Abstract: Fluid connectors assemblies that provide neutral fluid displacement are disclosed. A fluid connector assembly may include first member and a second member. A deformable sleeve is located on a post of the second member. A septum is located on an opening of the first member. The first member and the second member each include an opening. The sleeve can seal off the opening of the post from fluid entry. However, when the post of the second member is inserted into the first member, a septum of the first member displaces a sleeve of the second member, causing the sleeve to uncover the opening. Further, the septum seals each of the first member and the second member and the displaced sleeve forms a fluid path through the first and second member, with the sleeve regulating fluid flow.

Abstract: A method is provided to modulated vascular adaptation within a tumor so that therapy uptake is increased. The method includes providing a pressure directed therapy system having an infusion lumen, an occluder, a pressure sensor to sense pressure distal of the occluder. The distal end of the system is advanced to a target artery of an organ. The pressure in the target artery is reduced by expanding the occluder at the distal end of the system. Then, the therapy is infused through the infusion lumen and into the target artery. Upon sensing decreased pressure and thus vessel adaptation, infusion is stopped until vessel re-adaptation occurs. Then infusion resumes. The infusion continues in a cycle of therapy infusing, sensing pressure and determining vessel adaptation, waiting, and resuming once re-adaptation occurs until the therapy dose is delivered to the patient.

Abstract: A medication fluid delivery device and methods are provided with the delivery device having a dispensing unit and a drive unit that are attachable together. The dispensing unit includes a dispenser for delivering medication fluid to a user and a reservoir configured to be filled with a variable amount of medication fluid received from a medication fluid injector. The drive unit includes a control unit that controls the drive unit and causes medication fluid in the reservoir to be pumped through the dispenser and includes a registration mechanism configured to act with the dispensing unit to determine a state the reservoir including an initial level of the filled reservoir.

Abstract: A drug solution administration device that detects an administration condition of a drug solution with higher accuracy. The drug solution administration device includes a pusher, a drive mechanism configured to move the pusher forward and backward with respect to a distal end opening of the drug solution container, and a control unit configured to control operation of the drive mechanism. The drive mechanism includes a motor configured to generate driving force for moving the pusher forward and backward, and a rotation detection unit configured to detect rotation of the motor. The control unit has an operation confirmation function of confirming an operating condition of the motor on the basis of a detection result of the rotation detection unit. After confirming that the motor is stopped by the operation confirmation function, the control unit starts reverse rotation of the motor to determine whether or not the pusher moves backward.

Abstract: An electroosmotic drive module comprises: a porous dielectric film; two electrodes respectively provided on opposite sides of the porous dielectric film; and a porous insulating layer, one electrode being disposed between the porous dielectric film and the insulating layer. An implantable electroosmotic micropump comprises a housing, and at least one electroosmotic drive module is provided in the housing. There are a plurality of electroosmotic drive modules, and the plurality of electroosmotic drive modules are connected in series end to end, such that heterogeneous integrated assembly between different materials such as electrodes, films, and housings can be achieved.

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.

Abstract: A system for preparing a medicament for use by a medicament user includes a proportioning machine with a controller and pumping and clamping actuators to engage a fluid circuit having pumping and clamping portions that engage with respective actuators of the proportioning machine. The fluid circuit includes a mixing container that is initially empty and later filled with two different concentrated medicaments from different concentrate containers and with purified water. The proportioning machine is configured to receive purified water and to mix it with the concentrated medicaments to produce a medicament and to output the medicament to a medicament consumer in such a way that to the medicament consumer the medicament appears to be provided from a bag of medicament. Custom mini batches of medicament may be produced by varying the amount of the concentrates and water.

Abstract: Disclosed herein are systems and methods for automated insulin delivery that provide for adaptive closed loop control that can modify the stored basal profile used by the closed loop algorithm to better reflect the user's actual needs. Actual delivery rates calculated by the closed loop algorithm can be compared to the user's stored profile. If the differences between the actual delivery rates and the stored profile are statistically significant, the stored profile can be modified.

Abstract: Systems comprising: an analyte sensor for providing an analyte signal representative of an analyte level; a controller in data communication with the analyte sensor and programmed to provide a recommended medication dose based on the analyte level and a medication type, the controller comprising a user interface for inputting the medication type; and a model-based safety mechanism integrated with the controller for evaluating the recommended medication dose. Wherein the model-based safety mechanism overrides the recommended medication dose and provides a safety medication dose when the model-based safety mechanism detects a risk of insulin deprivation.

Abstract: Aspects of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such aspects can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some aspects can include a sheath comprising an inner layer comprising a reinforcing layer rolled into a spiral slidable configuration and encapsulated within a polymer layer comprising a tether portion and an outer layer disposed over the inner layer. The disclosed sheath is configured to locally expand from a predetermined first diameter d1 to an expanded second diameter d2 during application of a radial outward force by passage of the medical device through the sheath.

