Patents Examined by Jacqueline A. DiRamio
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Patent number: 7338811Abstract: The invention is directed to novel IC chips containing substances used particularly in bioassays. Furthermore, the invention is directed to assay methods and kits using these chips.Type: GrantFiled: March 25, 2003Date of Patent: March 4, 2008Assignee: Vincogen CorporationInventor: Derhsing Lai
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Patent number: 7297502Abstract: The present invention provides devices, methods and kits for detecting the presence of an analyte in a liquid sample. The invention provides devices having a positive control area covered with an opaque, movable material, such as an ink, dye, or other material, that is moved on the device by the flow of liquid sample, thereby exposing the positive control area underneath. Using the interaction of colored signals from the positive control area and the analyte binding area, a recognizable symbol is revealed on the device that correlates with the test results, and appears as the test is conducted.Type: GrantFiled: December 17, 2004Date of Patent: November 20, 2007Assignee: Oakville Hong Kong Company LimitedInventors: Fei Gao, Shujiang Wu, Huikang Chen, DengFeng Xiong, Jinn-nan Lin, James McMenamy
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Patent number: 7291497Abstract: The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device.Type: GrantFiled: September 10, 2004Date of Patent: November 6, 2007Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, Shaunak Roy, John Howard, Chengwang Wang
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Patent number: 7288413Abstract: Methods for testing a fecal sample for the presence of hemoglobin, comprising performing a chemical fecal occult blood test on the sample and then performing an immunochemical fecal occult blood test on a portion of the sample exposed to the chemical reagents used in the chemical fecal occult blood test.Type: GrantFiled: August 12, 2005Date of Patent: October 30, 2007Assignee: Beckman Coulter, Inc.Inventor: Leslie Goulden
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Patent number: 7279136Abstract: A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.Type: GrantFiled: December 13, 2005Date of Patent: October 9, 2007Inventors: James M. Takeuchi, Xuedong Song, Kaiyuan Yang, Ning Wei, Shawn R. Feaster
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Patent number: 7276343Abstract: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.Type: GrantFiled: June 24, 2003Date of Patent: October 2, 2007Assignee: Fujirebio Inc.Inventors: Kazushige Moriyama, Tetsuji Tanimoto, Tatsuki Matsuno, Yoshihiro Ashihara
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Patent number: 7258837Abstract: This invention provides a microfluidic device for use in the detection of one or more analytes in a fluid using solid-phase affinity binding assays. The device offers a practical, easy-to-use, portable, inexpensive, robust analytical system for the parallel and quantitative detection of multiple analytes. In addition, this invention provides methods and devices for the formation of concentration gradients of capture molecules immobilized on a solid phase.Type: GrantFiled: December 5, 2002Date of Patent: August 21, 2007Assignee: University of WashingtonInventors: Paul Yager, Elena Garcia
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Patent number: 7259019Abstract: Multiwell plate applications are describe for use with a plurality of fibres having an extraction phase coated thereon in combination with a positioning device. The device and method described are able to perform adsorption of components of interest from a biological system in high volume.Type: GrantFiled: August 19, 2005Date of Patent: August 21, 2007Inventors: Janusz B. Pawliszyn, Heather L. Lord, Marcel Musteata
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Patent number: 7252938Abstract: Methods and devices for producing a polymer at a location of a substrate are provided. In the subject methods, a fluid droplet containing a first monomer labeled with a first detectable label is deposited from a fluid deposition device onto a location of a substrate surface having a second monomer labeled with a second detectable label. The first and second detectable labels are then detected to determine any misalignment between the fluid deposition device and the location of the substrate surface during deposition. Also provided are algorithms that perform the subject methods, as well as fluid deposition devices that include the subject algorithms. The subject invention also includes arrays produced according to the subject methods and kits that include the subject arrays.Type: GrantFiled: February 25, 2003Date of Patent: August 7, 2007Assignee: Agilent Technologies, Inc.Inventors: Eric M. Leproust, Douglas A. Amorese
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Patent number: 7247443Abstract: Sensor constructs for detecting the presence of an analyte in a sample comprise a molecular scaffold, a pair of labels which interact via Förster resonance energy transfer, and at least one molecular recognition domain. When the analyte is bound by the molecular recognition domain, the Förster resonance energy interaction between the pair of labels is disrupted, resulting in a changed optical signal.Type: GrantFiled: March 17, 2005Date of Patent: July 24, 2007Assignee: University of HawaiiInventor: Wei-Wen Su
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Patent number: 7244622Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: GrantFiled: January 5, 2005Date of Patent: July 17, 2007Assignee: Applera CorporationInventors: Timothy M. Woudenberg, Michael Albin, Reid B. Kowallis, Yefim Raysberg, Robert P. Ragusa, Emily S. Winn-Deen
