Patents Examined by James Rogers
  • Two-stage ultrafiltration/diafiltration
    Patent number: 8772461
    Abstract: The present invention provides a method for concentrating a protein, in particular a method for concentrating a plasma product, in particular IgG, using glycine in a (two-stage ultrafiltration/diafiltration approach.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: July 8, 2014
    Assignee: Grifols Therapeutics Inc.
    Inventors: Martin Gonzalez, Woody D. Wood, Fred H. Earp
  • Functionalizing implantable devices with a poly (diol citrate) polymer
    Patent number: 8758796
    Abstract: The present invention is directed to a novel poly(diol citrates)-based coating for implantable devices. More specifically, the specification describes methods and compositions for making and using implantable devices coated with citric acid copolymers or citric acid copolymers impregnated with therapeutic compositions and/or cells.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: June 24, 2014
    Assignee: Northwestern University
    Inventors: Guillermo Ameer, Jian Yang, Melina Kibbe
  • Composition for promoting ketone body production
    Patent number: 8758740
    Abstract: Provided is a composition for promoting ketone body production that comprises a water insoluble polymer of a ?-hydroxy short-medium chain fatty acid such as homopolymer of ?-hydroxybutyric acid or a copolymer of ?-hydroxybutyric acid and ?-hydroxyvaleric acid. The composition is useful for the treatment or prevention of a disease or condition that can be treated by promoting ketone body production.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: June 24, 2014
    Assignee: Earthus, Inc
    Inventor: Masaki Kuriyama
  • Local system for the release of active principle and process for its manufacture
    Patent number: 8758827
    Abstract: A local system for the release of active principle is described which consists of approximately spherical or rotation symmetrical bodies which are composed essentially of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide or barium sulphate and one or more pharmaceutical active principles, in particular antibiotics, and which are produced by radical polymerization, radical polymerization activators effective in the temperature range of 10-80° C. or residues of these polymerization activators from the groups of aromatic amines, heavy metal salts and barbiturates not being contained therein.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: June 24, 2014
    Assignee: Heraeus Medical GmbH
    Inventors: Klaus-Dieter Kuhn, Sebastian Vogt
  • Use of complement inhibitors to treat ocular diseases
    Patent number: 8753625
    Abstract: The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases include age-related macular degeneration, diabetic retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5b, C6, C7, C8, C9, or C5b-9.
    Type: Grant
    Filed: November 4, 2006
    Date of Patent: June 17, 2014
    Assignee: Genentech, Inc.
    Inventors: Sek Chung Fung, Zhengbin Yao
  • Two-phase, water-absorbent bioadhesive composition
    Patent number: 8753669
    Abstract: An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: June 17, 2014
    Assignees: A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Corium International, Inc.
    Inventors: Gary W. Cleary, Mikhail M. Feldstein, Valery G. Kulichikhin, Danir F. Bairamov
  • Methods for the treatment or prevention of hemorrhagic conditions
    Patent number: 8716237
    Abstract: The present invention relates to a method for treatment or prevention of a hemorrhagic condition in a patient by administering plasminogen activator inhibitor-1 (“PAI-1”) and/or an inhibitor of deubiquitinating enzyme CYLD (“CYLD”) to a patient. Pharmaceutical compositions that include one or both of PAI-1 and an inhibitor of CYLD are also disclosed.
    Type: Grant
    Filed: July 22, 2008
    Date of Patent: May 6, 2014
    Assignee: University of Rochester
    Inventors: Jian-Dong Li, Jae Hyang Lim
  • Frictionless molecular rotary motors
    Patent number: 8715635
    Abstract: A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: May 6, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Ehud Keinan
  • Coating system
    Patent number: 8703110
    Abstract: Embodiments of the invention include a system comprising: an Acetoxy curable silicone Binder; and an active agent blended with the silicone binder, effective for one or more of radiopacification, lubricity, elution of a secondary compound such as a drug, echogenic properties, thermal or electrically insulative properties or chemical indicators wherein the silicone binder effectiveness is not substantially changed by the active agent.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: April 22, 2014
    Inventor: Steven J. Ferry
  • Phase transitioning hydrogels
    Patent number: 8703157
    Abstract: A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly(vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: April 22, 2014
    Assignees: DePuy Synthes Products, LLC, Drexel University
    Inventors: Kristin B. Kita, Nigel G. Smith, Anthony M. Lowman, Garland W. Fussell, Michael F. Keane
  • Controlled-release pharmaceutical tablets
    Patent number: 8703191
    Abstract: Controlled-release tablets exhibiting excellent storage stability are achieved by granulating a pharmaceutically active agent with a hydroxyalkylcelluose, blending the resulting granules with an extragranular phase composed of a particulate material that provides a sustained-release matrix, and compressing the blend into a tablet form, which may be optionally coated, such as with an enteric coating composition, to provide delayed release and/or to enhance stability of the active agent.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: April 22, 2014
    Assignee: Intelgenx Corp.