Abstract: A vial adapter comprises an adapter body comprising a top wall and a sidewall projecting from the top wall in a longitudinal direction to form a receptacle with a distal side of the top wall. The receptacle is configured to receive at least a portion of a barrel head of an injection vial. A movable part comprises a base part and a spike fixed to the base part. The spike extends through the top wall in a distal direction into the receptacle. The movable part is movable relative to the adapter body from an undeployed position into a deployed position. An interlock is operable to lock the movable part in the undeployed position, and an actuating member extending into the receptacle is coupled to the interlock and operable to unlock the interlock when actuated.

Abstract: A treatment system includes a treatment tool, an imaging apparatus, and a control device. The treatment tool is configured to perform treatment on a living tissue by applying treatment energy from an end effector to the living tissue based on supplied electric power. The imaging apparatus captures an image of the living tissue in a state in which the treatment energy is applied from the end effector to the living tissue. The control device includes a processor to control the imaging apparatus by acquiring the captured image, determining whether an abnormality has occurred in the end effector based on the acquired captured image, and executing an instruction to stop supply of the electric power to the treatment tool when determining that the abnormality has occurred in the end effector.

Abstract: A modular, wearable sensor and drug administration device is disclosed. The device includes removable modules such as sensors and drug administration apparatuses within a single wearable device. The device may be comfortable and modules may be easily removed and replaced. The sensors and drug administration devices may be used in concert to monitor and administer drug to a patient. Such a device may improve a patient's quality of life.

Abstract: A closed-loop system for blood pressure control that accounts for various mechanisms of the cardiovascular system. In some example cases, a pharmacokinetic-pharmacodynamic model of the cardiovascular system's response to cardiovascular system actuators, such as vasoactive drugs, is generated. Two example actuators are employed in the example framework: phenylephrine, to raise blood pressure, and nicardipine, to lower blood pressure. The pharmacodynamic components employs a two-element Windkessel model. A model predictive control framework is built based on the pharmacokinetic-pharmacodynamic model.

Abstract: A portable insulin pump can utilize readings from a sensor incorporated into an infusion set used with the pump to deliver insulin to a patient to determine if the infusion set is or is likely to become dislodged from the patient. Readings from the sensor that are inconsistent with expected readings or a range of expected readings can indicate that the infusion set has become dislodged from the patient.

Abstract: A sheath, including a sheath body, a handle, and a traction wire. The traction wire includes a first traction wire. The handle includes a first guide rail member and a first slider. The first slider is connected to the first traction wire. A first groove is provided on an outer wall of the first guide rail member along an axial direction. The first groove includes a first bottom and a first side wall. The first slider slides in the first groove along the first side wall so as to drive the first traction wire to move. At least part of the outer wall of the first guide rail member is radially recessed to a central shaft of the first guide rail member to form the first groove.

Abstract: An adapter for connecting a first connector to a second connector can include a proximal portion configured to linearly engage the first connector with a snap-fit engagement. The adapter can include a distal portion configured to rotationally engage the second connector. Rotation of the adapter relative to the second connector can advance a male luer of the first connector into substantially sealing engagement with a female luer on the second connector. The adapter can be configured to displace a collar on the first connector when coupled to the first connector. The second connector can include a proximal portion that is configured to engage the first connector, such as with a snap-fit engagement.

Abstract: A method, system, and computer-readable medium are provided for a dual mode Closed-Loop Control (CLC) system integrating each of (i) an adaptive, personalized Model Predictive Control (MPC) control law that modulates the control strength of insulin infusion depending on recent past control actions, glucose measurements, and their derivative(s), (ii) an automatic Bolus Priming System (BPS) that commands additional insulin injections upon the detection of enabling metabolic conditions (e.g., an unannounced meal), and (iii) a hyperglycemia mitigation system (HMS) to avoid prevailing hyperglycemia.

Abstract: In an aspect, the present disclosure provides an insulin delivery device configured to be positioned on a body of a subject via a single puncture site in said body of said subject, wherein said insulin delivery device is configured to deliver an insulin or insulin analog formulation to said subject via said single puncture site, wherein said insulin delivery device comprises a sensor configured to measure a glucose concentration in said body of said subject via said single puncture site, and wherein said delivering and said measuring are performed at substantially the same time for a time period of at least 1 hour subsequent to said positioning, while maintaining a sensitivity of said sensor of at least 50% of an initial sensitivity of said sensor.

Abstract: A sensor system capable of detecting tissue counter pressure from patients that utilize infusion pumps to administer their medication is provided. Embodiments include a retrofitted piece that is placed between the user's infusion set and pump, as well as a “smart” infusion set configured for measuring characteristics of a fluid traveling therethrough. Hardware is provided that couples with the sensor to store, analyze, and compare data to distinguish between normal and non-normal injection/infusion profiles. An alert system notifies the user of a malfunction within the pump, within the infusion set, or at the injection/infusion site.