Abstract: An apparatus for treating a tissue site comprising a negative-pressure source configured to be fluidly coupled to the tissue site; an instillation source configured to be fluidly coupled to the tissue site; and a controller operatively coupled to the negative-pressure source and to the instillation source. The controller can be configured to operate the negative-pressure source and the instillation source to intermittently deliver negative pressure to the tissue site for a negative-pressure interval and deliver instillation fluid to the tissue site for an instillation interval. A purge volume of instillation fluid may be delivered to the tissue site at a purge frequency. In some examples, the purge volume may be delivered through the second fluid conductor and removed through the first fluid conductor during a negative-pressure interval.

Abstract: The present disclosure relates to an audible indicator for use with a drug delivery device comprising a resilient force member configured to reside in one of a relaxed state and a biased state. The audible indicator comprises a retainer adapted to maintain the resilient force member in the biased state. The resilient force member releases stored energy to impact a surface to generate an audible signal when the resilient force member changes from the biased state into the relaxed state.

Abstract: An enteral feeding device permitting diversion of gastrointestinal fluid from an afferent limb to an efferent limb of gastrointestinal tract in a subject is provided. The device can be used to reduce leakage from around device and thus reduce morbidity associated with such leakage. In certain embodiments the enteral feeding device is a jejunostomy tube (J-tube). Also provided are methods for positioning and using the enteral feeding device. Also provided are kits for positioning and using the enteral feeding device.

Abstract: The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

Abstract: An activation assembly for a medicament delivery device is presented having a delivery member cover provided with legs and configured to be biased in a proximal direction, a movable sleeve configured to be received between the legs, and an activation sleeve configured to be biased in the proximal direction, wherein the delivery member cover is configured to be moved in an axial direction between a first position and a second position, wherein movement of the delivery member cover from the first position to the second position causes movement of the movable sleeve from a first movable sleeve position to a second movable sleeve position. The delivery member cover axially displaces the activation sleeve in a distal direction when the delivery member cover moves towards the second position, thereby causing a first actuation of a sensor.

Abstract: An apparatus and methods for use are provided, where the apparatus includes: (a) a first catheter having a proximal end and a distal end, and wherein a distal portion of the first catheter includes a first one or more outlets, (b) a first tubular housing having a proximal end and a distal end, wherein the first tubular housing is coupled to the first catheter proximal to the at least one first outlet, (c) one or more pressure sensors coupled to the distal end of the first tubular housing, and (d) a second catheter having a proximal end and a distal end, wherein a distal portion of the second catheter includes a second one or more outlets, and wherein the distal end of the second catheter is configured to be positioned substantially within one of (i) the first catheter or (ii) a second tubular housing coupled to one or more of the first catheter and the first tubular housing, when the second catheter is in a first position.

Abstract: A drug delivery device includes a housing defining a shell, a container, a drive mechanism, a needle assembly having first and second ends, a fluid flow connection, and a flow adapter, each of which is at least partially disposed within the housing. The container has first and second ends and an inner volume to contain a medicament to be administered to a user. The drive mechanism is adapted to exert a force to urge the medicament out the second end of the container. The fluid flow connection is coupled to the second end of the container and the first end of the needle assembly and is adapted to allow the medicament to flow from the container to the needle assembly. The flow adapter includes at least one protrusion for generating a minor head loss to the medicament flowing within the fluid flow connection and helps to reduce variations of injection rates due to variations in drug product viscosities.

Abstract: The present specification is directed to systems, devices, and methods of portable enteral pump systems for feeding and/or flushing an ambulatory patient. Embodiments provide an enteral pumping device that may be loaded by a patient from a front and a top side of the pumping device and is therefore more convenient to use. Further, embodiments incorporate a single rotor pump for dual-use purposes of feeding nutrients and flushing fluids to the patient. A pinch valve is placed between the parallel sides of the two tubes to cut off fluid flow when required. At least one sensor is also placed between the rotor pump and an outlet. The sensors are used to detect occlusions and the type of disposables used, among other purposes.

Abstract: Needle shroud assemblies comprising a needle shroud and a support component. At least one of the needle shroud assemblies includes: a shroud body having an inner surface forming a cavity; a shroud beam arranged on the shroud body and biased radially outwards, wherein the support component is arranged on the inner surface of the shroud body and configured to form an inner radial support surface for the shroud body and/or for the shroud beam.

Abstract: A method of performing a gas arthroscopy by injecting a joint capsule with sealant prior to insufflation with gas. This sealant can be any biocompatible gel or liquid with sufficient viscosity or sealing capability to prevent air embolisms while performing gas arthroscopy.

Abstract: A multiple lumen central venous catheter with the lumens exit ports on the distal sides of the catheter; enclosed in a separate casing that has exit ports in the walls at its distal end; that allows the enclosed catheter to rotate in the casing, allowing the exit ports in the catheter to align or non-align to open and close the individual lumens at the distal end.

