Patents Examined by J. E. Thomas
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Patent number: 4894445Abstract: A method for preparing a coordination complex of an isonitrile ligand and a radioisotope of Tc, Ru, Co, Pt, Re, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Nb and Ta from a non-radioactive metal adduct of the isonitrile.Type: GrantFiled: June 25, 1986Date of Patent: January 16, 1990Assignee: E. I. Du Pont De Nemours and CompanyInventors: Alan P. Carpenter, Jr., Leo J. Maheu, Michael A. Patz, Thomas H. Tulip, Karen E. Linder, Vinayakam Subramanyam, Jeffery S. Thompson
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Patent number: 4886623Abstract: A liquid crystal compound represented by formula: ##STR1## wherein R.sub.1 represents a straight chain alkyl group having from 4 to 18 carbon atoms; R.sub.2 represents a straight chain alkyl group having from 2 to 6 carbon atoms or a branched alkyl group having from 3 to 6 atoms and having a methyl group as a side chain; and m and n each represents 1 or 2, is disclosed.The liquid crystal compound of formula (I) is optically and electrically stable and exhibits fast electro-optical switching in image display.Type: GrantFiled: December 23, 1987Date of Patent: December 12, 1989Assignee: Takasago International CorporationInventors: Shigeru Mitsuhashi, Hitoshi Kondo, Tetsuharu Okazaki, Shinji Endoh, Hiroko Kudo, Akio Yamaguchi, Haruki Tsuruta, Susumu Akutagawa
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Patent number: 4883611Abstract: Dichroic coloring agents which have a blue to blue-violet hue and have not been used to date for liquid crystal displays are disclosed. These coloring agents are represented by the following formula: ##STR1## wherein X is S or NH; R.sub.1 is a hydrogen atom, halogen atom, alkyl group or alkoxy group; and R.sub.2 is a hydrogen atom, alkyl group, aryl group or aralkyl group.Type: GrantFiled: September 9, 1988Date of Patent: November 28, 1989Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Keisuke Takuma, Sizuo Kuroda, Tsukasa Oyama, Hiroshi Aiga
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Patent number: 4882084Abstract: The optically active compounds of the formula: ##STR1## wherein R.sup.1 is an alkyl or an alkyloxy group having a carbon number of 1-18, R.sup.2 is an alkyl group having a carbon number of 1-18, and A is a biphenyl group or a biphenyl group having a halogen atom or a cyano group are provided.The optically active compounds are useful for liquid crystal elements, especially for components of ferroelectric liquid crystal mixtures inducing high value of spontaneous polarization.Type: GrantFiled: October 28, 1987Date of Patent: November 21, 1989Assignee: Chisso CorporationInventors: Kouji Ohno, Shinichi Saito, Kazutoshi Miyazawa, Makoto Ushioda, Hiromichi Inoue, Naoyuki Yoshida
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Patent number: 4882085Abstract: An optically active lactic acid derivative represented by the following formula (I): ##STR1## wherein R represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 1 to 18 carbon atoms; C* represents an asymmetric carbon atom; l is 0 or 1; m is 1 or 2; A represents a group selected from the following groups (a) and (b):(a) hydroxyl group, halogen, benzyloxy group, phenoxy group, toluenesulfonic acid group, acetyloxy group trifluoroacetyloxy group; ##STR2## (wherein R' is an alkyl group or alkoxy group having 4 to 18 carbon atoms, n is 0 or 1, ##STR3## with proviso that when A is selected from the group in the above group (a), l is 1 and m is 1 or 2; and when A is selected from the groups in the above group (b), m=n=1 when l is 0, or m and n are 0, 1 or 2 and m+n is 1 or 2 when l is 1, and ##STR4##Type: GrantFiled: December 28, 1988Date of Patent: November 21, 1989Assignee: Canon Kabushiki KaishaInventors: Kazuo Yoshinaga, Kazuharu Katagiri, Akira Tsuboyama, Hiroyuki Kitayama, Kenji Shinjo, Chieko Hioki
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Patent number: 4880560Abstract: An optically active lactic acid derivative represented by the following formula (Ia) or (Ib): ##STR1## wherein R is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 1-16 carbon atoms,R.sup.1 is an alkyl group having 4-16 carbon atoms,m and n are respectively 1 or 2,k is 0 or 1, andC* is an asymmetric carbon atom.A liquid crystal composition containing the lactic acid derivative and a liquid crystal device using the liquid crystal composition are also disclosed.Type: GrantFiled: January 3, 1989Date of Patent: November 14, 1989Assignee: Canon Kabushiki KaishaInventors: Kazuo Yoshinaga, Kazuharu Katagiri, Kenji Shinjo
