Abstract: An apparatus for treating a hemorrhaging wound and returning blood to the body includes at least one vacuum hose; tubing to return blood to the body; a reservoir to temporarily contain the blood, an ejectable filter between the vacuum hose and the reservoir, a temperature regulator to regulate the temperature in the reservoir; at least one pressure regulator connected to the at least one vacuum hose; a vacuum pump connected to the at least one pressure regulator, and an infusion pump connected to the tubing to return blood to the body. Blood is returned to the body via multi access catheter and/or consistent with present and future rapid infusion procedural methods that could change according to severity of injuries and the need for alternate vascular access points and/or infusion delivery protocols.

Abstract: A detachable phototherapy device includes a substrate layer including a first portion, a second portion, and a bend portion connecting the first portion with the second portion. The detachable phototherapy device further includes a conductive layer printed on a first substrate surface of the substrate layer. The detachable phototherapy device further includes a plurality of light sources electrically coupled to the conductive layer. Further, the detachable phototherapy device includes a first electrode coupled to the first portion, and a second electrode coupled to the second portion. Also, the detachable phototherapy device includes a battery including a first battery terminal, and a second battery terminal. The battery is electrically coupled to one of the first electrode and the second electrode, at one of the first battery terminal and the second battery terminal, respectively, in a non-use state of the detachable phototherapy Device.

Abstract: A pressure bag (1) has a substantially rectangular shape in a plan view, and also has a bag-like shape with an opening (11) through which a bag-shaped container (50) is placed into and taken out of a housing chamber (10) in a first short side (13a) of the substantially rectangular shape. The pressure bag (1) has a double structure in which an inner sheet (20) and an outer sheet (30) are laid one on top of another so that the outer sheet (30) is located on the opposite side of the inner sheet (20) from the housing chamber (10). A pressure chamber (15) is provided between the inner sheet (20) and the outer sheet (30). The inner sheet (20), the outer sheet (30), and the pressure chamber (15) extend from one side to another side of the housing chamber (10) via a first long side (14a).

Abstract: A self-IV injection device is provided. The self-IV device comprises fixing means to fix the device with respect to an arm of a user, an optical sensor, an IV needle, a drive, and a processor. The self-IV injection device is configured to detect, using the optical sensor, positions of marks placed on the arm of the user, and based on the detected positions of marks placed on the arm of the user, determine, using the processor, a suitable IV injection spot. The self-IV injection device also moves the IV needle, using the drive, to the determined suitable IV injection spot such that the IV needle penetrates a vein of the user.

Abstract: A liquid feeding pump for feeding liquid in a liquid feeding tube, the liquid feeding pump including: a mounting portion to which a first clip member mounted to the liquid feeding tube is mountable; an adapter detachably attachable to the mounting portion; and a detection unit configured to detect mounting of the first clip member to the mounting portion, wherein: the adapter has a shape that disables detection by the detection unit of mounting of the first clip member by the detection unit and enables detection by the detection unit of mounting of a second clip member having a shape different from a shape of the first clip member.

Abstract: Fluid connectors assemblies that provide neutral fluid displacement are disclosed. A fluid connector assembly may include first member and a second member. A deformable sleeve is located on a post of the second member. A septum is located on an opening of the first member. The first member and the second member each include an opening. The sleeve can seal off the opening of the post from fluid entry. However, when the post of the second member is inserted into the first member, a septum of the first member displaces a sleeve of the second member, causing the sleeve to uncover the opening. Further, the septum seals each of the first member and the second member and the displaced sleeve forms a fluid path through the first and second member, with the sleeve regulating fluid flow.

Abstract: A method is provided to modulated vascular adaptation within a tumor so that therapy uptake is increased. The method includes providing a pressure directed therapy system having an infusion lumen, an occluder, a pressure sensor to sense pressure distal of the occluder. The distal end of the system is advanced to a target artery of an organ. The pressure in the target artery is reduced by expanding the occluder at the distal end of the system. Then, the therapy is infused through the infusion lumen and into the target artery. Upon sensing decreased pressure and thus vessel adaptation, infusion is stopped until vessel re-adaptation occurs. Then infusion resumes. The infusion continues in a cycle of therapy infusing, sensing pressure and determining vessel adaptation, waiting, and resuming once re-adaptation occurs until the therapy dose is delivered to the patient.

Abstract: A medication fluid delivery device and methods are provided with the delivery device having a dispensing unit and a drive unit that are attachable together. The dispensing unit includes a dispenser for delivering medication fluid to a user and a reservoir configured to be filled with a variable amount of medication fluid received from a medication fluid injector. The drive unit includes a control unit that controls the drive unit and causes medication fluid in the reservoir to be pumped through the dispenser and includes a registration mechanism configured to act with the dispensing unit to determine a state the reservoir including an initial level of the filled reservoir.

