Patents Examined by H. Sarah Park
  • Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
    Patent number: 9403851
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: August 2, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Drug delivery polymer and uses thereof
    Patent number: 9381253
    Abstract: Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: July 5, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Longyan Liao
  • Bioactive load-bearing composites
    Patent number: 9381275
    Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: July 5, 2016
    Assignee: Orthovita, Inc.
    Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Conrad
  • Microspheres for controlled- or sustained-release delivery of therapeutics
    Patent number: 9381159
    Abstract: A new microsphere formulation (composition) for controlled- or sustained-release delivery of therapeutic ingredient(s), mainly peptides and proteins not over 10K in molecular weight, comprises at least a therapeutic ingredient, a helping agent (such as PH sensitive agent whose solubility is a function of pH) and a biodegradable polymer. The therapeutic ingredient(s) and the helping agent are in the form of fine particles, less than 1O um in diameter, encapsulated in the polymer which forms the microsphere matrix. A method for preparing the composition comprises a step of in-situ precipitating the therapeutic ingredient(s) and the helping agent to the fine particles and successive steps for forming the microspheres. Such a microsphere formulation offers a well-controlled release profile for prolonged period and encapsulation efficiency over 95%.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: July 5, 2016
    Inventors: Tuo Jin, Zhenhua Hu, Weien Yuan
  • Coated capsules and tablets of a fatty acid oil mixture
    Patent number: 9370493
    Abstract: Compositions comprising a fatty acid oil mixture and at least one free fatty acid in a coated capsule or a coated tablet form suitable for oral administration, and methods of use thereof, are disclosed. Further disclosed are preconcentrates comprising a fatty acid oil mixture, at least one surfactant, and optionally at least one free fatty acid, in a coated capsule or a coated tablet form, and methods of use thereof. The preconcentrates are capable of forming a self-nanoemulsifying drug delivery system (SNEDDS), a self-microemulsifying drug delivery system (SMEDDS), or self-emulsifying drug delivery systems (SEDDS) in an aqueous solution.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: June 21, 2016
    Assignee: Pronova Biopharma Norge AS
    Inventors: Jo Erik Johnsrud Klaveness, Gunnar Berge, Svein Olaf Hustvedt, Preben Houlberg Olesen, Anette Müllertz
  • Rotary die system
    Patent number: 9364441
    Abstract: A rotary die system that includes first and second axially aligned, coacting rotary dies positioned adjacent one another. Each die includes a working surface having a plurality of recesses defined therein. The recesses in the first die are each configured to align with a recess in the second die to form a product cavity upon coaction of the first and second dies. The product cavity is configured to receive a product. Each recess in at least one of the first or second dies includes a pin therein that is configured to puncture a film that at least partially surrounds the product.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: June 14, 2016
    Assignee: BARLEAN'S ORGANIC OILS, LLC
    Inventor: John Puckett
  • Compositions containing silicon resin, oil and gelling agent
    Patent number: 9351919
    Abstract: The invention relates to a composition, especially a cosmetic composition, comprising at least one silicon resin comprising at least one T unit, at least one phenylated oil and at least one gelling agent, as well as to methods of using such compositions.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: May 31, 2016
    Assignee: L'OREAL
    Inventors: Yoriko Bukawa, Hy Si Bui, Kimberly Bradshaw
  • Method of treating multiple sclerosis
    Patent number: 9351961
    Abstract: The invention provides methods for treating multiple sclerosis by administering biotin. The invention also provides methods for treating sequelae after multiple sclerosis attacks by administering biotin.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: May 31, 2016
    Assignee: Assistance Publique Hopitaux De Paris
    Inventor: Frédéric Sedel
  • Silica microcapsules, process of making the same and uses thereof
    Patent number: 9346682
    Abstract: The present document describes a microcapsule having silica shells, processes for making the same, processes for functionalizing said microcapsules and processes for encapsulating active agent in said microcapsules.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: May 24, 2016
    Assignee: LES INNOVATIONS MATERIUM
    Inventors: Mathilde Gosselin, Shaoyong Yu, Nabil Ghezal, Cé Guinto Gamys
  • Stable laquinimod preparations
    Patent number: 9340307
    Abstract: The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3?-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: May 17, 2016
    Assignee: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Muhammad Safadi, Daniella Licht, Ioana Lovinger, Aharon M. Eyal, Tomas Fristedt, Karl Jansson
  • Method for treating glaucoma
    Patent number: 9339514
    Abstract: A method of treating glaucoma or other eye disease in a patient is provided. The method includes injecting an eye of the patient with a cohesive monophasic gel containing cross-linked hyaluronic acid or its salt. The injection can be under the scleral flap and/or conjunctiva of the eye, thereby creating and maintaining a conjunctival bleb, and/or the injection can be in the supra-scleral and/or supra-choroidal (sub-scleral) space of the eye thereby reducing the intraocular pressure.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: May 17, 2016
    Assignee: APTISSEN SA
    Inventors: Gilles Bos, Philippe Sourdille
  • Compositions for increasing hair growth
    Patent number: 9333209
    Abstract: Cosmetic skin and hair care compositions for enhancing the growth and appearance of mammalian hair in an individual are provided, which compositions comprise a dose of an L-type calcium channel blocker effective to promote anagen phase of the hair cycle. As shown herein, anagen phase promotion can result in more rapid hair growth.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: May 10, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anthony Oro, Ricardo Ei Dolmetsch, Gozde Yucel
  • Cosmetic composition comprising silica aerogels particles and hydrocarbon-based oils
    Patent number: 9320689
    Abstract: The present invention relates to a composition comprising a mixture of: hydrophobic silica aerogel particles with a specific surface area per unit of mass (SM) ranging from 500 to 1500 m2/g and a size expressed as the mean volume diameter (D[0.5]) ranging from 1 to 1500 ?m, and at least a first and at least a second hydrocarbon-based oil chosen from branched esters, pentacrythritol esters, hydrogenated polyolefins and fatty acid triglycerides, and mixtures thereof, the first hydrocarbon-based oil being present in a content of greater than or equal to 40% by weight of the mixture of the first and second oils.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: April 26, 2016
    Assignee: L'OREAL
    Inventors: Guillaume Cassin, Sylvie Poret Fristot
  • Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol
    Patent number: 9314470
    Abstract: Described are transdermal drug delivery systems for the transdermal administration of levonorgestrel and ethinyl estradiol, comprising an acrylic polymer matrix. Methods of making and using such systems also are described.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: April 19, 2016
    Assignee: NOVEN PHARMACEUTICALS, INC.
    Inventors: Prashant Patel, Viet Nguyen, Jun Liao
  • Methods for improving the bioactivity characteristics of a surface and objects with surfaces improved thereby
    Patent number: 9315798
    Abstract: A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: April 19, 2016
    Assignee: Exogenesis Corporation
    Inventors: Joseph Khoury, Laurence B. Tarrant, Sean R. Kirkpatrick, Richard C. Svrluga
  • Local drug delivery devices and methods for treating cancer
    Patent number: 9301926
    Abstract: Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 ?m to about 1000 ?m, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: April 5, 2016
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Laura Indolfi, Elazer R. Edelman, Robert S. Langer, Jeffrey W. Clark, David T. Ting, Cristina Rosa Annamaria Ferrone, Matteo Ligorio
  • Body cosmetic for wetted skin
    Patent number: 9301914
    Abstract: A body cosmetic for application to wetted skin after showering, and the like, which provide high moisturizing effects, all over body spreadability, and easy application with a non-greasy and non-sticky feeling. An oil-in-water body cosmetic for application to wetted skin, which contains the following components (A) to (D): (A) from about 0.1% to about 1% of block copolymer; (B) from about 3% to about 10% branched fatty acid ester; (C) from about 3% to about 20% hydrocarbon oil; and (D) from about 5% to about 50% glycerin.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: April 5, 2016
    Assignee: Kao USA, Inc.
    Inventors: Jessica Rustici, Alisa Smith, Paula Thueneman
  • Sublingual films
    Patent number: 9283219
    Abstract: The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: March 15, 2016
    Assignee: Cynapsus Therapeutics, Inc.
    Inventors: Nathan John Bryson, Anthony John Giovinazzo, Scott David Barnhart, Michael Clinton Koons
  • Encapsulation device, medical capsules, and encapsulation method
    Patent number: 9283147
    Abstract: An encapsulation device includes: a fluid injection device that injects a first liquid forming a core; a liquid film holder that holds in film form a second liquid forming a shell containing the core; and a liquid contact device that makes the shell in contact with a third liquid, in which the first liquid is injected toward a liquid film of the second liquid retained by the liquid film holder to form a core, the core is wrapped with the second liquid on passing through the liquid film of the second liquid, thereby forming the shell, and the shell is made in contact with the third liquid to induce chemical reaction.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: March 15, 2016
    Assignee: Seiko Epson Corporation
    Inventors: Taki Hashimoto, Yoshiki Fukui
  • Sustained release beads and suspensions including the same for sustained delivery of active ingredients
    Patent number: 9271938
    Abstract: Sustained-released beads providing active ingredients over an extended period of time to an individual orally ingesting the sustained release beads. The sustained-release beads can be part of a suspension wherein the sustained-release beads are suspended and evenly dispersed in the suspension. Binding agents are used to form the structural framework of the sustained released beads and retain the active ingredients without chemical or electrical bonding. The components of the dispersion medium are GRAS designated, making the suspension suitable for use as a food product.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: March 1, 2016
    Assignee: NANO PHARMACEUTICAL LABORATORIES LLC
    Inventor: Robert Niichel