Patents Examined by Howard T. Mars
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Patent number: 5420120Abstract: Topically administrable C-21 thioether glucocorticoid steroid derivatives are disclosed as effective anti-inflammatory agents for the treatment of ophthalmic inflammatory disorders. These C-21 thioether derivatives do not cause a significant increase in intraocular pressure as a side effect.Type: GrantFiled: December 17, 1993Date of Patent: May 30, 1995Assignee: Alcon Laboratories, Inc.Inventor: John J. Boltralik
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Patent number: 5420119Abstract: Carbapenem compounds of formula (I): ##STR1## [in which: A is a fully saturated heterocyclic group, of which at least one ring atom is nitrogen; R.sup.1 is hydrogen or methyl; R.sup.2 is hydrogen or alkyl; R.sup.3 is hydrogen or a negative ion; Q is: (i) --B--N.sup.+ R.sup.8 R.sup.9 R.sup.10, where R.sup.8, R.sup.9 and R.sup.10 are alkenyl, alkynyl or optionally substituted alkyl, and B is alkylene or alkylidene; (ii) a heterocyclic group of which one ring atom is a >N.sup.+ R.sup.11 R.sup.12, where R.sup.11 and R.sup.12 are alkenyl, alkynyl or optionally substituted alkyl; (iii) alkyl substituted by a heterocyclic group as defined in (ii) above; or (iv) alkyl substituted by an aromatic heterocyclic group, of which one ring atom is ##STR2## or R.sup.2 and Q, and the nitrogen to which they are attached, form a group of formula (II): ##STR3## where m and n are 1, 2 or 3; R.sup.6 is optionally substituted alkyl; and R.sup.Type: GrantFiled: October 27, 1993Date of Patent: May 30, 1995Assignee: Sankyo Company, LimitedInventors: Isao Kawamoto, Masao Miyauchi, Eiji Nakayama, Rokuro Endo, Satoshi Ohya, Yukio Utsui
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Patent number: 5416064Abstract: A cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. A therapeutic agent for killing selected cell populations comprising: (a) a cytotoxic amount of one or more maytansinoids linked to a cell binding agent, and (b) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting a cell population or tissue suspected of containing cells from said selected cell population with a cytotoxic amount of a cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. An N-methyl-alanine-containing ester of maytansinol or an analogue of maytansinol, said N-methyl-alanine-containing ester comprising a linking group capable of linking an N-methyl-alanine-containing maytansinoid ester to a chemical moiety. N-methyl-cysteine-containing ester of maytansinol or an analogue of maytansinol.Type: GrantFiled: December 7, 1992Date of Patent: May 16, 1995Assignee: ImmunoGen, Inc.Inventors: Ravi J. Chari, Victor S. Goldmacher, John M. Lambert, Walter A. Blattler
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Patent number: 5416068Abstract: .alpha.-Phenylacrylic acid derivatives I ##STR1## n=1; y=1;R.sup.1 =methylR.sup.2 =methyl, ethyl or methoxymethylR.sup.3 =H;R.sup.4 is 2,5-dimethylphenyl, 2,5-dichloropehnyl, 2-methyl-5-chlorophenyl, 2,4-dimethylphenyl, 2-chloro-5-methylphenyl, 2,3,5-trimethylphenyl or 2-methyl-5-isopropylphenyl.W=oxygen;A is --O--, --S--, --OCH.sub.2 --, --SCH.sub.2 --, --CH.dbd.CH--, --CO--OCH.sub.2 -- or --N(CH.sub.3) --CH.sub.2 --; methods for their preparation, agents containing them for combating injurious fungi and pests, and their use.Type: GrantFiled: January 3, 1994Date of Patent: May 16, 1995Assignee: BASF AktiengesellschaftInventors: Wassilios Grammenos, Reinharad Kirstgen, Klaus Oberdorf, Hubert Sauter, Franz Roehl, Rainer Otter, Eberhard Ammermann, Gisela Lorenz, Uwe Kardorff, Christoph Kuenast
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Patent number: 5416263Abstract: 4,4'-Diamino-1,1'-dianthraquinonyl compounds which are obtained in a known manner and which are easy to agglomerate or aggregate owing mainly to their too fine particle size are conditioned by heating an aqueous suspension consisting essentially of the 4,4'-diamino-1,1'-dianthraquinonyl compound and water in the presence or absence of a mineral acid or an alkali. The thus obtained 4,4'-diamino-1,1'-dianthraquinonyl pigments are used in paints, printing inks, coloring of plastics and the like. The aqueous suspension is preferably prepared by desulfonating a 4,4'-diamino-1,1'-dianthraquinonyl-3,3'-disulfonic acid compound in a mineral acid such as sulfuric acid and then mixing the desulfonation reaction mixture with water or by once isolating the resulting 4,4'-diamino-1,1'-dianthraquinonyl compound and mixing the isolated compound with water.Type: GrantFiled: May 10, 1993Date of Patent: May 16, 1995Assignee: Sumitomo Chemical Co., Ltd.Inventors: Iwao Sakaguchi, Katsutoshi Numano, Toshiaki Kishimoto, Hiroki Inoue, Yoshiaki Hayashi, Keisuke Ito
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Patent number: 5416215Abstract: A process is described for preparing 2,2,6,6-tetramethylpiperidine-N-oxyl and its 4-position substituted derivatives by oxidation of 2,2,6,6-tetramethylpiperidine and its 4-position substituted derivatives in the presence of hydrogen peroxide and low concentrations of divalent metal salts.Type: GrantFiled: June 9, 1993Date of Patent: May 16, 1995Assignee: Huels AktiengesellschaftInventors: Wilfried Buschken, Manfred Kaufhold, Peter Bickert
