Patents Examined by Howard T. Mars
  • Patent number: 5493059
    Abstract: A process for the preparation of tertiary alkyl ethers, in particular methyl-tert.-butyl-ether (MTBE), from iso-olefins and aliphatic alcohols by means of a fractionation tower is disclosed, in which the main characteristic of the fractionation tower consists in that the reaction mixture is caused to flow through the catalytic trays in transversal direction relatively to the axis of the same fractionation tower.
    Type: Grant
    Filed: May 27, 1993
    Date of Patent: February 20, 1996
    Assignees: Eniricerche SpA, Snamprogetti SpA, Ecofuel SpA
    Inventors: Domenico Sanfilippo, Maria Lupieri, Francesco Ancillotti
  • Patent number: 5446035
    Abstract: New 20-methyl-substituted vitamin D derivatives of general formula I ##STR1## are described in whichR.sup.1 means a hydrogen atom, a hydroxy group or an alkanoyloxy group with 1 to 12 carbon atoms or a benzoyloxy group,R.sup.2 means a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group andR.sup.3 means a saturated or unsaturated, straight-chain or branched hydrocarbon radical with up to 18 C atoms, which optionally contains carbocyclic structures, optionally substituted with one or more hydroxy, oxo, amino group(s) and/or one or more halogen atom(s) as well as optionally exhibits one or more oxygen, sulfur and/or nitrogen atom(s) as a bridging link or links in the hydrocarbon radical, and a process for their production.Relative to calcitriol, the new compounds exhibit a greatly improved induction of cell differentiation (HL-60) and are suitable for the production of pharmaceutical agents.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: August 29, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Gunter Neef, Andreas Steinmeyer, Gerald Kirsch, Katica Schwarz, Ruth Thieroff-Ekerdt, Herbert Wiesinger, Martin Haberey
  • Patent number: 5443971
    Abstract: A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centers which comprises selective reaction of at least one isomer with a reagent catalyzed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of Formula (1): ##STR1## wherein: Z is --H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; andY is formyl or protected formyl.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: August 22, 1995
    Assignee: Zeneca Limited
    Inventors: Andrew J. Blacker, John Crosby, John A. L. Herbert
  • Patent number: 5443970
    Abstract: A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres, which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyranone is of Formula (1): ##STR1## wherein: Z is --H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; andY is optionally substituted hydrocarbyl.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: August 22, 1995
    Assignee: Zeneca Limited
    Inventors: Andrew J. Blacker, John Crosby, John A. L. Herbert
  • Patent number: 5441990
    Abstract: Part of CO-rich syngas, including volatile metal or any acid impurities, reacts with water making cleaned, heated, H.sub.2 -enriched syngas. The rest of the impure CO-rich syngas is combined with hot, H.sub.2 -enriched syngas making cleaned, H.sub.2 -rich syngas, useful for making methanol or oxo compounds.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: August 15, 1995
    Assignee: Texaco Inc.