Abstract: A drug solution administration device that detects an administration condition of a drug solution with higher accuracy. The drug solution administration device includes a pusher, a drive mechanism configured to move the pusher forward and backward with respect to a distal end opening of the drug solution container, and a control unit configured to control operation of the drive mechanism. The drive mechanism includes a motor configured to generate driving force for moving the pusher forward and backward, and a rotation detection unit configured to detect rotation of the motor. The control unit has an operation confirmation function of confirming an operating condition of the motor on the basis of a detection result of the rotation detection unit. After confirming that the motor is stopped by the operation confirmation function, the control unit starts reverse rotation of the motor to determine whether or not the pusher moves backward.

Abstract: An electroosmotic drive module comprises: a porous dielectric film; two electrodes respectively provided on opposite sides of the porous dielectric film; and a porous insulating layer, one electrode being disposed between the porous dielectric film and the insulating layer. An implantable electroosmotic micropump comprises a housing, and at least one electroosmotic drive module is provided in the housing. There are a plurality of electroosmotic drive modules, and the plurality of electroosmotic drive modules are connected in series end to end, such that heterogeneous integrated assembly between different materials such as electrodes, films, and housings can be achieved.

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.

Abstract: A system for preparing a medicament for use by a medicament user includes a proportioning machine with a controller and pumping and clamping actuators to engage a fluid circuit having pumping and clamping portions that engage with respective actuators of the proportioning machine. The fluid circuit includes a mixing container that is initially empty and later filled with two different concentrated medicaments from different concentrate containers and with purified water. The proportioning machine is configured to receive purified water and to mix it with the concentrated medicaments to produce a medicament and to output the medicament to a medicament consumer in such a way that to the medicament consumer the medicament appears to be provided from a bag of medicament. Custom mini batches of medicament may be produced by varying the amount of the concentrates and water.

Abstract: Disclosed herein are systems and methods for automated insulin delivery that provide for adaptive closed loop control that can modify the stored basal profile used by the closed loop algorithm to better reflect the user's actual needs. Actual delivery rates calculated by the closed loop algorithm can be compared to the user's stored profile. If the differences between the actual delivery rates and the stored profile are statistically significant, the stored profile can be modified.

Abstract: Systems comprising: an analyte sensor for providing an analyte signal representative of an analyte level; a controller in data communication with the analyte sensor and programmed to provide a recommended medication dose based on the analyte level and a medication type, the controller comprising a user interface for inputting the medication type; and a model-based safety mechanism integrated with the controller for evaluating the recommended medication dose. Wherein the model-based safety mechanism overrides the recommended medication dose and provides a safety medication dose when the model-based safety mechanism detects a risk of insulin deprivation.

Abstract: Aspects of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such aspects can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some aspects can include a sheath comprising an inner layer comprising a reinforcing layer rolled into a spiral slidable configuration and encapsulated within a polymer layer comprising a tether portion and an outer layer disposed over the inner layer. The disclosed sheath is configured to locally expand from a predetermined first diameter d1 to an expanded second diameter d2 during application of a radial outward force by passage of the medical device through the sheath.

Abstract: A vial adapter comprises an adapter body comprising a top wall and a sidewall projecting from the top wall in a longitudinal direction to form a receptacle with a distal side of the top wall. The receptacle is configured to receive at least a portion of a barrel head of an injection vial. A movable part comprises a base part and a spike fixed to the base part. The spike extends through the top wall in a distal direction into the receptacle. The movable part is movable relative to the adapter body from an undeployed position into a deployed position. An interlock is operable to lock the movable part in the undeployed position, and an actuating member extending into the receptacle is coupled to the interlock and operable to unlock the interlock when actuated.

Abstract: A treatment system includes a treatment tool, an imaging apparatus, and a control device. The treatment tool is configured to perform treatment on a living tissue by applying treatment energy from an end effector to the living tissue based on supplied electric power. The imaging apparatus captures an image of the living tissue in a state in which the treatment energy is applied from the end effector to the living tissue. The control device includes a processor to control the imaging apparatus by acquiring the captured image, determining whether an abnormality has occurred in the end effector based on the acquired captured image, and executing an instruction to stop supply of the electric power to the treatment tool when determining that the abnormality has occurred in the end effector.

Abstract: A modular, wearable sensor and drug administration device is disclosed. The device includes removable modules such as sensors and drug administration apparatuses within a single wearable device. The device may be comfortable and modules may be easily removed and replaced. The sensors and drug administration devices may be used in concert to monitor and administer drug to a patient. Such a device may improve a patient's quality of life.

Abstract: A closed-loop system for blood pressure control that accounts for various mechanisms of the cardiovascular system. In some example cases, a pharmacokinetic-pharmacodynamic model of the cardiovascular system's response to cardiovascular system actuators, such as vasoactive drugs, is generated. Two example actuators are employed in the example framework: phenylephrine, to raise blood pressure, and nicardipine, to lower blood pressure. The pharmacodynamic components employs a two-element Windkessel model. A model predictive control framework is built based on the pharmacokinetic-pharmacodynamic model.

Abstract: A portable insulin pump can utilize readings from a sensor incorporated into an infusion set used with the pump to deliver insulin to a patient to determine if the infusion set is or is likely to become dislodged from the patient. Readings from the sensor that are inconsistent with expected readings or a range of expected readings can indicate that the infusion set has become dislodged from the patient.