    Inventors: Horst G. Zerbe, Nadine Paiement
  • Side-chain crystallizable polymers for medical applications
    Patent number: 8703113
    Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: April 22, 2014
    Assignee: REVA Medical Inc.
    Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
  • Protein purification using HCIC and ion exchange chromatography
    Patent number: 8697847
    Abstract: The present invention provides methods for purifying proteins. In particular, the methods employ a two-step non-affinity chromatography process without the use of an in-process tangential flow filtration step.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: April 15, 2014
    Assignee: Medarex, L.L.C.
    Inventors: Alahari Arunakumari, Gisela M. Ferreira
  • Method for making a porous polymeric material
    Patent number: 8697108
    Abstract: Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second liquid is added to a polymer solution, the second liquid causing the solution to increase in viscosity. With sufficient polymer and second liquid present, the increase in viscosity can be up to that of a gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. A second material may be incorporated into the chambers, thereby creating a microstructure filling the voids of the macrostructure.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: April 15, 2014
    Assignee: Kensey Nash Corporation
    Inventors: Timothy A. Ringeisen, Scott M. Goldman
  • Material for separation of a biomolecule
    Patent number: 8691544
    Abstract: A Product is described and which contains at least one type of ligand bound to a separation material and which allows selective binding or cleavage of a biomolecule for example in human blood.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: April 8, 2014
    Assignee: Glycorex Transplantation AB
    Inventor: Kurt G. I. Nilsson
  • HSP60, HSP60 peptides and T cell vaccines for immunomodulation
    Patent number: 8691772
    Abstract: The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: April 8, 2014
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Irun R. Cohen, Alexandra Zanin-Zhorov, Guy Tal, Francisco Quintana, Meirav Pevsner, Osnat Lider, Lihi Lider
  • Synthetic diblock copolypeptide hydrogels for use in the central nervous system
    Patent number: 8691204
    Abstract: This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: April 8, 2014
    Assignee: The Regents of the University of California
    Inventors: Timothy J. Deming, Michael V. Sofroniew, Chu-Ya Yang, BingBing Song, Yan Ao
  • Aldol-crosslinked polymeric hydrogel adhesives
    Patent number: 8679536
    Abstract: Adhesives formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. The use of the adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described. The adhesive may also be used for industrial and consumer applications.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: March 25, 2014
    Assignee: Actamax Surgical Materials, LLC
    Inventor: Samuel David Arthur
  • Methods for sealing an orifice in tissue using an aldol-crosslinked polymeric hydrogel adhesive
    Patent number: 8679537
    Abstract: Methods for sealing an orifice in tissue in the body of a living animal using an adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. Methods for using the adhesive for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: March 25, 2014
    Assignee: Actamaz Surgical Materials, LLC
    Inventor: Samuel David Arthur
  • Sustained release matrix systems for highly soluble drugs
    Patent number: 8679535
    Abstract: Disclosed are sustained release oral solid dosage forms comprising a therapeutically effective amount of a medicament having a solubility of more than about 10 g/l; a pH modifying agent; and a sustained release matrix comprising a gelling agent, said gelling agent comprising a heteropolysaccharide gum and a homopolysaccharide gum capable of cross-linking said heteropolysaccharide gum when exposed to an environmental fluid, said dosage form providing a sustained release of said medicament after oral administration to human patients.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: March 25, 2014
    Assignee: Endo Pharmaceuticals Inc.
    Inventors: Anand R. Baichwal, Troy W. McCall, Lirong Liu, Steve Labudzinski