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Patent number: 5416242Abstract: Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carbon atoms, and/or a salt thereof.Type: GrantFiled: August 1, 1994Date of Patent: May 16, 1995Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro
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Patent number: 5416240Abstract: Polyoxyalkylene glycols are prepared by a process in which tetrahydrofuran is polymerized with a total of not more than 95 mol %, based on the amount of tetrahydrofuran used, of one or more comonomers from the group consisting of the cyclic ethers and acetals in the absence of water and in the presence of a monohydric alcohol or of a monocarboxylic acid with the aid of an anhydrous heteropoly acid catalyst, and the polyoxyalkylene glycol is liberated from the resulting polyoxyalkylene glycol monoethers or polyoxyalkylene glycol monoesters by cleavage of the monoether or monoester bond.Type: GrantFiled: March 2, 1993Date of Patent: May 16, 1995Assignee: BASF AktiengesellschaftInventors: Hans-Juergen Weyer, Rolf Fischer, Gerhard Jeschek, Franz Merger, Herbert Mueller
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Patent number: 5416216Abstract: Novel piperidine compounds of the formula (I) ##STR1## in which R.sub.1 is e.g. hydrogen or methyl, n is e.g. 1 and A is e.g. --COR.sub.2 with R.sub.2 being C.sub.1 -C.sub.18 alkyl.The said compounds are effective as light stabilisers, heat stabilizers and oxidation stabilisers for organic materials.Type: GrantFiled: February 18, 1994Date of Patent: May 16, 1995Assignee: Ciba-Geigy CorporationInventors: Roberto Scrima, Graziano Zagnoni
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Patent number: 5414143Abstract: Polyoxyalkylene glycol monoethers of monohydric alcohols are prepared by a process in which tetrahydrofuran or a mixture of tetrahydrofuran with a total of not more than 95 mol %, based on the amount of tetrahydrofuran used, of one or more comonomers from the group consisting of the cyclic ethers and acetals is polymerised in the absence of water and in the presence of a monohydric alcohol and of an anhydrous heteropoly acid catalyst.Type: GrantFiled: March 2, 1993Date of Patent: May 9, 1995Assignee: BASF AktiengesellschaftInventors: Hans-Juergen Weyer, Rolf Fischer, Gerhard Jeschek, Herbert Mueller
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Patent number: 5414147Abstract: A method for improving the conversion of isobutylene in the MTBE reaction process while simultaneously producing a substantially methanol-free MTBE utilizes an increased methanol to isobutylene molar ratio in the reaction process and methanol-free C4 hydrocarbons as reflux. The use of a methanol-free C4 hydrocarbon stream as reflux eliminates the excess methanol generated by increasing the methanol to isobutylene molar ratio without requiring a higher reflux ratio or changing operating conditions. The method permits isobutylene conversion of more than 98% while producing a purified MTBE with less than 0.5% methanol content.Type: GrantFiled: August 24, 1993Date of Patent: May 9, 1995Assignee: Global Octanes CorporationInventor: Kunio Koga
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Patent number: 5414146Abstract: Porous metallosilicate catalyst (e.g. Zeolite Beta) is active at low temperature for converting lower alkanol (e.g. methanol) and C.sub.4 -C.sub.7 tertiary alkenes to high octane ether product. Such catalytic reaction is especially useful in multizone catalytic reactor systems employing catstill rectification.Type: GrantFiled: August 23, 1993Date of Patent: May 9, 1995Assignee: Mobil Oil CorporationInventors: Weldon K. Bell, Steven H. Brown, Mohsen N. Harandi, Jeffrey C. Trewella
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Patent number: 5412124Abstract: Disclosed herein are a naphthoquinone derivative represented by the following formula: ##STR1## wherein R.sup.1 means a hydrogen atom or methyl group, R.sup.2 is a hydrogen atom or methyl group, n stands for 0 or an integer of 1-9, and a linkage is a single bond or double bond with the proviso that if n is an integer of 2-9, the linkages may be identical with or different optionally from each other, such as a vitamin K derivative; and a process for producing the naphthoquinone derivative at a high yield without forming any geometric isomer; as well as 1,4,4.sub.a,5,8,9.sub.a -hexahydro-4.sub.a .alpha.-alkenyl-1.alpha.,4.alpha.-methanoanthraquinone derivatives and 1,4,4.sub.a,5,8,9.sub.a -hexahydro-1.alpha.,4.alpha.-methanoanthraquinone derivatives which are useful as intermediates for the preparation of the naphthoquinone derivatives.Type: GrantFiled: July 26, 1994Date of Patent: May 2, 1995Assignee: Eisai Chemical Co., Ltd.Inventors: Kimio Hamamura, Chiaki Seki, Masayuki Konishi
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Patent number: 5409960Abstract: Pentane (or similar light hydrocarbon) is used in a gas conversion process to consume the exothermic heat of reaction in the Fischer-Tropsch process, and expanded to produce the energy to drive the air plant compressors.Type: GrantFiled: June 15, 1994Date of Patent: April 25, 1995Assignee: Exxon Research and Engineering CompanyInventor: Thomas M. Stark
