Patents Examined by Jagadishwar Samala
  • Magnetic and fluorescent reverse nanoassemblies
    Patent number: 9597418
    Abstract: The present invention relates to magnetic and fluorescent nanoassemblies having reverse architectures. Especially, the nanoassemblies of the invention comprise a fluorescent core and magnetic nanoparticles contacting the surface of the fluorescent core. The nanoassemblies of the invention may further be coated by a polymer, which may optionally be functionalized. The invention further relates to a process for manufacturing the nanoassemblies of the invention. The invention is also directed to the use of the nanoassemblies of the invention, especially for multimodal imaging, in vitro and/or in vivo diagnostics through multimodal imaging, and/or therapy.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: March 21, 2017
    Assignees: UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Elena Ishow, Adrien Faucon
  • Compound and photoacoustic imaging contrast medium containing the compound
    Patent number: 9592307
    Abstract: The present invention provides a compound which exhibits a high degree of accumulation into a tumor even when some extent of time has passed after performing administration and which facilitates an increase in the intensity of photoacoustic signal produced by the tumor. A compound produced by bonding of a polyethylene glycol and a specific cyanine based compound.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: March 14, 2017
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Fumio Yamauchi, Satoshi Ogawa, Kengo Kanazaki, Daisuke Sasaguri, Atsushi Takahashi, Masato Minami, Tatsuki Fukui
  • Method, compounds and preparations for the identification of sentinel lymph nodes
    Patent number: 9579405
    Abstract: The present invention relates to methods for the identification of a sentinel lymph node and to compounds and preparations used in said methods.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: February 28, 2017
    Assignee: GE Healthcare AS
    Inventors: Audun Tornes, Jonnny Ostensen, Henrik Rasmussen, Lars Hoff
  • Lanthanoid complex capsule and particle contrast agents, methods of making and using thereof
    Patent number: 9579404
    Abstract: The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods of making and using the compositions. The solid lipid particles or capsules contain micelle cores stabilized by a hyperbranched polymer shell based from a crosslinked DOTA derivative compound or crosslinked lanthanoid-DOTA derivative complex. These solid lipid particles or capsules can be used in various applications, such as contrast agents or drug delivery vehicles.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: February 28, 2017
    Assignee: New York University
    Inventor: Marc Anton Walters
  • Process for the preparation of chelated compounds
    Patent number: 9567350
    Abstract: The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: February 14, 2017
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Federico Maisano, Federico Crivellin
  • Combinations and modes of administration of therapeutic agents and combination therapy
    Patent number: 9561288
    Abstract: The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents (such as an anti-VEGF antibody), or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: February 7, 2017
    Assignee: ABRAXIS BIOSCIENCE, LLC
    Inventors: Neil P. Desai, Patrick Soon-Shiong
  • Hydroxylapatite material, and method for the production thereof
    Patent number: 9561305
    Abstract: The invention relates to a hydroxylapatite material, for the production of which a nanoscale hydroxylapatite paste is subjected to a thermal treatment.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: February 7, 2017
    Assignee: AAP BIOMATERIALS GMBH
    Inventors: Elvira Dingeldein, Lydia Heimann, Georgiana Gasqueres, Marco Wolfstadter
  • Compositions, methods, and systems for the synthesis and use of imaging agents
    Patent number: 9555138
    Abstract: The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: January 31, 2017
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Richard R. Cesati, Heike S. Radeke, Suresh K. Pandey, Ajay Purohit, Simon P. Robinson
  • Actinium-225 compositions of matter and methods of their use
    Patent number: 9555140
    Abstract: The present invention is directed to improved methods for generating compositions comprising actinium-225.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: January 31, 2017
    Assignee: Los Alamos National Security, LLC
    Inventors: Eva Rachel Birnbaum, Jonathan W. Engle, Francois Meiring Nortier
  • Method for synthesizing radiopharmaceuticals using a cartridge
    Patent number: 9550704
    Abstract: The present invention relates to a method for synthesizing a radiopharmaceutical using a cartridge, which makes it possible to carry out several steps of reaction required for synthesizing a radiopharmaceutical in the cartridge filled with a polymer. A method for synthesizing a radiopharmaceutical according to the present invention enables each step's reaction to be carried out with the solution confined in the cartridge so as not to flow out, thus being simplified compared to the conventional methods for synthesizing radiopharmaceuticals, and expediting the synthesis thereof.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: January 24, 2017
    Assignee: FUTURECHEM CO., LTD.