    Inventors: Allen M. Robin, Robert M. Suggitt
  • Patent number: 5426252
    Abstract: Chloromethane compounds including carbon tetrachloride and the chlorofluoromethane compounds, such as dichlorodifluoromethane, can be catalytically hydrodechlorinated, e.g., in the case of dichlorodifluoromethane to monochlorodifluoromethane and/or difluoromethane, by treatment with hydrogen in the presence of a transition metal carbide catalyst, for example, a Group IVB metal carbide, such as tungsten carbide, supported on an oxidic support, such as alumina, optionally with a passivating layer of ceramic, such as silicon carbide, between the oxidic support and catalyst. The catalyst preferably has a surface area of no less than about 1 m.sup.2 /gm.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: June 20, 1995
    Assignee: Akzo Nobel NV
    Inventor: Fawzy G. Sherif
  • Patent number: 5426102
    Abstract: Novel compounds of the general formula I ##STR1## and the pharmacologically tolerable addition salts thereof with acids are described, in which eitherIa) R.sup.11 represents a hydrogen atom in the .beta.-configuration and each of R.sup.12 and R.sup.13 represents a hydrogen atom, orIb) R.sup.11 represents a hydrogen atom in the .beta.-configuration and R.sup.12 and R.sup.13 together represent a second bond, orIc) R.sup.11 and R.sup.12 together represent a second bond and R.sup.13 represents a hydrogen atom, orId) R.sup.11 represents a hydrogen atom in the .alpha.-configuration and R.sup.12 and R.sup.13 together represent a second bond,and in Ia), Ib), Ic) or Id)X represents an oxygen atom, the hydroxyimino grouping >N.about.OH or two hydrogen atoms,R.sup.1 represents a hydrogen atom or a methyl group,R.sup.2 represents a hydroxy group, a C.sub.1 -C.sub.10 -alkoxy group or a C.sub.1 -C.sub.10 -acyloxy group, andR.sup.3 and R.sup.
    Type: Grant
    Filed: June 22, 1993
    Date of Patent: June 20, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Schwede, Eckhard Ottow, Gunter Neef, Arwed Cleve, Krzysztof Chwalisz, Horst Michna
  • Patent number: 5426242
    Abstract: Compounds of the structure:H(OCH.sub.2 CH.sub.2).sub.k ORO X.sub.m (CH.sub.2 CH.sub.2 O).sub.n H (I)where R is a divalent hydrocarbyl or hetero-substituted hydrocarbylgroup having up to 10 carbon atoms,X is --CH.sub.2 CH(R.sup.1)O-- or --(CH.sub.2).sub.4 O--,R.sup.1 is methyl or ethyl,m is from 0.5 to 3.0 andk+n is from 3 to 10the number of X groups not exceeding 25% by weight of the compound are disclosed. Such compounds are useful as hydraulic fluids. R is typically --(CH.sub.2).sub.x -- where x is from 4 to 10. A process for preparing an alkoxylating agent with a diol HOROH in a first step and further reacting the product of the first step with ethylene oxide is also disclosed. A typical diol is 1,6-hexanediol; a typical alkoxylating agent is propylene oxide.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: June 20, 1995
    Assignee: International Specialty Chemicals Limited
    Inventor: John R. Moxey
  • Patent number: 5426256
    Abstract: Perchloroethylene and hydrogen chloride are made by thermal noncatalytic chlorination of hydrocarbons and/or their partially chlorinated derivatives using carbon tetrachloride as a reactive diluent under conditions which maximize consumption of carbon tetrachloride and minimize the production of heavy ends, such as hexachlorobenzene and other tarry products.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: June 20, 1995
    Assignee: Vulcan Materials Company
    Inventor: Jimmie T. Petrosky
  • Patent number: 5426250
    Abstract: 1,4-butanediol is prepared from allyl alcohol containing allyl acetate and water. The allyl alcohol is subjected to a hydroformylation reaction in the presence of an organic solvent, a rhodium complex, and a phosphorous compound under an atmosphere of carbon monoxide and hydrogen, to produce a hydroformylation product, which is extracted with an alkaline aqueous solution in the presence of carbon monoxide and/or hydrogen. After the extraction, an extracted raffinate solution containing the rhodium complex in the organic solvent is recycled through the same hydroformylation process, while the extracted aqueous solution containing the hydroformylation product is subjected to a hydrogenation reaction in the presence of hydrogen, with a hydrogenation catalyst added, to produce 1,4-butanediol.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: June 20, 1995
    Assignee: Darien Chemical Corporation
    Inventors: Shien C. Chen, Cheng C. Chu, Fu S. Lin, June Y. Chou
  • Patent number: 5424335
    Abstract: The purge gas from a methanol synthesis loop is subjected to a further step of methanol synthesis, preferably while in indirect heat exchange with the purge gas undergoing heating to the synthesis inlet temperature so that the reacted purge gas, containing synthesized methanol, leaves the synthesis catalyst at a temperature below the maximum temperature achieved by the reacting purge gas during passage over the catalyst.The synthesis loop can be operated less efficiently, eg at a lower pressure or with added carbon dioxide, than is conventional since the additional methanol produced from the purge gas compensates for the loss of loop efficiency.The addition of the purge gas synthesis stage enables existing plants to be uprated by lowering the loop pressure, thus enabling a greater throughput through the synthesis gas compressor to be achieved.