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Patent number: 5410093Abstract: An improved method for recovering purified poly(tetramethylene ether) glycol or similar polyether polyol from an aqueous solution of polymer containing an alkaline metal catalyst residue involving the addition of a stoichiometric excess of magnesium sulfate or sulfite followed by evaporation of water and separation of molten polymer from precipitated solid phase (i.e., from magnesium hydroxide, alkaline metal sulfate/sulfite, and excess magnesium sulfate/sulfite). Such a process results in essentially complete removal of any basic transesterification catalyst and water without significant lost of poly(tetramethylene ether) glycol or the like.Type: GrantFiled: February 17, 1994Date of Patent: April 25, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventor: Suriyanarayanan Dorai
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Patent number: 5410095Abstract: A process for the manufacture of pentafluorodimethyl ether is disclosed which involves contacting at least one starting compound selected from the group consisting of compounds having a formula (CF.sub.3 OCF.sub.2 CO.sub.2)A and compounds having he formula (CF.sub.3 OCF.sub.2 CO.sub.2).sub.2 A' wherein A is selected from the group consisting of hydrogen, ammonium, alkali metals (e.g., sodium or potassium) and R (wherein R is a C.sub.1 to C.sub.4 alkyl group) and A' is an selected from the group consisting of alkaline-earth metals (e.g., magnesium or calcium), with at least one hydroxylic compound selected from the group consisting of water, mono-alcohols of the formula R'OH (wherein R' is a C.sub.1 to C.sub.12 straight or branched chain alkyl group) and alkanediols of the formula R" (OH).sub.2 (wherein R" is a C.sub.2 to C.sub.8 alkylene group) at temperature of about 120.degree. C. to 170.degree. C.Type: GrantFiled: July 29, 1994Date of Patent: April 25, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventors: Paul R. Resnick, Allen C. Sievert
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Patent number: 5407663Abstract: Patients may effectively be treated for inflammatory conditions of the mouth using aqueous anti-inflammatory steroids in solutions that can be swished and expectorated as a mouthwash. Such therapy would allow direct contact of the medication with the diseased mucous membranes and would contact areas of the oral cavity that would not usually be reached with application of creams, gels, or ointments. Compositions containing antifungal agents in addition to steroids are particularly useful.Swishing for three to five minutes, then expectorating the aqueous anti-inflammatory-containing, results in maintenance of contact of the active agents with the oral cavity surfaces for a longer time than would application of gels containing those agents. The mode of application is simple and is not repugnant to the patient as is the application of creams, gels, or ointments.Type: GrantFiled: April 4, 1994Date of Patent: April 18, 1995Inventor: Drore Eisen
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Patent number: 5401887Abstract: The present invention is a cyclic process for the preparation of ethyl tert.-alkyl ethers by the reaction of an alcohol, ethanol, with an iso-olefin such as isobutylene or isoamylene wherein an effluent from the reaction zone is separated in a distillation column to provide an overhead effluent stream and a bottoms effluent stream comprising ethyl tert.-alkyl ether and unreacted ethanol. The unreacted ethanol is recovered in an adsorption zone comprising a selective adsorbent selected from the group consisting of zeolite 13X, sodium zeolite Y, alumina, silicalite and mixtures thereof. The invention is useful in recovering unreacted ethanol from the bottoms effluent stream and returning the unreacted ethanol to the reaction zone. The invention reduces the cost of this separation which is complicated by the formation of an azeotrope between the unreacted alcohol and the ether.Type: GrantFiled: February 25, 1994Date of Patent: March 28, 1995Assignee: UOPInventors: Henry Rastelli, Carmen M. Yon, Stanley J. Frey
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Patent number: 5401864Abstract: A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 is acyl of 1 to 8 carbon atoms, by reducing an intermediary to form an alcohol, oxidizing the alcohol to form an aidehyde, which is subjected to the action of an acyloxylation agent.Type: GrantFiled: October 29, 1993Date of Patent: March 28, 1995Assignee: Roussel-UclafInventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
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Patent number: 5399727Abstract: A process for the preparation of a compound of the formula ##STR1## comprising reacting a compound of the formula ##STR2## with chlorosulfonic in an organic solvent wherein the reaction is effected at -20.degree. C. to -10.degree. C. and the temperature is then allowed to rise to 0.degree. C. to 5.degree. C.Type: GrantFiled: June 2, 1993Date of Patent: March 21, 1995Assignee: Roussel-UclafInventors: Jean Buendia, Patrick Roussel, Michel Vivat