Patents Examined by J. E. Thomas
  • Patent number: 4943427
    Abstract: A diagnostic agent for heart disease comprising a radiolabeled monoclonal antibody having specificity to cardiac myosin heavy chain or its active fragment is disclosed. The diagnostic agent is useful for topographic diagnosis of heart disease such as myocardial infarction and myocardial disease by imaging.
    Type: Grant
    Filed: March 25, 1985
    Date of Patent: July 24, 1990
    Assignee: Yamasa Shoyu Kabushiki Kaisha
    Inventors: Yoshio Yazaki, Masahito Sugi
  • Patent number: 4938947
    Abstract: The present invention relates to an aerosol composition for in vivo imaging or ex vivo diagnosis of tumors, which composition contains one or more soluble fragments of bacterial wall or cell peptidoglycan or equivalent synthetic compounds which are labelled with a radioactive, paramagnetic or fluorescent element and encapsulated in liposomes and a substrate which can be used for administration by aerosol.
    Type: Grant
    Filed: January 4, 1988
    Date of Patent: July 3, 1990
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Yves-Claude Nicolau, Alain Le Pape, Rita Barot-Ciorbaru
  • Patent number: 4937067
    Abstract: The metabolic activity of the adrenal gland can be monitored by intravenously injecting an infusate composed of low density lipoproteins labelled with a radioisotope that is suitable for extracorporeal imaging and subsequently measuring the intensity of radioisotope accumulation in organs of the body. By monitoring the accumulation at the sites of the adrenal glands, the metabolic activity can be localized and the level of activity can be assessed.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: June 26, 1990
    Assignee: Massachusetts Institute of Technology
    Inventor: Robert S. Lees
  • Patent number: 4931208
    Abstract: A ferroelectric liquid crystal composition having a long helical pitch and a light switching element having a quick response property are provided. This composition comprises (1) at least one member selected from the group consisting of liquid crystal compounds having a smectic C phase and no helical structure and liquid crystal compounds having only a nematic phase as a liquid crystal phase and no helical structure and (2) at least one chiral smectic liquid crystal compound.
    Type: Grant
    Filed: August 3, 1988
    Date of Patent: June 5, 1990
    Assignees: Chisso Corporation, Hitachi, Ltd.
    Inventors: Kenji Furukawa, Kanetsugu Terashima
  • Patent number: 4927917
    Abstract: There are provided compounds which give quasi-liquid crystals, which comprise a mesogenic group, which can contain bridging groups, a bridging group and a spiropyran moiety having a 2H pyran ring, a terminal group being attached to the mesogenic group. The mesogenic group contains two aromatic, heterocyclic or cycloaliphatic ring structures. The compounds are prepared by a coupling reaction of mesogenic groups with a spiropyran compound via a suitable bridging group. There is provided a process for producing quasi-liquid crystalline (QLC) films which are useful for producing a wide variety of devices based on the optical non-linearity of generation of second harmonics by such films. Such devices can also be based on ferroelectric, pyroelectric, piezoelectric effects and photoactivity of such oriented QLC films.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: May 22, 1990
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Valeri A. Krongauz, Felix P. Shvartsman
  • Patent number: 4925591
    Abstract: Disclosed is a mesomorphic compound having a .beta.-hydroxycarboxyl group as the chiral source, which is represented by the formula: ##STR1## wherein m and n are integers of from 1 to 18, X.sub.1 and X.sub.2 independently represent fluorine, chlorine or hydrogen, Y represents ##STR2## or --O--, Z represents a direct bond, ##STR3## --CH hd 2O-- or --OCH.sub.2 --, and * indicates the asymmetric carbon. The mesomorphic compound is valuable as a ferroelectric liquid crystal or an additive to a ferroelectric liquid crystal or to a compound showing the SmC phase and having no chiral group.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: May 15, 1990
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Jun Nakauchi, Mioko Uematsu, Keiichi Sakashita, Yoshitaka Kageyama, Seiji Hayashi, Kenji Mori
  • Patent number: 4925278
    Abstract: Compounds of the formula ##STR1## wherein m represents is the number 0 or 1; A is a single covalent bond, --CH.sub.2 --CH.sub.2 --, --OCH.sub.2 --, --COO-- or --OOC--; rings B, C and D are 1,4-phenylene optionally substituted with cyano, halogen or lower alkyl; Y.sup.1 and Y.sup.2 are hydrogen or one of them also is cyano; and R.sup.1 and R.sup.2 each represents C.sub.1 -C.sub.18 -alkyl or C.sub.2 -C.sub.18 alkenyl, either of which is optionally halogen-substituted, in which one CH.sub.2 group or two non-adjacent CH.sub.2 groups is/are optionally replaced by oxygen; with the provisos that at least one of R.sup.1 and R.sup.2 has a chiral carbon atom or a C-C double bond or both when A is --COO-- and at least one of R.sup.1 and R.sup.2 has a C-C double bond when A is a single covalent bond, their preparation, liquid crystalline mixtures containing these compounds and their use for electro-optical purposes are described.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: May 15, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Buchecker, Hans-Jurgen Fromm, Stephen Kelly, Martin Schadt
  • Patent number: 4923633
    Abstract: A compound suitable for use in a ferroelectric smectic liquid crystal composition having a structure which contains two chiral centers derived from alpha hydroxy carboxylic acid groups and having the formula: ##STR1## wherein R.sub.1 is n-alkoxy containing 1-12 carbo atoms and R.sub.2 is n-alkyl containing 1-12 carbon atoms. Methods of preparation and details of liquid crystal mixtures containing these compounds are described.
