Patents Examined by Golam M M Shameem
  • Benzene, pyridine, and pyridazine derivatives
    Patent number: 9656956
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: May 23, 2017
    Assignee: Esanex, Inc.
    Inventors: Kenneth He Huang, Jeron Eaves, Gunnar Hanson, James Veal, Thomas Barta, Lifeng Geng, Lindsay Hinkley
  • Surfactant-enabled transition metal-catalyzed chemistry
    Patent number: 9656985
    Abstract: In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: May 23, 2017
    Assignee: MYCELL TECHNOLOGIES, LLC
    Inventor: Volker Berl
  • Procedure for the synthesis of N-benzyl-N-cyclopropyl-1H-pyrazole-4-carboxamide derivatives
    Patent number: 9656965
    Abstract: A new one-step process for the preparation of pyrazole carboxamide derivatives of the general formula (I) by reaction of 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbaldehyde with an amine or its salt.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: May 23, 2017
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Peter Bruchner, Sergii Pazenok
  • Phosphorus functional antimicrobial coatings for metal surfaces
    Patent number: 9642369
    Abstract: The invention relates to quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds, processes for preparing quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds, antimicrobial coating compositions comprising quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds and method of treating a surface with said compositions to provide a durable, antimicrobial-treated surface.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: May 9, 2017
    Assignee: Nano Safe Coatings Incorporated
    Inventors: Lukasz Porosa, Gideon Wolfaardt, Daniel Foucher
  • Method for producing glycolide
    Patent number: 9643949
    Abstract: A method for producing a GL comprising: (I) a heating step of heating a mixture either under normal pressure or reduced pressure at a temperature at which a polyglycolic acid (PGA) undergoes depolymerization, the mixture containing the PGA and a polyethylene glycol ether which is represented by the formula: X—O—(—CH2CH2—O—)p—Y (wherein X and Y are each independently an alkyl group or an aryl group having from 2 to 20 carbon atoms, and p is an integer from 1 to 5) and which has a molecular weight of from 150 to 450 and a boiling point of from 130 to 220° C.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: May 9, 2017
    Assignee: KUREHA CORPORATION
    Inventors: Kazuyuki Yamane, Yoshiko Ikeyama
  • Process for preparing 4,6-BIS (aryloxy) pyrimidine derivatives
    Patent number: 9643935
    Abstract: Process for preparing 4,6-bis(aryloxy)pyrimidine derivatives. A process is provided for preparing 4,6-bis(aryloxy)pyrimidine derivatives. The process is conducted in water as reaction medium and catalyzed by one or more tertiary-amine catalyst(s). It has been found that a water based reaction substantially free of organic solvents can be carried out providing excellent yields by the addition of one or more tertiary-amine catalysts to the reaction medium. This provides a clean reaction and produces the desired product in high yields.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: May 9, 2017
    Assignee: CHEMINOVA A/S
    Inventor: Karl Bernhard Lindsay
  • Method for producing indoline compound
    Patent number: 9643921
    Abstract: Provided is a method for producing a compound represented by a formula (6), the method comprising: a step of mixing a compound represented by a formula (4) and a compound represented by a formula (5) to form a salt consisting of the compound represented by the formula (4) and the compound represented by the formula (5); and a step of removing a protecting group P1 of the salt. In the following formulae, P1 is a protecting group and P2 is a protecting group.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: May 9, 2017
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Takahiro Motoyama, Katsunori Takata, Yasuaki Fukuhara, Masato Uemura, Tatsunori Sado, Atsuyuki Kasai
  • Resveratrol selenide preparation for treating cancer
    Patent number: 9637448
    Abstract: A trans-resveratrol selenide for treating cancer has such a structure as: wherein hydroxyls at position 3, 4 and 5 are replaceable, at least one hydroxyl at position 3, 4, 5 is replaced with R, R is alkali metal ion and selenium coordination complex, and The trans-resveratrol selenide preparation is able to treat various cancers, such as lung cancer, lymphoma, stomach cancer, liver cancer, small intestine cancer, colorectal cancer and gynecologic cancer, and has a good curative effect.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: May 2, 2017
    Assignee: Shanghai Ai Qi Ecological Technology Co., Ltd.