Abstract: An intra-cavity circulation heat perfusion apparatus, comprising a casing, an electromagnetic induction heating means, and a controller. The electromagnetic induction heating means comprises a tray and an electromagnetic induction coil; the tray is used for bearing a heating tank; a master control unit of the controller controls the electromagnetic induction coil to be electrified to heat the heating tank, so as to indirectly heat a medicinal liquid in a liquid storage chamber; a data acquisition unit is used for acquiring medicinal liquid temperature values of the heating tank, a liquid outlet pipeline, and a liquid return pipeline and transferring same to the master control unit; the master control unit controls a power control unit according to the medicinal liquid temperature values to control a heating power of the electromagnetic induction coil.

Abstract: The present disclosure relates to a sheath remover for removing a protective needle sheath from a drug cartridge. The sheath remover includes a resilient ring and one or more resilient legs attached to the ring and extending in a proximal direction. Each leg includes an inwardly directed ledge arranged at a proximal end of the leg. The ring consists of a resilient material allowing inward deflection of a proximal end of the ring. The present disclosure further relates to a method for assembling and a method for using the sheath remover.

Abstract: A medical device (100) includes an insulin pen (102), a pen needle (104) and a force sensor (106). The device also includes a microprocessor (206) to receive a signal from the force sensor (106). Audible and/or visual indicators (218, 220) provide feedback to a user to encourage proper injection technique. The device may also include an adaptor assembly comprising a sensor housing (306) and a first sensor (304) within the sensor housing, and a transfer needle assembly (308), the transfer needle assembly providing a connection (310) for a pen needle, and providing a fluid conduit between the pen needle (312) and the insulin pen (302). A second force sensor (314) is associated with a thumb button of the insulin pen (302).

Abstract: A device for intravascular intervention can comprise an interventional element, an elongate manipulation member having a retention portion, and a joining element. The elongate element can comprise a distally located attachment portion. The interventional element includes a proximal end portion with a hole therethrough, the attachment portion of the elongate member extending through the hole at the bend such that first and second segments of the elongate member each extend proximally from the hole. A retention portion includes an arm extends proximally of the hole and a shoulder protruding radially outwardly from a proximal portion of the arm. A joining element circumferentially surrounds at least a portion of the retention portion and at least a portion of the first and second segments of the elongate member such that a proximal end of the joining element is positioned distal to the shoulder of the retention portion.

Abstract: A system for confirmation of fluid delivery to a patient at the clinical point of use is provided. The system includes a wearable electronic device. The wearable electronic device has a housing; at least one imaging sensor associated with the housing; a data transmission interface; a data reporting accessory for providing data to the user; a microprocessor for managing the at least one imaging sensor, the data transmission interface, and the data reporting accessory; and a program for acquiring and processing images from the at least one imaging sensor. The system further includes a fluid delivery apparatus; and one or more identification tags attached to or integrally formed with the fluid delivery apparatus. The program processes an image captured by the at least one imaging sensor to identify the one or more identification tags and acquires fluid delivery apparatus information from the one or more identification tags.

Abstract: An overtube assembly for use with an elongate medical tool includes an overtube including a flexible tubular body having a proximal end and distal end. The flexible tubular body includes a split extending from the proximal end to the distal end. The overtube assembly further includes an inflatable balloon coupled to a distal portion of the flexible tubular body. The flexible tubular body is disposable over a section of the elongate medical tool by inserting the elongate medical tool through the split.

Abstract: An automatic feedback mechanism for a medicament delivery device that notifies a user of a start of expulsion of medicament from a medicament container is presented where a plunger rod, a tubular extension member arranged to receive the plunger rod in the radial space, and wherein the tubular extension member has flexible tongues configured to releasably lock the plunger rod in a pre-tensioned state. The tubular operation member is arranged to receive the tubular extension member, where the tubular operation member in a first position is arranged to press the flexible tongues radially inwards to lock the plunger rod in the pre-tensioned state. A first resilient member is arranged inside the plunger rod to exert a force in the proximal direction. A signal generating member is arranged to partially surround the plunger rod such that movement of the signal generating member distally hits the inner distal surface generating an audible signal.

Abstract: Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics).

Abstract: An injection system can have a Syringe Dose and Position Apparatus (SDPA) mounted to a syringe. The SDPA can have one or more circuit boards. The SDPA can include one or more sensors for determining information about an injection procedure, such as the dose measurement, injection location, and the like. The SDPA can also include a power management board, which can be a separate board than a board mounted with the sensors. The syringe can also include a light source in the needle. Light emitted from the light source can be detected by light detectors inside a training apparatus configured to receive the injection. The syringe can have a power source for powering the sensors and the light source. The SDPA and the power source can be mounted to the syringe flange.