Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

Abstract: A venous access port assembly having a base, a peripheral surface, and a septum. The base defines an interior reservoir. The peripheral surface includes integrally molded X-ray discernable indicia identifying that the assembly is rated for power injection. The X-ray discernable indicia may extend through a height of the peripheral surface from a top surface to a bottom surface thereof. According to one aspect, the peripheral surface may be formed from X-ray discernable material, and the X-ray discernable indicia may be formed from the X-ray discernable material, or they may be formed by voids in the X-ray discernable material. According to another aspect, the peripheral surface may be formed from a radiotransparent or radiolucent material and applied with a radiopaque agent, and the X-ray discernable indicia may be one or more voids in the radiopaque agent or may be portions of the peripheral surface applied with the radiopaque agent.

Abstract: A priming assembly for a drug delivery device includes a hub, a base connected to the hub and moveable relative to the hub between a first position and a second position, with the base defining a passageway, a cap defining an interior chamber and a passageway in fluid communication with the interior chamber, and a needle connected to the hub and positioned within the interior chamber of the cap, where the passageway of the base is in fluid communication with the passageway of the cap when the base is in the first position, and where the passageway of the base is isolated from the passageway of the cap when the base is in the second position.

Abstract: A system may include a flow sensor and a base. The flow sensor may be configured to connect to the base. The flow sensor may include a flow tube including a fluid inlet at a first end of the flow tube, a fluid outlet at a second end of the flow tube opposite the first end of the flow tube, and a fluid injection port between the first end and the second end of the flow tube. The base may include a short range wireless communication device including a curved coil antenna.

Abstract: An elastic physiological patch includes a patch assembly and an implant assembly. The patch assembly includes an electronic device, and a soft patch body defining a chamber for receiving the electronic device. The implant assembly is mountable to the electronic device and includes an implant which is capable of being driven to partially pass through the patch body and which is adapted to be implanted in the skin of a subject. The implant and the patch body cooperatively seal the chamber.

Abstract: Disclosed herein are puncturing devices and puncturing systems including the puncturing devices. Such puncturing devices and systems include those that sense a difference between venous blood and arterial blood as a function of blood oxygen, impedance, or pressure. As a result, the puncturing devices and systems are able to differentiate between a venipuncture and an arterial puncture. Methods of the puncturing devices and systems for differentiating between a venipuncture and an arterial puncture for are also disclosed.

Abstract: A catheter may include an inner liner, at least one support structure over the inner liner, and an outer jacket over the at least one support structure. In some examples, the catheter includes a tip jacket positioned over a distal portion of the outer jacket and extend beyond a distal-most part of the inner liner and a distal-most part of the outer jacket to define a single-layer catheter tip. In some examples, the at least one support structure may include a braid and a coil. The catheter may include a marker band over a distal portion of one of the braid or the coil. The other of the braid or the coil ends proximally of a proximal end of the marker band, such that the catheter includes a location with lower radial and/or flexural stiffness proximal of the marker band.

Abstract: A catheter assembly includes: a catheter; and an inner needle inserted through the catheter. The catheter includes: a catheter body; and a flexible portion that is located at a distal portion of the catheter body and forms a most distal portion of the catheter. An elastic modulus of the catheter body is greater than an elastic modulus of the flexible portion. The catheter has a mixed region in which the catheter body and the flexible portion overlap each other in a radial direction.

Abstract: Intravesical drug delivery devices are provided which may include an elongated body formed of a matrix system of a drug dispersed in a silicone, wherein the elongated body has a first end, an opposed second end, and an intermediate portion between the first and second ends, and wherein the silicone of the matrix system is cured to bias the elongated body in a coiled retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of a patient and the coiled retention shape which is suited to retain the device within the urinary bladder.

Abstract: An autonomous drug delivery system advantageously utilizes physiological monitor outputs so as to automatically give a bolus of a rescue drug or other necessary medication when certain criteria and confidence levels are met. An emergency button is provided to manually trigger administration of the rescue drug. The rescue drug may be an opioid antagonist in response to an analgesia overdose, a hypotensive drug to avert an excessive drop in blood pressure or an anti-arrhythmia drug to suppress abnormal heartbeats, to name a few.

Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.

Abstract: An electroporation device with a needle array removably attached thereto, the needle array having a body, a shroud movable with respect to the body between a rest position and one or more actuated positions, and an auto-lock assembly. Where the auto-lock assembly is adjustable between a locked configuration, where the shroud is not movable with respect to the body, and an unlocked configuration, where the shroud is movable with respect to the body, and where biasing the shroud from the rest position to the one or more actuated positions and back to the rest position adjusts the auto-lock from the unlocked configuration to the locked configuration.

Abstract: A plunger head for a fluid injection device includes a transducer disposed in the plunger head to measure a compressive force when applied to the plunger head. The plunger head also includes a power source and a microcontroller disposed in the plunger head. The microcontroller is coupled to the power source and the transducer, and the microcontroller is coupled to enter a high-power mode in response to sensing application of the compressive force to the plunger head.

Abstract: A medical device is provided that includes a fine needle aspiration device and an incision device, which are inserted into a body with an endoscope. The fine needle aspiration device includes an injection needle and an injection needle tube, which surrounds the injection needle. A first limiting unit limits the length of the needlepoint of the injection needle protruding from the injection needle tube. A syringe is connected to the injection needle for tissue collection and medicine injection. A second limiting unit limits the connection between the injection needle and the syringe. The incision device includes a knife and a knife tube that surrounds the knife. A third limiting unit limits the length of the cutting edge of the knife protruding from the knife tube.

Abstract: A flow control apparatus comprising a housing capable of receiving a portion of the feeding set, a pumping device configured to receive the feeding set and may produce a fluid flow in the feeding set and deliver fluid to a subject, an ultrasonic sensor may be configured to produce a sensor signal indicative of a condition of the feeding set, and a control circuit in communication with the ultrasonic sensor for receiving the sensor signal from the ultrasonic sensor indicative of the condition of the feeding set. The ultrasonic sensor may comprise a plurality of sensor components which may be configured to emit an ultrasonic signal in a first direction, and in a second direction opposite the first direction through the feeding set.

Abstract: The present invention relates to drug delivery systems that cannot be reloaded or reused and further include a passive safety shield system.

Abstract: A medical instrument or device, such as a catheter, has echogenic properties, in addition to or as an alternative to radiopaque properties, to facilitate detection of the medical instrument or device during medical procedures using suitable imaging methods, such as ultrasound imaging and/or x-ray imaging methods. In example embodiments, an example catheter has a relatively increased radiopacity and echogenicity to facilitate a clinician with detecting the catheter with ultrasound imaging and/or x-ray imaging methods to assist the clinician with the insertion, placement, and/or maintenance of the catheter, for example.

Abstract: A plastic flange for a medical container, the plastic flange defining an opening, the opening being surrounded by a peripheral collar, the collar providing a support to a user's fingers, wherein the flange comprises connecting means for connecting the flange to an external surface of a tubular barrel of the medical container, and wherein the flange further comprises a remotely readable electronic component for remote identification of the medical container, the remotely readable electronic component being embedded into the plastic flange.

Abstract: An automatic injection device including a reusable driving assembly having a forward injection end and an engagement element and a disposable cassette assembly including an injectable liquid to be injected at an injection site, wherein the disposable cassette assembly is removably insertable into the reusable driving assembly at the forward injection end and is removably retained within the reusable driving assembly by snap fit engagement therewith, the snap fit engagement being effected at least partially by the engagement element, which is displaced rearwardly by insertion of the disposable cassette assembly in the reusable driving assembly.

Abstract: A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism comprises an actuator and a fluid chamber having a restricted outlet. The actuator is adapted to urge fluid from the fluid chamber through the restricted outlet. The feedback mechanism also has an indicator that is adapted to provide feedback to the user after a predetermined volume of fluid has passed from the fluid chamber through the restricted outlet during use of the injection device.