Patents Examined by Jagadishwar Samala
  • Patent number: 9974869
    Abstract: Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: May 22, 2018
    Assignee: Cancer Targeted Technology LLC
    Inventors: Clifford Berkman, Bea Langton-Webster, Xiaobing Wang
  • Patent number: 9950002
    Abstract: A nanotheranostic probe and its use to facilitate diagnoses, treatment and targeting of amyloid deposits are disclosed herein.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: April 24, 2018
    Assignee: Regents of the University of Minnesota
    Inventor: Karunya K. Kandimalla
  • Patent number: 9925207
    Abstract: Methods of treating, preventing and/or managing myelodysplastic syndromes are disclosed. Specific methods encompass the administrations of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidin-2,6-dione in combination with 5-azacytidine.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: March 27, 2018
    Assignee: Celgene Corporation
    Inventor: Jerome B. Zeldis
  • Patent number: 9907757
    Abstract: The present invention relates to coated particles and pharmaceutical dosage forms comprising the active substances sensitive to environmental influences. The coating of the present invention provides stability and protection of the active substance to environmental influences and in particular from oxidation and/or environmental humidity by coating.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: March 6, 2018
    Assignee: Lek Pharmaceuticals d.d.
    Inventors: Vlasta Humar, Mateja Burjak, Rok Grahek, Mateja Salobir, Janez Kerc, Klemen Kocevar
  • Patent number: 9896479
    Abstract: Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: February 20, 2018
    Assignee: Kay M. Brummond
    Inventor: Kay M. Brummond
  • Patent number: 9884132
    Abstract: The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of PSMA inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens. Because they present multiple copies of the pharmacophore, multivalent ligands can bind to receptors with high avidity and affinity, thereby serving as powerful inhibitors. The modular multivalent scaffolds of the present invention, in one or more embodiments, contains a lysine-based (?, ?-) dialkyne residue for incorporating two or more antigen binding moieties, such as PSMA binding Lys-Glu urea moieties, exploiting click chemistry and one or more additional lysine residues for subsequent modification with an imaging and/or therapeutic nuclides or a cytotoxic ligands for tumor cell killing.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: February 6, 2018
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Sangeeta Ray, Ronnie C. Mease, Hassan Shallal
  • Patent number: 9872928
    Abstract: The present invention provides a diagnostic agent for a therapeutic effect on cancer, containing a compound represented by formula (1-0). (In formula (1-0), R represents —O(CH2)n—, —O(CH2)nOC2H4—, —CH2O(CH2)n—, or —CH2O(CH2)nOC2H4—, n represents an integer of 1 to 5, and Q1 represents F or —OCH3.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: January 23, 2018
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Hideo Tsukada, Masakatsu Kanazawa, Norihiro Harada, Shingo Nishiyama
  • Patent number: 9867560
    Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: January 16, 2018
    Assignee: Profusa, Inc.
    Inventors: Soya Gamsey, Natalie Wisniewski, Kristen Helton, William McMillan
  • Patent number: 9861713
    Abstract: Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: January 9, 2018
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Ronnie Charles Mease, Ying Chen
  • Patent number: 9844598
    Abstract: Systemic administration of intact, bacterially derived minicells results in rapid accumulation of the minicells in the microenvironment of a brain tumor, in therapeutically significant concentrations, without requiring endothelial endocytosis/transcytosis across the blood brain barrier or any other mechanism by which, pursuant to conventional approaches, nanoparticles have entered into that microenvironment. Accordingly, a wide variety of brain tumors, both primary and metastatic, can be treated by administering systemically a therapeutically effective amount of a composition comprised of a plurality of such minicells, each minicell being a vehicle for an active agent against the tumor, such as a radionuclide, a functional nucleic acid or a plasmid encoding one, or a chemotherapeutic agent.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: December 19, 2017
    Assignee: EnGeneIC Molecular Delivery Pty Ltd
    Inventors: Himanshu Brahmbhatt, Jennifer MacDiarmid
  • Patent number: 9833522
    Abstract: The present invention provides a composition for use with photoacoustic or thermoacoustic imaging, comprising a sufficient amount of the graphene-like nanoparticles or graphitic nano- or microparticles and one or more physiologically acceptable carriers or excipients. The present invention also provides methods of using the graphene-like nanoparticles or graphitic nano- or microparticles as PAT/TAT contrast agents.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: December 5, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Balaji Sitharaman, Gaurav Lalwani
  • Patent number: 9827334
    Abstract: The present invention relates to a process for the preparation of Ioforminol, a contrast agent useful in X-ray imaging. More particularly, the invention relates to preparation of Ioforminol from a compound mixture comprising 1-formylamino-3,5-bis(2,3-bis(formyloxy)propan-1-ylcarbamoyl)-2,4,6-trioodobenzene by a process comprising in situ hydrolysis and a bis-alkylation.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: November 28, 2017
    Assignee: GE Healthcare AS
    Inventors: Mikkel Thaning, Andreas Olsson, Christian Glogard
  • Patent number: 9827313
    Abstract: The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: November 28, 2017
    Assignees: SNU R&DB FOUNDATION, THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC, INSTITUTE FOR BASIC SCIENCE
    Inventors: Taeghwan Hyeon, Kun Na, Daishun Ling, Wooram Park, Sin-jung Park, Yang Lu, Kyoung Sub Kim, Michael J. Hackett, Byung Hyo Kim, Hyeona Yim, Yong Sun Jeon
  • Patent number: 9829481
    Abstract: The instant invention relates to novel compounds useful for visualizing cell senescence, their preparation and use. In particular, this invention relates to novel fucose and amino-quinoline derivatives useful as senescence traces and their preparation.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: November 28, 2017
    Assignee: EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET
    Inventors: Jonathan Cotton, Bernd Pichler, Kerstin Fuchs, Anna Teske, Marcel Krueger, Christian Kesenheimer, Klaus Schulze-Osthoff, Dominic Hildebrand
  • Patent number: 9821290
    Abstract: The present invention teaches devices and methods for hyperpolarization by parahydrogen induced polarization. The invention teaches several significant improvements over previous designs, including a heating block, an enhanced solenoid component, and pinch valves and tubing that provide a sterile environment for the sample. All of these advancements can be accomplished while keeping costs to produce the device relatively low.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: November 21, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Shawn Wagner, Jose Agraz, Debiao Li
  • Patent number: 9820969
    Abstract: This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: November 21, 2017
    Assignee: TRANSLATUM MEDICUS INC.
