Abstract: Topical skin care compositions are described that include effective amounts of anti-inflammatory, antioxidant, silica and sugar compounds. In addition, methods of treating skin conditions are described, which include applying topically to a site of treatment a therapeutically effective amount of a composition comprising anti-inflammatory, antioxidant, silica and sugar compounds.
Abstract: The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nanoparticles in medicine.
Type:
Grant
Filed:
February 22, 2017
Date of Patent:
August 17, 2021
Inventors:
Daniel Palmer, Rhian Groves, Paul Seaman, Victoria Cavalier-Hirth, Alessandro Pace
Abstract: An oral solid formulation includes irinotecan or a pharmaceutically acceptable salt thereof as an active ingredient, and an acidifying agent.
Type:
Grant
Filed:
June 20, 2016
Date of Patent:
August 17, 2021
Assignee:
HANMI PHARM. CO., LTD.
Inventors:
Caleb Hyung Min Park, Myeong Ki Jung, Jin Cheul Kim, Yong Il Kim, Jae Hyun Park, Jong Soo Woo
Abstract: The present invention relates to the use of non-bioconvertible C3-substituted pregnenolone derivatives of formula (I), with no significant affinity for hormonal receptors or receptors of the central nervous system, in the treatment of substance use disorders, and in particular of alcohol use disorder.
Type:
Grant
Filed:
November 4, 2016
Date of Patent:
August 3, 2021
Assignee:
MAPREG
Inventors:
George F. Koob, Barbara Jean Mason, Olivier George, Etienne Baulieu, Isabelle Villey
Abstract: The present invention relates to the treatment of mixed lineage leukemia. In particular, the present invention relates to therapies involving the induction of proteolysis of the MLL fusion proteins that result from the chromosomal translocations affecting the MLL gene at 11q23.
Abstract: The present invention relates to novel N-acyl-diarysulfonamides acting as inhibitors of bacterial aminoacyl-tRNA synthetase. These can be used as medicines or as constituent of medicines for the treatment of bacterial infections.
Type:
Grant
Filed:
February 11, 2016
Date of Patent:
July 27, 2021
Assignee:
Oxford Drug Design Limited
Inventors:
Aigars Jirgensons, Einars Loza, Michael Charlton, Paul William Finn, Lluis Ribas De Pouplana, Adelaide Saint-Léger
Abstract: Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Abstract: Disclosed herein are compounds of the formula: (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.
Type:
Grant
Filed:
February 12, 2016
Date of Patent:
July 13, 2021
Assignee:
REATA PHARMACEUTICALS, INC.
Inventors:
Xin Jiang, Bradley William Caprathe, Chitase Lee, Gary Bolton, Christopher F. Bender, Melean Visnick
Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (?-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.
Type:
Grant
Filed:
November 2, 2018
Date of Patent:
June 22, 2021
Assignees:
Massachusetts Institute of Technology, Politecnico di Milano
Inventors:
Umberto Capasso Palmiero, James C. Kaczmarek, Daniel Griffith Anderson, Davide Moscatelli
Abstract: Compounds having the following Formula I and/or Formula II and methods of their use and preparation are disclosed:
Type:
Grant
Filed:
August 20, 2018
Date of Patent:
June 22, 2021
Assignee:
Gilead Sciences, Inc.
Inventors:
Mark J. Bartlett, Britton Kenneth Corkey, Jennifer Leigh Cosman, Kristyna M. Elbel, Elfatih Elzein, Rao V. Kalla, Dmitry Koltun, Xiaofen Li, Eric Q. Parkhill, Thao Perry
Abstract: Disclosed herein are methods for treating solid tumors by direct injection into the tumors of chemotherapeutic particles, methods for inhibiting tumor metastasis by administering chemotherapeutic particles to a subject having a tumor, and compositions that include chemotherapeutic particles, small amounts of a polysorbate, and a carrier.
Type:
Grant
Filed:
July 15, 2019
Date of Patent:
June 15, 2021
Assignee:
CritiTech, Inc.
Inventors:
Mike Baltezor, Gere diZerega, Charles Decedue, Sam Campbell, Matt McClorey
Abstract: Compositions comprising at least two of a corticosteroid, a non-steroidal anti-inflammatory drug (NSAID), and an antibiotic find use in treating or preventing eye conditions in subjects in need thereof. Methods of treatment or prevention of eye conditions comprise administering an effective amount of the disclosed compositions to the affected eye(s). Methods of preparing a composition comprising an NSAID, a corticosteroid, and an antibiotic comprise separately complexing the NSAID and antibiotic with cyclodextrin.
Abstract: Provided is a drug or method for treating or preventing a condition, disorder, or disease of the corneal endothelium caused by transforming growth factor-? (TGF-?) signals, mitochondrial abnormalities, and/or endoplasmic reticulum (ER) associated stress in corneal endothelial cells, using p38 MAP kinase inhibitors. The present invention provides a drug which includes p38 MAP kinase inhibitors, and which is for treating or preventing a condition, disorder, or disease of the corneal endothelium caused by TGF-? signals and/or mitochondrial abnormalities in corneal endothelial cells. In the preferred embodiment, the condition, disorder, or disease of the corneal endothelium is Fuchs' corneal endothelial dystrophy.
Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
Type:
Grant
Filed:
July 12, 2012
Date of Patent:
April 13, 2021
Assignee:
Vanderbilt University
Inventors:
L. Jackson Roberts, II, Venkataraman Amarnath, David G. Harrison, Annet Kirabo
Abstract: This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.
Type:
Grant
Filed:
May 31, 2018
Date of Patent:
April 13, 2021
Assignee:
SENTINEL ONCOLOGY LIMITED
Inventors:
Robert George Boyle, David Winter Walker, Richard Justin Boyce, Scott Peterson, Francine Farouz, Cong Hung Vo
Abstract: The present invention relates to 5-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives of the general formula (I) or pharmaceutically acceptable salts or propharmacons thereof for use as BCRP inhibitors, wherein at least one hydrogen atom in at least one of the phenyl groups A and B is substituted by a substituent RH, which has a Hammett constant ?p greater than 0.23. For corresponding compounds, surprisingly a particularly high inhibitory activity against BCRP has been discovered which can be exploited for suppressing the multidrug resistance modulator BCRP, thus providing an improvement in efficacy of BCRP affected drugs. This has useful implications for cancer and HIV treatment.
Abstract: Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).