Abstract: A method of enhancing the wound-healing process in animals utilizing glycyl-1-histidyl-1-lysine: copper(II) (GHL-Cu) is disclosed. GHL-Cu functions as a superoxide dismutase which detoxifies tissue-damaging oxygen radicals, but does not evoke an antigenic response. A method of treating inflammatory conditions in animals and a method of reducing the traumatic effects in animals occurring subsequent to major tissue damage utilizing GHL-Cu is also disclosed.

Abstract: Disclosed is a process for purifying Factor VIII:C in high yield and potency from source material containing Factor VIII:C, Factor VIII:R and other plasma proteins and factors comprising the steps of: adsorbing Factor VIII:C onto a hydrophobic interaction matrix, separating unwanted proteins from Factor VIII:C and eluting Factor VIII:C by a solution containing a surface active agent.

Abstract: A nutritonal fat suitable for enteral and parenteral products is disclosed. This fat consists essentially of from about 50 to 100% by weight triglycerides having the formula: ##STR1## wherein each R.sup.1 group is selected from n-heptanoyl, n-octanoyl, n-nonanoyl, n-decanoyl and n-undecanoyl groups; and the R.sup.2 groups comprise from 0 to about 90% saturated acyl groups selected from n-heptanoyl, n-octanoyl, n-nonanoyl, n-decanoyl, n-undecanoyl, lauroyl, myristoyl, palmitoyl, stearoyl and mixtures thereof; from 0 to about 90% oleoyl groups; from about 10 to 100% linoleoyl groups; and from 0 to about 10% linolenoyl groups.

Abstract: Glycosylated plasminogen activator (t-PA) having a glycosylation pattern significantly different than exhibited by t-PA from Bowes melanoma cells is obtained from cultured normal human colon fibroblast cells (CCD-18Co).

Abstract: Secretion of gastric acid in the stomach of mammals is inhibited by parenteral administration of alpha-transforming growth factor.

Abstract: Nail polish compositions comprising pigment material, and film forming material, wherein the pigment material is present in amounts not less than about 2.0% by weight and said nail polish composition has a Newtonian viscosity not greater than about 600 cps.

Abstract: An improved, viscous, transparent, pyrogen-free, isotonic, succinylated atelocollagen solution provides an effective medium for use in viscosurgery and as a replacement for vitreous.

Abstract: A method and preparation for the stimulation of tear secretion. The method involves topically applying to the ocular surface gastrointestinal hormones and/or biologically active peptides and their precursors, derivatives, and fragments which activate vasoactive intestinal peptide receptors of lacrimal gland tissue. The preparation contains a peptide of hormone that activates the vasoactive intestinal peptide receptor such as glucagon or vasoactive intestinal peptide, a vehicle and may also contain an ophthalmic preservative.

Abstract: Diseases of animals and man caused by enveloped viruses can be inhibited by the use of non-toxic lectins. Suitable compositions and methods of administration of such lectins are described.

Abstract: Nail polish compositions comprising pigment material, and film forming material, wherein the pigment material is present in amounts not less than about 2.0% by weight and said nail polish composition has a Newtonian viscosity not greater than about 600 cps.

Abstract: A nailpolish remover composition is disclosed. This composition comprises 30-60% acetone, 10-35% ethyl acetate, 5-20% ethyl alcohol, 5-20% water and 3-15% glycerin, wherein the percentages are on a volume basis, and the ethyl alcohol solubilizes the glycerin in the acetone.

Abstract: Calcium (Ca.sup.2+) channel blockers, such as nifedipine and verapamil, are used in the treatment of thromboembolic diseases such as stroke and peripheral vascular occlusive diseases, especially arterial and venous thrombosis, vasculitis, myelofibrosis disease and hemolytic anemias. Such diseases arise from platelet hyperactivation and the Ca.sup.2+ channel blockers restore the platelets to their normal aggregation characteristics. Diagnostic procedures for detecting platelet hyperactivation and defective calcium handling/transport indicative of certain peripheral obstructive diseases using chlorotetracycline as a detectable fluorescent probe as a means of assessing a patient's response to Ca.sup.2+ channel blockers in the therapy of such diseases are also described.

Abstract: Polypeptides containing a substantial proportion of L-histidine are effective fungicidal agents. They are particularly effective against C. albicans and have a high degree of safety and nontoxicity because of their structural similarity to naturally occuring histidine-rich polypeptides which are unique to the salivas of humans and old world monkeys.

Abstract: Disclosed herein are improved cationic hair conditioning compositions comprising an amine oxide and, water and sufficient acid to provide a pH for said composition of from about 3.8 to about 2.4 and an amine oxide concentration from about 0.5% to about 10% based on the total weight of said hair conditioning composition.

Abstract: Skin care preparations and methods are disclosed which contain an effective amount to smooth the skin or reduce scale, of a uronic acid or derivative thereof and particularly a uronic acid urea condensate.

Abstract: A method for the stimulation of the appetite of human and non-human animals comprising administration to the brain of the animal a polypeptide designated Pancreatic Hormone III or a pharmaceutically acceptable salt or metal complex thereof.

Abstract: Parathymyosin alpha is a novel peptide isolated from mammalian thymus and contains approximately 105 amino acid residues. It bears a high degree of homology to prothymosin alpha both in sequence and amino acid composition. Parathymosin alpha acts as a blocker or modulator or prothymosin alpha activity.

Abstract: Placenta extracts and kojic acid or kojic acid derivatives are formulated into cosmetic bases to make cosmetic compositions. The cosmetic compositions exhibit an enhanced whitening effect for the skin due to the action of the placenta extract and kojic acid or kojic acid derivatives.

Abstract: Method for regulating serum calcium levels in mammals by orally administering a composition which includes a polypeptide hormone such as parathyroid hormone (PTH) or calcitonin. The polypeptide hormone is protected from destruction in the digestive tract by encapsulation in liposomes. The liposome preferably includes a cationic amphiphilic agent so that the surface of the liposome has a net positive charge. Agents for enhancing the action of the liposome encapsulated hormones are also disclosed.

Abstract: The present invention discloses a new approach to the therapy of cancer in humans based on the administration of lymphokine activated killer (LAK) cells and interleukin-2 (IL-2). Twelve patients with metastatic cancer who had failed standard available therapy were treated. LAK cells were generated from peripheral blood mononuclear cells obtained at multiple leukaphereses and incubated in the recombinant-derived lymphokine, IL-2. Following three to four days of incubation in IL-2, the resulting LAK cells were capable of lysing fresh tumor cells but not normal cells. These LAK cells were reinfused into the autologous patient, along with the intravenous administration of recombinant IL-2 every 8 hours. Patients received up to 90 doses of IL-2 and from 2.8 to 12.6.times.10.sup.10 activated cells from up to 14 sequential leukaphereses. Six patients showed objective regression of established cancer.