    Type: Grant
    Filed: November 30, 1987
    Date of Patent: May 8, 1990
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: George W. Gray, David Lacey, Kenneth J. Toyne, David Coates, Adam Jackson, Richard M. Scrowston
  • Patent number: 4915491
    Abstract: This invention provides novel acrylic copolymers which exhibit nonlinear optical response, and which have utility as a transparent optical component in optical light switch and light modulator devices.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: April 10, 1990
    Assignee: Hoechst Celanese Corporation
    Inventors: Ronald N. DeMartino, Hyun-Nam Yoon, James B. Stamatoff
  • Patent number: 4915868
    Abstract: Optically active esters of 1-acylproline of the general formula ##STR1## in which at least one of the radicals R.sup.1 and R.sup.2 is a mesogenic radical, are suitable as dopes in ferroelectric liquid-crystal mixtures. Proline derivatives in which only the R.sup.1 radical is mesogenic are preferred.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: April 10, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter Gunther, Dieter Ohlendorf, Rainer Wingen
  • Patent number: 4913839
    Abstract: A ferroelectric liquid crystal polymer comprising the recurring units represented by the following general formula: ##STR1## in which k is an integer of from 1 to 30,R.sub.1 is ##STR2## R.sub.2 is --COOR.sub.3, --OCOR.sub.3, --OR.sub.3, or --R.sub.3, in whichR.sub.3 is ##STR3## R.sub.4 is --CH.sub.3 or Cl, m is 0 or an integar of from 1 to 10,n is 0 or an integar of from 1 to 10, providing that n is not 0, when R.sub.4 is --CH.sub.3.The ferroelectric liquid crystal polymer of the present invention not only exhibits a ferroelectricity even at temperatures in the vicinity of a room temperature, but also has so fast response speed to the external factors as to be able to display motion pictures, and may be advantageously used as display elements for large size screens and a curved screens.
    Type: Grant
    Filed: April 18, 1989
    Date of Patent: April 3, 1990
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Shunji Uchida, Kazuharu Morita, Kenji Hashimoto
  • Patent number: 4914224
    Abstract: An optically active carboxylic acid derivative represented by the general formula ##STR1## wherein R represents a normal alkyl group having 1 to 20 carbon atoms, m and n represent 0 or 1 but are not 1 at the same time, X represents a hydrogen or halogen atom, Y represents a hydrogen or fluorine atom, provided that when Y is a hydrogen atom, X is a halogen atom, and that when n is 0, Y is ahydrogen atom, and Q* represents an optically active alkyl or 1-alkoxyethyl group having an asymmetric carbon atom.
    Type: Grant
    Filed: January 28, 1987
    Date of Patent: April 3, 1990
    Assignees: Dainippon Ink and Chemicals, Inc., Kawamura Institute of Chemical Research
    Inventors: Tadao Shoji, Sadao Takehara, Toru Fujisawa, Masashi Osawa, Hiroshi Ogawa, Yoshi Arai, Jitsuo Kurokawa
  • Patent number: 4911861
    Abstract: Polyphenyl-based liquid crystal compounds represented by the following general formula (1) and liquid crystal composition containing the same: ##STR1## wherein R.sup.1 represents a straight or branched C.sub.1-18 alkyl group, haloalkyl group, aralkyl group or haloaralkyl group with or without optically active carbon, R.sup.2 represents a straight or branched C.sub.1-6 alkyl group, haloalkyl group or aralkyl group with or without optically active carbon, W represents (1) --OCO-- or --COO--, in which case T represents a halogen atom or a methyl group, or (2) a single bond, --O-- or --OCOO--, in which case T represents a halogen atom, X represents --OCO--, --COO--, --C.dbd.C--, --CH.dbd.N--, --N.dbd.CH, Y represents single bond, --O--, --COO--, --OCO--, --CH.sub.2 --, --OCH.sub.2 --, --COOCH.sub.2 -- or --OCOCH.sub.2 --, Z.sub.1 and Z.sub.2 represent a hydrogen or halogen atom, a cyano group or nitro group, Z.sub.1 may be the same or different from Z.sub.
    Type: Grant
    Filed: November 16, 1987
    Date of Patent: March 27, 1990
    Assignee: Ajinomoto Co., Inc.