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Patent number: 4880561Abstract: Disclosed is an optically active cyclopropane compound represented by the formula (1): ##STR1## wherein R is an alkyl or cycloalkyl group, n is 0 or 1, Y.sup.4 is --CO.sub.2 CH.sub.2 --, --OCO-- or --OCH.sub.2 --, Y.sup.1, Y.sup.2 and Y.sup.3 independently represent --CO.sub.2 --, --OCO--, --O--, a direct bond or --CH.sub.2 O--, Z.sup.1, Z.sup.2, and Z.sup.3 independently represent ##STR2## A.sup.1, A.sup.2 and A.sup.3 independently represent fluorine, bromine, chlorine, a cyano group or hydrogen, and the mark ##STR3## indicates an asymmetric carbon atom. The optically active cyclopropane compound includes a compound which exhibits a ferroelectric liquid crystalline characteristic, and a compound which does not exhibit a ferroelectric liquid characteristic when used alone, but, can be used as a constituent of a ferroelectric liquid crystal composition.Type: GrantFiled: April 16, 1987Date of Patent: November 14, 1989Assignee: Ajinomoto Co., Inc.Inventors: Tatsuru Tabohashi, Takao Sakurai, Ryoichi Higuchi, Naoko Mikami, Eri Yamamoto, Koji Takeuchi
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Patent number: 4880616Abstract: A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.Type: GrantFiled: December 17, 1987Date of Patent: November 14, 1989Assignee: Nihon Medi-Physics Co., LtdInventors: Makoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
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Patent number: 4874545Abstract: The novel compounds are chiral esters of .alpha.-substituted phenylalkanoic acids and mesogenic hydroxy compounds, the symbols in the general formula (I) ##STR1## being defined as follows: MO=molecular radical of a mesogenic hydroxy compound MOH after removal of one H, the radical MO being expressed by the general formula (II)R.sup.2 --(A.sup.1).sub.n1 --(B--).sub.n2 (A.sup.2).sub.n3 --O (II)whereR.sup.2 =straight-chain or branched (C.sub.1 -C.sub.12)-alkyl, it being possible for one or two non-adjacent CH.sub.2 groups to be replaced by O and/or S atoms, or, if n1=1, also F, Cl, Br, CN or CF.sub.3,A.sup.1, A.sup.2 =independently of one another 1,4-phenylene, diazine-2,5-diyl, diazine-3,6-diyl, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 1,3-dithiane-2,5-diyl or 1,4-bicyclo(2,2,2)octylene, it being possible for these groups also to be at least monosubstituted by F, Cl, Br, CN, CF.sub.3 and/or (C.sub.1 -C.sub.12)-alkyl (one or two non-adjacent CH.sub.Type: GrantFiled: June 12, 1987Date of Patent: October 17, 1989Assignee: Hoechst AktiengesellschaftInventors: Gerd Heppke, Gunter Scherowsky, Christian Bahr, Lutz Lehmann
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Patent number: 4865762Abstract: Polymers contain, as mesogenic groups, groups which produce a discotic phase, and furthermore can contain pleochroic dyes.The novel polymers possess novel properties, and combinations of properties, which the conventional polymers which form liquid-crystalline phases do not possess.The polymers can be used in electro-optical displays, in storage elements, as electrically or photo-electrically conductive polymers and as strain sensors.Type: GrantFiled: May 12, 1987Date of Patent: September 12, 1989Assignee: BASF AktiengesellschaftInventors: Willi Kreuder, Peter Neumann, Karl-Heinz Etzbach, Hans-Josef Sterzel, Helmut Ringsdorf
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Patent number: 4866199Abstract: An optically active ester compound is provided represented by the following general formula: ##STR1## wherein R.sub.1 is a normal alkyl group having from 6 to 18 carbon atoms; m is zero or one, n is zero or one, and m+n is one or two; X is --CO--O-- or --O--CO--; p is 3 to 6; Y is a hydrogen atom or chlorine atom; R.sub.2 is hydrogen or a normal alkyl group having from 1 to 11 carbon atoms but may be a hydrogen atom only when Y is a chlorine atom; and *C represents an asymmetric carbon atom. The ester compound of the present invention is useful as a ferroelectric liquid crystal compound.Type: GrantFiled: March 8, 1988Date of Patent: September 12, 1989Assignee: Adeka Argus Chemical Co., Ltd.Inventors: Toshihiro Shibata, Masaki Kimura, Norio Kurosawa
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Patent number: 4865835Abstract: There are disclosed liposomes to which are linked agents which are capable of binding an anti-tumor antibody. The liposomes are useful in the detection and treatment of tumors by reason of their ability to remove non-specifically distributed anti-tumor antibodies from vascular and other extra-cellular spaces.Type: GrantFiled: May 27, 1986Date of Patent: September 12, 1989Inventor: Richard H. J. Begent
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Patent number: 4861581Abstract: Disclosed is a method for measuring the effectiveness of therapy intended to kill malignant cells in vivo in a mammal, comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of the mammal but not to external cellular components, wherein the monoclonal antibody is labeled; contacting the labeled antibody with tissue of a mammal that has received therapy to kill malignant cells in vivo, and determining the effectiveness of the therapy by measuring the binding of the labeled antibody to the internal cellular component. The internal cellular component is preferably insoluble intracellular antigen, and the label is preferably a radionuclide, a radiopaque material, or a magnetic resonance-enhancing material. Also disclosed is a method whereby the antibody to insoluble intracellular antigen is conjugated to an antineoplastic agent, so that upon administration of the antibody-antineoplastic agent conjugate, antineoplastic agent may be delivered to the tumor.Type: GrantFiled: December 5, 1986Date of Patent: August 29, 1989Assignee: Cancer Biologics, Inc.Inventors: Alan L. Epstein, Clive R. Taylor
