A production method of a compound represented by the formula (III-1a), the formula (III-1b), the formula (III-1c) and/or the formula (III-1d); wherein each symbol is as described in DESCRIPTION, or a salt thereof, including reacting a compound represented by the formula (Ia) or (Ib): wherein each symbol is as described in DESCRIPTION, or a salt thereof with a compound represented by the formula (II): wherein each symbol is as described in DESCRIPTION, or a salt thereof, in the presence of an aluminum compound and a chiral amine compound.Type: GrantFiled: April 9, 2015Date of Patent: January 30, 2018Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Hironori Yamashita, Kazuhiro Miwa
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Patent number: 9879250Abstract: There is provided a protein stabilizer containing a compound represented by Formula (1) as an active ingredient. The protein stabilizer is capable of stabilizing a protein in a solution state for a long period of time without affecting an assay system, the protein being not limited to enzymes, labeling substances such as fluorescent substances and chemiluminescent substances, and assay target substances. There is also provided a protein stabilization method containing making the protein coexist with the compound represented by Formula (1) in a water-containing solution. In Formula (1), X is a hydrogen atom or a methyl group, and n is an integer of 3 to 17.Type: GrantFiled: August 6, 2015Date of Patent: January 30, 2018Assignee: NOF CORPORATIONInventors: Fumio Nakashima, Masaru Matsuda, Tomozumi Noda, Satoshi Yamada
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Patent number: 9862682Abstract: Provided herein are functionalized pegylated cyanine compounds containing a reactive group suitable for labeling a biomolecule or pharmaceutical compositions and methods of use thereof. In one embodiment, the compounds are based on formula I shown below. In other embodiments, the compounds can be pegylated at one or more of the following locations R1, R4, R6, R9, or L.Type: GrantFiled: January 6, 2017Date of Patent: January 9, 2018Assignee: BROADPHARMInventors: Hanzhong Zhang, Hongyuan Chen, Mikhail Kondratenko, Si Wang, Qiwen Zhong
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Patent number: 9861970Abstract: This invention pertains to hydroformylation catalysts containing a mixture of isomeric forms of halo-phosphorus ligands. This invention also describes a procedure for preparing isomers of certain halophosphite ligands, which contain the phosphorus atom in a macrocyclic ring.Type: GrantFiled: December 8, 2016Date of Patent: January 9, 2018Assignee: Eastman Chemical CompanyInventors: Thomas Allen Puckette, Xiaopeng Shan, Jody Lee Rodgers, Brian E. Green
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Patent number: 9855249Abstract: The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or II to a patient in need thereof:Type: GrantFiled: October 2, 2015Date of Patent: January 2, 2018Assignee: FLATLEY DISCOVERY LAB, LLCInventors: Bridget M. Cole, Andrew Kolodziej
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Patent number: 9855241Abstract: Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.Type: GrantFiled: December 14, 2016Date of Patent: January 2, 2018Assignee: VANDA PHARMACEUTICALS INC.Inventors: Marlene Michelle Dressman, Louis William Licamele, Mihael H. Polymeropoulos
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Patent number: 9856212Abstract: The present disclosure relates to acaricide, specifically to a kind of biphenyl compounds and uses thereof. The general formula I is as follows: wherein: each substituent is defined as that in the description. The compounds of the general formula I show high acaricidal activities and can be used for controlling various harmful mites.Type: GrantFiled: April 18, 2017Date of Patent: January 2, 2018Assignee: Shenyang Sinochem Agrochemicals R&D Co., Ltd.Inventors: Lixin Zhang, Jing Zhang, Lanfeng Ban, Hongfei Wu, Yuquan Song, Haibo Yu, Peng Li, Jingbo Xu, Libao Xu
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Patent number: 9845283Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.Type: GrantFiled: August 9, 2016Date of Patent: December 19, 2017Assignee: INSPYR THERAPEUTICS, INC.Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
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Patent number: 9845330Abstract: The present invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2,3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for treating Mycobacterium tuberculosis, MDR-TB and XDR-TB either alone or in combination with other anti-tubercular agents. In the present invention, new generation 6-nitro-2,3-dihydronitroimidazooxazoles agents also show acceptable pharmacokinetic properties and synergistic or additive effects with known anti-tubercular drugs.Type: GrantFiled: March 31, 2014Date of Patent: December 19, 2017Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Parvinder Pal Singh, Gurunadham Munagala, Reddy Yempalla Kushalava, Inshad Ali Khan, Nitin Pal Kalia, Vikrant Singh Rajput, Amit Nargotra, Sanghapal Damodhar Sawant, Ram Asray Vishwakarma
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Patent number: 9840500Abstract: It relates to the use of compounds of formula (I?), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, as anticancer agents and as agents for generating induced pluripotent stem cells. Compounds of formula (I?), wherein R2? is an alcoxy group, a hydrocarbon chain or a ring system, and R1, R3, and R4 are as defined herein, are dual inhibitors of histone methyltransferases and DNA methyltransferases. It also relates to the compounds of formula (I?), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein R2? is phenyl or 5- to 6-membered heteroaromatic ring, both optionally fused to another rings (i.e., compounds of formula (I)). It also relates to pharmaceutical or veterinary compositions containing compounds of formula (I).Type: GrantFiled: March 30, 2015Date of Patent: December 12, 2017Assignee: FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADAInventors: Xabier Aguirre Ena, Julen Oyarzabal Santamarina, Felipe Prósper Cardoso, Maria Obdulia Rabal Gracia, Juan Roberto Rodríguez Madoz, Edurne San José Enériz