    Inventors: Dae Yoon Chi, Byoung Se Lee, Jae Hak Lee, So Young Chu, Woon Jung Jung
  • Sustained release pheromone preparation targeting insect pest having carboxylic acid as pheromone substance
    Patent number: 9545102
    Abstract: Targeting an insect pest having a carboxylic acid compound as a pheromone substance, provided is a sustained release pheromone preparation enabling a high amount of pheromone to be released during the control period. More specifically, provided is a sustained release pheromone preparation, comprising: a carboxylic acid compound to be released, and an ethylene-vinyl acetate copolymer membrane through which the carboxylic acid compound can permeate, wherein the preparation is targeted for an insect pest having the carboxylic acid compound as a pheromone substance.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: January 17, 2017
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Tatsuya Fujii, Tatsuya Hojo, Naoki Ishibashi, Ryuichi Saguchi, Takehiko Fukumoto
  • Radiotherapeutic particles and suspensions
    Patent number: 9539346
    Abstract: The present invention relates to a particle or pharmaceutical composition comprising one, more particles or a suspension of same or different particles comprising a degradable compound and an alpha emitting radionuclide and/or a radionuclide generating alpha emitting daughter. The particles are beneficial for use in the treatment of cancer.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: January 10, 2017
    Assignee: Oncoinvent AS
    Inventors: Roy Hartvig Larsen, Sara Westrøm
  • Method to improve the tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting
    Patent number: 9539345
    Abstract: Disclosed herein is a method of improving tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting, and the multivalent ligands for tumor diagnosis.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: January 10, 2017
    Assignees: Korea Research Institute of Bioscience and Biotechnology, National Cancer Center
    Inventors: Yoonkyung Kim, Ju Young Heo, June-key Chung, Young-Hwa Kim, Seok Ki Kim, Se Hun Kang
  • Method for collecting metal-containing fullerene
    Patent number: 9522199
    Abstract: A method for recovering an endohedral metallofullerene comprises a complexation step of adding a Lewis acid comprising titanium halide or tin halide to a reaction solution formed by dissolving crude fullerenes in a solvent, thereby forming a complex of the endohedral metallofullerene and the Lewis acid, a filtering step of filtering the reaction solution to separate the complex, and a washing step of removing the Lewis acid from the complex to obtain the endohedral metallofullerene. The obtained endohedral metallofullerene is soluble in a solvent. This method provides a high recovery yield of the endohedral metallofullerene.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: December 20, 2016
    Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Kazuhiko Akiyama, Tatsuyuki Hamano, Hisanori Shinohara, Yusuke Nakanishi
  • Photodynamic diagnostic agent and photobleaching inhibitor
    Patent number: 9517267
    Abstract: The objects of the present invention are to inhibit photobleaching of porphyrins as well as to provide a superior photodynamic diagnostic agent and a photodynamic diagnostic method employing the photobleaching inhibitor for porphyrins. The present invention provides a photodynamic diagnostic agent containing a precursor of porphyrins and a gallic acid. The present invention also provides a photobleaching inhibitor for porphyrins containing a gallic acid.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: December 13, 2016
    Assignees: SBI Pharmaceuticals Co., Ltd., Tokyo Institute of Technology
    Inventors: Masahiro Ishizuka, Tohru Tanaka, Shun-ichiro Ogura, Takuya Ishii
  • Compound and photoacoustic imaging contrast medium containing the compound
    Patent number: 9517278
    Abstract: The present invention provides a photoacoustic imaging contrast medium which exhibits a high degree of accumulation into a tumor even when some extent of time has passed after performing administration and which facilitates an increase in the intensity of photoacoustic signal produced by the tumor. A compound produced by covalent-bonding of an organic dye which absorbs light in the near-infrared wavelength region and a PEG having a branch.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: December 13, 2016
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Atsushi Takahashi, Fumio Yamauchi, Masato Minami, Satoshi Ogawa, Kengo Kanazaki, Satoshi Yuasa
  • Use of riluzole for treating or preventing the adverse effects of antineoplastic agents
    Patent number: 9511045
    Abstract: This invention relates to riluzole for use in the treatment or prevention of adverse effects associated with the administration of anticancer agents having neurotoxic effects, such as, for example, platinum salts, taxanes and periwinkle alkaloids.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: December 6, 2016
    Assignee: UNIVERSITE D'AUVERGNE CLERMONT I
    Inventors: Jérôme Busserolles, Abdelkrim Alloui, Michel Lazdunski, Alain Eschalier
  • Molecular probes for multimodality imaging and tracking of stem cells
    Patent number: 9492571
    Abstract: The invention relates to novel multi-modality probes for imaging, tracking and analyzing stem cells and related biological samples, and methods of preparation and use thereof. The molecular probes of the invention are constructed, for example, by utilizing (a) the high selectivity of long hydrocarbon chains for binding to plasma membranes of cells, (b) a near-infrared (NIR) dye for optical imaging, and (c) a radionuclide for PET or SPECT imaging. The in vitro and in vivo data of the optical and radiolabeled probes demonstrated their utility for detecting the presence of stem cells with multiple imaging modalities.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: November 15, 2016
    Assignee: University of Massachusetts
    Inventors: Brian D. Gray, Mary Rusckowski, Koon Y. Pak
  • Methods and compositions for radiohalogen protein labeling
    Patent number: 9486546
    Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: November 8, 2016
    Assignee: GENENTECH, INC.
    Inventors: Charles Andrew Boswell, Leslie A. Khawli, Jan Marik, Simon Williams
  • Curcumin coated magnetite nanoparticles for biomedical applications
    Patent number: 9468691
    Abstract: The present invention discloses biocompatible, stable curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles (USPION) for biomedical applications. Disclosed herein is also a simple one-pot process for the synthesis of biocompatible, stable curcumin or its derivatives coated ultra-small superparamagnetic iron oxide nanoparticles in absence of a linker or binder. The curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles of the present invention retains the medicinal, radical scavenging and fluorescence properties of curcumin.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: October 18, 2016
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Alias Joy Pattayil, Kunnoth Naduvilidam Jayaprabha