    Type: Grant
    Filed: November 23, 1993
    Date of Patent: June 13, 1995
    Assignee: Imperial Chemical Industries PLC
    Inventor: Peter E. J. Abbott
  • Patent number: 5424462
    Abstract: The present invention provides a method for producing (+)-estrone derivatives, characterized in that it comprises starting from a certain cyclopentadiene derivative, reacting the derivative with a certain diene compound by an asymmetric Diels-Alder reaction, and via intermediates obtaining a (+)-estron derivative represented by the following formula: ##STR1## wherein R is alkyl of 1-20 carbon atoms. According to the present invention, (+)-estron derivatives can be obtained by limited steps from the starting materials of dicyclopentadiene derivatives.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: June 13, 1995
    Assignee: Chisso Corporation
    Inventors: Seiichi Takano, Kunio Ogasawara
  • Patent number: 5424461
    Abstract: A process for preparing 1-amino-4-hydroxyanthraquinone by treating 1,4-dihydroxyanthraquinone with ammonia in an aqueous medium comprises treating with ammonia in the presence of a base and of a catalytic amount of a reducing agent at from 60.degree. to 150.degree. C. and at from 1 to 30 bar.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: June 13, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Erwin Hahn, Manfred Patsch, Heike Kilburg
  • Patent number: 5424460
    Abstract: The present invention relates to new fluorinated hexane compounds corresponding to the following general formula (II): ##STR1## in which X'.sub.2, X'.sub.3 and X'.sub.4 are the same or different, and denote a halogen or a pseudohalogen, preferably a halogen, more preferably chlorine and fluorine, with the condition that, when R.sub.1 is hydroxyl, cyano, amido, imido, ethoxy, benzyloxy, cyclohexyloxy and tert-butoxy, not all the halogens can simultaneously be chlorine and R.sub.4, R.sub.3 and R.sub.5 are simultaneously equal to H;R.sub.1 denotes a hydrogen, a hydrocarbon chain such as an alkyl chain, alkoxy, cycloalkyl ether, an aromatic group, aromatic ether or an alkoxy, carbonyl, carboxyl or acyloxy, cyano, amido, imido or hydroxyl group;R.sub.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: June 13, 1995
    Assignee: Rhone-Poulenc Chimie
    Inventors: Lucette Duhamel, Pierre Duhamel, Bertrand Leblond, Jean-Marie Poirier
  • Patent number: 5424306
    Abstract: A storage stable form of the pivaloyloxymethyl ester of the carbapenem derivative known as (1R, 5S, 6S)-2-[(4R)-2-oxo-4-pyrrolidinylthio]-6-[(1R)-1-hydroxyethyl]-1-methyl-1-c arbapen-2-em-3-carboxylic acid in crystalline form.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: June 13, 1995
    Assignee: Sankyo Company, Limited
    Inventors: Isao Kawamoto, Masao Miyauchi, Roruro Endo
  • Patent number: 5422375
    Abstract: A method of conducting a continuous multi-phase catalytic reaction such as the conversion of syngas to higher hydrocarbon fuels. Gaseous reactants are introduced via a gas permeable plate into a slurry which includes the product and a finely divided catalyst. The liquid product is separated from the remainder of the slurry by means of a filter unit including a filter member. A pressure differential is established across the filter member by means of a constant level device within the filter unit which maintains a level of filtrate within the filter unit below the level of the slurry. The slurry is maintained in a constant state of agitation by the introduction of the gaseous components as a steam of bubbles. Fluctuations in the pressure differential across the filter member prevent the filter member from clogging, and the gas space is above the filtrate and the slurry are in communication.