    Inventors: Gong Chen, Kunyuan Song
  • Crystal form of Cefathiamidine compound and preparation method therefor
    Patent number: 9637502
    Abstract: A novel crystalline form of Cefathiamidine compound and its preparation method, characterizing in its X-ray powder diffraction pattern and differential scanning calorimetry thermogram. Dissolving Cefathiamidine compound with a purity of 98% or higher in a solvent at a temperature of 30˜45° C. to form a solution, whose concentration is controlled within 0.05˜0.2 g/mL, and then adding a solventing-out agent to the solution, wherein the amount of the solventing-out agent is 3˜5 times (in volume) of that of the solvent; followed by cooling the solution down to 0˜10° C. at a rate of 0.2˜1° C./min; continuing to stir for 1˜3 hours, and separating the obtained solid-liquid suspension to provide a novel crystalline form of Cefathiamidine compound after drying.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: May 2, 2017
    Assignees: TIANJIN UNIVERSITY, HAINAN LINGKANG PHARMACEUTICAL CO., LTD
    Inventors: Hongxun Hao, Linggang Tao, Zhihong Sun, Baohong Hou, Jun Lv, Qiuxiang Yin, Yongli Wang, Junbo Gong, Chuang Xie, Ying Bao
  • Process for producing dihydro-2H-pyran derivatives
    Patent number: 9630940
    Abstract: Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: April 25, 2017
    Assignee: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
    Inventors: Pandurang V. Chouthaiwale, Fujie Tanaka
  • Cephalosporin derivatives and pharmaceutical compositions thereof
    Patent number: 9630977
    Abstract: The present invention relates to novel cephalosporin derivatives represented by X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: April 25, 2017
    Assignee: Legochem Biosciences, Inc.
    Inventors: Young Lag Cho, Joung Yul Yun, Sang Eun Chae, Chul Soon Park, Hyang Sook Lee, Kyu Man Oh, Hye Jin Heo, Dae Hyuck Kang, Young Jae Yang, Hyun Jin Kwon, Tae Kyo Park, Sung Ho Woo, Yong Zu Kim
  • Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
    Patent number: 9624214
    Abstract: The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: April 18, 2017
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Alexandros Vakalopoulos, Markus Follmann, Ingo Hartung, Philipp Buchgraber, Rolf Jautelat, Jorma Haβfeld, Niels Lindner, Alexey Gromov, Frank Wunder, Johannes-Peter Stasch, Gorden Redlich, Volkhart Min-Jian Li, Eva Maria Becker-Pelster, Andreas Knorr
  • Aryl- and heteroaryl-pyrrolidine-2-carboxamide compounds
    Patent number: 9624169
    Abstract: The application relates to novel compounds and their use in treating and preventing diseases and conditions mediated by modulation of voltage-gated sodium channels. Novel aryl- and heteroaryl-pyrrolidine-2-carboxamide compounds and pharmaceutically acceptable salts or solvates thereof and their use are described.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: April 18, 2017
    Assignee: SciFluor Life Sciences, Inc.
    Inventors: Ben C. Askew, Takeru Furuya
  • Triptolide prodrugs
    Patent number: 9623035
    Abstract: The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: April 18, 2017
    Assignee: Regents of the University of Minnesota
    Inventors: Ingrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
  • Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions
    Patent number: 9623005
    Abstract: The present invention relates to the treatment of trauma haemorrhage or trauma haemorrhage-induced organ injury and associated disorders (in particular stoke, burns and brain injury) using the anti-malarial compound artemisinin and its derivatives. The present invention also relates to the treatment of myocardial infarction and coronary heart disease (and associated disorders) using the anti-malarial compound artemisinin and its derivatives. The present invention also relates to the use of artemisinin and its derivatives in coronary artery bypass surgery, heart transplantation, and diseases associated with ischaemia-reperfusion.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: April 18, 2017
    Assignee: Queen Mary University of London
    Inventor: Christoph Thiemermann
  • Imidazopyrimidine derivatives
    Patent number: 9617266
    Abstract: Compounds of the formula I in which X, R1 and R2 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: April 11, 2017
    Assignee: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Dieter Dorsch, Ansgar Wegener, Oliver Poeschke, Michael Busch, Jeyaprakashnarayanan Seenisamy
  • Method for producing ethylene oxide
    Patent number: 9611236
    Abstract: [Problem] To provide a method by which an amount of production of ethylene glycol as a by-product is reduced and a yield of ethylene oxide can be improved in a process for producing ethylene oxide. [Solution] An embodiment of the present invention relates to a method for producing ethylene oxide.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: April 4, 2017
    Assignee: NIPPON SHOKUBAI CO., LTD.
    Inventors: Shingo Iguchi, Yukimasa Kawaguchi
  • Furan-2,5-dicarboxylic acid purge process
    Patent number: 9604202
    Abstract: Disclosed is an oxidation process to produce a crude carboxylic acid product carboxylic acid product. The process comprises oxidizing a feed stream comprising at least one oxidizable compound to generate a crude carboxylic acid slurry comprising furan-2,5-dicarboxylic acid (FDCA) and compositions thereof. Also disclosed is a process to produce a dry purified carboxylic acid product by utilizing various purification methods on the crude carboxylic acid.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: March 28, 2017
    Assignee: EASTMAN CHEMICAL COMPANY
    Inventors: Kenny Parker, Mesfin Janka, Ashfaq Shaikh, Lee Partin
  • Intermediates and methods for the synthesis of halichondrin B analogs
    Patent number: 9604993
    Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: March 28, 2017
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Charles E. Chase, Atsushi Endo, Francis G. Fang, Jing Li
  • Production of polyketides and other natural products
    Patent number: 9605001
    Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: March 28, 2017
    Assignee: Buck Institute for Research On Aging
    Inventors: Matthew Alan Gregory, Steven James Moss