Patents Examined by Jacqueline M. Stone
  • Method for the stabilization of deferoxamine to chelate free ions in physiological fluid
    Patent number: 4863964
    Abstract: A method for scavenging free iron or aluminum in fluids such as physiological fluids involves a provision in such fluids of a soluble polymer substrate having chelator immobilized thereon. According to the invention preferred such compounds comprise polysaccarides or proteins having a deferoxamine moiety thereon. Such a compound can be used for the treatment of iron overload, as well as to inhibit cell damage from oxidation/reduction reactions. In one embodiment, cell damage during reperfusion is inhibited, through provision of the chelating moiety at the site of reperfusion.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: September 5, 1989
    Assignee: Biomedical Frontiers, Inc.
    Inventors: Bo E. Hedlund, Philip E. Hallaway, Samuel S. Panter, John W. Eaton
  • Use of growth hormone for nitrogen retention under hypocaloric conditions
    Patent number: 4863901
    Abstract: A method and composition for effecting protein accretion in an animal. The composition comprises a hypocaloric dietary component comprising a metabolizable source of nitrogen, carbohydrate, and, optionally, at least one of a triclyeride source, minerals, and vitamins, in conjunction with growth hormone.The method comprises administering an effective amount of the hypocaloric dietary component and growth hormone, orally or parenterally, to effect a positive nitrogen balance under hypocaloric conditions.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: September 5, 1989
    Assignee: Brigham & Women's Hospital
    Inventor: Douglas W. Wilmore
  • Combination therapy using interleukin-2 and tumor necrosis factor
    Patent number: 4863727
    Abstract: Anti-tumor activity in mammals can be augmented by administering to the mammalian host a synergistically effective amount of TNF and IL-2 or of TNF and IFN-.beta., or of TNF, IL-2 and IFN-.beta. in combination. The composition of TNF and IL-2 and/or IFN-.beta. may be prepared in vitro or administered separately to the host. If the TNF and IL-2 are administered sequentially, the TNF must be administered prior to the IL-2 to obtain synergy. The composition is useful for treating such cancers as mastocytoma, melanoma, leukemia, lymphoma, mammary adenocarcinoma, and pharyngeal squamous cell carcinoma.
    Type: Grant
    Filed: November 16, 1988
    Date of Patent: September 5, 1989
    Assignee: Cetus Corporation
    Inventors: Robert Zimmerman, Jeffrey L. Winkelhake
  • Method of preparing treatment compositions for use in plastic or cosmetic surgery
    Patent number: 4863733
    Abstract: There are disclosed methods for use in plastic or cosmetic surgery in which a predetermined volume of blood is withdrawn from a donor-patient; and the blood is separated to yield a fraction containing 38% globulins and 54% albumin. This fraction is heated and then reintroduced in conjunction with the respective cosmetic surgery procedures, such as the treatment of scars, breast augmentation, lines near the mouth, in the forehead, and the like. There are also disclosed the corresponding compositions for use in plastic surgery, and these compositions may additionally contain compositions with anesthetic properties and/or coagulants.
    Type: Grant
    Filed: August 28, 1985
    Date of Patent: September 5, 1989
    Inventors: Jack P. Startz, deceased, by Jonathan D. Startz, heir, by Jerry A. Startz, heir, by James A. Startz, heir, by Janet West, heir
  • Protein and mineral water-containing cosmetic compositions
    Patent number: 4863897
    Abstract: This invention relates to cosmetic, health- and body-preserving compositions of high biological value, optimizing the biological processes occurring in the skin cells and providing the most preferable function of the enzyme system of the cells connected with the age of the organism.The compositions of the invention contain in addition to the commonly used carrier and additive and/or filling materials and active ingredients, mineral waters of a native condition, medicinal waters and/or the mixtures thereof and/or the mixtures thereof with fermented or non-fermented plant juices and/or optionally inorganic materials playing the role of trace elements in the living organism as well as proteins.
    Type: Grant
    Filed: August 3, 1987
    Date of Patent: September 5, 1989
    Assignee: Caola Kozmetikai es Haztartasvegyipari Vallalat
    Inventors: Laszlo Dede, Maria Dede nee Pal, Laszlo Bogdany, Olga Bogdany nee Forgacs
  • Use of TNF for the prevention or treatment of radiation damage
    Patent number: 4861587
    Abstract: The use of TNF for the prophylaxis and therapy of radiaton damage is described.
