Patents Examined by James O. Thomas, Jr.
  • Manufacture of tertiary butyl hydroperoxide
    Patent number: 4128587
    Abstract: The concentration of tertiary butyl alcohol in the isobutane feed to a reactor for the preparation of tertiary butyl hydroperoxide is controlled to be within the range from about 10% to about 30% whereby the conversion and selectivity and reaction rates provide advantageous results.
    Type: Grant
    Filed: November 26, 1976
    Date of Patent: December 5, 1978
    Assignee: Atlantic Richfield Company
    Inventor: John C. Jubin
  • 1-(Norborn-5'-en-2'-yl) or 1-(norborn-2'-yl) substituted 1-alken-3-ols and alkan-3-ols
    Patent number: 4128509
    Abstract: 1-(Norborn-5'-en-2'-yl) or 1-(norborn-2'-yl) substituted 1-alken-3-ols and alkan-3-ols characterized by the structural formulae ##STR1## wherein R.sup.1 represents hydrogen or methyl, R represents an alkyl with from 1 to 8 carbon atoms, and R.sup.2 and R.sup.3 represent hydrogen or an alkyl with from 1 to 8 carbon atoms, provided that R and R.sup.2 can be --CH.sub.2 --.sub.n wherein n represents the integer 2, 3 or 4. The compounds have very pleasant, lasting floral-woody aromas and are useful as components in fragrance compositions.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: December 5, 1978
    Assignee: Monsanto Company
    Inventor: Alfred A. Schleppnik
  • Amino acid derivatives
    Patent number: 4128721
    Abstract: New derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: December 5, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Miguel A. Ondetti
  • Process for the manufacture of acetic acid ethyl ester
    Patent number: 4128727
    Abstract: Acetic acid ethyl ester is prepared by passing ethylene over a fixed-bed catalyst composed of silicon dioxide, which has a surface from 50 to 200 m.sup.2 /g and which is impregnated with H.sub.2 SO.sub.4, diethylsulfate or ethylsulfuric acid or mixtures of these compounds, with periodically alternating quantities of acetic acid, at a temperature from 130.degree. to 170.degree. C, the acid concentration, calculated on ethylene, varying constantly over a range from 0.01 to 40% by mole.
    Type: Grant
    Filed: December 12, 1977
    Date of Patent: December 5, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ernst I. Leupold, Hans-Jurgen Arpe, Albert Renken, Ernst-Gunther Schlosser
  • Synthesis of Vitamin E
    Patent number: 4127608
    Abstract: A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.
    Type: Grant
    Filed: May 17, 1977
    Date of Patent: November 28, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gary L. Olson, Galbriel Saucy
  • Preparation of 1-phenyl-2,2,2-trihalogeno-ethanol esters
    Patent number: 4127728
    Abstract: A process for the preparation of a substituted 1-phenyl-2,2,2-trihalo-ethanol ester of the formula ##STR1## in which R is alkyl, halogenoalkyl, alkoxy, cycloalkyl or optionally substituted phenyl, benzyl, phenoxy, or phenylsulfonyl,X is halogenoalkyl with 1-3 carbon atoms and 1-3 halogen atoms,Y is halogen, cyano, nitro, alkyl, alkoxy, alkylmercapto, sulfoalkoxy or optionally substituted methylenedioxy, andn is an integer from 0 to 3,Comprising reacting a compound of the formula ##STR2## WITH A HALOGENATED ALDEHYDE OF THE FORMULAX CHOin the presence of a Friedel-Crafts catalyst at a temperature of about -70 to +100.degree. C thereby to form a complex alcoholate, and reacting the complex alcoholate with an acid halide of the formula ##STR3## OR WITH A CORRESPONDING ACID ANHYDRIDE AT A TEMPERATURE OF ABOUT -70 TO +100.degree. C.
    Type: Grant
    Filed: August 24, 1976
    Date of Patent: November 28, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Schmidt, Wolfgang Kramer, Eckart Kranz
  • 2-Formamido phenylguanidines and processes for their preparation and use
    Patent number: 4127670
    Abstract: N-(2-formamidophenyl)-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(formamido)-phenyl group are anthelminetic agents. The compounds, of which N-(2-formamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoformanilide.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: November 28, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hartmund Wollweber, Heinrich Kolling, Herbert Thomas
  • 4,5-Seco-steroids
    Patent number: 4127589
    Abstract: Novel 4,5-seco-steroids having anti-inflammatory activity are disclosed herein.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: November 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Christopher M. Cimarusti, Seymour D. Levine
  • Amino acid derivatives
    Patent number: 4127729
    Abstract: New derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: November 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Miguel A. Ondetti
  • Phenolics methylation using a modified alumina catalyst
    Patent number: 4126749
    Abstract: Aluminas derived from aluminum alkoxide hydrolysis are calcined at 1150.degree.-1800.degree. F for a period of time ranging 0.5 to about 12 hours to develop specific pore volume and pore diameter characteristics prior to use as a catalyst in the vapor phase and liquid phase methylation of phenol, monosubstituted, and di-substituted phenols. The calcining at higher temperatures gives increased catalyst life, lower isomerization and disproportionation, and higher orthomethylation activity.
    Type: Grant
    Filed: July 20, 1977
    Date of Patent: November 21, 1978
    Assignee: Continental Oil Company
    Inventor: Bruce E. Leach
  • Process for the high pressure methylation of 2,6-xylenol
    Patent number: 4126750
    Abstract: High pressure methylation of 2,6-xylenol to produce 2,3,6-trimethylphenol is accomplished by maintaining the methanol/2,6-xylenol feed at temperature and pressures sufficient to keep the feed liquid in a reactor head then forcing the feed through orifices, expanding the feed into a mixed vapor liquid phase, the feed after expansion being in the range of reaction conditions of pressure and temperature while in the presence of the catalyst where the reaction takes place. The process avoids the current problems of uneven feed mixtures and catalyst tube plugging.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: November 21, 1978
    Assignee: Continental Oil Company
    Inventors: Ronald L. Poe, John F. Scamehorn, Cortlan R. Schupbach
  • Process for the production of 2,2-dimethyl-5-(2,5-xylyloxy)valeric acid
    Patent number: 4126637
    Abstract: A process is provided for the production of 2,2-dimethyl-5-(2,5-xylyloxy)valeric acid which comprises subjecting 2,2-dimethyl-5-(2,5-xylyloxy)valeraldehyde to oxidation with elemental oxygen in a three-phase reaction mixture comprising a water immiscible organic solvent for said valeraldehyde, an aqueous alkaline solution, and a noble metal catalyst.
    Type: Grant
    Filed: June 17, 1977
    Date of Patent: November 21, 1978
    Assignee: Warner-Lambert Company
    Inventors: Om P. Goel, William M. Pearlman
  • Aminosulfonylcarboxylic acids and their salts
    Patent number: 4126634
    Abstract: Aminosulfonylcarboxylic acids and their manufacture from diamines and chlorosulfonylcarboxylic acids.
    Type: Grant
    Filed: August 1, 1977
    Date of Patent: November 21, 1978
    Assignee: BASF Aktiengesellschaft
    Inventors: Lucien Thil, Martin Fischer, Wolfgang Kindscher
  • X-ray contrast agents
    Patent number: 4125599
    Abstract: 5-Gluconamido-2,4,6-triiodo-N-methylisophthalamic acid, 3-acetamido-2,4,6-triiodo-5-trishydroxymethylacetamidobenzoic acid, related compounds and salts and esters thereof are useful as x-ray contrast agents. The corresponding acyl halides are useful as intermediates.
    Type: Grant
    Filed: August 19, 1976
    Date of Patent: November 14, 1978
    Assignee: Mallinckrodt, Inc.
    Inventor: Philip E. Wiegert
  • Aryl substituted cycloalkanones
    Patent number: 4125714
    Abstract: Aryl substituted tertiary carbinols, useful as anti-viral agents and insecticides, are prepared by reacting the Grignard reagent derived from an arylalkyl or arylalkenyl iodide with a dialkyl ketone or an alkyl alkenyl ketone; or by reacting an arylalkyl or arylalkenyl ketone with an alkyl- or alkenylmagnesium halide. Corresponding cyclic tertiary carbinols are also prepared via intermediate cyclic ketones.
    Type: Grant
    Filed: August 29, 1974
    Date of Patent: November 14, 1978
    Assignee: Sterling Drug Inc.
    Inventors: Guy D. Diana, William B. Hinshaw, Jr.
  • Method for the disproportionation of highly alkylated phenols with phenol
    Patent number: 4125736
    Abstract: This invention provides an improved process for the disproportionation of highly alkylated phenols with phenol using an improved magnesium oxide catalyst promoted with tungsten oxide, silica sol, and sodium silicate. The method provides a catalyst having a high reactivity, high surface area, and high crush strength compared to known magnesium oxide, tungsten oxide catalysts. The catalyst is useful in phenol methylation and disproportionation. The effect of silica sol and sodium silicate is synergistic since these materials alone will not catalyze these reactions. Surprisingly, the catalyst will not disproportionate olefins.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: November 14, 1978
    Assignee: Continental Oil Company
    Inventor: Bruce E. Leach
  • Aryl substituted ketones
    Patent number: 4125541
    Abstract: Aryl substituted tertiary carbinols, useful as antiviral agents and insecticides, are prepared by reacting the Grignard reagent derived from an arylalkyl or arylalkenyl iodide with a dialkyl ketone or an alkyl alkenyl ketone; or by reacting an arylalkyl or arylalkenyl ketone with an alkyl- or alkenylmagnesium halide.
    Type: Grant
    Filed: August 29, 1974
    Date of Patent: November 14, 1978
    Assignee: Sterling Drug Inc.
    Inventors: Guy D. Diana, William B. Hinshaw, Jr.
  • Hypolipemic .alpha.-aryloxy para substituted phenyl acetic acid compounds
    Patent number: 4125729
    Abstract: This invention discloses .alpha.-aryloxy para substituted phenyl acetic acid compounds that are useful in lowering sterol and triglyceride serum levels.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: November 14, 1978
    Assignee: American Cyanamid Company
    Inventors: Ronald I. Trust, Francis J. McEvoy, Jay D. Albright
  • Process for the preparation of norpatchoulenol and intermediates therefor
    Patent number: 4124648
    Abstract: A process for the preparation of norpatchoulenol is described according to the reaction scheme: ##STR1## Novel intermediates of formulae ##STR2## wherein R.sup.1 is methyl or benzyl and ##STR3## wherein R.sup.1 is methyl or benzyl and X is hydroxy, trityloxy, tosyloxy or halogen, are also described.
    Type: Grant
    Filed: February 21, 1974
    Date of Patent: November 7, 1978
    Assignee: Societe Anonyme des Etablissements Roure-Bertrand Fils & Justin Dupont
    Inventors: Pierre Pesnelle, Paul J. Teisseire
  • Process for preparing substituted oxyacetaldehydes and acetals thereof
    Patent number: 4124644
    Abstract: A process is described for the preparation of substituted oxyacetaldehydes and acetals thereof according to the reaction sequence: ##STR1## WHEREIN R.sub.1 and R.sub.2 are each lower alkyl or R.sub.1 and R.sub.2, taken together form a lower alkylene group; wherein R.sub.3 is alkyl, alkenyl or alkadienyl and X is halogen selected from the group consisting of chlorine and bromine, the reaction (i) being carried out (1) using a "phase transfer agent" and (2) in a two phase system.
    Type: Grant
    Filed: January 11, 1978
    Date of Patent: November 7, 1978
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark A. Sprecker, John J. Kryschuk, John B. Hall