    Inventors: Ryoichi Higuchi, Takao Sakurai, Tatsuru Tabohashi, Naoko Mikami, Kiriko Akaiwa, Eri Yamamoto, Koji Takeuchi
  • Patent number: 4911862
    Abstract: An optically active carboxylic acid derivative represented by the general formula ##STR1## wherein R represents a normal alkyl group having 1 to 20 carbon atoms, m and n represent 0 or 1 but are not 1 at the same time, X represents a hydrogen or halogen atom, Y represents a hydrogen or fluorine atom, provided that when Y is a hydrogen atom, X is a halogen atom, and that when n is 0, Y is a hydrogen atom, and Q* represents an optically active alkyl or 1-alkoxyethyl group having an asymmetric carbon atom.
    Type: Grant
    Filed: June 23, 1988
    Date of Patent: March 27, 1990
    Assignees: Dainippon Ink and Chemicals, Inc., Kawamura Institute of Chemical Research
    Inventors: Tadao Shoji, Sadao Takehara, Toru Fujisawa, Masashi Osawa, Hiroshi Ogawa, Yoshi Arai, Jitsuo Kurokawa
  • Patent number: 4911863
    Abstract: The invention relates to ferroelectric smectic liquid crystal mixtures and compounds. The invention also relates to electro-optical devices incorporating these mixtures.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: March 27, 1990
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: Ian C. Sage, John A. Jenner, Hans A. Kurmeier, Pauluth Detlef, Claus Escher, Eike Poetsch
  • Patent number: 4909957
    Abstract: Liquid crystalline compounds having an optically active .gamma.-lactone ring of the formula: ##STR1## wherein R.sup.1 is a group selected from the group consisting of ##STR2## n and e are each independently 0 or 1; R.sup.3 is an alkyl group having 1 to 15 carbon atoms; R.sup.2 is a group of the formula: --(CO).sub.m --R.sup.4 ; m is 0 or 1; R.sup.4 is hydrogen atom or an alkyl having 1 to 15 carbon atoms; and the symbol * is an asymmetric carbon atom, and an intermediate thereof, and process for the production of the same.
    Type: Grant
    Filed: September 7, 1988
    Date of Patent: March 20, 1990
    Assignee: Daiso Co., Ltd.
    Inventors: Kazuhiko Sakaguchi, Naoya Kasai, Yoshikazu Takehira, Tohru Kitamura, Yutaka Shiomi
  • Patent number: 4906402
    Abstract: A compound having ferroelectric liquid crystal properties of the formula: ##STR1## wherein A is the residue of a liquid crystal material or a liquid crystal compatible material;X is O or S;n is 0 or 1;Y is any inert group which does not cause the melting point of the compound of Formula I to exceed 200.degree. C.;R.sup.1 is selected from H, C.sub.1-4 -alkyl and halogen; andR.sup.2 is C.sub.1-4 -alkyl or halogen;provided that R.sup.1 and R.sup.2 are different. In a suitable environment the compound is capable of alignment in two metastable states and is therefore suitable for use in multiplex-addressed, liquid crystal devices, such as flat bed large area screens and displays.
    Type: Grant
    Filed: September 1, 1987
    Date of Patent: March 6, 1990
    Assignee: Imperial Chemical Industries, PLC
    Inventors: David A. Jackson, Peter A. Gemmell
  • Patent number: 4898724
    Abstract: Particle-emitting radionuclides, e.g. Samarium-153, have been complexed with organic aminoalkylenephosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions for the therapeutic treatment of calcific tumors in animals.
    Type: Grant
    Filed: May 14, 1987
    Date of Patent: February 6, 1990
    Assignee: The Dow Chemical Company
    Inventors: Jaime Simon, David A. Wilson, Wynn A. Volkert, David E. Troutner, William F. Goeckeler
  • Patent number: 4897254
    Abstract: Certain particle-emitting radionuclides, e.g. Samarium-153, have been complexed with certain alkylenepolyaminocarboxylic acid chelants. Compositions containing these complexes have been found useful in the treatment of calcific tumors in animals. The stability constant, log K, of the useful complexes is from about 14 to about 17 and the molar ratio of chelant to radionuclide in the compositions is such that the chelant is present in an amount sufficient to inhibit uptake of the radionuclide by soft tissue.
    Type: Grant
    Filed: March 3, 1987
    Date of Patent: January 30, 1990
    Assignee: The Dow Chemical Company
    Inventors: Jaime Simon, Wynn A. Volkert, David A. Wilson, David E. Troutner, William F. Goeckeler
  • Patent number: 4895672
    Abstract: A liquid crystal substance having a low viscosity and good compatibility thereof with existing liquid crystals at low temperatures in addition to a large optical anisotropy value and a high clearing point and a liquid crystal composition containing the substance are provided, which substance is a 4-(trans-4-alkylcyclohexylmethyloxy)-4'-substituted-tolan expressed by the formula ##STR1## wherein R.sup.1 is 1-10C alkyl and R.sup.2 is 1-10C alkyl or F or Cl.
    Type: Grant
    Filed: August 17, 1988
    Date of Patent: January 23, 1990
    Assignee: Chisso Corporation
    Inventors: Yasuyuki Goto, Toshiharu Suzuki