    Type: Grant
    Filed: April 14, 1987
    Date of Patent: August 29, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Renate Urbaschek, Bernhard Urbaschek, Daniela Maennel
  • Method of enhancing the solubility of tissue plasminogen activator
    Patent number: 4857320
    Abstract: The solubility of tissue plasminogen activator in aqueous solution is enhanced by incorporating therein arginine or a non-toxic salt of arginine in an amount effective to increase the solubility of the t-PA without substantially inhibiting its potential biological activity upon administration.
    Type: Grant
    Filed: February 19, 1987
    Date of Patent: August 15, 1989
    Assignee: Monsanto Company
    Inventor: Arthur J. Wittwer
  • Non-aqueous ivermectin formulation with improved antiparasitic activity
    Patent number: 4853372
    Abstract: Ivermectin, an antiparasitic agent which is insoluble and unstable in water, is formulated in glycerol formal and propylene glycol. These liquid formulations are suitable for parenteral administration for the treatment of parasitic infections and demonstrate improved efficacy and a broadened spectrum over previous formulations.
    Type: Grant
    Filed: November 28, 1986
    Date of Patent: August 1, 1989
    Assignee: Merck & Co., Inc.
    Inventors: James B. Williams, Russell U. Nesbitt
  • Stable hydrocortisone-based composition for use in local corticotherapy
    Patent number: 4853379
    Abstract: A stable hydrocortisone-based composition comprises hydrocortisone solubilized in a mixture of an aliphatic alcohol, propyleneglycol and dimethyl coco-benzylammonium chloride.
    Type: Grant
    Filed: October 15, 1986
    Date of Patent: August 1, 1989
    Assignee: Societe Anonyme dite: L'Oreal
    Inventors: Braham Shroot, Carole Le Foyer de Costil, Liliane Ayache
  • Tissue plasminogen activator oligosaccharide from normal human colon cells
    Patent number: 4851517
    Abstract: Glycosylated plasminogen activator (t-PA) having a glycosylation pattern significantly different than exhibited by t-PA from Bowes melanoma cells is obtained from cultured normal human colon fibroblast cells (CCD-18Co).
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: July 25, 1989
    Assignee: Monsanto Company
    Inventors: Joseph Feder, William R. Tolbert, Thomas W. Rademacher, Raj B. Parekh, Raymond A. Dwek
  • Fibrinophilic urokinase complex and method for production thereof
    Patent number: 4851345
    Abstract: This invention discloses a fibrinophilic urokinase complex which is a complex of urokinase with a urokinase inhibitor or tissue activator inhibitor and has a molecular weight of 97,500.+-.3,000 and a method for the production of this fibrinophilic urokinase complex from urine. The urokinase complex can be used, as a thrombolytic agent exhibiting an outstanding ability to dissolve thrombus.
    Type: Grant
    Filed: September 11, 1986
    Date of Patent: July 25, 1989
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Shigeru Hayashi, Kaneo Yamada
  • Therapeutic treatment of abnormal cell growth with follicle regulatory protein
    Patent number: 4849402
    Abstract: A method of treating patients exhibiting neoplasms of gonadal origin is provided comprising administering a therapeutically effective dose of Follicle Regulatory Protein (FRP). The method may be used both pre- and post-operatively.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: July 18, 1989
    Assignee: Decatur-FRP/Partners
    Inventor: Donald L. Morton
  • Method for promoting epithelial healing and prevention of epitheliam destruction
    Patent number: 4849406
    Abstract: A method of determining the presence of epithelial lesions is provided wherein a sample of a body fluid taken from an epithelial region suspected to have said lesions is tested for the presence of a proteolytic activity. The lesion is then treated by applying a therapeutically effective amount of a proteinase inhibitor in the form of a physiologically acceptable preparation, a pharmaceutical preparation of aprotinin being particularly preferred.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: July 18, 1989
    Assignee: Labsystems Oy
    Inventor: Eeva-Marjatta Salonen
  • Ointment for the treatment of decubiti ulcers
    Patent number: 4847084