    Type: Grant
    Filed: February 24, 1993
    Date of Patent: June 6, 1995
    Assignee: Den Norske Stats Oljeselskap AS
    Inventors: Erling Rytter, Petter Lian, Trond Myrstad, Per T. Roterud, Age Solbakken
  • Patent number: 5422366
    Abstract: Fungal nail infections are treated by depriving aerobic fungi of oxygen by forming an oxygen barrier over the exposed surface of an infected nail. Conveniently, the oxygen barriers are formed by applying a liquid film-forming carrier comprising an oxygen-scavenging substance, such as transition metal chelate or complex of salicylic acid or a salicylate, an oxidizable organic acid or alcohol in combination with a catalyzing agent, or a polycarboxylic acid chelate or complex of a transition metal or transition metal salt.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: June 6, 1995
    Assignee: Advanced Oxygen Technologies, Inc.
    Inventors: Medwin M. Mintzis, N. Ross Buckenham, Donald G. Rosellini
  • Patent number: 5420359
    Abstract: Normally liquid chlorofluoroether compositions consisting or consisting essentially of one or a selected mixture of perhalogenated chlorofluoroether compounds are provided by direct fluorination of the corresponding chloroether or chlorofluoroether precursors. The compositions are useful, for example, as heat transfer agents, blood substitutes, and solvents.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: May 30, 1995
    Assignees: Minnesota Mining and Manufacturing Company, HemaGen/PFC
    Inventors: George G. I. Moore, Richard M. Flynn, Robert J. Kaufman, Thomas J. Richard
  • Patent number: 5420365
    Abstract: Process for the preparation of 2,4-hexadiyne-1,6-diol of the formula IHO-CH.sub.2 -CH.sub.2 -C.ident.C-.ident.C-CH.sub.2 -OH (I)by the reaction of diacetylene of the formula IIH-C.ident.C-C.ident.C-H (II)with formaldehyde of the formula IIIH.sub.2 C=O (III),in the presence of a silver catalysts, in which the reaction is carried out in the presence of a polar organic solvent at temperatures ranging from 0.degree. to 150.degree. C. and under pressures ranging from 0.01 to 10 bar.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: May 30, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Stefan Rittinger, Norbert Rieber
  • Patent number: 5420119
    Abstract: Carbapenem compounds of formula (I): ##STR1## [in which: A is a fully saturated heterocyclic group, of which at least one ring atom is nitrogen; R.sup.1 is hydrogen or methyl; R.sup.2 is hydrogen or alkyl; R.sup.3 is hydrogen or a negative ion; Q is: (i) --B--N.sup.+ R.sup.8 R.sup.9 R.sup.10, where R.sup.8, R.sup.9 and R.sup.10 are alkenyl, alkynyl or optionally substituted alkyl, and B is alkylene or alkylidene; (ii) a heterocyclic group of which one ring atom is a >N.sup.+ R.sup.11 R.sup.12, where R.sup.11 and R.sup.12 are alkenyl, alkynyl or optionally substituted alkyl; (iii) alkyl substituted by a heterocyclic group as defined in (ii) above; or (iv) alkyl substituted by an aromatic heterocyclic group, of which one ring atom is ##STR2## or R.sup.2 and Q, and the nitrogen to which they are attached, form a group of formula (II): ##STR3## where m and n are 1, 2 or 3; R.sup.6 is optionally substituted alkyl; and R.sup.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: May 30, 1995
    Assignee: Sankyo Company, Limited
    Inventors: Isao Kawamoto, Masao Miyauchi, Eiji Nakayama, Rokuro Endo, Satoshi Ohya, Yukio Utsui