Abstract: Dental cream in contact with a polyolefin resin surface of a package such as a laminate tube, a mechanical dispenser or a flexible sachet. The dental cream contains a dentally acceptable water-insoluble alkaline earth metal salt, a liquid vehicle and a gelling agent. The liquid vehicle contains water, glycerine and sorbitol and, as an additive to prevent syneresis due to contact between the dental cream and the polyolefin resin, propylene glycol which acts also as a preservative against bacterial contamination of the product.

Abstract: Calcium (Ca.sup.2+) channel blockers, such as nifedipine and verapamil, are used in the treatment of thromboembolic diseases such as stroke and peripheral vascular occlusive diseases, especially arterial and venous thrombosis, vasculitis, myelofibrosis disease and hemolytic anemias. Such diseases arise from platelet hyperactivation and the Ca.sup.2+ channel blockers restore the platelets to their normal aggregation characteristics. Diagnostic procedures for detecting platelet hyperactivation and defective calcium handling/transport indicative of certain peripheral obstructive diseases using chlorotetracycline as a detectable fluorescent probe as a means of assessing a patient's response to Ca.sup.2+ channel blockers in the therapy of such diseases are also described.

Abstract: A composition useful for the treatment of cancer comprises a colloidal or semi-colloidal suspension of DNA-repressor proteins derived from a finely divided mammal nerve tissue, particularly brain tissue.A method of treating cancer comprises administering to the patient a suitable daily dosage of the above composition, accompanied by the administration of suitable doses of immuno globulin (gamma-globulin), during a period of from 45 to 60 days.

Abstract: A bath preparations comprise a cyclodextrin clathrate compound of a component of milk. The bath preparations may further comprise egg white and/or at least one vitamin selected from the goup consisting of vitamin A, vitamins B, vitamin C, Vitamin D, vitamin E, vitamin F and vitamin P. The bath preparations may be used together with a saccharifying enzyme, which is mixed with the bath preparations or which is insulated from the bath preparations.A method for producing the bath preparations comprises contacting milk, which is selected from the group consisting of cow's milk, components of cow's milk, powdered milk, evaporated milk, components of evaporated milk, raw cream and components of raw cream, with cyclodextrin to form a cyclodextrin clathrate compound of the component of milk, and mixing the cyclodextrin clathrate compound of the component of milk with other raw materials of baths.

Abstract: A novel cyanoimidazole nucleoside and derivative thereof, particularly 4-cyanoimidazolium-5-olate nucleoside and acyl derivatives thereof, and pharmaceutically acceptable salts thereof which are useful as antitumor agents and immunosuppressants, are prepared by dehydrating carboxamide derivatives of the formula: ##STR1## wherein R is an acyl group, and then, if desired, deacylating.

Abstract: There are disclosed carbocyclic analogs of 2-amino-6-substituted-purine ribofuranosides and 2-amino-6-substituted-8-azapurine ribofuranosides. These compounds are useful in the treatment of viral infections.

Abstract: A method for preparing sulfur and/or selenium containing phosphoanhydrides that have at least a triphosphate moiety is disclosed, together with a cyclo-intermediate formed during the reaction. The method includes reacting a first compound having an available and reactive group selected from phosphorodihalidate, thiophosphorodihalidate, and selenic phosphorodihalidate (the compound having a remaining portion that does not interfere with the reaction), with a second compound having an available and reactive group selected from phosphate, thiophosphate, and selenic phosphate (the second compound also having a remaining segment that does not interfere with the reaction). The selection of the reactive groups is such that at least one of the reactive groups is the thio or selenic variant, and the selection of the remaining portion and segment are such that at least one is attached to a linking group selected from phosphate, thiophosphate, and selenic phosphate that links it to the available and reactive group.

Abstract: Oral and dental preparations containing as an active ingredient an anti-caries effective amount of a C.sub.2-4 alkoxylated trihydric to hexahydric C.sub.3-12 aliphatic polyol wherein at least one hydroxyl moiety is esterified with phosphoric acid, or a physiologically compatible water soluble salt thereof.

Abstract: An anti-bacterial composition capable of being activated in the gastro-intestinal tract of mammals is provided. Said composition comprises an effective amount of lactoferrin and lactoperoxidase, and an activating system present in sufficient amounts to activate said lactoperoxidase in the gastro-intestinal tract. In accordance with another aspect of the present invention, the anti-bacterial composition is introduced into the gastro-intestinal tract of mammals as a component of foodstuff and/or animal feedstuff. In accordance with yet another aspect of the present invention, a method for treating gastro-intestinal infections is disclosed. This method for treating gastro-intestinal infections in mammals comprises introducing the above anti-bacterial composition into the intestinal tract of mammals.