    Abstract: These 2 formulae provide a new and unique method of healing decubiti ulcers. Formula #1 contains Fibrinolysin and Desoxyribonuclease, Combined-Bovine-with Chloramphenicol Ointment, Chlorophyll Ointment 0.5%, and Povidone-Iodine Ointment 10% in equal parts of each. Formula #2 contains Fibrinolysin and Desoxyribonuclease, Combined-Bovine-Ointment, Chlorophyll Ointment 0.5%, and Povidone-Iodine Ointment 10% in equal parts of each. This new unique method of healing decubiti ulcers depends on a combination of actions which include enzymatic debriding properties, infection control, wound odor control, and promotes granulation that produces a clean base for total healing of the ulcer in a much shorter time than any formulae for this purpose heretofore.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: July 11, 1989
    Inventor: Morris Y. Mintz
  • Human calcitonin peptide with salmon calcitonin-like characteristics
    Patent number: 4845080
    Abstract: The invention relates to a substance from the calcitonin group, which substance can be isolated from the human body or can be obtained in a different manner, but clearly differs from the known human calcitonin-(1-32), the said substance having hypocalcaemic activity.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: July 4, 1989
    Assignee: Ciba-Geigy Corporation
    Inventor: Jan A. Fischer
  • Method for treating hematopoietic diseases
    Patent number: 4845078
    Abstract: A therapeutic agent for treating a hematopoietic disease containing, as an active ingredient, a glycoprotein which is recovered from human urine and acts upon the human bone marrow cells to stimulate the differentiation and proliferation of granulocytes-monocytes lineages thereof, or an active peptide fragment thereof or a derivative of said fragment, said therapeutic agent being administered after transplantation of the bone marrow.
    Type: Grant
    Filed: August 8, 1986
    Date of Patent: July 4, 1989
    Assignees: Green Cross Corporation, Morinaga Milk Industry Co., Ltd.
    Inventor: Tohru Masaoka
  • Method of inducing ovulation
    Patent number: 4845077
    Abstract: A method of inducing ovulation by administering exogenous human menopausal gonadotropins employs FSH as the exogenous human menopausal gonadotripin in the absence of exogenous LH, preferably in conjunction with a gonadotropin releasing factor antagonists. One particular application of the method is in vitro fertilization.
    Type: Grant
    Filed: July 9, 1987
    Date of Patent: July 4, 1989
    Assignee: Serono Laboratories, Inc.
    Inventor: Gary D. Hodgen
  • Composition for treating impaired lactation
    Patent number: 4839171
    Abstract: Composition for treating impaired lactation is described according to the preferred embodiment of the teachings of the present invention for oral administration to swine. The composition according to the teachings of the present invention includes blood albumin meal to provide a rich source of nutrients such as amino acids. Blood albuin helps insure that the osmotic pressure of the blood and interstitial tissue fluid around the mammary gland alveoli is optimized. Psyllium seed is further provided in the composition according to the teachings of the present invention as a natural laxative and as an effective aid in the treatment of constipation. Specifically, an oily, mucilaginous mass is formed when the psyllium seed comes in contact with water or fluid in the digestive tract and lubricates the digestive tract to help stimulate evacuations.
    Type: Grant
    Filed: February 27, 1987
    Date of Patent: June 13, 1989
    Assignee: Techmix, Inc.
    Inventor: Martin J. Nelson
  • Skin treatment composition and method for treating burned skin
    Patent number: 4837019
    Abstract: Skin treatment compositions are provided which counteract moisture loss and promote healing of burned or sunburned skin which include a unique moisturizing component formed of polyglycerylmethacrylate, glycerine, allantoin, panthenol, amino acid complex, and fibronectin.
    Type: Grant
    Filed: August 11, 1986
    Date of Patent: June 6, 1989
    Assignee: Charles of the Ritz Group Ltd.
    Inventors: Arthur C. W. Georgalas, George E. Deckner
  • Test tube assembly for serum separation
    Patent number: 4836987
    Abstract: A coagulant or hemostatic comprises, as an effective ingredient, at least one compound consisting of a lignan skelton having oxygen-containing side chains or rings.
    Type: Grant
    Filed: September 8, 1988
    Date of Patent: June 6, 1989
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Toshiko Shibata, Hiroji Ina, Kazuo Ina