Abstract: N,N'-Bridged-bis[(O and/or N-substituted)-2-alkyl-2-hydroxyethylamines] of the formula ##STR1## are prepared by condensing an epoxide of the formula ##STR2## and a diamine of the formula R'NH--X--NHR'. The products and dicarbanilates, acid-addition salts, N,N'-dioxides and N,N'-diammonium quaternary salts derived therefrom have antibacterial activity in vitro and are useful as antibacterial agents.
Abstract: Hydroxysulfobetaines having the formula ##STR1## wherein Y represents two to five substituted nitrogens connected by --(CH.sub.2).sub.m -- groups, selected from the group consisting of ##STR2## WITH THE PROVISO THAT AT LEAST ONE OF Y is B); R.sub.1 is an alkyl and R.sub.2 is a member selected from the group consisting of hydrogen and alkyl, where the sum of the carbon atoms in R.sub.1 + R.sub.2 is from 9 to 22; R.sub.3 is a member selected from the group consisting of hydrogen, hydroxyethyl and alkyl having from 1 to 5 carbon atoms; R.sub.4, R.sub.5 and R.sub.6 are individually members selected from the group consisting of hydroxyethyl and alkyl having from 1 to 5 carbon atoms; R.sub.7 is a member selected from the group consisting of ##STR3## and R.sub.4 ; X.sup..crclbar. is a member selected from the group consisting of --(CH.sub.2).sub.n -- SO.sub.3.sup..crclbar. and --CH.sub.2 -- CH(OH) -- CH.sub.2 -- SO.sub.3.sup..crclbar. ; m is an integer from 2 to 6; n is an integer from 1 to 4; (anion).sup..crclbar.
Type:
Grant
Filed:
July 14, 1977
Date of Patent:
February 13, 1979
Assignee:
Henkel Kommanditgesellschaft auf Aktien
Inventors:
Manfred Petzold, Karl Mahall, Irmhild Goebel
Abstract: In hydroformylating an ethylenically-unsaturated compound to produce a formyl-substituted derivative using as catalyst rhodium hydrido carbonyl in complex combination with a disphosphino ligand, a high ratio of the normal aldehyde to the iso-aldehyde in the product can be obtained even at very low ratios of ligand to rhodium in the catalyst mixture by using as the ligand a cyclic compound having in the ring two adjacent carbon atoms between the trans position of which the minimum and maximum attainable dihedral angels are, respectively, at least about 90.degree. and not more than about 180.degree., each of these adjacent carbon atoms being substituted with a phosphinomethyl group, the phosphinomethyl groups being in trans relationship to one another. If there are maintained in the reaction zone at least about 1.5 moles of the ligand per atom of rhodium, the desired results are obtained and higher ligand:rhodium ratios are not necessary.
Abstract: This invention relates to vinyl quaternaries and polymers thereof; and to the preparation thereof from ethylene dihalides and tertiary amines.
Abstract: A new class of compounds having fabric softening properties is formed by hydroxamic betaines having the general formula R.sup.1 (R.sup.2)(R.sup.3)N.sup.+ -- R.sup.4 -- CO -- NH--O.sup.- in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 are hydrocarbon groups having i-25 carbon atoms with the proviso that the betaine contains not more than 45 carbon atoms, at least one carbon chain of at least 12 carbon atoms and the carbon chain of R.sup.4 between the quaternary N-atom and the CO-- group is no longer than 4 carbon atoms. The compounds, which can be used in a fabric softening rinse composition as well as in a detergent composition, remain in dispersion during the washing process, but deposit onto the fabric when the pH decreases during subsequent rinsing.
Abstract: Alkylphenols are manufactured by reacting phenols with olefins, stripping the reaction mixture by means of an inert gas, cooling the phenol-containing gas mixture and removing the unconverted phenol. The products are starting materials for the manufacture of dyes, pesticides, pharmaceuticals, emsulfiers, dispersing agents, stabilizers, antioxidants, plasticizers, corrosion inhibitors, disinfectants, seed dressings, stabilizers against ageing, crop protection agents and scents.
Type:
Grant
Filed:
October 19, 1977
Date of Patent:
February 6, 1979
Assignee:
BASF Aktiengesellschaft
Inventors:
Karl G. Baur, Hans Hellbach, Rolf Platz, Kurt Taglieber
Abstract: A three-step process for the production of chrysanthemic acid esters and their homologues of the formula: ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or C.sub.1 -C.sub.6 alkyl,R.sub.3 and R.sub.4 are C.sub.1 -C.sub.6 alkyl or halogen or, together with the C atom to which they are attached, form a cycloalkyl group, andR.sub.5 is C.sub.1 -C.sub.6 alkyl,Which comprises:(1) decarboxylating a lactone of the formula: ##STR2## (2) treating the resulting decarboxylated lactone to effect ring cleavage, halogenation and esterification to form an ester of the formula: ##STR3## in which X is Cl, Br or I, and (3) TREATING THE ESTER X with a base to effect internal condensation whereby the desired product of formula I is obtained.The esters I are valuable intermediates for the preparation of synthetic pyrethroids having insecticidal activity.
Type:
Grant
Filed:
May 23, 1977
Date of Patent:
February 6, 1979
Assignee:
A/S Cheminova
Inventors:
Per D. Klemmensen, Hans Kolind-Andersen, Hans B. Madsen
Abstract: This invention relates to the compounds: N-(mercaptoacy)-cysteine represented by the following formula wherein Z is selected from the group consisting of CH.sub.3 --CH<, (CH.sub.3).sub.2 C<, (CH.sub.2).sub.2 < and CH.sub.
Type:
Grant
Filed:
February 23, 1978
Date of Patent:
January 30, 1979
Assignee:
Santen Pharmaceutical Co., Ltd.
Inventors:
Tadashi Fujita, Masayuki Oya, Hideo Takashina, Tadashi Iso
Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol and the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
Abstract: This specification discloses a vapor phase process for oxidizing acetaldehyde to peracetic acid, acetic acid being also formed at the same time, in an elongated reaction zone into which oxygen is fed through a plurality of oxygen injection sites spaced along the length of the reaction zone. The reaction gas mixture velocity through the reaction zone in the areas of the oxygen injection sites is maintained in excess of the flame velocity of the reaction gas mixture and the reaction zone temperature is maintained between about 140.degree. C. and about 180.degree. C.
Abstract: Metallo phthalocyanines which have been rendered water soluble by substituting an alkali metal or alkaline earth metal sulfate or carboxylate salt onto the phthalocyanine structure have been found to be effective catalysts for the oxidation of aromatic compounds having benzylic carbon atoms to form the corresponding hydroperoxides.
Abstract: The hydrogen fluoride-catalyzed carbonylation of formaldehyde to prepare glycolic acid can be carried out with a significant reduction in by-product formation and at a significantly improved rate by incorporating minor amounts of acetic acid in the reaction medium.
Abstract: An N-substituted carboxylic acid amide of the formula ##STR1## wherein A is a valency bond or an oxygen or sulphur atom or a methylene, ethylene, vinylene, ethyleneoxa or ethylenethia radical,V is a trivalent hydrocarbon radical containing up to 4 carbon atoms,R.sub.1 and R.sub.2 each independently is hydrogen, a halogen atom, a hydroxyl group or an alkyl or alkoxy radical,R.sub.3 is hydrogen, a hydroxyl group or an alkoxy radical,Y is an alkylene radical containing up to 3 carbon atoms,X is a valency bond or a divalent aliphatic hydrocarbon radical containing up to 6 carbon atoms, andD is a hydroxymethyl, formyl, free or esterified carboxyl or an N-substituted carbamoyl radical, or a physiologically compatible salt thereof, characterized by hypoglycaemic and hypolipidaemic activity.
Type:
Grant
Filed:
April 6, 1977
Date of Patent:
January 23, 1979
Assignee:
Boehringer Mannheim GmbH
Inventors:
Manfred Hubner, Ruth Heerdt, Elmar Bosies, Hans Kuhnle, Felix H. Schmidt
Abstract: A process for the preparation of dialkyl (p-aminobenzoyl) glutamates is disclosed. Dialkyl (p-Aminobenzoyl) glutamates are useful as intermediates in the synthesis of N-{p-([(2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as 4-amino-N.sup.10 -methylpteroylglutamic acid. The compound zinc N-(p-methylaminobenzoyl)-L-(+)-glutamate, is also disclosed.
Abstract: Amine salts of tertiary amino acids have been found to be effective as catalysts for polyurethane synthesis and they have been found to exhibit delayed action, in many instances, in the polymerization of urethanes. Typically, the amine salts of tertiary amino acids are formed by initially reacting a primary or secondary amine with an aldehyde and disubstituted acid to form a Mannich adduct and then reacting the resulting Mannich acid adduct with an amine.
Type:
Grant
Filed:
December 1, 1976
Date of Patent:
January 16, 1979
Assignee:
Air Products and Chemicals, Inc.
Inventors:
Ibrahim S. Bechara, Philip J. Zaluska, Rocco L. Mascioli
Abstract: Compounds of the formula ##STR1## exhibit, in the pre-emergence process and in the post-emergence process, a good herbicidal action against a number of dicotyledonous weeds, they are well tolerated in monocotyledonous crops, such as wheat, barley, rice, sorghum and maize, and are also selectively active in some dicotyledonous crops such as soy beans, groundnuts and the like.
Type:
Grant
Filed:
July 18, 1977
Date of Patent:
January 16, 1979
Assignee:
Hoechst Aktiengesellschaft
Inventors:
Gerhard Horlein, Hubert Schonowsky, Hermann Bieringer, Peter Langeluddeke
Abstract: Sulfonyl carbazates containing at least one group of:--SO.sub.2 --NHNH--COO--wherein the oxygen and the sulfur atoms attach to various organic groups are useful as high temperature blowing agents for gas-expandable polymers. Additionally, novel polyfunctional and secondary-alkyl substituted sulfonyl carbazates have been discovered.
Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol and the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
Abstract: Novel benzophenone derivatives having anti-allergy activity, and pharmaceutical formulations and methods of treatment utilizing benzophenone derivatives.
Type:
Grant
Filed:
October 11, 1977
Date of Patent:
January 16, 1979
Assignee:
Eli Lilly and Company
Inventors:
Delme Evans, John C. Saunders, William R. N. Williamson