Patents Examined by James Rogers
  • Filler for affinity chromatography and method for isolating immunoglobulin
    Patent number: 9051355
    Abstract: Provided are a filler for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. The filler for affinity chromatography is a filler in which a protein represented by the following formula (1) is immobilized on a carrier. R—R2??(1) wherein R represents an amino acid sequence consisting of 4 to 300 amino acid residues containing a region consisting of 4 to 20 contiguous histidine residues; and R2 represents an amino acid sequence capable of binding to immunoglobulin, the amino acid sequence consisting of 50 to 500 amino acid residues containing Z domain of Protein A or a fragment thereof, or a variant thereof, provided that the R binds to C-terminus or N-terminus of the R2.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: June 9, 2015
    Assignee: JSR CORPORATION
    Inventors: Kouji Tamori, Tetsuo Fukuta, Masaaki Miyaji, Yong Wang, Takayoshi Abe, Yusuke Okano, Masaki Momiyama, Takahiro Kawai
  • Sustained release small molecule drug formulation
    Patent number: 9044450
    Abstract: An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having Cmax to Cmin ratio less than 200 and lag time less than 0.2.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: June 2, 2015
    Assignee: DURECT CORPORATION
    Inventors: Andrew S. Luk, Gunjan H. Junnarkar, Guohua Chen
  • Method for providing a ?-lactoglobulin product and an ?-enriched whey protein isolate
    Patent number: 9035031
    Abstract: The present invention relates to isolation of whey proteins and the preparation of a whey product and a whey isolate. In particular the present invention relates to the isolation of a ?-lactoglobulin product and the isolation of an ?-enriched whey protein isolate from whey obtained from an animal. The ?-enriched whey protein isolate provided by the present invention is besides from being low in ?-lactoglobulin also high in ?-lactalbumin and immunoglobulin G.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: May 19, 2015
    Assignee: UPFRONT CHROMATOGRAPHY A/S
    Inventors: Marie Bendix Hansen, Allan Otto Fog Lihme, Malene Fog Lihme
  • Iron oxide nanocapsule, method of manufacturing the same, and MRI contrast agent using the same
    Patent number: 9028875
    Abstract: Provided is an iron oxide nanocapsule which has extremely excellent water dispersibility, which is very stable in the body and which has very excellent MRI contrast ability, a method of manufacturing the same, and an MRI contrast agent using the same. The method of manufacturing the iron oxide nanocapsule includes the steps of: thermally decomposing an iron complex to prepare hydrophobic ligand-bonded iron oxide nanoparticles; and encapsulating the hydrophobic ligand-bonded iron oxide nanoparticles by a carboxymethyldextrandodecylamine conjugate encapsulation material or a dextran-linoleic acid conjugate encapsulation material to form an iron oxide nanocapsule.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: May 12, 2015
    Assignee: Hanwha Chemical Corporation
    Inventors: Eun Byul Kwon, Bong-Sik Jeon, Eung Gyu Kim, Ju Young Park, Wan Jae Myeong
  • Fluorinated aromatic materials and their use in optoelectronics
    Patent number: 9024094
    Abstract: Fluorinated aromatic materials, their synthesis and their use in optoelectronics. In some cases, the fluorinated aromatic materials are perfluoroalkylated aromatic materials that may include perfluoropolyether substituents.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: May 5, 2015
    Assignee: The University of South Dakota
    Inventor: Haoran Sun
  • Method to improve the sorbent efficiency of protein A chromatography using switching column with continuous feeding
    Patent number: 9024000
    Abstract: The present invention relates to a method to improve the sorbent efficiency of protein A chromatography using switching column with continuous feeding. In the chromatography method of the present invention, the increased usage efficiency of the absorbent (resin), the decreased processing time, the decreased operation cycle of column compared to that of single batch-type column, and the reduced amount of used resin are achieved and thus, the target protein can be purified at a high efficiency and a low cost.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: May 5, 2015
    Assignee: Celltrion, Inc.
    Inventors: Su Hi Jeon, Jin-Il Kim
  • Embolic devices
    Patent number: 9011884
    Abstract: Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: April 21, 2015
    Assignee: MicroVention, Inc.
    Inventors: Michael Constant, Edward Michael Keeley, Joshua Garretson, Gregory M. Cruise
  • Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics
    Patent number: 9000048
    Abstract: The present invention provides therapeutic formulations, including therapeutic emulsions and nanoemulsions, and related methods for the delivery of fluorinated therapeutic compounds, including an important class of low boiling point perfluorinated and/or perhalogenated volatile anesthetics. Emulsion-based fluorinated volatile anesthetic formulations compatible with intravenous administration are provided that are capable of delivering and releasing amounts of fluorinated volatile anesthetic compounds effective for inducing and maintaining anesthesia in patients. Intravenous delivery of the present emulsion-based fluorinated volatile anesthetic formulations permits anesthetic levels in a patient to be selectively adjusted very rapidly and accurately without the need to hyperventilate patients and without the use of irritating agents.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: April 7, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Sandro Mecozzi, Robert A. Pearce, Jonathan P. Fast
  • Poly (diol-co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices
    Patent number: 8992967
    Abstract: The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: March 31, 2015
    Assignee: Northwestern University
    Inventors: Guillermo Ameer, Hongjin Qiu, Jian Yang
  • CD93 or use of soluble fragment thereof
    Patent number: 8993343
    Abstract: The present invention relates to an anti-inflammatory composition using the antibody specifically binding to CD93 or its soluble fragment, and a diagnostic method and a diagnostic kit for inflammatory disease using CD93 or its soluble fragment specific antibody or aptamer.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: March 31, 2015
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Young Woo Park, Jae Won Jeon, Joon-Goo Jung, Hye In Choi, Myung-ho Sohn, Ho youn Kim, Mi-La Cho, Young-Soon Jang, Ji-Hun Moon, Ji Hyun Park
  • Method to produce an immunoglobulin preparation with improved yield
    Patent number: 8993734
    Abstract: The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: March 31, 2015
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Leopold Bruckschwaiger, Sonja Svatos, Julia Nürnberger, Wolfgang Teschner, Harald Arno Butterweck, Hans-Peter Schwarz, Thomas Gundinger, Bernhard Koelbl, Reinhard Grausenburger, Azra Pljevljakovic
  • Methods and compositions for treating autoimmune disease
    Patent number: 8986684
    Abstract: The disclosure relates to OX-2/CD200 (herein referred to as CD200) antibodies and methods of treating autoimmune disease.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: March 24, 2015
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventor: Yi Wang
  • Method of inhibiting complement activation with factor Bb specific antibodies
    Patent number: 8981060
    Abstract: A process of inhibiting the adverse effects of alternative complement pathway activation products in a subject includes administering to the subject an amount of anti-factor Bb antibody effective to selectively inhibit formation of an alternative complement pathway activation products C3a, C5a, and C5b-9, and activation of neutrophils, monocytes, and platelets.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: March 17, 2015
    Assignee: Novelmed Therapuetics, Inc.
    Inventor: Rekha Bansal
  • Block copolymer and nanofiller composites
    Patent number: 8974915
    Abstract: PU/ZnO nanocomposites are provided wherein the addition of less than 1 vol % 33 nm ZnO nanoparticles into a PU matrix effect a decrease in the Young's Modulus and storage modulus of the polymer, while simultaneously effecting an increase glass transition temperature of the polymer. Detailed experiments are described (e.g., FTIR, DMTA, FESEM and AFM) that suggest that the reaction between hydroxyl groups of the ZnO nanoparticles and isocyanate groups of the polyurethane prepolymer disrupts the self-assembly of the phase separation in PU. Phase separation is responsible for the good mechanical properties of PU. Further, detailed experiments suggest that the increase of the glass transition temperature results from the crosslinking effect of the ZnO nanoparticles.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: March 10, 2015
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Junrong Zheng, Rahmi Ozisik, Richard W. Siegel
  • Composition comprising a benzimidazole and process for its manufacture
    Patent number: 8968776
    Abstract: The invention provides new benzimidazole compositions, comprising: (a) a core containing said benzimidazole active ingredient; (b) an intermediate layer; and (c) an enteric layer; said core being substantially free of binder. The invention also provides a process for manufacturing the composition of the invention.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: March 3, 2015
    Assignee: UCB, Inc.
    Inventors: Pawan Seth, Benoît Schmitt
  • Bone graft substitute composition
    Patent number: 8968465
    Abstract: A composition includes calcium sulfate hemihydrate, stearic acid, an accelerant, and a mixing solution. The composition can be injected, e.g., through a needle, and is capable of setting, e.g., in vivo, in a relatively short period of time to a relatively high hardness.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: March 3, 2015
    Assignee: Wright Medical Technology, Inc.
    Inventors: Jantzen Cole, Timothy Smith
  • Polymer-metal complex composite having MRI contrast ability and MRI contrasting and/or antitumor composition using the same
    Patent number: 8961949
    Abstract: The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood. The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: February 24, 2015
    Assignee: Japan Science and Technology Agency
    Inventors: Kazunori Kataoka, Sachiko Kaida, Horacio Cabral, Michiaki Kumagai, Masaki Sekino
  • Purification of proteins using hydrophobic interaction chromatography
    Patent number: 8946395
    Abstract: The present invention is directed to methods for purifying a protein of interest, e.g., an antibody, from a sample comprising the protein of interest and at least one impurity, e.g., an aggregate, by employing a hydrophobic interaction chromatography (HIC) method that allows for binding of both the protein of interest and the at least one impurity under strong binding conditions. The present invention is based, at least in part, on the finding that both flow through and bind-elute techniques can be combined to achieve greater purification and recovery of a protein of interest, e.g., an antibody, under isocratic wash conditions and strong binding conditions.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: February 3, 2015
    Assignee: AbbVie Inc.
    Inventors: Matthew Omon Herigstad, Linda E. Rich, Stephen Ming-teh Lu, Natarajan Ramasubramanyan
  • Composition for hard tissue repair
    Patent number: 8946317
    Abstract: The composition for hard tissue repair of the present invention is characterized by comprising 5 to 98.95 parts by weight of a monomer (A), 1 to 75 parts by weight of a (meth)acrylate polymer (B) and 0.05 to 20 parts by weight of a polymerization initiator composition (C) containing an organoboron compound (c1), with the proviso that the total amount of the components (A), (B) and (C) is 100 parts by weight. The composition undergoes small-scale heat generation during curing and can ensure a sufficient working time.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: February 3, 2015
    Assignee: Mitsui Chemicals. Inc.
    Inventors: Noriaki Asada, Shinya Aoki, Hiroshi Naruse, Shoichi Miyakoshi, Masami Arata
  • Method of treating cancer
    Patent number: 8940299
    Abstract: A method for inducing apoptosis of a neoplastic cell expressing C3aR or C5aR includes administering at least one complement antagonist to the cell so that the at least one complement antagonist substantially reduces or inhibits the activity of protein kinase B in the neoplastic cell.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: January 27, 2015
    Assignee: Case Western Reserve University
    Inventors: M. Edward Medof, Michael G. Strainic, Young A Choi