    Inventor: Shelley Romayne Boyd
  • Patent number: 9810700
    Abstract: The present disclosure provides fluorogenic compounds useful for preparing fluorescent calcium ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators in methods of detection, discrimination and quantification of metal ions. The subject fluorogenic compounds and fluorescent ion indicators can include a chelating group based on a 2-aminophenoxyethylene glycol 2-aminoethyl ether, N,N,N?,N?-tetraacetic acid (PEGTA) moiety or precursor thereof where the phenyl group of the PEGTA is substituted with or fused with a fluorophore moiety of interest. The subject methods find use in the detection of intracellular calcium ions. Also provided are kits for use in practicing the subject methods.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: November 7, 2017
    Assignee: AAT Bioquest, Inc.
    Inventors: Zhenjun Diwu, Haitao Guo, Ruogu Peng, Qin Zhao, Jinfang Liao, Feng Liu
  • Patent number: 9801961
    Abstract: The present invention relates to compounds of general formula wherein R1 is (a) phenyl, optionally substituted by one or two substituents selected from 3H, halogen, lower alkyl, di-methyl-amino, NHC(O)-lower alkyl, C(O)O-lower alkyl, lower alkoxy, OC(3H)3, O11CH3, OCH2CH218F, lower alkoxy substituted by halogen, hydroxy, lower alkyl substituted by hydroxy, S-lower alkyl, (b) heterocyclyl group, (c) benzo[d][1,3]dioxol-5-yl, (d) 2,3-dihydrobenzo[b][1,4]dioxin-6-yl, (e) indolin-2-one, or (f) heteroaryl, selected from the group consisting of thiophenyl, benzofuranyl, benzothiophenyl, pyrazinyl, and benzothiazolyl; R2 is hydrogen, lower alkyl or lower alkyl substituted by halogen; R3 is lower alkyl, C(3H)3, 11CH3, lower alkyl substituted by halogen, —(CH2)2—O-lower alkyl substituted by halogen or cycloalkyl; or R2 and R3 form together with the N-atom to which they are attach a ring containing —CH2CH2CHRCH2CH2—, —CH2CH2CHRCH2—, —CH2CHRCH2—, —CH2CH2—NR—CH2CH2—, —CH2CH2—O—CH2CH2—, or, R is hydrogen, halog
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: October 31, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Henner Knust, Matthias Koerner, Dieter Muri
  • Patent number: 9795694
    Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, one aspect of the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro and in vivo via magnetic resonance and florescence imaging by using modified carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using the modified carbazole-based fluorophore. The modified carbazole-based fluorophore according to an embodiment of the present invention is prepared by conjugating a carbazole-based fluorophore with magnetic nanoparticles to form a conjugate which is permeable to blood brain barrier of a subject being introduced therewith.
    Type: Grant
    Filed: February 21, 2016
    Date of Patent: October 24, 2017
    Assignee: Hong Kong Baptist University
    Inventors: Yinhui Li, Di Xu, See-Lok Ho, Chung-Yan Poon, Hei-Nga Chan, Hung Wing Li, Ricky M. S. Wong
  • Patent number: 9796730
    Abstract: The present invention relates to novel halogenated benzoxazines, methods for their production, their use for the diagnosis of diseases and their use for the production of medicaments for the diagnosis of diseases, preferably dementia diseases and in particular the Alzheimer's disease, in humans and/or animals.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: October 24, 2017
    Assignee: EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET
    Inventors: Christian Kesenheimer, Florian Maier, Ramona Stumm, Bernd Pichler