Abstract: Provided herein are methods of modulating hormone concentrations in a subject comprising the administration of a composition comprising a chemosensory receptor ligand, wherein the composition is adapted to deliver the ligand to one or more regions of the intestine of said subject. Also provided are methods directed to the modulation of circulating concentrations of one or more of GLP-1 (total), GLP-1 (active), GLP-2, oxyntomodulin, PYY (total), PYY 3-36, CCK, GIP, insulin, C-peptide, glycentin, uroguanylin amylin, and ghrelin (total), ghrelin (active) and glucagon.
Type:
Grant
Filed:
October 18, 2011
Date of Patent:
November 8, 2016
Assignee:
AMBRA BIOSCIENCE LLC
Inventors:
Alain D. Baron, Martin R. Brown, Christopher R. G. Jones, Mark S. Fineman
Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
Type:
Grant
Filed:
August 4, 2014
Date of Patent:
November 1, 2016
Assignee:
ELCELYX THERAPEUTICS, INC.
Inventors:
Alain D. Baron, Mark S. Fineman, Nigel R. A. Beeley
Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
Type:
Grant
Filed:
July 11, 2012
Date of Patent:
November 1, 2016
Assignee:
ELCELYX THERAPEUTICS, INC.
Inventors:
Alain D. Baron, Mark S. Fineman, Nigel R. A. Beeley
Abstract: A web material containing one or more active agents and methods for making same are provided.
Type:
Grant
Filed:
September 22, 2015
Date of Patent:
November 1, 2016
Assignee:
The Procer & Gamble Company
Inventors:
Mark Robert Sivik, Gregory Charles Gordon, Frank William Denome, Alyssandrea Hope Hamad-Ebrahimpour, Stephen Joseph Hodson, Brian Patrick Croll, John Gerhard Michael, Andreas Josef Dreher, Paul Dennis Trokhan
Abstract: Topical pharmaceutical gel compositions of diclofenac sodium are provided. The topical gel compositions contain at least about 10% w/w diclofenac sodium and are suitable for once-a-day topical application.
Abstract: A topical pharmaceutical gel composition of diclofenac sodium suitable for once-a-day topical application is provided. The topical gel composition contains at least about 10 % w/w of diclofenac sodium and once-a-day application of the composition provides relief from pain or inflammation comparable to that achieved with four times daily application of diclofenac sodium 1 % or 3 % topical gel.
Abstract: Provided is a cationic group-containing cellulose ether which, when incorporated in a hair wash, is able to give an excellent smoothness property and its sustained feeling, finger combability and coated feeling in rinsing, and which, when incorporated in a skin cleanser, is able to give an excellent moist feeling to the skin after washing, and also provided are a surfactant composition, a hair wash composition, a skin cleanser composition, a hair conditioner composition and a hair treatment composition containing the cationic group-containing cellulose ether.
Abstract: A cationized glycerolated cellulose which, when blended in a hair cosmetic, is able to impart excellent smoothness and its long-lasting feeling at the time of rinsing and to impart a moist feeling and softness to the hair after drying and, when blended in a skin cleanser, is able to impart an excellent moisturizing feeling after drying; a surfactant composition containing the same; and a hair cosmetic composition and a skin cleanser composition each containing the surfactant composition, are provided. [1] A cationized glycerolated cellulose having a specified structure, which has a main chain derived from an anhydroglucose, wherein a degree of substitution of a cationized alkylene oxy group per the anhydroglucose unit is from 0.01 to 0.18, and a degree of substitution of a glycerol group per the anhydroglucose unit is from 0.5. to 5.
Abstract: Compositions and methods for the prevention and treatment of blepharitis, where the compositions include verbascoside, oligopeptide-10, and sulfonated shale oil, and the preparation of such compositions.
Abstract: Various embodiments of a multifunctional hairbrush are disclosed. The multifunctional hairbrush is configured to deliver a bioactive compound/biologically active molecule or a mixture of bioactive compounds/biologically active molecules for growth and protection of hair. Furthermore, the multifunctional hairbrush can be integrated with a low intensity light module to activate a bioactive compound/biologically active molecule or a mixture of bioactive compounds/biologically active molecules for growth and protection of hair.
Abstract: The present invention relates to a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein a compound selected from the group consisting of an IP, an ester of an IP, and/or a pharmaceutically acceptable salt thereof, or a combination thereof, is/are covalently bound to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. The covalent bond between the IP and the metal, metal alloy or metal oxide surface can be further assisted by the use of a linker. An implant according to the invention provides for a modulated and/or improved osseointegrative effect when implanted into a body, such as a mammalian body, by virtue of the coating comprising covalently bound phytate.
Type:
Grant
Filed:
December 26, 2012
Date of Patent:
September 6, 2016
Assignees:
LABORATORIES SANIFIT, S. L., NUMAT BIOMEDICAL, S. L.
Inventors:
Marta Monjo Cabrer, Joan Perelló Bestard, Joana María Ramis Morey, Fernando Tur Espinosa, María del Mar Arriero Sánchez, Eva Martín Becerra, Bernat Isern Amengual, Rubén Henríquez Paláez
Abstract: A design for dynamically adjusting parameters applied to a surgical instrument, such as an ocular surgical instrument, is presented. The method includes detecting surgical events from image data collected by a surgical microscope focused on an ocular surgical procedure, establishing a desired response for each detected surgical event, delivering the desired response to the ocular surgical instrument as a set of software instructions, and altering the surgical procedure based on the desired response received as the set of software instructions.
Abstract: The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
Abstract: The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
Type:
Grant
Filed:
February 3, 2016
Date of Patent:
August 30, 2016
Assignee:
Cynapsus Therapeutics, Inc.
Inventors:
Nathan John Bryson, Anthony John Giovinazzo, Scott David Barnhart, Michael Clinton Koons
Abstract: The present invention relates to an antimicrobial topical composition and process for making such composition. The composition comprises of ionic silver, silver nanoparticles, and oxygen, combined within a gel medium and applied topically. The composition optimizes the ionic silver and silver nanoparticle ratio providing for sufficient ionic silver to be delivered as an immediate antimicrobial agent, and sufficient nanoparticle silver to provide time release for conversion to silver ions for continuing antimicrobial effectiveness.
Abstract: A biological information acquisition method for acquiring information on a living body on a basis of a quantified value of a physiologically active substance originated from the living body, includes a step of collecting the physiologically active substance from a body surface of the living body.
Abstract: The present invention provides compositions for extended release of an active ingredient, comprising a lipid-saturated matrix formed from a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.
Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
Type:
Grant
Filed:
February 2, 2015
Date of Patent:
August 2, 2016
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko