Patents Examined by Henry R. Jiles
  • Patent number: 4690942
    Abstract: The invention relates to 1-aryl-2-fluoro-2-azolyl alkanones, alkanols, esters and ethers of formula I ##STR1## wherein Az is 1H-1,2,4-triazole, 4H-1,2,4-triazole or 1H-imidazole;T is --C(O)--, --CH(OH)-- or one of the groups ##STR2## wherein R.sub.7 is C.sub.1 -C.sub.6 alkyl which is unsubstituted or substituted by C.sub.1 -C.sub.3 -alkoxy, halogen or cyano, or is C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, 2-furyl, 2-tetrahydrofuryl, or is phenyl or benzyl, each unsubstituted or substituted by halogen, nitro, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkyl and/or C.sub.1 -C.sub.3 haloalkoxy;R.sub.8, R.sub.9 and R.sub.10 are each independently hydrogen, nitro, halogen, cyano, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkoxy, --COO(C.sub.1 -C.sub.3 alkyl), NH.sub.2 or NHCOCH.sub.3 ;R is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.1 and R.sub.2 are each independently hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: September 1, 1987
    Assignee: CIBA-GEIGY Corporation
    Inventors: Willy Frick, Alfred Meyer, Robert Nyfeler
  • Patent number: 4690709
    Abstract: Novel N'-phenyl-N-methylurea derivatives of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a methyl group or a methoxy group, R.sub.2 is a hydrogen atom or a lower alkyl group, R.sub.3, which may be the same or different, is a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group or a trifluoromethyl group, n is an integer of 0 to 5, X is a hydrogen atom or a halogen atom, Y is an oxygen atom or a sulfur atom and Z is a straight or branched C.sub.1 -C.sub.8 alkylene group which may have no less than one atom of oxygen and/or sulfur at the terminal of and/or inside the carbon chain, which shows a pronounced herbicidal activity against a wide variety of weeds in the cultivation of crop plants as well as a notable fungicidal activity agaist a wide variety of phytopathogenic fungi causing plant diseases to crop plants without any material toxicity to mammals and fish or chemical injury to said crop plants.
    Type: Grant
    Filed: November 3, 1980
    Date of Patent: September 1, 1987
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Ichiki Takemoto, Seizo Sumida, Ryo Yoshida, Katsuzo Kamoshita
  • Patent number: 4691030
    Abstract: An alkenylsuccinic anhydride having a high quality is obtained at a low temperature in a high yield by subjecting an olefin having 2 to 90 carbon atoms and maleic anhydride to addition reaction under heating in the presence of a solid acid/base catalyst.
    Type: Grant
    Filed: December 13, 1985
    Date of Patent: September 1, 1987
    Assignee: Mitsubishi Monsanto Chemical Company
    Inventor: Kiyoharu Fujino
  • Patent number: 4689338
    Abstract: 1H-Imidazo[4,5-c]quinolin-4-amines which are antivirals. Pharmacological methods of using such compounds and pharmaceutical compositions containing such compounds are also described.
    Type: Grant
    Filed: November 15, 1985
    Date of Patent: August 25, 1987
    Assignee: Riker Laboratories, Inc.
    Inventor: John F. Gerster
  • Patent number: 4689177
    Abstract: Use of nitrogen-containing tridithiocarbamic acid compositions as reverse demulsifiers.
    Type: Grant
    Filed: October 15, 1986
    Date of Patent: August 25, 1987
    Assignee: Petrolite Corporation
    Inventors: Neil E. S. Thompson, Robert G. Asperger
  • Patent number: 4689068
    Abstract: Isothioureas of the formula ##STR1## where X, Y and Z are each hydrogen, halogen, alkyl, alkoxy, haloalkyl, unsubstituted or substituted aryloxy or unsubstituted or substituted arylalkoxy, R.sup.1 is alkyl, R.sup.2 is alkyl or methoxy and R.sup.3 is benzoyl which may be monosubstituted or disubstituted by alkyl, halogen or haloalkyl, or is a radical of the formula ##STR2## where A is oxygen or sulfur, R.sup.4 is alkyl, alkoxyethyl, haloalkyl or phenyl and R.sup.5 is methyl, ethyl, phenyl, alkoxy, alkoxyethoxy, haloalkoxy, phenoxy, alkylamino, dialkylamino or alkylthio, a process for their preparation, and their use for controlling undesirable plant growth.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: August 25, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl Kiehs, Bruno Wuerzer, Norbert Meyer
  • Patent number: 4689337
    Abstract: Insecticidal and fungicidal compounds of the formula (I): ##STR1## wherein R.sup.1, X, Y, and Z are as defined in the specification and R.sup.2 is a 1H-azol-1-yl group containing 2 or 3 nitrogen atoms are disclosed.
    Type: Grant
    Filed: March 22, 1985
    Date of Patent: August 25, 1987
    Assignee: Imperial Chemical Industries PLC
    Inventors: Michael J. Bushell, Paul A. Worthington
  • Patent number: 4687777
    Abstract: Thiazolidinedione derivatives of the formula: ##STR1## and pharmacologically acceptable salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for treatment of diabetes and hyperlipemia.
    Type: Grant
    Filed: January 17, 1986
    Date of Patent: August 18, 1987
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kanji Meguro, Takeshi Fujita
  • Patent number: 4687853
    Abstract: Hetarylmethane leuco dyestuffs of the formula ##STR1## wherein R denotes halogen, alkyl, alkoxy, aryl or aryloxy,A denotes an aromatic-carbocyclic or -hetero-cyclic radical,B denotes hydrogen, halogen, alkyl, aryl, alkylcarbonyl, arylcarbonyl, amino, monoalkylamino, dialkylamino, arylamino, aralkylamino or acylamino,X denotes CH or N,Y denotes ##STR2## R.sub.6 denotes hydrogen or alkyl, m denotes 4-6 andn denotes O and 1-4 andwherein the cyclic and acyclic radicals in turn can be substituted by nonionic radicals, are used as color formers in pressure-copyable and thermoreactive recording materials.
    Type: Grant
    Filed: March 8, 1985
    Date of Patent: August 18, 1987
    Inventors: Hans-volker Runzheimer, Ulrich Nehen, Gert Jabs
  • Patent number: 4687775
    Abstract: This invention relates to 2-[(imidazo[1,2-a]pyridinylmethyl)-sulfinyl]-1H-benzimidazoles that are useful in the treatment and prevention of ulcers.
    Type: Grant
    Filed: July 17, 1986
    Date of Patent: August 18, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Gilbert W. Adelstein, Alan E. Moormann, Stella S. T. Yu
  • Patent number: 4687864
    Abstract: The present invention describes 5-fluoro-3-oxaprostacyclin (PGI.sub.2) derivatives of Formula I. These compounds are useful for the treatment of platelet dysfunction, atherosclerosis, hypertension and tumor cell metastasis. Also disclosed is the process for preparing them and the appropriate intermediates. ##STR1## wherein R.sup.1 is: (a) Na, K, or 1/2 Ca, or other pharmaceutically acceptable cation(b) NR.sup.3 .sub.2 with the adjacent connecting oxygen omitted, where R.sup.3 =H, methyl, ethyl, isopropyl or a combination of these groups;(c) Alkyl of 1 to 6 carbon atoms, either branched or straight chain(d) Hydrogenwherein OH on carbon 15 is optionally on carbon 16;wherein X=OCH.sub.3 or OC.sub.2 H.sub.5 when neither C.sub.5 -C.sub.6 or C.sub.6 -C.sub.7 is a double bond and nothing if C.sub.5 -C.sub.6 or C.sub.6 -C.sub.7 is a double bond;wherein R.sup.
    Type: Grant
    Filed: September 18, 1985
    Date of Patent: August 18, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Stevan W. Djuric, Leland J. Chinn, Kurt J. Rorig
  • Patent number: 4687845
    Abstract: A method for the preparation of a thiazine derivative, having insecticidal properties, of the formula ##STR1## where each R is hydrogen or an appropriate aromatic or aliphatic substituent and X is hydrogen, halogen or lower alkyl, the method comprising reacting together a sulphur donor, a compound of the formula Y.sub.2 C.dbd.CXNO.sub.2 where Y is halogen (preferably chlorine) or another appropriate leaving group and a compound of the formulaH.sub.2 NCR.sub.2 CR.sub.2 CR.sub.2 OSO.sub.3 H.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: August 18, 1987
    Assignee: Fine Organics Limited
    Inventors: John Hollowood, Arthur Jackson, Graham Heyes
  • Patent number: 4687865
    Abstract: A process is provided for preparing a 7-oxabicycloheptane amino alcohol intermediate of the general structure ##STR1## (wherein the above structures represents (D) or (L) isomers) which is useful in preparing thromboxane A.sub.2 receptor antagonists. This intermediate is prepared by reacting mesoanhydride with an aryl amine ##STR2## wherein R is alkyl, CH.sub.2 OH, CO.sub.2 H or CO.sub.2 alkyl, to form the acid ##STR3## which is reduced by treatment with lithium aluminum hydride or diisobutylaluminum hydride or Red-Al to form the alcohol ##STR4## wherein R.sup.1 is CH.sub.2 OH when R is CO.sub.2 H, CO.sub.2 alkyl or CH.sub.2 OH, and R.sup.1 is alkyl when R is alkyl; where in the above alcohol R.sup.1 is CH.sub.2 OH, such alcohol compound is treated with an alkyl chloroformate in the presence of base such as an alkali metal alkoxide to form the alcohol ##STR5## which undergoes cleavage by treatment with alkali metal, ammonia and acid to form the amino alcohol intermediate.Where in the above alcohol R.sup.
    Type: Grant
    Filed: June 4, 1986
    Date of Patent: August 18, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John K. Thottathil
  • Patent number: 4685956
    Abstract: Herbicidally active 1-aryl-5-hydrazinopyrazoles of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents cyano or nitro,R.sup.3 represents hydrogen, or represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, or represents a radical ##STR2## or represents a radical --SO.sub.2 --R.sup.7, R.sup.4 represents hydrogen, or represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, or represents a radical ##STR3## or represents a radical --SO.sub.2 --R.sup.7, R.sup.5 represents hydrogen: or, in the case where R.sup.4 represents hydrogen, also represents a radical ##STR4## or represents a radical --SO.sub.2 --R.sup.7, or represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, wherein, in each case,X represents oxygen or sulphur,R.sup.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: August 11, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4685959
    Abstract: Novel pyridyloxyphenoxyalkanoates, alkenoates, R-enantiomers and derivatives thereof possess herbicidal activity selectively in the presence of broadleaf crops with preemergent or postemergent applications.
    Type: Grant
    Filed: December 17, 1985
    Date of Patent: August 11, 1987
    Assignee: The Dow Chemical Company
    Inventors: Richard B. Rogers, Cleve A. I. Goring
  • Patent number: 4685957
    Abstract: Plant growth regulants and herbicides of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents cyano or nitro,R.sup.3 and R.sup.4 independently of one another each represent hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl or halogenoalkyl or represent optionally substituted aryl, orR.sup.3 and R.sup.4 together represent a divalent alkylene radical,R.sup.5 represents hydrogen or alkyl andAr represents optionally substituted phenyl, or represented optionally substituted pyridyl.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: August 11, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Otto Schallner, Jorg Stetter, Klaus Lurssen, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4686231
    Abstract: Novel compounds, compositions and pharmaceutical a method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprising administering an effective, 5-lipoxygenase pathway inhibiting amount of a 4,5-diaryl-2(substituted)-imidazole or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: August 11, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Don E. Griswold, Nabil Hanna, Henry M. Sarau
  • Patent number: 4686033
    Abstract: The efficiency of metals separation using ore flotation is improved by the use of certain substituted hydrocarbylene trithiocarbonates as suppressants for undesired metals.
    Type: Grant
    Filed: November 27, 1985
    Date of Patent: August 11, 1987
    Assignee: Phillips Petroleum Company
    Inventors: Clarence R. Bresson, Robert M. Parlman, James B. Kimble
  • Patent number: 4686227
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.3 is hydrogen, halogen or ar(lower)alkoxy, andR is lower alkanoyl, nitroso, amino, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, haloformyl, aminomethyleneamino which may be substituted with cyano or lower alkyl, iminomethylamino which may be substituted with cyano or lower alkyl, or a group of the formula: --A--R.sup.2 in whichA is lower alkylene andR.sup.2 is di(lower)alkylamino, cyano, lower alkoxy, N-containing heterocyclic group which may have suitable substituent(s), lower alkynyloxy, lower alkenyloxy, lower alkylthio, amino(lower)alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, hydroxy, lower alkanoyloxy, heterocyclicamino (lower)alkylthio having two oxo groups, hydrogen or a group of the formula: ##STR2## in which R.sup.4, R.sup.5 and R.sup.6 are each lower alkyl andX is an acid residue,and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 17, 1985
    Date of Patent: August 11, 1987
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Ikuo Ueda, Youichi Shiokawa, Masayuki Kato, Nobukiyo Konishi, Atsushi Akahane
  • Patent number: 4685783
    Abstract: A series of photochromic compounds are disclosed which have the property of undergoing a reversible color change when exposed to unfiltered sunlight and reverting to their original color in the absence of U.V. light at room temperature. These compounds have the general formula: ##STR1## represents an adamantylidene or a substituted adamantylidene group;R.sub.1 represents hydrogen, alkyl, aryl, aralkyl or a heterocyclic group,X represents oxygen or > NR.sub.2, in which R.sub.2 is hydrogen, aryl, alkyl or aralkyl and ##STR2## represents an aromatic group, an unsaturated heterocyclic group or a benzannelated heterocyclic group.The photochromic compounds of the invention are useful in the manufacture of photoreactive lenses, particularly plastic lenses.
    Type: Grant
    Filed: September 5, 1984
    Date of Patent: August 11, 1987
    Assignee: The Plessey Company P.L.C.
    Inventors: Harold H. Heller, Stephen N. Oliver, John Whittal, William Johncock, Paul J. Darcy, Clive Trundle