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Patent number: 9840519Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.Type: GrantFiled: November 14, 2016Date of Patent: December 12, 2017Assignee: Array BioPharma, Inc.Inventors: Steven W. Andrews, Kevin Ronald Condroski, Julia Haas, Yutong Jiang, Gabrielle R. Kolakowski, Jeongbeob Seo, Hong-Woon Yang, Qian Zhao
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Patent number: 9834532Abstract: The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.Type: GrantFiled: September 29, 2014Date of Patent: December 5, 2017Assignee: BOSTON BIOMEDICAL, INC.Inventors: Zhiwei Jiang, Chiang Jia Li, Wei Li, David Leggett
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Patent number: 9834537Abstract: Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.Type: GrantFiled: November 27, 2013Date of Patent: December 5, 2017Assignee: Korea Institute of Science and TechnologyInventors: Eun Joo Roh, Changjoon Justin Lee, Soo Jin Oh, Seok Jin Hwang, Jong Hoon Jung
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Patent number: 9834510Abstract: What is described is a compound of formula I wherein X is an ethene, or an unsubstituted or substituted arene or heteroarene; Y is a bond, an ethene, or an unsubstituted or substituted arene or heteroarene; Z is S or O; L is a linear or branched alkylene of 1 to 6 carbons; R1 and R2 are independently a linear or branched alkyl or alkenyl of 1 to 18 carbons; R3 and R4 are independently a linear or branched alkyl of 1 to 6 carbons; n is 0 to 6; and m, p, q, and r are independently 1-18; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 29, 2016Date of Patent: December 5, 2017Assignee: Arcturus Therapeutics, Inc.Inventors: Joseph E. Payne, Padmanabh Chivukula, Steven P. Tanis
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Patent number: 9828328Abstract: A method for preparing 3-methyl-2-nitrobenzoic acid is disclosed wherein 1,3-dimethyl-2-nitrobenzene is combined with an oxidation catalyst in the presence of an oxygen source and an initiator, provided that less than 99% of the 1,3-dimethyl-2-nitrobenzene is oxidized. A method for preparing compounds of Formula 7 and Formula 11 is also disclosed wherein the method is characterized by using 3-methyl-2-nitrobenzoic acid as prepared by the method disclosed above. wherein R1 is C1-C7 alkyl, C3-C6 cycloalkyl or C4-C7 alkylcycloalkyl.Type: GrantFiled: May 29, 2015Date of Patent: November 28, 2017Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Stephen Ernest Jacobson, Donald J. Dumas, Rupert Spence, Sarah May Crawford, Venkateswara Rao Surisetty
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Patent number: 9822064Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.Type: GrantFiled: August 9, 2016Date of Patent: November 21, 2017Assignee: Inspyr Therapeutics, Inc.Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
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Patent number: 9822067Abstract: The present invention relates to a process for purifying adiponitrile (ADN), wherein crude ADN is introduced into a rectification apparatus (R1). The rectification apparatus (R1) comprises a first side draw and preferably also a second side draw, the first side draw being disposed below the crude ADN introduction point and the optional second side draw being disposed above the crude ADN introduction point. The first side draw is used to draw off a gaseous stream comprising ADN while the optional second side draw is used to draw off undesired by-products such as 1-amino-2-cyanocyclopentene (ACCP) which are often generated in ADN production and consequently may be present in the crude ADN. The gaseous stream from the first side draw of (R1) is introduced into a second rectification apparatus (R2). (R2) is used to separate off ADN from remaining high boilers and any other by-products present, pure ADN being drawn off from (D2) as overhead product.Type: GrantFiled: February 3, 2015Date of Patent: November 21, 2017Assignee: BASF SE (Ellwanger & Baier Patentanwälte)Inventors: Hermann Luyken, Peter Pfab, Tim Jungkamp
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Patent number: 9822127Abstract: The present invention relates to the use of a class of novel isothiazolo[4,3-b]pyridine derivatives as well as to pharmaceutical compositions comprising one or more of said isothiazolo[4,3-b]pyridine derivatives and one or more pharmaceutically acceptable excipients as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as viral diseases.Type: GrantFiled: July 23, 2015Date of Patent: November 21, 2017Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Steven De Jonghe, Piet Herdewyn, Elena Bekerman, Shirit Einav, Gregory Neveu
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Patent number: 9815799Abstract: Provided are a surface-modifying agent that enables production of a coating film that preserves transparency of a substrate while displaying high water repellency and excellent stain resistance, particularly in terms of wipeability of oil-based ink, and also an article for which the surface-modifying agent is used. The surface-modifying agent includes a triazine skeleton, a (meth)acrylate group bonded to the triazine skeleton via an urethane bond, and a perfluoropolyether chain bonded to the triazine skeleton.Type: GrantFiled: February 17, 2015Date of Patent: November 14, 2017Assignee: DEXERIALS CORPORATIONInventors: Makiya Ito, Kenji Kobayashi, Nobuo Tano, Kyungsung Yun