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Patent number: 4857227Abstract: Mixtures of liquid crystal compounds from among different classes of liquid crystal ester compounds are disclosed. The mixtures exhibit freezing points substantially lower than the freezing point of either ester compound alone, so as to provide a substantially improved (widened) smectic C mesomorphic temperature range and protection against freezing or crystallization of liquid crystal material over a range of temperatures at which an electrooptic display device would typically be operated.Type: GrantFiled: July 2, 1987Date of Patent: August 15, 1989Assignee: Polaroid Corporation Patent DepartmentInventors: Timothy G. Adams, Roger F. Sinta
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Patent number: 4852977Abstract: Novel lactic acid derivatives which may be used as a component of a ferroelectric smectic liquid crystal mixture, which derivatives have the general formula: ##STR1## in which R.sub.1 is alkyl or alkoxy and R.sub.2 is alkyl. Liquid crystalline compositions containing these compounds are also described.Type: GrantFiled: August 19, 1986Date of Patent: August 1, 1989Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Lawrence K. M. Chan, David Coates, Peter A. Gemmell, George W. Gray, David Lacey, Kenneth J. Toyne, Daniel J. S. Young
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Patent number: 4851515Abstract: Compounds of the formula I:R+[.sup.99m TcNX.sub.4 ]- Iwherein R+ represents a cation and X represents a halo group, are prepared by reaction with an azide compound in the presence of a hydrohalic acid. The compounds are useful in production of .sup.99m Tc-labelled radio- pharmaceuticals by reaction with ligands and monoclonal antibodies or antibody fractions.Type: GrantFiled: August 23, 1985Date of Patent: July 25, 1989Assignee: The Commonwealth of AustraliaInventors: John Bonnyman, John Baldas
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Patent number: 4851209Abstract: A novel diagnostic procedure for the in vivo clinical evaluation of gastrointestinal ulcer disease and other diseases associated with loss of mucosal integrity in humans which comprises the oral administration of an effective amount of radio-labeled sucralfate or derivative or precusor thereof or a water soluble, physiologically compatible radiolabeled salt of sucrose suflate to the human host, followed by scintigraphic imaging of the gastrointestinal area of interest with scintigraphic imaging equipment.A novel radiopharmaceutical composition comprising an aqueous solution or suspension containing an amount of a radio-labeled sucralfate or derivative or precursor thereof or a water soluble, physiologically compatible radiolabeled salt of sucrose sulfate for in vivo scintigraphic imaging of the gastrointestinal or other muscosal areas in humans.Type: GrantFiled: May 16, 1985Date of Patent: July 25, 1989Assignee: The Regents of the University of CaliforniaInventors: Vasquez, Robert L. Bridges, Philip Braunstein, Anne-Line Jansholt
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Patent number: 4849209Abstract: .sup.1/3 Holmium in a carrier metallic hydroxide aggregate is disclosed for the treatment of arthritis and, in particular, rheumatoid arthritis. The compound disclosed preferably has a particle size of 1 to 40 microns, Beta energy emissions in the range of 1.76-1.84 MeV, low levels of gamma ray emissions and a radioactive half-life of 26.8 hours. The preferred metallic hydroxide is selected from the group consisting of Ferric Hydroxide, Aluminum Hydroxide, Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, Manganese Hydroxide and Stannous Hydroxide. Methods are also disclosed for the preparation of the compound, as well as for the methods of its administration to a patient in need thereof.Type: GrantFiled: January 28, 1987Date of Patent: July 18, 1989Assignee: Cadema Medical Products, Inc.Inventors: Ephraim Lieberman, Maurice Bordoni, Alfred Thornton
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Patent number: 4846999Abstract: A liquid crystal composition includes three liquid crystal materials, each selected from specified liquid crystal compounds. The composition has a low threshold voltage and a low viscosity.Type: GrantFiled: October 1, 1987Date of Patent: July 11, 1989Assignee: Casio Computer Co., Ltd.Inventor: Seiichi Kizaki
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Patent number: H692Abstract: A method of treating an animal for the prevention or control of infestation by insects of the Order Diptera which comprises application to the animal of a compound of formula ##STR1##Type: GrantFiled: October 27, 1987Date of Patent: October 3, 1989Assignee: Burroughs Wellcome Co.Inventors: Michael D. Matthewson, Gerald G. Blackman