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Patent number: 7241417Abstract: A device for carrying out a lateral flow assay on a sample comprising: (a) a sample containing unit comprising a sample container, said sample container being closed off at one end by a bottom wall, said bottom wall having a hole sealed by a plug; and (b) a housing located under said sample container and capable of holding a test strip, said sample containing unit and said housing being coupled so as to allow rotation one relative to the other, said housing comprising a cutting arrangement capable of cutting said plug; wherein rotation of said sample containing unit and said housing one relative to the other results in said cutting arrangement cutting said plug, thereby unplugging the hole in said bottom wall. Also disclosed is a method for determining the presence or absence of an analyte in a sample, using the device.Type: GrantFiled: July 26, 2005Date of Patent: July 10, 2007Assignee: Savyon Diagnostics Ltd.Inventors: Martin Jerome Lee, Zvi Greenberg, Eitan Rogel
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Patent number: 7238322Abstract: A self-contained apparatus using a gravitationally encouraged, interrupted, downward, diffusive and programmed flow of fluid to provide for rapid confirmatory immunological testing (“RCIT”) in, for example, a clinical, point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber carrying a source of conjugate having mobilizable binding members such as immunographic antigens or antibodies specific to the condition being tested conjugated to a detectable label such as colloidal gold. The specimen is premixed with a first measured, reactive mix buffer solution carried within an openable tank. The specimen and solution are temporarily held within an incubation reservoir formed behind a dam made from porous, diffusive material.Type: GrantFiled: October 26, 2005Date of Patent: July 3, 2007Assignee: DNT Scientific Research, LLCInventors: Naishu Wang, David F. Zhou
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Patent number: 7235406Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: GrantFiled: July 28, 2000Date of Patent: June 26, 2007Assignee: Applera CorporationInventors: Timothy W. Woudenberg, Michael Albin, Reid B. Kowallis, Yefim Raysberg, Robert P. Ragusa, Emily S. Winn-Deen
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Patent number: 7232689Abstract: Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems.Type: GrantFiled: August 23, 2005Date of Patent: June 19, 2007Inventor: Janusz B. Pawliszyn
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Patent number: 7211443Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: GrantFiled: February 24, 2003Date of Patent: May 1, 2007Assignee: Applera CorporationInventors: Timothy M. Woudenberg, Michael Albin, Reid B. Kowalis, Yefim Raysberg, Robert P. Ragusa, Emily S. Winn-Deen
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Patent number: 7201878Abstract: Aerosol particle analyzer (APA) for measuring an analyte in airborne particle is described. Airborne particles are first given an electrical charge and then drawn in air past an oppositely charged volume of an analysis liquid that exposed to the air at a small hole in a container, such as a capillary, that holds that analysis liquid. Electrostatic forces enhance the rate that the airborne particles collide with the small exposed volume of the analysis liquid in the hole. If the particles that collide with the analysis liquid contain the analyte, an optical property of the analysis liquid, such as the fluorescence, varies according to the amount of the analyte in the particles. This optical property is measured and the amount of analyte in the particles is determined from the measured optical property.Type: GrantFiled: March 26, 2004Date of Patent: April 10, 2007Assignee: The United States of America as Represented by the Secretary of the ArmyInventors: Horn-Bond Lin, Steven Clyde Hill
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Patent number: 7201879Abstract: An aerosol-into-liquid collector (ALC) for collecting gas-borne particles from a large volume of gas such as air into a small volume of liquid is described. The ALC uses a linear quadrupole to concentrate particles flowing in a gas and to help direct these concentrated particles toward a small volume of collection liquid so that these particles tend to combine with a small volume of collection liquid that can then be drawn from the ACL for further analysis. The particles in the gas are typically given a charge that is opposite to that of the charge imparted to the volume of collection liquid so that electrostatic forces help draw particles from the flowing gas into the small volume of liquid. The linear quadrupole focuses toward it axis particles that have the charge, mass and mobility to be stable in the linear quadrupole.Type: GrantFiled: November 19, 2004Date of Patent: April 10, 2007Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Steven Clyde Hill, Horn-Bond Lin
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Patent number: 7189522Abstract: The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules such as aptamers, nucleic acids, etc. located at the junction of the first and second sorbent materials. The first and second sorbent strips touch each other at the test site location.Type: GrantFiled: June 30, 2005Date of Patent: March 13, 2007Assignee: Chembio Diagnostic Systems, Inc.Inventor: Javanbakhsh Esfandiari
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Patent number: 7153475Abstract: Aerosol particle analyzer (APA) for measuring the amount of analyte in airborne particle is described. The APA uses an analysis liquid. In most embodiments, this analysis liquid is chosen so that when it is mixed with the particles, an optical property of the analysis liquid (AL) varies according to the amount of the analyte in the particles. Airborne particles are drawn into the instrument, and detected using optical methods such as light scattering or laser-induced fluorescence. When a particle of interest is detected, a charged droplet of the analysis liquid (CDAL) is ejected so that it collides with the detected particle and moves into a horizontally oriented linear quadrupole that is in an airtight container, except for small orifices to let the CDAL enter and exit.Type: GrantFiled: May 9, 2005Date of Patent: December 26, 2006Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Steven Clyde Hill, Richard Kounai Chang, Jean-Pierre Wolf