Abstract: Novel depolymerized and supersulfated heparin having a molecular weight comprised between 2000 and 9000 and a sulfation degree of at least 2.5, in which all of the primary hydroxy groups are sulfated; a process for its preparation by reacting a heparin of natural origin, or a fraction thereof with a sulfuric acid/chlorosulfonic acid mixture; and pharmaceutical compositions containing it as active ingredient, having potential antithrombotic, hypolipemic and fibrinolytic activity and useful in the prevention of thrombosis and for the treatment of atherosclerosis.

Abstract: Pharmaceutical preparations having diuretic activity and comprising a peptide of the formula ##STR1## wherein (a) R.sub.1 and R.sub.2 are hydrogen and R.sub.3 is --OH, or ##STR2## or Y, or wherein (b) R.sub.1 is hydrogen, R.sub.2 is CH.sub.2 OH or ##STR3## and R.sub.3 is --OH or Y, or wherein (c) R.sub.1 is --CH.sub.2 OH and R.sub.2 is hydrogen or ##STR4## and R.sub.3 is --OH or Y, or wherein (d) R.sub.1 is ##STR5## R.sub.2 is hydrogen or --CH.sub.2 OH and R.sub.3 is --OH, --NHCH.sub.2 COOH, or Y, andwhereinX is hydrogen, methyl, prolyl, or an N-protective group, andY is --NH.sub.2, --OR.sub.4, wherein R.sub.

Abstract: Acylated cyanamide compounds useful for ethanol deterrence of the formula RCONHCN, wherein R is a lipophilic acyl group or is derived from an (N-substituted)-alpha-aminoacyl group.

Abstract: There is provided a dental caries-preventive composition containing an antibody and a nonionic surface active agent, said antibody being obtained from an animal immunized with cells or cell components of Streptococcus mutans. The dental caries-preventive composition inhibits the formation of dental plaque and prevents dental caries. It keeps the antibody stable for a long period of time and hence permits the antibody to exhibit its effect with certainty over a long period of time.

Abstract: Polypeptides containing a substantial proportion of L-histidine are effective fungicidal agents. They are particularly effective against C. albicans and have a high degree of safety and nontoxicity because of their structural similarity to naturally occuring histidine-rich polypeptides which are unique to the salivas of humans and old world monkeys.

Abstract: The invention concerns peptides, having the pharmaceutical property of enhancing the immune response, having the structure: ##STR1## wherein R.sup.1 is alkanoyl,R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl,R.sup.2 is hydrogen, carboxy, protected carboxy or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety is substituted by hydroxy or not substituted,R.sub.b.sup.2 is hydrogen or lower alkyl,R.sup.p is hydrogen, carboxy or protected carboxy,R.sup.q is carboxy, protected carboxy or a group of the formula ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above, R.sup.r is hydrogen or amino protective group,m is an integer 1 to 3, andn is an integer 1.

Abstract: The invention provides an ointment useful in treating skin irritations and promoting the healing of wounds. The preferred embodiment comprises a mixture of the raw gel of the aloe vera plant with a base, such as Aquaphor. A method for making the ointment composition is also disclosed.

Abstract: Compounds having one or two substituents at the 3-position, represented by the general formula ##STR1## wherein R.sub.1 is an optionally acylated or protected amino group and X is hydrogen atom or methoxy group, or a pharmaceutically acceptable salt thereof; when used either alone or in combination with a .beta.-lactam antibiotic, show excellent .beta.-lactamase inhibitory activity and can be used as drugs for use in humans and domestic animals.

Abstract: A surgical or irrigation solution which provides the anterior and posterior chamber of the eye with protection during surgical procedures that require irrigation. This irrigation solution is composed of a HEPES buffered Eagle's Minimum Essential Media (MEM) with Earle's Salts, without phenol red, supplemented with mixed isomers of 99% pure, chondroitin sulfate, MEM non-essential amino acids, 2-mercaptoethanol, and sodium pyruvate. Other solutions include a balanced salt solution, chondroitin sulfate, buffers and 2-mercaptoethanol. The solution can also be used in other surgical or medical applications.

Abstract: A method of producing oncolysis and regression of malignant tumors and other malignant conditions without adverse effects on normal body cells is described. A calorically and compositionally defined nutritional regimen providing a minimum of amino acids and fatty acids and a maximum of carbohydrates is administered concurrently with a drug regimen of an agent or agents that uncouple oxidative phosphorylation, most preferably 2,4-dinitrophenol.

Abstract: An improved method is described for producing oncolysis, including regression of malignant tumors or other malignant conditions, without adverse effects upon normal body cells. In addition to a calorically and compositionally defined nutritional regimen providing a minimum of amino acids and fatty acids and a maximum of carbohydrate, administered concurrently with a drug regimen of an agent or agents that uncouple oxidative phosphorylation (most preferably 2,4-dinitrophenol), there is also concurrently administered a selected amount of a substantially non-toxic fatty acid oxidation inhibitor capable of effectively lowering the mitochondrial .beta.-oxidation rate of fatty acids.